Prescription or Poison?: The Benefits and Dangers of Herbal Remedies
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About this ebook
Amitava Dasgupta
Amitava Dasgupta received his Ph. D in chemistry from Stanford University and completed his fellowship training in Clinical Chemistry from the Department of Laboratory Medicine at the University of Washington School of Medicine at Seattle. He is board certified in both Toxicology and Clinical Chemistry by the American Board of Clinical Chemistry. Currently, he is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Kansas Medical Center and Director of Clinical Laboratories at the University of Kansas Hospital. Prior to this appointment he was a tenured Professor of Pathology and Laboratory Medicine at the University of Texas McGovern medical School from February 1998 to April 2022. He has 252 papers to his credit. He is in the editorial board of four journals including Therapeutic Drug Monitoring, Clinica Chimica Acta, Archives of Pathology and Laboratory Medicine, and Journal of Clinical Laboratory Analysis.
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Reviews for Prescription or Poison?
18 ratings8 reviews
- Rating: 3 out of 5 stars3/5The best thing about this book is the thorough research done and the citing of references and studies to back up the author's writings. The book has been thoroughly researched. The laws in America for the testing of prescription drugs are such that there is data on the prescriptions while the herbs have no such requirement. Therefore the studies are not always available on the herbs or any of the alternative treatments. The author is so cautious it seems he always errs on the side of caution going with the prescription drug with a study over a very old plant based remedy which doesn't have a study on it. He is playing it safe, almost acting like a lawyer in his attempt to be so cautious. I also note the bias in the subtitle "the benefits and dangers of herbal remedies" YET he does not discuss negative known side effects of prescription drugs! What I wound up liking the most about this book was the thorough explanation of various alternative treatments and supplements. I learned more about the general nature of homeopathy than I'd read elsewhere for example. I also learned something I'd not seen in my readings about herbal tinctures: that a study has proven the shaking action of the plant matter in the menustrum is vital to the herbal medicine making process.Who is this book for is another question to be answered. There is too much here for the layperson reader to buy and use to look up say, how to best treat their common head cold. I would bet only a small number of very interested laypeople would buy this book to inform themselves and if they did they'd not read it cover to cover as they'd not care to know the best or worst treatments for a lot of conditions they don't suffer from and also of treatments they may have never even heard of in their life.The book probably is best for western medical doctors who want to know more about integrating what they call alternative medicine or for alternative medicine providers to use and inform themselves with. As I read the book I kept thinking it is so fear-based that I kept putting it down vowing to not ever want to take anything! It has so many warnings of kidney failure or liver damage (a main worry of the now commonly taken Lipitor cholesterol lowering drug). My opinion after reading the book was to think that the factory made prescription drugs are safer but if you read the package inserts required by law to be included with the medicine you will learn they have plenty of dangers themselves!
- Rating: 2 out of 5 stars2/5I found this resource to be disappointing. The warnings are given in a luke-warm fashion, the medications are listed generically when most people reading the book are aware only of the trade names and the repetition of language in various chapters made me wonder about the veracity if the comments. I am also doubtful that this is the "first book about the dangers of alternative remedies". The case studies are banal and lack substance. A less than compelling reference for this important topic.
