BIMM 110 Molecular Basis of Human Disease

TA: George Chen gtchen@ucsd.edu

OH: Tu 12:30-1:30 Sierra Summit or by appointment See Announcements
Section: W 4:00-4:50 Center 203

Problem Set 10
Announcements:
• FRIDAY SECTION: Friday June 5th, 4-6pm, Cog Sci Building (CSB) 5
• Final Exam: Monday June 8th, 3-6pm, Mandeville Auditorium
• Review session with Professor Zhang: Saturday June 6th, 10am-12pm, Center 105
• This problem set covers lecture 17 and 18.
• GOOD LUCK ON THE FINAL!

1. Describe how insulin works to lower blood glucose levels. In what ways may a body become
resistant to insulin?

2. How have twin studies contributed to our understanding of the onset of Type I diabetes?
Type II diabetes?

3. Risk for type II diabetes is largely determined by family history, age, _____________, and
____________________.

4. What did the Diabetes Control and Complications Trial (DCCT) indicate about the treatment
of diabetes?
5. What are the molecular mechanisms by which GLP-1 drugs work?

6. Embryonic stem cells are obtained from the _________________________________ of a

developing embryo. One example of adult stem cells are blood stem cells, which can be
obtained from ____________________________. The process of blood cell differentiation is
known as ___________________________.

7. Describe the potential use of embryonic stem cells for tissue repair. What issues must be
considered?

8. True/False. The efficiency of inducible pluripotent stem cell production is unaffected by the
loss of Myc expression.

9. Why are cancer stem cells resistant to traditional anti-cancer therapy? What is believed to be
the result of this inability to kill off cancer stem cells?

10. Explain how scientists demonstrated the existence of blood stem cells.