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Predisposing factors: vascular insufficiency disorders genitourinary infections respiratory infections IV drug use immunocompromising diseases history of blood-

stream infections Indwelling prosthetic devices


Open wounds/ fractures

Microorganisms gain entry by way of blood

Microorganisms lodge into an area where circulation slows

Microorganisms grow

Increase pressure Ischemia


Vascular compromise of the periosteum Infection through the bone cortex and marrow

Cortical devascularization Debridement necrosis

fever, night sweats, chills, restlessness, nausea and malaise constant bone pain, swelling, tenderness, warmth at the infection site, restricted movement of the affected part

Formation of new bone

Separation of devitalized bone from living bone Continues to be an infected island

Sequestra

Involcrum

Difficulty to reach by blood borne antibiotics

Chronic stage Development of sinus tract Turns to scar tissue Systemic signs may be diminished with constant bone pain, Swelling, tenderness, warmth at the infection site
Site for continued microorganism growth

Enlarged sequestrum

drainage from sinus tracts

Sequestrum move out to the soft tissue revascularized Removal by the normal immune process

Remission and exacerbation Excessive vascular insufficiency

Healing

Loss of organ function

Amputation

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