- Rating: 4 out of 5 stars4/5With the proliferation of alternative therapies, medicines, and supplements, many people are justifiably concerned about their safety and use. It also seems as if the scientific and medical communities are more interested in rejecting the efficacy of such treatments than to reasonably discuss them with patients and others. This book, however, does well at bridging the gap. It is written by a doctor who understands the value that supplements and alternative therapies can provide. The book describes all kinds of popular supplements and therapies-- different herbs, vitamins, essential oils, homeopathy, etc. He describes either their history or the means by which the various therapies seem to work. He cites the research that shows the benefits or lack thereof from these practices, and perhaps most importantly, points out which ones are dangerous for people and which herbs, supplements, and other therapies conflict with medicines or other therapies. If you are interested in supplements, alternative therapies, and the like, and want to know how they work and for what, or if you take such things and are concerned about possible conflicts with other medicines, then this book is highly recommended.*-- received as part of early review program
- Rating: 5 out of 5 stars5/5I was a bit apprehensive going into this book, because I assumed the overall message would be "those who trust in herbal supplements are fools. Everyone needs to trust western medicine, and swallow our pills, because if you don't, we'll loose money to those dirty herb-selling hippies who are stealing our business." I did exaggerate a bit. I'm not that paranoid. Though, it is easy to believe that someone may only be motivated to write a book because of money, or the fear of losing money to competitors. I didn't trust that the author would be fair, or would have an un-biased approach. I was pleasantly surprised to find out that he was fair. He listed and explained the pros and cons of herbal remedies & other types of alternative medicine as well. The overall message of the book seemed to be, "some herbal remedies are safe, some are not. Here's what we know, here's what we don't know. Don't assume that just because the remedy has been used for thousands of years, that it's going to be safe now -- because the methods used in preparing the herbs are not the same methods that were used thousands of years ago." This book educates the reader & it's unbiased. It's worth the read -- although I would've liked to read more about how western medicine can be dangerous too. It's true, that just because an herb is natural doesn't mean it's safe --- BUT just because it's been tested in a lab, doesn't mean it's safe either. ...maybe I am paranoid. lol, all the same, this book deserves five stars
- Rating: 5 out of 5 stars5/5It would be a high estimate if I had to guess at the number of times I have considered a herbal supplement I read about in a magazine, heard rave reviews on from family and friends, or noticed on store display. After all, don't we all want a "miracle" cure for what ails us or to find ways to increase health odds? Each of those times, how handy a book like Prescription or Poison?: The Benefits and Dangers of Herbal Remedies would have been! I admit that I'm somewhat of a "Chicken Little" when it comes to trying new supplements. It takes me several days just to decide on a multi-vitamin. Needless to say, I do my research. Most herbs and supplements are unregulated and the information on the Internet is speculative. Family doctors, I've found, are not up-to-date on most herbal remedies and more importantly, drug interaction is a huge issue if you are taking any prescription or OTC medicine. What a find, a blessing, it is to have all my questions answered in one handy book! Prescription or Poison?: The Benefits and Dangers of Herbal Remedies is written in an easy-to-understand style, filled with quick-consult tables and charts, and contains information on every current supplement including Chinese and ayurvedic medicines. This guide even includes a section on food, drink, and tobacco drug interaction concerns.The author, Dr. Amitava Dasgupta, holds a MS in analytic chemistry from the University of Georgia and a PhD in organic chemistry from Stanford University, among a laundry list of other credentials. I felt that not only in resume, but in the straight-forward wording anecdoted with actual case studies, that the information contained in Prescription or Poison?: The Benefits and Dangers of Herbal Remedies is trustworthy and worthy of a thorough read.The chapters on toxic and deadly supplements were a bit unnerving, but highly educational and led me to reconsider how I approach and store topical medications as well as internal supplements. (If you have children, I highly recommend reading these two chapter thoroughly!)Overall, Prescription or Poison?: The Benefits and Dangers of Herbal Remedies is a wise investment. A guide that should be part of everyone's home reference library. If you are currently using or considering using any herbal supplement (including fish or flax oils,) I highly recommend that you get your hands on a copy of this guide first.
- Rating: 4 out of 5 stars4/5I ordered this book for my wife because she uses herbal medicines, and she tells me it is extremely good and reveals serious dangers in many widely used products. I should say anyone using these products should consult this book before trying a new herbal medication.
- Rating: 4 out of 5 stars4/5Pretty interesting stuff. I like how it gives the pros and cons of using different herbal remedies. It doesn't try to make you think one way or the other, just presents the information for you to make your own opinion.
