L

Older Number 9O38946

The percutaneous absorption of drugs across human skin Parry, Gregory Eugene, Ph.D.f \
The Univenitr of Uuh, 1990

Copyright 1990 by Parry, Gregory Eugene. All right* reserved.

U-M-I

300N.ZeebRA Ann Artwr. MI 48106

TABLE OF CONTENTS ABSTRACT LIST OF FIGURES LIST OF TABLES PREFACE Chapter 1. PERCUTANEOUS ABSORPTION OF BENZOIC ACID ACROSS HUMAN SKIN I: IN VITRO EXPERIMENTATION AND MATHEMATICAL MODELING 1 Abstract Introduction Theoretical Section Materials and Methods Results and Discussion Conclusions Notation Acknowledgements Literature Cited 2. IN VITRO METHODS FOR ASSESSING THE PERCUTANEOUS ABSORPTION AND BIOAVAILABILrrY OF BETAMETHASONE DIPROPIONATE FORMULATIONS Abstract Introduction Materials and Methods Results and Discussion Conclusions Notation Acknowledgements Literature Cited 2 2 4 11 14 22 23 24 24 iv vfii xi xiv

26 27 27 28 34 51 52 53 53

3. A COMPREHENSIVE IN VITRO AND IN VWO STUDY OF THE SKIN BIOAVAILABnJTY OF ACYCLOVIR Abstract Introduction Materials and Methods Results and Discussion Conclusions Notation Acknowledgements Literature Cited 4. IN VITRO PERCUTANEOUS ABSORPTION OF ESTRADIOL AS A FUNCTION OF DELIVERY VEHICLE Abstract Introduction Theory Materials and Methods Results and Discussion Conclusions Notation Literature Cited Appendices A. EXPERIMENTAL APPARATUS B DERIVATION OF MATHEMATICAL MODELS C. COMPUTER USTING OF NUMERICAL MODELS D. EXPERIMENTAL DATA TABLES

55 56 56 57 61 84 87 88 88

90 91 91 92 94 96 Ill 112 113

.!.

115 121 133 157

vn