Datos de Dosis-Respuesta de Buspirona

Dosis (mg/kg) Log Dosis % Efecto

1/D
0.001
-3
0.07
1000
0.007
-2.1549
0.52
142.857
0.049
-1.3098
3.89
20.408
0.343
-0.4647
23.78
2.915
2.401
0.3804
70.65
0.416
16.807
1.2255
94.89
0.059

1/E Emax-E E/Emax-E LOG(E/Emax-E) E/D

14.286 94.82 0.000738 -3.131801911 70
1.923 94.37 0.00551
-2.258830611 74
0.257
91
0.042747 -1.369091791 79
0.042 71.11 0.334411 -0.475718828 69
0.014 24.24 2.914604 0.464579551
29
0.011
0
#DIV/0!
#DIV/0!
5.6

Emax/E
1355.6
182.48
24.393
3.9903
1.3431
1.000

FACTOR
7

Mod Efec. mx

Modelo lineal
1
y = 20.125x - 38.138
R = 0.8522

100

Axis Title

Axis Title

150

50
0
-50

0.001

0.007

0.049
0.343
Axis Title

2.401

16.807

0
-1
-2
-3
-4

-3

-2.1549

Modelo lineal logaritmico

Mod Efec. mx. Sigmoide

-1.3098

Axis Title

150

Axis Title

-2.1549

y = 0.8976x - 4.0469
R = 0.9998
-0.4647
0.3804

y = 20.125x

100
50
0
-50

-3

-2.1549 -1.3098 -0.4647 0.3804

Axis Title

ogaritmico
y = 20.125x - 38.138
R = 0.8522

0.3804

1.2255

Datos de Dosis-Respuesta de Diacepam

Dosis (mg/kg)
Log Dosis
% Efecto
0.3
-0.5229
0.35
0.54
-0.2676
1.76
0.972
-0.0123
8.52
1.7496
0.2429
32.57
3.14948
0.4982
71.47
5.668704
0.7535
92.85

1/D
3.33333333
1.85185185
1.02880658
0.57155921
0.31751273
0.17640716

1/E Emax-E E/Emax-E

2.857 92.50
0.004
0.568 91.09
0.019
0.117 84.33
0.101
0.031 60.28
0.540
0.014 21.38
3.343
0.011 0.00
#DIV/0!

LOG(E/Emax-E)
-2.422
-1.714
-0.996
-0.267
0.524
#DIV/0!

factor
1.8

Modelo Lineal

Mod. Del Efe

100

1.000

80

0.500
0.000
y = 19.877x - 34.981
R = 0.8993

40
20
0
-20

0.3

0.54

0.972

1.7496

3.14948

5.668704

Axis Title

100

y = 19.877x - 34.981
R = 0.8993

80

Axis Title

60
40
20
0

-40

-1.000
-1.500
-2.000
-3.000

Modelo lienal logaritmico

-0.5229

-0.500

-2.500

-40

-20

Axis Title

Axis Title

60

-0.2676

-0.0123

0.2429

Axis Title

0.4982

0.7535

-0.5229

E/D
1.167
3.259
8.765
18.616
22.693
16.379

Emax/E
265.286
52.756
10.898
2.851
1.299
1.000

Mod. Del Efect Mx. Sigmoide

-0.5229

-0.2676

-0.0123

0.2429

0.4982

y = 0.7339x - 3.1767
R = 0.9995

Axis Title

Datos de Dosis-Respuesta de Difenhidramina

Dosis (mg/kg) Log Dosis % Efecto 1/D
1/E
Emax-E E/Emax-E LOG(E/Emax-E) E/D Emax/E
3
0.4771
0
0.333 #DIV/0! 98.65
0.000
#NUM!
0.000 #DIV/0!
4.8
0.6812
0.01
0.208 100.000 98.64
0.000
-3.994
0.002 9865.000
7.68
0.8854
0.37
0.130 2.703
98.28
0.004
-2.424
0.048 266.622
12.288
1.0895
9.11
0.081 0.110
89.54
0.102
-0.992
0.741 10.829
19.6608
1.2936
73
0.051 0.014
25.65
2.846
0.454
3.713 1.351
31.45728
1.4977
98.65 0.032 0.010
0.00
#DIV/0!
#DIV/0!
3.136 1.000
FACTOR
1.6

