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tablet
26.3mg
Malaria
Prevention: 0.5 mg base/kg PO qDay Treatment: 0.3 mg base/kg PO qDay for 14 days (not to exceed adult dose)
Other Information
Monitor: CBC
Contraindications
Hypersensitivity G-6-PD deficiency Pregnancy Not to be administered w/ other potentially hemolytic drugs or bone marrow depressants Diseases predisposing to graulocytopenia (eg, RA, SLE) Absorption: well absorbed Metabolism: hepatic to carboxyprimaquine (active) Half-life, Elimination: 3.7-9.6 hr Peak Plasma Time: 1-2 hr Excretion: urine (small amounts as unchanged drug)
Mechanism of Action
Disrupts Plasmodium mitochondria
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