- Rating: 5 out of 5 stars5/5I've studied herbal medicine for over 25 years now and this is the first reference book I would suggest to family members to help explain the benefits, and risks, of herbal medicine.Beginning with the demographics of herbal remedy users and running through safe, moderately safe and toxic herbal remedies plus special chapters on women's medicine, herbal/drug interactions and herbal/food interactions Prescription or Poison covers a lot of ground.It was a little disturbing to find that Black Cohosh was listed both in the safe category and the one describing herbal rememdies that cause liver damage. I did learn quite a bit about methyl salicylate (wintergreen) and how toxic it can be to children even when used as part of a muscle rub like Bengay - lock that stuff up and don't let your kids use it!If you take an herbal medicines or know someone who does - this is definitely a book to have and one to take with you on doctor's visits. I only hope they keep updating it with the newest information as it becomes available.
Book preview
Prescription or Poison? - Amitava Dasgupta
Table of Contents
Dedication
Title Page
Preface
Acknowledgements
CHAPTER 1 - Complementary and Alternative Medicines: Who Uses Them?
Is Any Herbal Remedy Safe?
Does the FDA Control the Sale of Herbal Supplements?
The Sale of Herbal Supplements Is on the Rise
Complementary and Alternative Medicines
The Benefits of Massage, Reiki, and Other Bio-Field Therapies
The Benefits of Acupuncture
The Benefits of Yoga, Meditation, and Prayer
Who Takes Herbal Supplements?
Common Herbal Supplements Taken by American Adults
Herbal Remedies and Medical Research
Conclusion
CHAPTER 2 - Some Relatively Safe and Effective Herbal Supplements
Generally Recognized as Safe (GRAS) Herbal Supplements
Other Dietary Supplements
Conclusion
CHAPTER 3 - Essential Oils and Fish-Oil Supplements: How Effective Are They?
Essential Fatty Acids (Omega-3 and Omega-6 Fatty Acids)
Essential Oils
Commonly Used Essential Oils
Fish Oil
Conclusion
CHAPTER 4 - Herbal Supplements That May Boost Your Immune System
The Immune System
Astragalus
Echinacea
Elderberry
Eucalyptus Oil
Garlic
Ginseng
Goldenseal
Honey
Hyssop
Larch Arabinogalactans
Licorice
Olive Leaf
Osha
Peppermint Oil
Sage
Other Miscellaneous Agents
Conclusion
CHAPTER 5 - Homeopathic Remedies: Relatively Safe Alternative Medicine
A Brief History of Homeopathy in the United States
Principles of Homeopathy
Current Acceptance of Homeopathy in the United States
Regulation of Homeopathic Remedies in the United States
Common Homeopathic Remedies
Does Homeopathy Work? The Scientific Research
Adverse Effects
Conclusion
CHAPTER 6 - Vitamins and Minerals
Vitamin A
Vitamin B Complex
Vitamin C
Vitamin D
Vitamin E
Vitamin K
Vitamin Toxicity
Mineral/Trace Elements
Do We Need Vitamin/Mineral Supplements?
Conclusion
CHAPTER 7 - Moderately Toxic Herbal Remedies That May Cause Organ Damage
Blood Tests to Check Liver Function
Herbal Supplements That Cause Liver Damage
Herbal Supplements That May Cause Kidney Damage
Herbal Supplements Toxic to the Heart and Miscellaneous Other Toxicities
Conclusion
CHAPTER 8 - Severely Toxic Herbal Remedies That May Even Cause Death
Herbal Supplements That Are Severely Toxic
Other Herbal and Natural Supplements You Should Avoid as Possibly Toxic
Conclusion
CHAPTER 9 - How Herbal Remedies Interact with Your Medicines
Drug-Drug and Drug-Herb Interaction
Who Is Most Vulnerable to Drug-Herb Interactions?
What Are the Chances of Experiencing Drug-Herb Interactions?