Modelo Lineal

Mod. Efe

120

1.000

100

60

0.4771
Axis Title

Axis Title

0.000

y = 20.599x - 41.906
R = 0.7675

80

40
20

-1.000
-2.000
-3.000

0
-20

4.8

-40

7.68

12.288

19.6608

31.45728

-5.000

Axis Title

Mod. Lienal Logaritmico

120

y = 20.599x - 41.906
R = 0.7675

100

Axis Title

80
60
40
20
0
-20
-40

0.4771

0.6812

0.8854

1.0895

Axis Title

-4.000

1.2936

1.4977

Mod. Efe. Mx. Sigmoide

y = 1.4777x - 5.4333
R = 0.9995
0.4771

0.6812

0.8854

Axis Title

1.0895

Datos de Dosis-Respuesta de Etanol

Dosis (mg/kg) Log Dosis % Efecto
625
2.7959
0.06
812.5
2.9098
0.33
1056.25
3.0238
1.8
1373.125
3.1377
9.36
1785.0625
3.2517
36.73
2320.58125
3.3656
76.54
3016.7556
3.4795
94.83
3921.7823
3.5935
99.04

1/D
1/E Emax-E E/Emax-E LOG(E/Emax-E) E/D Emax/E
0.0016 16.67 98.98
0.00
-3.22
0.000 1650.67
0.0012 3.03 98.71
0.00
-2.48
0.000 300.12
0.0009 0.56 97.24
0.02
-1.73
0.002 55.02
0.0007 0.11 89.68
0.10
-0.98
0.007 10.58
0.0006 0.03 62.31
0.59
-0.23
0.021 2.70
0.0004 0.01 22.50
3.40
0.53
0.033 1.29
0.0003 0.01
4.21
22.52
1.35
0.031 1.04
0.0003 0.01
0.00
#DIV/0!
#DIV/0!
0.025 1.00

factor
1.3

Mod efec

Modelo lineal
2.00

120

y = 16.868x - 36.072
R = 0.8915

100

1.00

60
40

Modelo lineal

20

Linear (Modelo lineal)

0.00
-1.00

-2.00

-20

-3.00

-40

-4.00

Axis Title

Mod. Lineal logaritmico

120
y = 16.868x - 36.072
R = 0.8915

100
80
Axis Title

Axis Title

Axis Title

80

60

Mod. Lineal logaritmico

40
Linear (Mod. Lineal
logaritmico)

20
0
-20
-40

Axis Title

Mod efec. Mx. sigmoide

y = 0.7582x - 3.9972
R = 0.9998
Mod efec. Mx. sigmoide
Linear (Mod efec. Mx.
sigmoide)

Axis Title

Datos de Dosis-Respuesta de Glucohesperetina

Dosis (mg/kg) Log Dosis
% Efecto
1/D
10
1
1.25
0.100
20
1.301
4.26
0.050
40
1.6021
13.5
0.025
80
1.9031
35.4
0.013
160
2.2041
65.8
0.006
320
2.5051
87.11
0.003
640
2.8062
95.95
0.002
1280
3.1072
98.81
0.001

1/E Emax-E E/Emax-E LOG(E/Emax-E) E/D

0.800 97.56
0.013
-1.892
0.125
0.235 94.55
0.045
-1.346
0.213
0.074 85.31
0.158
-0.801
0.338
0.028 63.41
0.558
-0.253
0.443
0.015 33.01
1.993
0.300
0.411
0.011 11.70
7.445
0.872
0.272
0.010 2.86
33.549
1.526
0.150
0.010 0.00
#DIV/0!
#DIV/0!
0.077

factor
2

Modelo lineal
120

2.000

y = 16.579x - 24.344
R = 0.9513

100

1.500
1.000

60

Modelo lineal

40

Linear (Modelo lineal)

20
10

20

40

80

0.000
-0.500
-1.000
-2.000

160 320 640 1280

-2.500

Axis Title

modelo lineal logaritmico

120

y = 16.579x - 24.344
R = 0.9513

100
80
Axis Title

0.500

-1.500

0
-20

Axis Title

Axis Title

80

60

modelo lineal
logaritmico

40

Linear (modelo lineal

logaritmico)

20
0
-20
Axis Title

Emax/E
79.048
23.195
7.319
2.791
1.502
1.134
1.030
1.000

sigmoide
y = 0.564x - 2.4837
R = 0.9992

1.301 1.6021 1.9031 2.2041 2.5051 2.8062

sigmoide
Linear (sigmoide)

Axis Title

Datos de Dosis-Respuesta de Haloperidol

Dosis (mg/kg) Log Dosis % Efecto
1/D
0.01
-2
0.74
100.000
0.021
-1.6778
1.94
47.619
0.0441
-1.3556
5.01
22.676
0.09261
-1.0333
12.31
10.798
0.194481
-0.7111
27.2
5.142
0.4804101
-0.3184
55.21
2.082
0.85766
-0.0667
72.6
1.166
1.80108
0.2555
87.58
0.555

