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Poorly Inadequate Emotional Chronic Medical Immuno Young

Over Poor Mal Inadequate Old


Sanitized Physical & Physical Diseases & Surgical Suppressant People
Crowding Hygiene nutrition Immunization Age
Environment Barriers Stressors (DM, athero) Treatments Drugs (corticosteroids)

Close inhibits enables increased depressed de- im-


offers an impaired
Contact produc- pathogen cortisol bone reduces inhibits creasing mature
environ blood flow
to tion of to gain activity marrow levels decreases inter- thymus immune
-ment
TB anti- access to production of: Immuno- leukin function systemm
for
patient bacteria bodies the body globulin synth
to decreased impaired binding to
colonize level of blood flow & impaired cell surface
leukocytes nutrient leuko- receptors
increased leuko- im-
exposure delivery to cytosis cytes & mono- paired
to pathogens systems
eosino- cytes activatn
phils of B
decreased
cells,
diminished phago-
impaired cyto-
cytotoxicity cytosis
immune im- toxic T
response to of natural paired cells,
immuni- killer cells release natural
zation de- killer
of hista-
creased cells,
mines,
phago- macro-
brady-
cytosis phages
kinin &
prosta- and
glandins other
cells of
the
immune
system

infected person sneezes and coughs/ transmits microorganism

Droplets Droplets Droplets


remain settle to infect
suspend surfaces cattle
ed in the
air are
spread
by air
currents

weakened defense system


person
person inhales
ingests
the droplets
food
increased susceptibility to infection

Mycobacterium tuberculosis infection

Bacteria is transmitted to the airways

PULMONARY TUBERCULOSIS

deposition in the alveoli