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Therapeutic Category Antifungal agent Pharmacologic class: Synthetic triazole Use\ Indications Pulmonary and extrapulmonary blastomycosis, nonmeningeal histoplasmosis For genital herpes Aspergillosis Onychomycosis Candidiasis Pharmacological Effects Interferes with fungal cell-wall synthesis by inhibiting ergosterol formation and increasing cell-wall permeability, leading to osmotic instability. Adverse Reaction CNS: headache, fever, dizziness, somnolence, fatigue, malaise, asthenia, pain, tremor, abnormal dreams, anxiety, depression. CV: heart failure, hypertension, edema, orthostatic hypotension. EENT: rhinitis, sinusitis, pharyngitis. GI: nausea, vomiting, diarrhea, abdominal pain, anorexia, dyspepsia, flatulence, increased appetite, constipation, gastritis, gastroenteritis, ulcerative stomatitis, gingivitis. GU: albuminuria. Hematologic: neutropenia. Hepatic: hepatotoxicity, liver failure, impaired hepatic function. Metabolic: hypokalemia, hypertriglyceridemia. Musculoskeletal: myalgia. Respiratory: pulmonary edema, upper respiratory tract infection. Skin: rash, pruritus. Precautions/Warnings/Contraindication Use cautiously in patients with hypochlorhydria; they may not absorb drug readily. Use cautiously in HIV-infected patients because hypochlorhydria can accompany HIV infection. Use cautiously in patients receiving other highly bound drugs. Pregnancy category: C Breast-feeding: Interactions: Alprazolam, midazolam, triazolam, diazepam, estazolam, flurazepam, quazepam: May increase and prolong drug levels, CNS depression, and psychomotor impairment. Avoid using together. Antacids, carbamazepine, H2-receptor antagonists, isoniazid, phenobarbital, phenytoin, rifabutin, rifampin: May decrease itraconazole level. Avoid using together. Dosing 100-400 mg once daily Brand Available: Capsules: Icon 100mg Rolac 100mg Sporanox 100mg