PRINCIPLES

OF RIBOSOME
STRUCTURE

A. S. SPIRIN

. .

.., 1998

Several basic principles

of structural organization
of the ribosome are formulated: 1) the ribosome
is constructed of two
unequal subparticles (ribosomal subunits); 2) the
core of each ribosomal
subparticle is formed by
high-polymer ribosomal
RNA self-folded into a
compact body of specific
conformation; 3) diverse
ribosomal proteins are
assembled on the RNA
core, each protein recognizing its specific binding
site.
: 1)
; 2) fl


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, 11, 1998

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. 2. Escherichia coli
() :
,
(30S) (50S) ;
,
(50S) , (30S) ( .. , , )

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(S). 3 106
70S 70S-,
(, )
80S-. :
70S

50S + 30S;

80S

60S + 40S.

..

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( 1500 ), 28S
(47004800 ) 18S (
1900 ). ,

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67

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68

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S1
L1
L2
L3
L4
S3
L9 L10
S4
L5
L11
S5/L6
L7/L12 S6
S7
L13
S8
L15 L16
L14
S10
L17
S9/S11
L18
S12/L20
L19
L21
L22
L23
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L24
L25
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S16
S18
S17
S19
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L29
L30

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L27
S21

L32/L33

. 4. (Escherichia coli) 70S

. S (small)
(30S) , L (large)
(50S) ( .. , , )

, 11, 1998

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69

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1. .. : . .: . ., 1986. 300 .
2. . . .: ,
1978. 700 .

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, 11, 1998