1/E Emax-E E/Emax-E LOG(E/Emax-E)

E/D
1.351 86.84
0.009
-2.069
74.000
0.515 85.64
0.023
-1.645
92.381
0.200 82.57
0.061
-1.217
113.605
0.081 75.27
0.164
-0.786
132.923
0.037 60.38
0.450
-0.346
139.859
0.018 32.37
1.706
0.232
114.923
0.014 14.98
4.846
0.685
84.649
0.011 0.00
#DIV/0!
#DIV/0!
48.626

FACTOR
2.1

Modelo Lineal
100

0.500

60

0.000

40

Modelo Linela

20

Linear (Modelo Linela)

Axis Title

Axis Title

80

-0.500
-1.000

-1.500

-20

-2.000
-2.500

Axis Title

Modelo lineal logaritmico

100

y = 13.413x - 27.534
R = 0.9114

80
Axis Title

1.000

y = 13.413x - 27.534
R = 0.9114

60
Modelo lineal
logaritmico

40
20

Linear (Modelo lineal

logaritmico)

0
-20
Axis Title

Emax/E
118.351
45.144
17.481
7.115
3.220
1.586
1.206
1.000

Modelo Efect. Mx. Sigmoide

y = 0.4603x - 2.5765
R = 0.9976

Modelo Efect. Mx.

Sigmoide
Linear (Modelo Efect.
Mx. Sigmoide)

Axis Title

Datos de Dosis-Respuesta de Hesperidina

Dosis (mg/kg) Log Dosis
% Efecto 1/D
10
1
34.97 0.100
21
1.3222
47.81 0.048
44.1
1.6444
60.95 0.023
92.61
1.9667
72.67 0.011
194.481
2.2889
81.92 0.005
480.4101
2.6816
89.66 0.002
857.66
2.9333
92.93 0.001
1801.08
3.2555
95.73 0.001

1/E Emax-E E/Emax-E LOG(E/Emax-E) E/D Emax/E

0.029 60.76
0.576
-0.240
3.497 2.737
0.021 47.92
0.998
-0.001
2.277 2.002
0.016 34.78
1.752
0.244
1.382 1.571
0.014 23.06
3.151
0.498
0.785 1.317
0.012 13.81
5.932
0.773
0.421 1.169
0.011 6.07
14.771
1.169
0.187 1.068
0.011 2.80
33.189
1.521
0.108 1.030
0.010 0.00
#DIV/0!
#DIV/0!
0.053 1.000

FACTOR
2.1

Modelo Lineal
120

2.000

y = 8.8845x + 32.1
R = 0.9498

100

1.500

80
60

Modelo Lineal

40
20

Linear (Modelo
Lineal)

Axis Title

Axis Title

Mod. Efec. Mx.

1.000
0.500
0.000
-0.500

Axis Title

Axis Title

Modelo Lineal logaritmico

120

y = 8.8845x + 32.1
R = 0.9498

Axis Title

100
80
60

Modelo Lineal
logaritmico

40

Linear (Modelo
Lineal logaritmico)

20
0

Axis Title

Mod. Efec. Mx. Sigmoide

y = 0.2912x - 0.5983
R = 0.9898
Mod. Efec. Mx.
Sigmoide
Linear (Mod. Efec.
Mx. Sigmoide)

Axis Title

Datos de Dosis-Respuesta de Morfina

Dosis (mg/kg) Log Dosis
% Efecto
1
0
11.27
2.1
0.3222
21.06
4.41
0.6444
35.91
9.261
0.9667
54.06
19.4481
1.2889
71.19
40.84
1.6111
83.84
85.766
1.9333
91.6
180.108
2.2555
95.81

1/D
1.000
0.476
0.227
0.108
0.051
0.024
0.012
0.006

1/E
0.089
0.047
0.028
0.018
0.014
0.012
0.011
0.010

Emax-E
84.54
74.75
59.90
41.75
24.62
11.97
4.21
0.00

E/Emax-E
0.133
0.282
0.599
1.295
2.892
7.004
21.758
#DIV/0!

