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Gold, 2009

40
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2002 . 600
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200-300 .
2,74 (2000 .);
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2020 . 3-
4,7 .



3.0
3.0
2.5
2.5

59%

64%

35%

+163%

7%

2.0
2.0
1.5
1.5
1.0
1.0
0.5
0.5
0.0 0

1965 - 1998 1965 - 1998 1965 - 1998 1965 - 1998 1965 - 1998
Source: NHLBI/NIH/DHHS


6


1970 2002 .

Source: Jemal A. et al. JAMA 2005

Number Deaths x 1000

:
, , 1980-2000
70
60
Men

50
40

Women
30
20
10
0
1980

1985

1990

1995

2000

Source: US Centers for Disease Control and Prevention, 2002

:


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Pulmonary Hypertension in COPD


Chronic hypoxia

Pulmonary vasoconstriction

Muscularization
Pulmonary hypertension

Intimal
hyperplasia
Fibrosis

Cor pulmonale

Obliteration
Edema

Death
Source: Peter J. Barnes, MD

Ep cells

CD4+ (Th2)

CD8+
(Tc1)

Ep cells

Source: Peter J. Barnes, MD

Source: Peter J. Barnes, MD


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FEV1

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160 g

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100%


35

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