PENICILINE DE SEMISINTEZ Peniciline stabile n mediu acid

FENETICILINA
PHENETHYCILLINUM (DCI)
O O CH CH3 O C NH N S CH3 CH3 COOH

Acid (2S, 5R, 6R)-3,3-dimetil-7-oxo-6-(fenoxipropionamido)-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic ((1-Fenoxietil)-penicilina sau (-fenoxietil)-penicilina)

Sinonime: Penicilina B; Penicilina MV.

CH3 H H S H2N C C C CH3 O C N CH COOH 6-APA

O + O CH C CH3 Clorura acidului alfa-fenoxipropionic O S N O Feneticilina CH3 CH3 Cl

N(C2H5)3 -+NH(C2H5)3Cl-

O CH CH3

C NH

COOH

PF: BROXIL (SmithKline Beecham, Olanda) capsule a 500 mg feneticilina potasica.

 PROPICILINA PROPICILLINUM (DCI)

O O CH CH2 CH3 O C NH N

CH3 CH3 COOH

Acid (2S, 5R, 6R)-3,3-dimetil-7-oxo-6-(2-fenoxibutiramido)-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic (1-Fenoxipropil-penicilina sau -Fenoxipropil-penicilina) Sinonim: Fenoxipropilpenicilina.
CH3 H H S H2N C C C CH3 O C N CH COOH 6-APA O + O CH C C 2H5 Cl Clorura acidului alfa-fenoxibutiric O O CH CH2 CH3 O C NH N S CH3 CH3 COOH N(C 2H5)3 -+NH(C 2H5)3Cl-

Propicilina

PF: BAYCILLIN MEGA (Bayer Vital, Germania) comprimate filmate a 1 mil. UI / cp.

 FENBENICILINA PHENBENICILLINUM (DCI)

O O CH C NH N O S CH3 CH3 COOH

Acid (2S, 5R, 6R)-3,3-dimetil-7-oxo-6-(2-fenoxi-2-fenilacetamido)-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic (-fenoxibenzilpenicilina)

CH3 H H S H2N C C C CH3 O C N CH COOH 6-APA O + O CH C C6H5 Clorura acidului alfa-fenoxifenilacetic O O CH C NH N O S CH3 CH3 COOH Cl N(C2 H5 )3 -+NH(C2H5)3Cl-

Fenbenicilina

 AZIDOCILINA AZIDOCILLINUM (DCI)

O C NH N3 O N CH3 CH3 COOH

Acid (2S, 5R, 6R)-6-(R)-2-azido-2-fenilacetamido- 3,3-dimetil-7-oxo 4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic

PF: LONGATREN (Bayer, Austria) comprimate a 750 mg azidocilin\ / cp. CLOMETOCILINA CLOMETOCILLINUM (DCI)
O Cl CH C NH N OCH3 S CH3 CH3 COOH

O Cl Acid (2S, 5R, 6R)-3,3-dimetil-7-oxo-6-2-(3, 4-diclorofenil)-2-metoxi-acetamido-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic (3,4-diclor--metoxibenzilpenicilina)

Sinonim: Penicilina 356.

 PF: RIXAPEN (Menarini, Belgia) comprimate a 500 mg

Peniciline rezistente la penicilinaza stafilococic

Peniciline rezistente la penicilinaz i instabile la aciditatea gastric

METICILINA SODIC| METHICILLINUM NATRICUM (DCI)
OCH3 O Na
+

C NH N OCH3 O

CH3 CH3 COO

-

. H2O

Sarea de sodiu a acidului (2S, 5R, 6R)-6-(2,6-dimetoxibenzamido)- 3,3-dimetil-7-oxo 4-tia-1azabiciclo 3. 2. 0 heptan-2-carboxilic Sinonim: Dimetoxifenecilina.

