Drug Monograph Warfarin

Generic name: Warfarin Brand Names: Coumadin Pharmacological category: Anticoagulant Indications/ uses: Prophylaxis and treatment of venous thrombosis, pulmonary embolism and thromboembolic disorders; atrial fibrillation with risk of embolism and as an adjunct in the prophylaxis of systemic embolism after myocardial infarction Mechanism of action: Interferes with hepatic synthesis of vitamin K-dependent coagulation factors (II, VII, IX, X) Adverse reactions: . Warnings/precautions: Cautious use in severe renal disease, Hemorrhage is the most serious risk. Women may be at risk of developing ovarian hemorrhage at the time of ovulation. Use with caution in traumas, infection (antibiotics and fever may alter affects), renal insufficiency, prolonged dietary insufficiencies (vitamin K deficiency), moderate-severe hypertension, , vasculitis, open wound, active TB. Use with caution in protein C deficiency. Pregnancy Category: D Dose: Infants and Children: 0.05-0.34 mg/kg/day Adults: 5-15 mg/day for 2-5 days Cardiovascular: Vasculitis, edema, hemorrhagic shock Central nervous system: Fever, lethargy, malaise, asthenia, pain, headache, dizziness, stroke Dermatologic: Rash, dermatitis, alopecia Gastrointestinal: Anorexia, nausea, vomiting, stomach cramps, abdominal pain, diarrhea, flatulence, gastrointestinal bleeding, mouth ulcers Genitourinary: hematuria Hematologic: Hemorrhage, leukopenia, unrecognized bleeding sites Neuromuscular & skeletal: Paresthesia, osteoporosis

Reference: Lexicomp