FACTOR
2.1

Modelo Lineal
120
100

1.000

80
60
40

Modelo Lineal

20

Linear (Modelo Lineal)

Axis Title

Axis Title

1.500

y = 13.16x - 1.1254
R = 0.976

0.500
0.000
-0.500
-1.000
-1.500

Axis Title

Modelo Lineal Logaritmico

120

y = 13.16x - 1.1254
R = 0.976

Axis Title

100
80
60

Modelo Lineal
Logaritmico

40

Linear (Modelo Lineal

Logaritmico)

20
0

Axis Title

DE50

LOG(E/Emax-E)
-0.875
-0.550
-0.222
0.112
0.461
0.845
1.338
#DIV/0!

E/D
11.270
10.029
8.143
5.837
3.661
2.053
1.068
0.532

Emax/E
8.501
4.549
2.668
1.772
1.346
1.143
1.046
1.000

Mod. Efec. Mx. Sigmoide

1.500

y = 0.3612x - 1.2863
R = 0.9948

1.000
Mod+Morfina!$34:$34
Efec. Mx. Sigmoide

0.500
0.000

Linear
(Mod+Morfina!$34:$34
Efec. Mx. Sigmoide)

-0.500
-1.000
-1.500

Axis Title

DE50

3.56118494

Datos de Dosis-Respuesta de Naringenina

Dosis (mg/kg) Log Dosis % Efecto 1/D
1/E
Emax-E E/Emax-E LOG(E/Emax-E) E/D
10
1
0
0.100 #DIV/0! 100.00
0.000
#NUM!
0.000
21
1.3222
0.01
0.048 100.000 99.99
0.000
-4.000
0.000
44.1
1.6444
0.16
0.023 6.250
99.84
0.002
-2.795
0.004
92.61
1.9667
1.73
0.011 0.578
98.27
0.018
-1.754
0.019
194.481
2.2889
16.38 0.005 0.061
83.62
0.196
-0.708
0.084
408.41
2.6111
68.55 0.002 0.015
31.45
2.180
0.338
0.168
857.66
2.9333
96.04 0.001 0.010
3.96
24.253
1.385
0.112
1801.08
3.2555
100
0.001 0.010
0.00
#DIV/0!
#DIV/0!
0.056
factor
2.1

Modelo Lineal
120

2.000

y = 16.666x - 39.64
R = 0.822

100

1.000
0.000
Axis Title

60
40
20

-1.000
-2.000
-3.000

0
10

-20

21

44.1

-40

92.61

194.481

408.41

857.66

1801.08

120

y = 16.666x - 39.64
R = 0.822

100
80
60
40
20
0
-20
-40

1.3222

1.6444

1.9667

-4.000
-5.000

Axis Title

Modelo Lineal Lorgaritmico

Axis Title

Axis Title

80

2.2889

Axis Title

2.6111

2.9333

3.2555

Emax/E
#DIV/0!
10000.000
625.000
57.803
6.105
1.459
1.041
1.000

Mod. Efec. Mx. Sigmoide

y = 1.0677x - 4.9928
R = 0.9994
1.3222

1.6444

1.9667

2.2889

Axis Title

2.6111

2.9333

Datos de Dosis-Respuesta de Pentobarbital

Dosis (mg/kg) Log Dosis
% Efecto
1
0
0.18
2.5
0.3979
1.85
6.25
0.7959
16.34
15.625
1.1938
66.89
39.0625
1.5918
95.43
97.656
1.9897
99.54

1/D
1.000
0.400
0.160
0.064
0.026
0.010

1/E
5.556
0.541
0.061
0.015
0.010
0.010

Emax-E
99.36
97.69
83.20
32.65
4.11
0.00

E/Emax-E
0.002
0.019
0.196
2.049
23.219
#DIV/0!

factor
2.5

Modelo Lineal
120

2.000

y = 23.66x - 36.104
R = 0.918

100

1.000
Axis Title

Axis Title

80
60
40

0.000
-1.000

20
-2.000

0
-20

2.5

6.25

15.625

39.0625

97.656

Axis Title

Modelo Lineal Logaritmico

120

y = 23.66x - 36.104
R = 0.918

100

Axis Title

80
60
40
20
0
-20

0.3979

0.7959

1.1938

Axis Title

1.5918

1.9897

-3.000

LOG(E/Emax-E)
-2.742
-1.723
-0.707
0.311
1.366
#DIV/0!