CH3 H H S H2N C C C CH3 O C N CH COOH

OCH3 O + C Cl OCH3 Clorura acidului 2,6-dimetoxibenzoic OCH3 O C NH N OCH3 O Meticilina CH3 CH3 COOH N(C2H5)3 -+NH(C2H5)3Cl-

6-APA

PF: STAFICYN (Firma, Italia) flacoane cu pulbere injectabil (1 g meticilin sodic)

Peniciline rezistente la penicilinaz i stabile la aciditatea gastric Peniciline cu structur izoxazolic OXACILINA SODIC| OXACILLINUM NATRICUM (DCI, FR X)
O Na
+

C NH N O CH3 O N

CH3 CH3 COO

-

. H O 2

Sarea de sodiu a acidului (2S, 5R, 6R)-3,3-dimetil-6-(5-metil-3-fenil-4-izoxazolcarboxamido)-7-oxo4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic Sinonim: Oxazocilina.

CH3 H H S H2N C C C CH3 O C N CH COOH

O + N O C

N(C2H5)3

+ Cl - NH(C2H5)3Cl

CH3

6-APA

Clorura acidului 3-fenil-5-metil-izoxazolil-4-carboxilic O C NH N O CH3 O Oxacilina N CH3 CH3 COOH

PF: OXACILINA (Antibiotice S.A.; Europharm; Lek Pharmatech, Romnia) capsule 250 mg oxacilina sodica / cps; pulbere pentru solutie injectabila (250 mg, 500 mg sau 1 g oxacilina sodica). BACTOCILL (SmithKline Beecham, SUA) - pulbere pentru solutie injectabila - 1 g i 2 g oxacilina sodica.

STAPENOR (Bayer, Austria) - pulbere pentru solutie injectabila - 1 g oxacilina sodica.

 CLOXACILINA SODIC| CLOXACILLINUM NATRICUM (DCI)

O Na
+

C NH N Cl O CH3 O N

CH3 CH3 COOH

. H2O

Sarea de sodiu a acidului (2S, 5R, 6R)-6-3-(o-clorofenil)-5-metil-4-izoxazolcarboxamido)- 3,3dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic

CH3 H H S H2N C C C CH3 O C N CH COOH Cl 6-APA O + N O C N(C2H5)3

+ Cl - NH(C2H5)3Cl

CH3

Clorura acidului 3-o-clorofenil-5-metil-izoxazolil-4-carboxilic O S N CH3 CH3 COOH

Na

C NH N Cl O CH3 O Cloxacilina

. H2O

 PF. ORBENIN (SmithKline Beecham, Australia; Singapore; Africa de Sud; Irlanda) capsule

250 [i 500 mg ; sirop 125 mg / 5 ml; pulbere pentru solu]ie injectabil\ (250 mg [i 500 mg);
AMPICLOX (Europharm SA, Romnia) capsule con]innd cloxacilin\ sodic\ (echivalentul a 250 mg cloxacilin\) [i ampicilin\ trihidrat (echivalentul a 250 mg ampicilin\ anhidr\).

DICLOXACILINA SODIC| DICLOXACILLINUM NATRICUM (DCI)

Cl O Na
+

C NH N Cl O CH3 O N

CH3 CH3 COOH

. H2O

Sarea de sodiu a acidului (2S, 5R, 6R)-6-3-(2,6-diclorofenil)-5-metil-4izoxazolcarboxamido)- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic

PF: DICLOCIL (Bristol-Myers Squibb) - capsule 250 i 500 mg ; pulbere pentru solutie injectabila (500 mg i 1000 mg);
DYNAPEN (Apothecon, SUA) - capsule 250 i 500 mg.

 FLUCLOXACILINA SODIC| FLUCLOXACILLINUM NATRICUM (DCI)

F O C NH N Cl O CH3 O N S CH3 CH3 COOH

Sarea de sodiu a acidului (2S, 5R, 6R)-6-3-(2-cloro-6-fluorofenil)-5-metil-4izoxazolcarboxamido)- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic Sinonim: Floxacilin\.

PF. FLOXAPEN (GlaxoSmithKline) - capsule 250 si 500 mg ; sirop (125 mg / 5 ml); pulbere pentru solutie injectabila (250 mg, 500 mg si 1000 mg).