How St. John’s Wort Can Interact with Drugs
Possible Interactions of Warfarin and Herbal Supplements
Possible Drug Interactions with Ginkgo Biloba
Possible Drug Interactions with Ginseng
Possible Drug Interactions with Kava
Possible Drug Interactions with Valerian
Other Miscellaneous Drug-Herb Interactions
Conclusion
CHAPTER 10 - Food, Alcohol, Fruit Juices, Smoking — and Your Meds
Food-Drug Interactions
Alcohol-Drug Interactions
Smoking and Your Medications
Possible Drug Interactions with Grapefruit Juice
Drug Interactions with Orange Juice
Drug Interactions with Pomelo, Cranberry, and Pomegranate Juices
Conclusion
CHAPTER 11 - Herbal Supplements, Alternative Therapies, and Women’s Health
Supplements and Remedies Used at Menopause
Supplements and Remedies Used During Pregnancy
Herbs That Are Effective in Treating Other Women’s Health Issues
Herbs That Are Not Effective or for Which There Is Insufficient Data
Aromatherapy, Acupuncture, and Acupressure
Conclusion
CHAPTER 12 - How Herbal Remedies May Affect Laboratory Test Results
Liver-Function Tests
Glucose Tests
Kidney Function Tests
Blood Electrolytes Tests
Thyroid Tests
Therapeutic Drug Monitoring
Digoxin Monitoring
Patients Using Herbal Remedies During Surgery
Herbal Remedies Contaminated with Western Drugs
Conclusion
CHAPTER 13 - Herbal Remedies That Are Misidentified or Contaminated with Heavy ...
Misidentification of Herbal Supplement
Unintentional Versus Intentional Contamination of Herbal Products
Heavy-Metal Contamination of Herbal Supplements
Pesticide Contamination of Herbal Supplements
Herbal Supplements Contaminated with Western Drugs
Traditional Chinese Medicine: Is There Any Good News?
Conclusion
CHAPTER 14 - An Introduction to Ayurvedic Medicine
The Basic Principles of Ayurvedic Medicine
Ayurvedic Medicines
Efficacy
Dangers of Ayurvedic Medicines: Heavy-Metal Toxicity
Conclusion
Appendix A: - Generic and Trade Names of Drugs Discussed in This Book
Appendix B: - Herbal Supplements You Should Avoid Because They Are Potentially Toxic
Notes
Glossary
Further Reading
Index
Copyright Page
DEDICATION
To my wife, Alice
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Important Note
The material in this book is intended to provide a review of information regarding the efficacy and toxicity of herbal remedies, as well as the interrelations between herbal supplements and Western drugs. Every effort has been made to provide accurate and dependable information. The contents of this book have been compiled through professional research and in consultation with medical and mental-health professionals. However, health-care professionals have differing opinions, and advances in medical and scientific research are made very quickly, so some of the information may become outdated.
Therefore, the publisher, authors, and editors, as well as the professionals quoted in the book, cannot be held responsible for any error, omission, or dated material. The authors and publisher assume no responsibility for any outcome of applying the information in this book in a program of self-care or under the care of a licensed practitioner. If you have questions concerning your nutrition or diet, or about the application of the information described in this book, consult a qualified health-care professional.
A Note on Usage
Throughout the book generic drug names are used, but occasionally trade names for well-known drugs are included in parenthesis to help ground the nonmedical reader. A full listing of generic and trade names used in this book appears in Appendix A.
Preface
Today, a significant percentage of Americans turn to complementary and alternative medicines to improve their health. These medicines include herbal remedies, traditional Chinese medicines, Ayurvedic medicines, and homeopathic remedies as well as noninvasive modalities such as massage, energy work, yoga, acupuncture, and meditation. In general, people who use these alternative therapies have a college degree and a decent income; also, more women than men use alternative therapies. People turn to complementary and alternative medicine thinking that such therapies are safe and effective and are a viable alternative to Western medicine. Although many alternative modalities such as energy work, massage, yoga, and meditation are safe and may also have efficacy, not all herbal remedies are safe. Because of a general misconception that anything natural
is safe, people use herbal remedies based on recommendations from friends, family members, or store clerks who might not be educated in medicine or pharmacology. Many users of herbal remedies suffer ill effects. Many books, readily available in health-food stores and bookstores, focus on the efficacy of a variety of herbal supplements with little discussion of toxicity, drug-herb interaction, and food-drug interaction. In addition, these books are mostly based on the personal experience of the authors rather than published information in medical literature.
