CONTROL NOS, 90/007,542 AND 90/007,859 ATTORNEY DOCKET NOS. 2233 10230 AND -10231 AMENDMENT TO THE C! AIMS Please amend claim 21, 27 and 32 as follows: 21, (Amended) A method comprising a) preparing a first DNA sequence [consisting essentially of DNA] encoding an immunoglobulin [consisting of an immunoglobulin] heavy chain and a second DNA sequence encoding an immunoglobulin light chain [or Fab region, sai having s munoglobulin ecificity for a particular known antigen}; b) inserting the DNA sequences of step a) into a replicable expression vector wherein cach sequence is operably linked to a suitable promoter; ©) transforming a prokaryotic or eukaryotic microbial host cell culture with the veetor of step b); 4) culturing the host cell so that said immunoglobulin heavy and light chains are produced as separate molecules in said transformed host cell; and ¢) recovering the immunoglobulin from the host cell culture, said immunoglobulin being capable of binding to @ known antigen. 27. (Amended) The method of claim 26 wherein the heavy chain and light chain [s or Fab region] are deposited within the cells as insoluble particles. 32. (Amended) The insoluble particles of heavy chain and light chains [or Fab region] produced by the method of claim 27. SUPPLEMENTAL AMENDMENT 13 FEBRUARY 2009 PAGE 2