Alte peniciline rezistente la penicilinaz i stabile la aciditatea gastric NAFCILINA SODIC| NAFCILLINUM NATRICUM (DCI)
OC2H5 O Na
+

C NH N O

CH3 CH3 COO

-

. H2O

Sarea de sodiu a acidului (2S, 5R, 6R)-6-(2-etoxi-1-naftamido)- 3,3-dimetil-7-oxo-4-tia-1azabiciclo 3. 2. 0 heptan-2-carboxilic

PF: UNIPEN (Wyeth Ayerst, SUA) capsule 250 si 500 mg ; pulbere pentru solutie injectabila (1000 mg si 2000 mg).

Peniciline cu spectru de activitate lrgit Aminopeniciline AMPICILINA SODIC| AMPICILLINUM NATRICUM (DCI, FR X)

O Na
+

CH C NH NH2 O N

CH3 CH3 COO

-

(2S, 5R, 6R)-6-(R)-2-amino-2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilat de sodiu Sinonim: Aminobenzilpenicilina.

CH3 H H S H2N C C C CH3 O C N

CH3 CH3

O + CH NH2 . HCl C Cl

dimetilanilina apa pH = 5

CH COO Si CH3

6-APA trimetilsilil ester

Clorura acidului alfa-amino-fenil acetic

O CH C NH NH2 O N

CH3 CH3 COOH

3 H2O

CH COOK + CH3 NH2 alfa-amino-fenil acetat de potasiu

C CH2 O

COOC2H5

- H2O

acetil acetat de etil

CH COOK CH3 N C CH2COOC2H5 Baza Schiff

CH COOK NH O H3C C CH C OC2H5 forma enaminica

(CH3)3C COCl clorura acidului pivalic - KCl

CH NH O

O C O

C O H3C C CH C OC2H5 C(CH3)3 agent de acilare (anhidrida mixta)

CH3 H H S H2N C C C CH3 O C N CH COO

-

NH(C2H5)3 O CH C NH N O H3C C CH2COOC 2H5 N S CH3 CH3 COO

-

6-APA sare cu trietilamina - (CH3)3C COOH acid pivalic

+ NH(C 2H5)3

H2O (HCl)
- CO2 -

O CH C NH NH2 O Ampicilina N

CH3 CH3 COOH

C2H5OH CH3COCH3 (C2H5)3N . HCl

 PF. AMPICILINA (Antibiotice SA; Europharm SA; Lek Pharmatech; Ropharma, Romnia) capsule cu 250 mg si 500 mg ampicilina anhidra, pulbere pentru suspensie orala (125 mg si 250 mg / 5 ml), flacoane cu 250 mg, 500 mg si 1000 mg pulbere uscata sterila ampicilina sodica pentru administrare parenterala; PAMECIL (Medochemie, Cipru) pulbere pentru solutie injectabila (500 mg si 1000 mg) STANDACILLIN (Biochemie, Austria) - capsule cu 250 mg si 500 mg ampicilina trihidrat;

granule pentru suspensie orala (125 mg si 250 mg / 5 ml), pulbere pentru solutie injectabila (500
mg, 1000 mg si 2000 mg).

Derivai biologic reversibili ai ampicilinei (proampiciline) PIVAMPICILINA CLORHIDRAT PIVAMPICILLINUM HYDROCHLORIDUM (DCI)
O CH C NH NH2 O N S CH3 CH3 COOCH2 OCO C(CH3)3 . HCl

(2S, 5R, 6R)-6-(R)-2-amino-2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2carboxilat de pivaloil-oxi-metil

O CH C NH NH2 O N

CH3 CH3 COOH

CH2O

HOOC C(CH3)3

O
-

H2O

CH C NH NH2 O N

CH3 CH3 COOCH2 OCO C(CH3)3

PF: PONDOCILLIN (Leo Pharma, Danemarca; Norvegia; Suedia) comprimate 500 mg; suspensie 35 mg /ml. TALAMPICILINA CLORHIDRAT TALAMPICILLINUM HYDROCHLORIDUM (DCI)
O CH C NH NH2 O N S CH3 CH3 COO O

