Tc dng ca cyclodextrins vi n nh v tc dng ca thuc n nh ca thuc 1.1.

1. Ngn nga s kt ta ca thuc Phn t CDs u tin c s dng ngn nga s kt ta li trong thuc ca nhng thuc tan km trong qu trnh bo qun 1.2. n nh i vi cc hp cht d b phn hy n nh ca cc hp cht d b phn hy trong cng thc l thc s cn thit duy tr hiu qu ca thuc.

Cyclodextrins handbook of pharmaceutical excipients

4. Cng thc ha hc v khi lng phn t -cyclodextrin C36H60O30 - cyclodextrin C42H70O35 - 972 - 1135 - 1297

Gama- cyclodextrin C48H80O40 Cc dn cht

+ Dimethyl - cyclodextrin : KLPT:1331 (DM -CD) + 2-hydroxyethyl- -cyclodextrin + Trimethyl- -cyclodextrin 5. Cu trc ha hc

6. nh ngha 7. ng dng 8. nh ngha cc cyclodextrin l cc oligosaccharide vng cha t nht 6 n v (+)-glucopyranose c gn vi nhau bi lin kt (14)glucoside. 3 cyclodextrin t nhin l , ,gama khc nhau kch thc vng v tan. Chng bao gm 6,7, hay 8 n v glucose nh sn.

cc cyclodextrin c mu trng, thc t khng mi, dng bt kt tinh nh, mn, c v hi ngt. mt vi cyclodextrin c tm thy dng bt v nh hnh. Bng 1: Tiu chun dc in ca -cyclodextrin Php th nh tnh M t Mu sc v trong ca dung dch PH Gc quay cc Gii hn nhim khun Tro sulfate Dc in Chu u 6.0 + Dc in M USP32-Anh NF27 +

Kim loi nng

Mt khi lng do lm kh Tp cht lin quan

nh lng (dng base khan)

9. tiu chun dc in xem bng 1, 2, 3 10.c tnh in hnh h s nn: 21.0-44.0% vi -cyclodextrin 11.