In this book, I present an unbiased view of the benefits and dangers of herbal remedies based on published articles in the medical literature as well as results published by our research group on herbal remedies. In Chapter 1, I discuss the demographics of people who use complementary and alternative medicine and the most popular herbal remedies in the United States. In Chapter 2, some safe and effective herbs are discussed. At present, scientific research shows that approximately fifty herbs are relatively safe, and some of them are also effective. Chapter 3 is dedicated to a discussion of essential oils and fish oils. Many essential oils have antibacterial properties, and tea tree oil is effective in treating minor skin rashes. Lavender oil has a soothing effect, and massage using essential oil has health benefits. Eating fish or taking fish oil supplements also has certain health benefits. In Chapter 4, herbal remedies that may boost the immune system are discussed. Echinacea is a safe herb and may be effective in reducing symptoms from flu and cold. Chapter 5 is dedicated to a discussion of homeopathic remedies. Although how homeopathy works cannot be explained with modern scientific theory, the efficacy of certain homeopathic remedies has been published in the medical literature. In addition, adverse effects from the use of homeopathic remedies are rare. In Chapter 6, vitamin and mineral supplements are discussed. Contrary to popular belief, vitamins in megadoses are toxic and excess intake of fat-soluble vitamins such as vitamins D, A, K, and E may increase mortality rather than prolong healthy life. For a healthy person, one multivitamin/mineral supplement a day is sufficient. However, pregnant women may need more folate and iron, and the elderly must also take multivitamin/multimineral supplements based on the recommendation of their physicians. Chapters 7 and 8 discuss herbal supplements that may cause organ damage, toxicity, and even death. In Chapter 9, I discuss herbal remedies that interact with Western drugs, causing toxicity. At the end of the book, trade names of all these drugs are listed for easy reference. Certain medications also interact with your food and drink. If you are taking certain medications for treating a chronic condition, you should consult with your doctor to see if you can drink grapefruit juice. Chapter 10 discusses drug-food interactions. Chapter 11 specifically addresses herbs used by women, while Chapter 12 covers the effects herbal medicines can have on the results of clinical laboratory tests. In Chapter 13, herbal medicines contaminated with lead and other toxic metals are discussed. Chapter 14 is devoted to discussion of Ayurvedic medicines, some of which contain heavy metals such as lead, arsenic, and mercury, either as a component or as a contaminant. Some traditional Chinese medicines produced in China and Hong Kong are contaminated with heavy metals or Western drugs. Consumers should be aware of taking such contaminated products.
Currently, there is a lot of enthusiasm among doctors, pharmacists, and scientists regarding herbal medicines because it is possible to isolate their active components, and these might be the drugs of the future. Many medical-school curriculums incorporate herbal medicine. Your doctor, nurse, and pharmacist should be knowledgeable about herbal remedies, and disclosing the remedies you are taking to your doctor is a good idea because he or she can likely guide you to avoid unwanted herbal supplements and take the ones which may help you. Your doctors, nurses, and pharmacists are committed to what is best for your health, and a holistic approach to treatment is sometimes useful. Like many physicians and scientists, I have received grants from pharmaceutical industries for conducting research, but none of us sell our souls to the pharmaceutical industry. It is not true that doctors are against complementary and alternative medicines because they are loyal to the pharmaceutical industries. Your doctor is committed to your well-being and your health. Certain herbal remedies may do more harm than good, and when your doctor asks you to stop taking such a supplement, he or she is looking at what is best for you and nothing else. Therefore, trust your doctor and disclose all herbal supplements you are taking. You will be glad that you did.
Acknowledgments
I would like to thank Jacqueline G. Garcia, MBA, EdD, for critically reading and editing the entire manuscript and providing helpful suggestions. Ms. Alice Wells also read the entire manuscript, and I thank her for her helpful comments. Last but not least, I thank my wife, Alice, for putting up with me during the long evening and weekend hours I devoted to writing this book.
—Amitava Dasgupta, PhD
Houston, Texas
CHAPTER 1
Complementary and Alternative Medicines: Who Uses Them?
