Erdosteine 300mg/capsule OD P.O.

DRUG NAME Generic name: Erdosteine Brand name: Ectrin 300mg Capsule 175 mg/5mL powder for suspension Category: Mucolytic MECHANISM OF ACTION Erdosteine contains two sulfhydryl groups, which are freed after metabolic transformation in the liver. The liberated sulfhydryl groups break the disulphide bonds, which hold the glycoprotein fibres of mucus together. This makes the bronchial secretions more fluid and enhances elimination. Absorption: Rapid absorption after oral admin. Distribution: Protein binding: 64.5%. Metabolism: Undergoes 1st-pass metabolism to form an active metabolite, Nthiodiglycolylhomocysteine. Excretion: Elimination half-life: About 1.46 hr (erdosteine), and about 1.62 hr (metabolite). Mainly via the urine, as metabolites. INDICATIONS CONTRAINDICATIONS ADVERSE SPECIAL NURSING DRUG PRECAUTIONS RESPOSIBILITTY REACTIONS As mucolytic in Active peptic ulcer. Epigastralgia, Pregnancy, >The product the treatment of nausea, lactation. contains sucrose. resp tract Erdosteine is vomiting, Keep this into disorders contraindicated in patients loose stools, consideration in and productive suffering from hepatic spasmodic case of diabetes or cough. cirrhosis and deficiency colitis, low-calorie diets. of the cystathionineheadache. synthetase enzyme. Phenylketonuria, due to the presence of aspartame, only for the powder for suspension.