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Diabetes Type 2

Family History

40 y/o and above Obesity


40 y/o and above 40 y/o and above

ed Insulin receptor

Insulin Resistance

ed Insulin Demand

Mutation of Insulin receptor gene

Pregnancy pre Stress

Insulin Deficiency

cell exhaustion

Impaired Insulin secretion

Defective gene (gene that stimulates Glucokinase Prodiuction)

Impaired receptor gene function ed stimulation on the production of insulin on cell

Hyperglycemia (FBS>180mg/dl)
Degenerative changes

Blood Osmolality

Blood viscosity

Blood sugar exceeds renal threshold

Glucose cannot enter cell

Gluconeogenesis activation

Fluid shifting from intracellular to extracellular

Blood Flow

Favors bacterial growth

Glycosuria

Cellular Starvation

Lipolysis

CHON breakdown

Intracellular DHN

Tissue Perfusion

Infection

Osmotic Diuresis

Sensation of hunger

Accumulation of by product

Muscle Wasting and poor wound healing

Thirst Sensation

Wound Healing

Urine Output

Polyphagia

Fatty Acid s Atherosclerosis

Ketones

Toxic to Brain tissue

Polyuria Polydipsia Gangrene Formation

Metabolic acidosis Ketonuria

Acetone Breath

Micropathy Macropathy

Amputation

Diabetic Ketoacidosis CVA, MI, PVD Neuropathy Loss of Sensation Tingling/numbness Weakness Retinopathy Loss of vision Blindness Nephropathy

ESRD

ISCHEMATIC DIAGRAM

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