For most of human history, herbal remedies were the only medicines available to treat various illnesses. About one hundred years ago, 59 percent of all medicines listed in the 1890 version of the U.S. Pharmacopeia were from herbal products.¹ Today, as many as one-third to approximately one-half of all drugs on the market are derived from plants or natural sources. For example, the antibiotic streptomycin is derived from a soil bacterium (Streptomyces griseus), while the immunosuppressant drug cyclosporine, which is used to prevent organ rejection in transplant recipients, is derived from a soil fungus. Several anticancer drugs, such as vincristine, vinblastine, and paclitaxel (Taxol), are also derived from plants. The widely used cardioactive drug digoxin is extracted from the foxglove plant (Digitalis lanata). So, the question is: Since herbal supplements are derived from plants, do we need to exercise caution in taking them in the same way we take precautions when using prescription drugs?
Myth: Anything natural is safe..
Reality: Some natural products are safe, but others can be toxic..
This book is an honest discussion of the benefits and dangers of herbal remedies and is based on published reports in medical journals.
The major differences between natural supplements and Western drugs are as follows:
1. When Western drugs are prepared from plants, specific manufacturing processes are employed to isolate the active natural ingredient from other crude plant products. In addition, rigorous quality-control procedures are in place to ensure that the amount of the active ingredient is constant or nearly consistent among all samples. So if you take one digoxin tablet containing 0.6 mg of digoxin today and you take another digoxin tablet six months later from a different prescription refill, you will ingest the same amount of digoxin. In the preparation of herbal supplements, such rigorous quality-control procedures are not always adhered to. For example, in different St.-John’s-wort preparations, the amount of the active ingredients may vary widely.
2. There is a big difference between taking crude natural products and the Western drugs prepared from them. Are you willing to eat fungus instead of taking a penicillin-containing antibiotic tablet in which the penicillin is derived from fungus? Think about another scenario. Can you run your car on crude oil? Not only must oil be refined first, but some manufacturers recommend that you use premium gasoline in your car. Many herbal supplements can be used as a starting material for future drugs, but just as oil needs refining and grapes need fermenting, natural active ingredients need to be isolated from the plant before they can be used as medicines.
3. Many plant products are toxic. When a tiger is on the prowl, a gazelle runs for its life. Unfortunately, plants can’t run away from danger. Therefore, they produce toxic substances to discourage animals from eating them. Frequently, these products are toxic to humans as well. In an herbal supplement, one ingredient might produce the desired therapeutic benefit, while other ingredients produce toxicity. Since all components are extracted together in making herbal supplements and good components are not usually separated from toxic components, toxicity may occur following the use of common herbal supplements.
4. Western medicines may also cause toxicity, but due to rigorous research, these toxic effects quickly become known to health-care providers. Toxicities of herbal supplements are not well studied. For example, during the 1990s, kava, an herbal supplement used as an antianxiety and sleep aid, was considered relatively safe and as effective as tricyclic antidepressants. However, now it is well established that long-term use of kava may cause severe liver toxicity and even death. It is interesting that the South Pacific Islanders who use kava drinks for religious ceremonies do not suffer from kava-induced liver toxicity. This may be due to the fact that they drink kava extract infrequently or they drink aqueous (water) extract of kava, which may not contain harmful chemicals. Most kava products sold in the United States are a water/alcohol extract of the plant.
5. Some herbalists argue that herbal remedies were used for thousands of years and that native people reaped the medical benefits and did not experience toxicity. The truth is, native people often chewed leaves or roots or prepared tea by boiling plant parts. Therefore, only small amounts of plant alkaloids (active ingredients as well as toxic substances) were extracted, which may have caused lesser toxicity. In addition, historical documentation of toxicity from herbal remedies may be poor because those native people may not have reported adverse effects out of respect for the healers. Today, herbal supplements are prepared using modern extraction techniques and therefore most likely contain more active ingredients, thus potentially causing more toxicity.