O . HCl

(2S, 5R, 6R)-6-(R)-2-amino-2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan2-carboxilat de 3-oxo-1,3-dihidroizobenzofuran-1-il Sinonim: Ampicilin-ftalidil clorhidrat

 BACAMPICILINA CLORHIDRAT BACAMPICILLINUM HYDROCHLORIDUM (DCI)

O CH C NH NH2 O N S CH3 CH3

CH3

. HCl

COO CH O COOC2H5

(2S, 5R, 6R)-6-(R)-2-amino-2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan2-carboxilat de 1-(etoxi-carbonil-oxi)-etil

PF: PENGLOBE (Astra Zeneca, UK-Suedia) comprimate 200 mg.

HETACILINA HETACILLINUM (DCI)

H3C HN CH3 N N O O S CH3 CH3 COOH

Acid (2S, 5R, 6R)-6-(R)-2,2-dimetil-5-oxo-4-fenil-1-imidazolinil- 3,3-dimetil-7-oxo-4-tia-1azabiciclo 3. 2. 0 heptan-2-carboxilic Sinonime: Etacilina; Fenazacilina.

O CH C NH NH2 O H3C HN
- H2 O

S N

CH3 CH3 COOH

H3C C CH3 O

CH3 N N O O

CH3 CH3 COOH

METAMPICILINA METAMPICILLINUM (DCI)

O CH C NH N CH2 O N S CH3 CH3 COOH

Acid (2S, 5R, 6R)-6-(R)-2-(metilen-amino)-2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic

 PF: DOMPIL (Spyfarma, Spania) capsule a 250 mg si 500 mg.

Derivai biologic ireversibili ai ampicilinei AMOXICILINA TRIHIDRAT AMOXICILLINUM TRIHYDRICUM (DCI, FR X)

O HO CH C NH NH2 O N S CH3 CH3 COOH

3 H2O

Acid (2S, 5R, 6R)-6-(R)-(-)-2-amino-2-(p-hidroxi-fenil)-acetamido- 3,3-dimetil-7-oxo-4-tia-1azabiciclo 3. 2. 0 heptan-2-carboxilic Sinonim: p-Hidroxiampicilin\.

HO

CH COONa+ CH3 NH2 alf a-amino-p-hidroxi f enil acetat de sodiu

C CH2 COOC2H5 - H2O O acetil acetat de etil

HO

CH COONa NH sare Dane O H3C C CH C OC2H5

C2H5O

COCl

HO

- NaCl

O C O C O NH O H3C C CH C OC2H5 OC2H5 CH agent de acilare (anhidrida mixta)

H H S CH3 H2N C C C CH3 O C N CH COOH 6-APA HO - C2H5 - CO OH

2

O CH C NH NH O H3C C O CH C OC2H5 N

CH3 CH3 COOH

H2O
-

HO

O CH C NH NH2 O amoxicilina N

CH3 CH3 COOH

C2H5COOH CH3COCH3

 PF: AMOXICILINA (Antibiotice SA; Lek Pharmatech; Europharm; Arena Group, Romnia /
Ozone Laboratories Ltd, UK) capsule 250 mg si 500 mg; pulbere pentru suspensie orala (125 mg / 5 ml; 250 mg / 5 ml);

OSPAMOX (Sandoz GmbH, Austria) comprimate filmate 500 mg si 1000 mg; capsule 250
mg; pulbere pentru suspensie orala (125 mg / 5 ml; 250 mg / 5 ml); DISPAMOX (Lek Pharmatech, Romnia) comprimate dispersabile 1000 mg;

RANOXIL (Ranbaxy Laboratories Ltd, India) - pulbere pentru suspensie orala (125 mg / 5 ml;
250 mg / 5 ml). AMOXIL (SmithKline Beecham, UK) - fiole a 250 mg, 500 mg sau 1 g amoxicilina sub forma

de sare de sodiu; capsule a 250 mg sau 500 mg; pulbere pentru preparare de sirop (125 sau 250 mg
/ 5 ml); pulbere pentru suspensie orala de uz pediatric (125 mg / 1,25 ml).

