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,

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.
, () [1],

[2] .

()

[3-9]

() [10-13], ,
,
[1, 2, 14-16].
()
, [10, 12,
17-24]. - [4]
[11].
[22, 25-30]
() () [15, 31-38].
, ,
[4, 39-41] [42-45]. ,

.
[1, 13, 14, 19, 22, 26, 46, 47],
[33, 36, 37, 48],
[32] ,
[49-51].

, , ,
-
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.

: 297
4561 ( 20 84 ).
4561
.
, 1,6 ( 3 . 8 )
. .
147 : 126 (36-84
) 21 (34-84 ). 56,49,2 .
, 100 ,
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100 108 .
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()
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1893
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).

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: (1893 ) (2031 ).
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: 324 ; 922 - ; 244 ; 105 - .

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( 53,90,3 ) 1007 (58,00,4 )
.
: () - 29 ;
() - 98 ; () - 169 ;
() - 70 ;
() - 291 (138 - , .., RR > 1,0 .
153 , .., RR < 1,0 .).

() 147 ,
1, 3, 6, 12,
18 .
(35 ), ..,
, (30 ),
( )
.

- (),
183 (127 , 97 - , 80 -
, 39 - ) 130 (
), :
( 5-20 )
( 1, 3, 6, 12 ).


, (,
, ),
( 1, 3, 6, 12, 18, 24 ).
- ,
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( 25 3 25 3
() ),
[52].
. 1.

. 1. : (RR1)
(RR) , D (RR2)


. (
) () ()
RR.
() ()
.
, .., () () ,
() () ,

() (), ,
.

. 2. () (): (1) RR , ,
(), () ( ); (2) -
() RR.

, ,
(), (RR).

,
(<0,06 , 0,06-0,2 0,2-0,4 ),
: () 0,03
, () - 0,1
() - 0,25 . RR,
, ,
, .., (%) RR [53].
. 2.

, ..,
[52], . 2.
,
RR
.
: (1)
(1 /) 5 ; (2) 0,4 //
10 ; (3) 0,8 // 10 ; (4)
.
RR , ,
(, ) .

: RR
() ( . .) .
.

, ,
(r).
2 ,
(R ).

.
[54]

(. 3). ,
, ( )
, (RR1 = 917 965
), (1 = 61 90 ;
= 4,0 5,6 ), (2921 -5 1594 -5
) ,
(2546 3362 ).

***

***

90

3000

80

***

60

60

2000

**

40

3
30

***

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90

RRB,
%

***

5
1200

60

400

***

RR, ,
/

80

,
-5

C,
%

,
%

320

***

240

40

160

20

80

,
%

60

***

30

800

**

***

1600

,
-5

***

20

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***

10

1000

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(*** p<0.001; ** p<0.01; * p<0.05).

(3,94 3,40
) (5,53 5,18 )
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: RR
( = 10 14
16% 22% ).
(RR = 45 52 ) ,
,

65%

61%

),
.


(RRB = 210 235 ).

(
,
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( = 15% 22% RRB = 185 233
)
.
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1

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(3) .


. [10-13], [37, 9], [1]
[2].

.


.
, (RRB)
(RRB) [55]. (4,1 . . 8,5 . .
)
(RR = 22 29 ),
( = 21% 28%
= 18% 32% ).
( = 61% 40% )
(RRB = 713 605 ),
(RRB = 23% 32% ).
(. 5).

. 6.
RRB, %

, / .
12

36

10

32

RRB,
780
740
700

28

660
620

24

580

20
2

540

. 5. (RRB, RRB)
() .

. 6. ,
.

(. 7)
:
(RRB, r = -0,51),
(r = -0,36).
(RRB, r = 0,42) (r = 0,43).
22

r = .51

18

, / . .

, / . .

22

14
10
6

r =.42

18
14
10
6
2

2
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400

550

700

850

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10

1000

22

40

50

22

r = .36

18

, / . .

, / . .

30

RRB, %

RRB,

14
10
6
2
-2

20

r =.43

18
14
10
6
2

20

, %

40

60

80

100

-2

15

30

45

60

, %

. 7. ()
: (RRB) (RRB),
() () .

, RRB (r = -0,75)
(RRB >700 ). ,
, ,
(
, -, ..). ,
,

.
.

[15, 31-33, 35-38] [11, 39-41],
[22, 25, 27, 28, 30], [10-13].

.

[56, 57]. . 8
, ,
.

(RR = 62 75 ; = 42 57
) ( = 29 30 ;
= 17 22 = 16 22 ). ,
, ,
( 20% 24%; 10%
26%) ( = 59% 49% ).
(RRB = 278 301 )
(RRB = 687 632 )
(RR1 = 963 941 ), .., .
( = 83
105 , = 5,2 / 6,8 / )
( = 1740 1261 -5 )
, ( = 3526 6712 ).

***

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1000

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800

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1 .

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600

2 .

3 .

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400

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80

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RR,

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***

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40

0. 4
1 .

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2000

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160

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40

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100

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0

200

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300

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80

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3 .

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0. 2

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120

2 .

***

K,

, %

. 8. (1 .) (2 .)
() : () (3 .) ()
(4 .) . *p<0.05 **p<0.01 ***p<0.001

( = 231
182 ) ( = 46 41 = 121 105
), ().

,
.
( 55 65 , 134 150 ) ( 250 277 ),
.
( 72 62 , 4,5 4,0 )
( 2007 2337 -5) ,

( = 79 84 ).
() () ,
, , ..,
.
,
: (RR 56 49
, 37 32 ), (
27 24 , 15 12 , 14 13 ), ..,
( 18 16% 19%) ,
( 62 64%).
(RRB 235 202 ),
, (RRB 714 719 )
(RR1 948 922 ) , .
,
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.
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-
.