6. One reason some herbal supplements may cause toxicity is the dosage. It is well documented that most drugs are toxic if given in high dosages. Even aspirin and acetaminophen (Tylenol) can kill you if you take too much, and emergency rooms worldwide commonly deal with life-threatening poisoning from these easily available over-the-counter drugs. Acetaminophen, if taken for a long time at a high dosage, can cause significant liver toxicity but is safe at the recommended dosage — a maximum of up to 2,000 mg (2 gm) per day — for a few days. Under a physician’s advice even a maximum dosage of up to 4,000 mg per day (4 gm) for a few days is tolerable, but people who consume alcohol may experience liver toxicity even with the lower recommended dosage of acetaminophen. Some popular over-the-counter (OTC) medications might contain acetaminophen under different names, so when combining medications, always make sure that the totals do not exceed the recommended dosage. If you consume alcohol on a daily basis, do not take acetaminophen or acetaminophen-containing medication without consulting a doctor. Do not consume alcohol when you take acetaminophen. Dosages of many herbal supplements are not determined by rigorous clinical trials, and in most cases are determined without any extensive study using human subjects. Toxicities of many herbal supplements such as kava have been documented to be dosage-related.
Just as safe drugs such as aspirin and acetaminophen, if taken at very high dosage, can cause life-threatening toxicity, toxicities of many herbal remedies may be related to high dosage.
Is Any Herbal Remedy Safe?
Of course, many herbal supplements are safe, as are several plant oils intended for topical use to treat local infection, skin rashes, and related problems. Tea-tree oil and eucalyptus oil have antibacterial properties and are a safe and effective way to treat a skin rash. However, if a rash does not resolve in four to seven days, you may need to contact a health-care provider. Green tea and various herbal teas such as ginseng tea are safe and can be used as health tonics. According to the authors of one published report, comfrey, life root, borage, calamus, chaparral, licorice, and Ma Huang are unsafe; relatively safe herbs include feverfew, garlic, ginkgo, Asian ginseng, saw palmetto, St. John’s wort, and valerian.²
Does the FDA Control the Sale of Herbal Supplements?
The U.S. Food and Drug Administration (FDA) regulates all prescription and nonprescription drugs sold in the United States. For example, phenylpropanolamine, a common ingredient of many over-the-counter cold medications, is no longer approved for use because it may cause toxicity to the heart. Within a few weeks following the FDA ban, all drug manufacturers withdrew cold medications containing phenylpropanolamine and replaced that active ingredient with a safer alternative. Herbal remedies are sold under the 1994 Dietary Supplement Health and Education Act and are classified as food supplements. According to this law, food supplements also include vitamins, minerals, amino acids, extracts, metabolites, etc. Manufacturers of herbal remedies are not allowed to claim any medical benefit from using their products, but they are not under surveillance by the FDA. Therefore, unlike drugs, dietary supplements can be manufactured and sold without demonstrating safety and efficacy to the FDA.
For a new drug, the manufacturer must demonstrate the safety and efficacy to the FDA before the drug can be sold legally in the United States. In contrast, for herbal remedies, the FDA has the burden to prove that a supplement is unsafe and/ or to recommend that the product be removed from the market. Unfortunately, even after recommending that an herbal supplement is not safe and should be withdrawn from the market, the FDA cannot legally force the manufacturer to stop producing or selling that particular product. For example, in 2002 the FDA issued a warning regarding the safety of kava because it had been reported that prolonged use of kava could cause serious liver damage. However, even today, kava products are widely available in health-food stores. The Canadian government also issued warnings against the use of kava, but two months after the advisory, twenty-two of thirty-four stores surveyed in Toronto recommended the use of kava and only nine mentioned any safety concerns. The authors in this Canadian study concluded that federal advisories may not affect the sales of unsafe products.³
