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    Essential Thrombocytosis, (Excess Platelets) A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Essential Thrombocytosis, (Excess Platelets) A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Essential Thrombocytosis, (Excess Platelets) A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Ebook95 pages50 minutes

    Essential Thrombocytosis, (Excess Platelets) A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions

    By Kenneth Kee

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    About this ebook

    This book describes Essential Thrombocytosis, Diagnosis and Treatment and Related Diseases
    Essential thrombocytosis (ET) is a medical disorder in which the bone marrow produces too many platelets.
    Platelets are a part of the blood that helps in blood clotting.
    Thrombocytosis is measured as a platelet count above the upper limit of the normal range (450 x 109/L in adults)
    It is essential to differentiate between true hematological disease causing primary thrombocytosis and secondary or reactive thrombocytosis produced by an overstated physiological response to a primary disorder.
    Primary or essential thrombocytosis is a chronic myeloproliferative disorder (produced by bone marrow).

    Causes
    Essential thrombocytosis happens from an overproduction of platelets.
    Untreated, ET becomes worse over time.
    Since these platelets do not work normally, blood clots and bleeding are frequent disorders.
    ET is part of a group of disorders known as myeloproliferative disorders.
    Others are:
    1. Chronic myelogenous leukemia (cancer that starts in the bone marrow)
    2. Polycythemia vera (bone marrow disease leading to a rise in the number of blood cells)
    3. Primary myelofibrosis (bone marrow disorder where fibrous scar tissue replaced the marrow)
    Many people with ET have a mutation of a gene (JAK2, CALR, or MPL).
    Essential thrombocytosis is most frequent in middle aged people.
    It can also be observed in younger people, particularly women under age 40.

    Symptoms
    Frequent symptoms of blood clots may be:
    1. Headache (most frequent)
    2. Tingling, coldness, or blueness in the hands and feet
    3. Feeling dizzy or lightheaded
    4. Vision problems
    5. Mini-strokes (transient ischemic attacks) or stroke
    If bleeding is a difficulty, symptoms may be:
    1. Easy bruising and nosebleeds
    2. Bleeding from the gastrointestinal tract, respiratory system, urinary tract, or skin
    3. Bleeding from the gums
    4. Prolonged bleeding from surgical procedures or tooth removal

    Diagnosis
    Most of the time, Essential thrombocytosis is found through blood tests done for other health complaints before symptoms occur.
    The doctor may detect an enlarged liver or spleen on physical examination.
    The patient may also have abnormal blood flow in the toes or feet that produces skin injuries in these areas.
    Other tests may be:
    1. Bone marrow biopsy
    2. Full blood count (FBC)
    3. Genetic tests (to look for a change in the JAK2, CALR, or MPL gene)

    Treatment
    The treatment requires an evaluation of the patient's risk and where possible taking remedial action.
    Patients with essential thrombocythemia are regarded as having high risk of:
    1. Thrombosis if they are older than 60 years or have a previous history of thrombosis
    2. Bleeding if platelet counts are above 1,500 x 109/L.
    Patients with low-risk essential thrombocythemia are normally treated with low-dose aspirin,
    The treatment of high-risk essential thrombocythemia is based on the use of cytoreductive therapy
    Hydroxyurea is the drug of choice and interferon alfa (IFN-α) is reserved for young patients or pregnant women
    In patients with low risk, simple observation may be acceptable.
    They are likely not to have a high risk of complications of surgery or pregnancy.
    Where there are symptoms of micro-vascular occlusion such as erythromelalgia, low-dose aspirin may be very effective.
    In high-risk patients, with very high platelet counts, the platelets must be decreased.
    Possible treatments are hydroxyurea, anagrelide or IFN-α.
    When there are acute complications, platelet-pheresis may attain a rapid drop in platelet count.
    If patients need elective surgery cyto-reductive therapy should be used to decrease the risk of both thrombosis and hemorrhage

    TABLE OF CONTENT
    Introduction
    Chapter 1 Essential Thrombocytosis
    Chapter 2 Causes

    LanguageEnglish
    PublisherKenneth Kee
    Release dateAug 6, 2018
    ISBN9780463268803
    Essential Thrombocytosis, (Excess Platelets) A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Author

