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  • Con Linearity of Drug Content in Microspheres 0 0 0 0.139 0.03 0.274 0.04 0.416 0.03 0.554 0.02 0.706 0.03 0.837 0.02

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    yashpandya01
    13 просмотров8 страниц
    This document contains standard curves for an active pharmaceutical ingredient (API) using different solvent systems. Standard curves were developed for the API in phosphate buffered saline at pH 7.4, 0.01N hydrochloric acid with various ratios of acetonitrile, and mixtures of phosphate buffered saline and acetonitrile. The absorbance was measured for API concentrations ranging from 0 to 30 μg/ml. Linear regression analysis was used to develop equation for the standard curves in each solvent system.

    Исходное описание:

    ss

    Оригинальное название

    Calibrations

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    This document contains standard curves for an active pharmaceutical ingredient (API) using different solvent systems. Standard curves were developed for the API in phosphate buffered saline at pH 7.4, 0.01N hydrochloric acid with various ratios of acetonitrile, and mixtures of phosphate buffered saline and acetonitrile. The absorbance was measured for API concentrations ranging from 0 to 30 μg/ml. Linear regression analysis was used to develop equation for the standard curves in each solvent system.

    Авторское право:

    Attribution Non-Commercial (BY-NC)
    Скачайте в формате XLS, PDF, TXT или читайте онлайн в Scribd
    Отметить как неприемлемый контент
    13 просмотров8 страниц

    Con Linearity of Drug Content in Microspheres 0 0 0 0.139 0.03 0.274 0.04 0.416 0.03 0.554 0.02 0.706 0.03 0.837 0.02

    Загружено:

    yashpandya01
    This document contains standard curves for an active pharmaceutical ingredient (API) using different solvent systems. Standard curves were developed for the API in phosphate buffered saline at pH 7.4, 0.01N hydrochloric acid with various ratios of acetonitrile, and mixtures of phosphate buffered saline and acetonitrile. The absorbance was measured for API concentrations ranging from 0 to 30 μg/ml. Linear regression analysis was used to develop equation for the standard curves in each solvent system.

    Авторское право:

    Attribution Non-Commercial (BY-NC)
    Скачайте в формате XLS, PDF, TXT или читайте онлайн в Scribd
    Отметить как неприемлемый контент
    из 8

    con

    linearity of drug content in microspheres


    0
    0
    5
    0.139
    0.03
    0

    con

    0.274

    0.04

    0.416

    0.03

    0.554

    0.02

    0.706

    0.03

    0.837

    0.02

    pbs pH 7.4
    0

    5
    10
    15
    20
    25
    30

    0.134
    0.284
    0.425
    0.545
    0.716
    0.833

    0.9

    0.03

    0.8

    0.03
    0.05
    0.03
    0.04

    Standard curve of API in PBS pH 7.4

    0
    0.04

    0.7

    Absorbance

    10
    15
    20
    25
    30

    0.6
    0.5

    y = 0.028x

    0.4
    0.3

    0.2
    0.1
    0

    con

    10
    15
    20
    Concentration g/ml

    1
    0.9

    Standard curve of API in 0.01N HCl (50:50)

    0.01n hcl
    0

    5
    10
    15
    20
    25
    30

    con

    0
    0.101
    0.213
    0.309
    0.407
    0.51
    0.613

    0
    0.04
    0.03
    0.04
    0.02
    0.03
    0.03

    acn + pbs ph 7.4 (50:50)

    5
    10
    15
    20
    25
    30

    0
    0.15
    0.29
    0.48
    0.615
    0.77
    0.912

    0
    0.02
    0.02
    0.03
    0.03
    0.02
    0.03

    Absorbance

    0.9
    0.8
    0.7
    0.6
    0.5
    0.4
    0.3
    0.2
    0.1
    0

    y = 0.0307x

    Standard curve of API in PBS pH 7.4 (80:20)

    1
    acn + pbs pH 7.4 (80:20)
    0
    0
    0

    0.149
    0.313
    0.471
    0.605
    0.797
    0.924

    0.03
    0.02
    0.03
    0.04
    0.02
    0.02

    0.9
    0.8
    0.7
    Absorbance

    5
    10
    15
    20
    25
    30

    10
    15
    20
    Concentration g/ml

    0.6
    0.5
    0.4
    0.3

    y = 0.0311x
    R = 0.9988

    0.2
    0.1
    0
    0
    con

    acn + 0.01n hcl (50:50)


    0
    0
    5
    0.2
    0.03

    10
    15
    20
    Concentration g/ml

    10
    15
    20
    25
    30

    Standard curve of API in 0.01N HCL (50:50)

    0.399

    0.02

    0.609

    0.03

    0.789

    0.04

    1.4

    1.019

    0.02

    1.2

    1.21

    0.02

    con

    acn + 0.01n hcl (80:20)


    0
    0
    0
    5
    0.179
    0.03

    Abosrbance

    1
    0.8
    0.6
    0.4
    0.2

    0.379

    0.02

    0.555

    0.03

    0.732

    0.04

    0.911

    0.03

    1.099

    0.02

    0.2
    0
    0

    10

    15
    Concentration g/ml

    Standard curve of API in 0.01N HCL (80:20)


    1.2
    1
    Abosrbance

    10
    15
    20
    25
    30

    0.8
    0.6
    0.4
    0.2
    0
    0

    10

    20

    Concentration g/ml

    0.9

    Standard curve of API

    0.8
    0.7
    Absorbance

    0.6

    0.5

    y = 0.028x - 0.0025
    R = 0.9998

    0.4
    0.3
    0.2

    0.1
    0

    f API in PBS pH 7.4

    10
    15
    20
    Concentration g/ml

    25

    y = 0.028x - 0.0009
    R = 0.9989

    of API in 0.01N HCl (50:50)

    30

    Standard curve of API in 0.01N HCl

    0.7
    0.6
    0.5
    Absorbance

    25

    0.4
    y = 0.0204x + 0.0021
    R = 0.9997

    0.3
    0.2
    0.1
    0
    0

    10
    15
    20
    Concentration g/ml

    25

    Concentration g/ml

    y = 0.0307x - 0.0013
    R = 0.9988

    20
    Concentration g/ml

    25

    30

    f API in PBS pH 7.4 (80:20)

    y = 0.0311x - 0.0016
    R = 0.9988

    20
    Concentration g/ml

    25

    30

    curve of API in 0.01N HCL (50:50)

    y = 0.0404x - 0.0025
    R = 0.9996

    20

    25

    30

    35

    Concentration g/ml

    ard curve of API in 0.01N HCL (80:20)

    y = 0.0365x + 0.0028
    R = 0.9998

    20

    Concentration g/ml

    30

    40

    - 0.0025
    R = 0.9998

    30

    y = 0.0204x + 0.0021
    R = 0.9997

    30

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