In many countries, herbal supplements are not well regulated. However, in 1978 Germany created an expert committee, called Committee E, to review herbal drugs and preparations from medicinal plants. Committee E issued a series of monographs on the safety and efficacy of herbal products that were based on a review of historical information; chemical, pharmacological, clinical, and toxicological study findings; case reports; epidemiological data; and unpublished manufacturers’ data. If an herb has an approved monograph, it can be marketed. (All 380 Commission E monographs are collected in book form; the commission no longer exists.) Currently, there is a push for streamlining regulation of the European market for herbal supplements. A directive released in 2004 by the European Parliament and the Council of Europe now provides the basis for regulation of herbal supplements in European markets. This directive requires that herbal medicines be authorized by the national regulatory authorities of each European country and that these products must be safe. The safety of a supplement will be established based on published scientific literature, and when safety is not deemed sufficient, it will be communicated to consumers. In Europe, there will be two kinds of herbal supplements in the future: herbal supplements with wellestablished safety and efficacy, and traditional herbal supplements, which do not have a recognized level of efficacy but are deemed to be relatively safe.⁴
The Australian government created the Complementary Medicines Evaluation Committee in 1997 to address regulatory issues regarding herbal remedies. The Canadian government implemented a policy on 1 January 2004 to regulate natural health products. Naturopaths, traditional Chinese-medicine practitioners, homeopaths, and herbalists in Canada are concerned that this policy will eventually affect their access to the products they need to practice effectively.⁵
The Sale of Herbal Supplements Is on the Rise
In the United States, the sale of herbal remedies skyrocketed from $200 million in 1988 to over $3.3 billion in 1997; to an estimated $15.7 billion a mere three years later, in 2000; and to an estimated $18.8 billion in 2003.⁶ The use of herbal remedies is also widespread in the European Community, with an estimated annual sale of $7 billion in 2001.⁷ It is estimated that roughly 20,000 herbal products are available in the United States, and in one survey, approximately one out of five adults reported using an herbal supplement within the past year. The ten most commonly used herbal supplements are echinacea, ginseng, ginkgo biloba, garlic, St. John’s wort, peppermint, ginger, soy, chamomile, and kava.⁸
Complementary and Alternative Medicines
Complementary and alternative medicines (CAM) include naturopathy, homeopathy, herbal supplements, traditional Chinese medicines, Indian Ayurvedic medicines, diet-based therapy, chiropractic, massage therapy, Reiki and other types of energy healing, acupuncture, yoga, biofeedback, hypnosis, meditation, and prayer. The use of the many modalities of CAM is on the rise in the United States and in many other countries around the world. In addition, people are also becoming increasingly interested in consuming organic food and following healthy diets. Although this book is focused on herbal remedies, a brief discussion of other types of complementary and alternative therapies may be helpful.
Many people approach CAM practitioners to address problems such as chronic pain and fatigue when there is a perception that these problems are not adequately addressed by their primary-care physician. A large number of people also believe that natural remedies are much safer than Western drugs. In addition, pseudo-medical jargon and elaborate marketing claims confuse many consumers and encourage them to believe in the efficacy of unproven alternative therapies.⁹ In Table 1.1, the estimated number of people using various types of CAM in 1999 and 2002 are listed.¹⁰ In 2002 the most commonly used CAM in the United States was herbal supplements, which were taken by an estimated 38 million adults, followed by relaxation techniques (29 million adults) and chiropractic (15 million adults). Among CAM users, 41 percent used two or more CAM therapies.¹¹
TABLE 1.1: Estimated U.S. Population Using Various Types of Complementary and Alternative Medicine in 1999 and 2002
The Benefits of Massage, Reiki, and Other Bio-Field Therapies
The National Center for Complementary and Alternative Medicine classifies therapeutic touch, healing touch, and Reiki as bio-field therapies and acknowledges the use of such subtle energy therapies for health benefits. These therapies are noninvasive and are based on compassionate touch and the presence of a provider who is willing to help the recipient. They take place in a calm and nurturing environment, in contrast to the traditional stressful environment of medical therapies. Healing-touch practices are found throughout the history of nursing, and the American Holistic Nurses Association endorses energy therapies.¹⁴
Noninvasive CAM can be fairly safe if the practitioner is properly trained. For example, massage therapy can provide relaxation and other benefits and is best if performed by a licensed massage therapist who has undergone extensive training procedures and who understands for which diseases or conditions massage therapy is not appropriate. If you go to an untrained therapist with