    Kenneth Kee

    Medical doctor since 1972.Started Kee Clinic in 1974 at 15 Holland Dr #03-102, relocated to 36 Holland Dr #01-10 in 2009.Did my M.Sc (Health Management ) in 1991 and Ph.D (Healthcare Administration) in 1993.Dr Kenneth Kee is still working as a family doctor at the age of 74However he has reduced his consultation hours to 3 hours in the morning and 2 hours inthe afternoon.He first started writing free blogs on medical disorders seen in the clinic in 2007 on http://kennethkee.blogspot.com.His purpose in writing these simple guides was for the health education of his patients which is also his dissertation for his Ph.D (Healthcare Administration). He then wrote an autobiography account of his journey as a medical student to family doctor on his other blog http://afamilydoctorstale.blogspot.comThis autobiography account “A Family Doctor’s Tale” was combined with his early “A Simple Guide to Medical Disorders” into a new Wordpress Blog “A Family Doctor’s Tale” on http://ken-med.com.From which many free articles from the blog was taken and put together into 1000 eBooks.He apologized for typos and spelling mistakes in his earlier books.He will endeavor to improve the writing in futures.Some people have complained that the simple guides are too simple.For their information they are made simple in order to educate the patients.The later books go into more details of medical disorders.He has published 1000 eBooks on various subjects on health, 1 autobiography of his medical journey, another on the autobiography of a Cancer survivor, 2 children stories and one how to study for his nephew and grand-daughter.The purpose of these simple guides is to educate patient on health disorders and not meant as textbooks.He does not do any night duty since 2000 ever since Dr Tan had his second stroke.His clinic is now relocated to the Buona Vista Community Centre.The 2 units of his original clinic are being demolished to make way for a new Shopping Mall.He is now doing some blogging and internet surfing (bulletin boards since the 1980's) startingwith the Apple computer and going to PC.The entire PC is upgraded by himself from XT to the present Pentium duo core.The present Intel i7 CPU is out of reach at the moment because the CPU is still expensive.He is also into DIY changing his own toilet cistern and other electric appliance.His hunger for knowledge has not abated and he is a lifelong learner.The children have all grown up and there are 2 grandchildren who are even more technically advanced than the grandfather where mobile phones are concerned.This book is taken from some of the many articles in his blog (now with 740 posts) A Family Doctor’s Tale.Dr Kee is the author of:"A Family Doctor's Tale""Life Lessons Learned From The Study And Practice Of Medicine""Case Notes From A Family Doctor"

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      Book preview

      Essential Thrombocytosis, (Excess Platelets) A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions - Kenneth Kee

      Essential Thrombocytosis,

      (Excess Platelets)

      A

      Simple

      Guide

      To

      The Condition,

      Diagnosis,

      Treatment

      And

      Related Conditions

      By

      Dr Kenneth Kee

      M.B.,B.S. (Singapore)

      Ph.D (Healthcare Administration)

      Copyright Kenneth Kee 2018 Smashwords Edition

      Published by Kenneth Kee at Smashwords.com

      Dedication

      This book is dedicated

      To my wife Dorothy

      And my children

      Carolyn, Grace

      And Kelvin

      This book describes Essential Thrombocytosis, Diagnosis and Treatment and Related Diseases which is seen in some of my patients in my Family Clinic.

      (What The patient Need to Treat Essential Thrombocytosis)

      This eBook is licensed for your personal enjoyment only. This eBook may not be re-sold or given away to other people. If you would like to share this book with another person, please purchase an additional copy for each reader.

      If you’re reading this book and did not purchase it, or it was not purchased for your use only, then please return to Smashwords.com and purchase your own copy.

      Thank you for respecting the hard work of this author.

      Introduction

      I have been writing medical articles for my blog: http://kennethkee.blogspot.com (A Simple Guide to Medical Disorder) for the benefit of my patients since 2007.

      My purpose in writing these simple guides was for the health education of my patients.

      Health Education was also my dissertation for my Ph.D (Healthcare Administration).

      I then wrote an autobiolographical account of his journey as a medical student to family doctor on his other blog: http://afamilydoctorstale.blogspot.com.

      This autobiolographical account A Family Doctor’s Tale was combined with my early A Simple Guide to Medical Disorders into a new Wordpress Blog A Family Doctor’s Tale on http://kenkee481.wordpress.com.

      From which many free articles from the blog was taken and put together into 800 eBooks.

      Some people have complained that the simple guides are too simple.

      For their information they are made simple in order to educate the patients.

      The later books go into more details of medical disorders.

      The first chapter is always from my earlier blogs which unfortunately tends to have typos and spelling mistakes.

      Since 2013, I have tried to improve my spelling and writing.

      As I tried to bring the patient the latest information about a disorder or illness by reading the latest journals both online and offline, I find that I am learning more and improving on my own medical knowledge in diagnosis and treatment for my patients.

      Just by writing all these simple guides I find that I have learned a lot from your reviews (good or bad), criticism and advice.

      I am sorry for the repetitions in these simple guides as the second chapters onwards have new information as compared to my first chapter taken from my blog.

      I also find repetition definitely help me and maybe some readers to remember the facts in the books more easily.

      I apologize if these repetitions are irritating to some readers.

      Chapter 1

      Essential thrombocytosis

      What is Essential thrombocytosis?

      Essential thrombocytosis (ET) is a medical disorder in which the bone marrow produces too many platelets.

      Platelets are a part of the blood that helps in blood clotting.

      Thrombocytosis is measured as a platelet count above the upper limit of the normal range (450 x 10⁹/L in adults)

      It is essential to differentiate between true hematological disease causing primary thrombocytosis and secondary or reactive thrombocytosis produced by an overstated physiological response to a primary disorder.

      There are a number of hematological disorders producing thrombocytosis.

      Primary or essential thrombocytosis is a chronic myeloproliferative disorder (produced by bone marrow).

      There are other hematological disorders which can cause thrombocytosis, such as other myeloproliferative neoplasms (MPNs), myelodysplastic syndromes (MDS) and overlap syndromes

      MPNs such as essential thrombocythemia, polycythemia vera and myelofibrosis are Philadelphia-negative clonal disorders of the bone marrow

      Incidence

      Primary thrombocytosis

      The incidence is about 30 in 100,000 populations.

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