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,
,
[58].
, .
. 9 ,

RR,

RR,

***

1000

RR,

RR,
***

**

800
600

***

400

**

***

**
200

*
0

RR,

***

120
2000

80

***
1000

***
40

***

**
***

***

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40

***

30

1 .
20

10

**

**
***
*

***

2 .
3 .

**

. 9.
() (1 .) () (2 .) II () (3 .). *p<0.05 **p<0.01
***p<0.001.


(RR = 952 942 ),
(RRB = 730 705 )
. II,
- (RR = 872
942 ) (RRB = 692 705 ).

(RRB = 223 240 ) (RRB = 191 240 )
,
. :

, -
.
, -
.
(RR = 45 56 ), ( = 11 14
), , .

: -

[11, 15, 31-33, 36-38, 48]


[11, 39-41],
[34, 43-45].
. ,
, , ,
[1, 10, 12, 15, 17-19].


[20, 59-61].

[10, 12, 17, 18, 21, 23, 24, 62].



. ,

, (. 8, 10).


(. 10).
(RR = 49 52 , = 32 42 ),
(12 13 ) (13 15 ).
(61 59%). (RRB =
225 238 ) (RRB =
739 726 ). ,
, ,
, , ,
,
[63].

(. 11).
,
, ,
(RR = 38 ), ( = 18
, = 9 , = 11 ), ,
( = 67%) .
, (RRB =
178 ) (RRB = 726 )
(RR1 = 903 ), .., ,
.
,
.
(. 11): (RR1 = 994 ),
(RR = 51 ) (RRB = 258 ) ,
( = 63%),
(RRB = 735 ), .., .

1 .
1000

2 .

3 .

80

800

*
60

600
40

*
400

20

200

*
0

RR,

RR,

RR,

RR,

RR, %

8000

80

6000

60

*
20

40

*
*

*
*

2000

, %

, %

, %

4000

, /

-5

. 10. () (1 .) () (2 .) () (3 .).*p<0.05

*
1200

***

60

***

**

1 .

***

2 .

3 .

4 .

***

900

40
600

***

***
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***

20

300

*
***

***

***

***

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RR,

RR,

RR,

80

RR, %

3000

2000

60

40

*
2

20

1000

*
**

***

*
0

, %

, %

, %

, /

-5

. 11. : () (1 .),
() (2 .), () () (3 .)
() (4 .) . *p<0.05 **p<0.01 ***p<0.001.

(RR1

1124

(RR = 57 ),
( = 61%) ( = 23%)
( = 15%) .

(RRB = 265 ),
, (RR1 = 1124
) (RRB = 23%)
(RRB = 860 ). ,

,
,
[11, 39].

. ,
.., (RR1 > 1,0 ) (RR1 1,0 )
,
. , ,

,
, ..,

:
( = 9 , = 10 ) (RRB = 160 ),
(RR1 = 879 ).
,
.

,

.

:

,

.
,
. RR,
, ,
(. 12) .

. 12. ( )
: (),
(), ().

.

[22, 25, 27, 28, 30].

[22, 27, 47, 58].


[58, 64]
. ,
.

,
,
(RR = 32 47 ) (RRB = 146 238
) (RR1 = 891 1019 )
(. 13).
RR1,
65

*
45

25

12

18 .

RRB,
300

**

**

200

**

**

*
100

12

18 .

. 13.
(*** p<0.001; ** p<0.01; *
p<0.05).

13,

( )
( ) ( )
. 6 - 12 .
,

..,

.

3 .,
(RRB = 204 279 ) ( = 15 27%)
. ,

. ,
(RRB)
: (R = 0,39),
(R = 0,36), 6 . (R = 0,62).
. 14.

. 14. ( )
.


, ,

.

().


[49 - 51, 54],
[65, 66].
, ,

.
.

(. 15)
.
1

. 15. ( )
: 1 - , 2 - 3 , 3 12 .


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( 1 . ),
. 3
- -
, (RR, , ). 6
, (, ), ,
, .
, (
)

, 3 , ,
.
( 6 ),
.

***

600

50

3600

400

0,2

2400

200

0,1

1200

RR,

RR,

0,3

90

40
4

30

60

20

10

30

RR, ,

1000

25

750

20

**

15

500

10

250

RR,

)
60

1600

RR, %

100

*
45

RR,

300

1200

200
30

**

15
0

RR, , RR,

800

50

4
100

400
0

RR,

,
-5

,
/

. 16. ,
: ) - 1 , ) - 3 , ) - 6 , ) 12 (*** p<0.001; ** p<0.01; * p<0.05).

,
, , ,
.
, , ,

.
, -
. ,
(. 15),
.

[67].
RR,

. 17.
(V) (S) : ; - .

(. 17) ,
,

(1-3 ) (4 )
(2, 5-6 ) , ,
(7-8 ).
, . .,
. .

, ,
,
( )
- (
).
(. 17) ,
. , , ,

..,

(1-3) (4)
(5-8) ,

) ( )
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(
) (
) :
, , -
.

RR (
).

(1 8- )
. ,

) ,
( ) ()
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.

, (. 12).

.


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,
.

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,
.
,
. ,
, -

.
.
,

. ,

, .

, .., ,
, ,
.

. ,
(
),
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,
[56, 67].

, ,
,
. ,
,
() , (RR),
(RRB).

(RRB), ( ).
,
, ,
,
.
, (
), ,
,

. , ,
. ,
,
.
,
,
.

( ), , ..,
.


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