 EPICILINA EPICILLINUM (DCI)

O CH C NH NH2 O N

CH3 CH3 COOH

Acid (2S, 5R, 6R)-6-(R)-2-amino-2-(1,4-ciclohexadien-1-il)-acetamido- 3,3-dimetil-7-oxo-4-tia-1azabiciclo 3. 2. 0 heptan-2-carboxilic

Sinonim: Dihidroampicilina.

CH3 Li / NH3 NaOCH3

C CH2

COOCH3

O acetilacetat de metil CH COONa NH2 1,4-ciclohexadienil-alfaamino-acetat de sodiu - H2O

CH COOH NH2 acid alfa-aminofenil acetic

CH COONa NH O H3C C CH C OCH3 sare Dane

C2H5O COCl - NaCl

O CH COO C OC2H5 NH O H3C C CH C OCH3 anhidrida mixta

H2N O

S N 6-APA - C2H5OH - CO2 H2O

CH3 CH3 COOH NH O CH C O NH O N S CH3 CH3 COOH

H3C C CH C OCH3

O CH C NH O epicilina N NH2

- CH3COOH - CH3COCH3

CH3 CH3 COOH

 CICLACILINA CYCLACILLINUM (DCI)

O C NH NH2 O N S CH3 CH3 COOH

Acid (2S, 5R, 6R)-6-(1-aminociclohexancarboxamido)- 3,3-dimetil-7-oxo-4-tia-1azabiciclo 3. 2. 0 heptan-2-carboxilic

PF. CILINASE (Dovalle, Brazilia) comprimate a 500 mg. Amidinopeniciline

AMDINOCILINA
AMDINOCILLINUM (DCI)

CH N N O

CH3 CH3 COOH

Acid (2S, 5R, 6R)-6-(hexahidro-1H-azepin-1-il)-metilenamino3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic Sinonime: Mecilinam; Amidinopenicilina HX; Penicilina Hx.

 PF. COACTIN (Roche, Elvetia) pulbere pentru solutie injectabila (250 mg, 500 mg i 1000 mg).

AMDINOCILIN PIVOXIL AMDINOCILLINUM PIVOXYLUM (DCI)

CH3 CH3 COOCH2

CH N N O

O O C C(CH3)3

(2S, 5R, 6R)-6-(hexahidro-1H-azepin-1-il)-metilenamino- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilat de 2,2-(dimetil-1-oxopropoxi) metil Sinonime: Pivmecilina; Pivamdinocilina.
N CH N N O S CH3 CH3 COOH
+

CH2O

HOOC C(CH3)3
-

H2O

CH N N O

CH3 CH3 COOCH2

O O C C(CH3)3

-Carboxipeniciline
CARBENICILINA CARBENICILLINUM (DCI)
O CH C NH COOH O N CH3 CH3 COOH

Acid (2S, 5R, 6R)-6-(-carboxi-fenilacetamido)- 3,3-dimetil-7-oxo-4tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic

2

CH COOH COOH

PCl5

HCl - 2 POCl3
-2

CH COCl COCl

C C O COCl cetena

H2N + O N

CH3 CH3 COOH O CH C NH COCl O O CH C NH COOH O N CH3 CH3 COOH N S CH3 CH3 COOH

HOH
- HCl

 PF. CARBENICILINA (Antibiotice SA, Romnia) - flacoane cu pulbere uscata sterila, sare de sodiu, echivalent cu 1 g sau 5 g carbenicilina.

INDANIL CARBENICILINA
INDANYL CARBENICILLINUM (DCI)
O CH C NH N O COO S CH3 CH3 COOH

Acid (2S, 5R, 6R)-6--(5-indaniloxi) carbonil-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1azabiciclo 3. 2. 0 heptan-2-carboxilic Sinonim: Carindacilina.

PF. GEOCILLIN (Pfizer, USA) comprimate

 FENIL CARBENICILINA PHENYL CARBENICILLINUM (DCI)

O CH C NH N O COO S CH3 CH3 COOH

Acid (2S, 5R, 6R)-6--(fenoxicarbonil)-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic Sinonim: Carfecilina. TICARCILINA TICARCILLINUM (DCI)

O CH C NH COOH O N

CH3 CH3 COOH

Acid (2S, 5R, 6R)-6-(-carboxi-3-tienilacetamido)- 3,3-dimetil-7-oxo-4-tia-1azabiciclo 3. 2. 0 heptan-2-carboxilic

H2N

S N

CH3 CH3 COOH

S CH COOH COOH

SOCl2

S CH COCl COOH

+
O

- HCl

O CH C NH COOH O N

CH3 CH3 COOH

PF. TICAR (SmithKline Beecham, USA) pulbere sterila injectabila (1 g si 5 g ticarcilina);

TICARPEN (SmithKline Beecham, Fran]a; Olanda; Spania)

TEMOCILINA TEMOCILLINUM (DCI)

O CH C NH COOH O

OCH3 N

CH3 CH3 COOH

Acid (2S, 5R, 6R)-6-(carboxi-3-tienilacetil) amino-6-metoxi- 3,3-dimetil-7-oxo4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic

 PF: NEGABAN (Eumedica, Elvetia) - pulbere sterila injectabila (1 g temocilina sodica).

Ureidopeniciline

PIPERACILINA
PIPERACILLINUM (DCI)
NH C O N N C2H5 O O O O CH C NH N S CH3 CH3 COOH

Acid (2S, 5R, 6R)-6-(R)-2-(4-etil-2,3-dioxo-1-piperazin-carboxamido)-2fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic

O CH NH2
-fenilglicina

O (C2H5)3N N COCl CH
-

COOH + H5C2

COOH

- (C2H5)3NH Cl
clorura de 4-etil-2,3-dioxo1-piperazino-carbonil

NH C O N N C2H5 O O

H2 N

S N

CH3 CH3
-

acid -(4-etil-2,3-dioxo-1-piperazino+

+
O

COO (C2 H5 ) 3NH

O CH C NH NH O C O N N C2H5 O O N

carbonilamino)-fenilacetic

CH3 CH3 COOH

ClCOOC2H5

 PF: PIPRIL (Wyeth, Austria; Irlanda) - pulbere sterila injectabila (1 g sau 2 g piperacilina sodica);
PIPRACIL (Lederle, USA)

AZLOCILINA AZLOCILLINUM (DCI)

O CH C NH NH C O N O N H O N

CH3 CH3 COOH

Acid (2S, 5R, 6R)-6-(R)-2-(2-oxo-1-imidazolidincarboxamido)-2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-

azabiciclo 3. 2. 0 heptan-2-carboxilic

O CH C NH NH2 O
ampicilina

S N

CH3 CH3 COOH

O + Cl C N

O NH (C 2H5)3N
+

- (C2H5)3NH Cl
N-cloro-carbonil-imidazolidin2-ona

O CH C NH NH O C O N O N H N

CH3 CH3 COOH

PF: SECUROPEN (Bayer, Germania; Austria; Irlanda) pulbere sterila pentru solutie injectabila (2g si 5 g azlocilina).

 MEZLOCILINA MEZLOCILLINUM (DCI)

O CH C NH NH C O N O N SO2 CH3 O N S CH3 CH3 COOH

Acid (2S, 5R, 6R)-6-(R)-2-3-(metil-sulfonil)-2-oxo-1-imidazolidin-carboxamido-2fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic

PF. BAYPEN (Bayer, Germania; Austria; Fran]a; Italia; Spania; Israel) - pulbere sterila pentru solutie injectabila (echivalentul a 1g si 2 g mezlocilina).