E/D
0.180
0.740
2.614
4.281
2.443
1.019

Emax/E
553.000
53.805
6.092
1.488
1.043
1.000

Mod. Efec. Mx. Sigmoide

2.000

y = 1.025x - 3.7737
R = 0.9999

1.000
0.000
0

0.3979

0.7959

-1.000
-2.000
-3.000

Axis Title

1.1938

1.5918

Datos de Dosis-Respuesta de Rocuronium

Dosis (mg/kg) Log Dosis % Efecto
1/D
0.033
-1.4815
0.06 30.303
0.0495
-1.3054
0.35 20.202
0.07425
-1.1293
2.2 13.468
0.111375
-0.9532
12.45 8.979
0.167062
-0.7771
47.35 5.986
0.250593
-0.601
85.05 3.991
0.37589
-0.4249
97.3 2.660
0.563835
-0.2488
99.56 1.774

1/E Emax-E E/Emax-E LOG(E/Emax-E)

E/D
Emax/E
16.667 99.50
0.001
-3.220
1.818 1659.333
2.857 99.21
0.004
-2.452
7.071 284.457
0.455 97.36
0.023
-1.646
29.630 45.255
0.080 87.11
0.143
-0.845
111.785 7.997
0.021 52.21
0.907
-0.042
283.428 2.103
0.012 14.51
5.861
0.768
339.395 1.171
0.010
2.26
43.053
1.634
258.852 1.023
0.010
0.00
#DIV/0!
#DIV/0!
176.576 1.000

factor:
1.5

Modelo Lineal

Mod Efec

120

y = 17.437x - 35.426
R = 0.8996

100

2.000
1.000

60

Axis Title

Axis Title

80

40
20
0
-20
-40

0.033

0.0495

0.07425 0.111375 0.167062 0.250593 0.37589 0.563835

120

Axis Title

80

y = 17.437x - 35.426
R = 0.8996

60
40
20
0
-20
-40

-1.4815 -1.3054 -1.1293 -0.9532 -0.7771

Axis Title

-1.4815
-1.000
-2.000
-3.000
-4.000

Axis Title

Modelo Lineal Logaritmico

100

0.000

-0.601

-0.4249 -0.2488

Mod Efec. Mx. Sigmoide

y = 0.8073x - 4.0584
R = 0.9998

-1.4815

-1.3054

-1.1293

-0.9532

Axis Title

-0.7771

-0.601

-0.4249

Datos de Dosis-Respuesta de Rolipram

Dosis (mg/kg) Log Dosis % Efecto 1/D
0.033
-1.4815
2.89
30.303
0.0825
-1.0835
6.96
12.121
0.20625
-0.6856
15.84
4.848
0.515625
-0.2877
32.14
1.939
1.28906
0.1103
54.37
0.776
3.222656
0.5082
74.99
0.310
8.05664
0.9062
88.3
0.124
20.1415
1.3041
95
0.050

1/E Emax-E E/Emax-E LOG(E/Emax-E) E/D Emax/E

0.346 92.11
0.031
-1.503
87.576 32.872
0.144 88.04
0.079
-1.102
84.364 13.649
0.063 79.16
0.200
-0.699
76.800 5.997
0.031 62.86
0.511
-0.291
62.332 2.956
0.018 40.63
1.338
0.127
42.178 1.747
0.013 20.01
3.748
0.574
23.270 1.267
0.011 6.70
13.179
1.120
10.960 1.076
0.011 0.00
#DIV/0!
#DIV/0!
4.717 1.000

factor
2.5
1.500

Modelo Lineal

1.000
y = 14.895x - 20.715
R = 0.9722

100

Axis Title

80

0.000
-0.500

60

-1.000

40

-1.500

20

-2.000

0
-20

0.033

0.0825

0.20625 0.515625 1.28906 3.222656 8.05664 20.1415

Axis Title

Modelo Lineal logaritmico

120

y = 14.895x - 20.715
R = 0.9722

100
80
Axis Title

0.500
Axis Title

120

60
40
20
0
-20

-1.4815 -1.0835 -0.6856 -0.2877

0.1103

Axis Title

0.5082

0.9062

1.3041

Mod. Efec. Mx. Sigmoide

1.500
y = 0.4302x - 1.9746
R = 0.9973

1.000

Axis Title

0.500
0.000
-0.500

-1.4815

-1.0835

-0.6856

-0.2877

-1.000
-1.500
-2.000

Axis Title

0.1103

0.5082

0.9062

Datos de Dosis-Respuesta de Succinilcolina

Dosis (mg/kg) Log Dosis
% Efecto
0.033
-1.4815
0.21
0.0495
-1.3054
1.18
0.07425
-1.1293
6.43
0.111375
-0.9532
28.37
0.1670625
-0.7771
69.54
0.250593
-0.601
92.94
0.37589
-0.4249
98.7
0.563835
-0.2488
100

1/D
30.303
20.202
13.468
8.979
5.986
3.991
2.660
1.774

1/E
4.762
0.847
0.156
0.035
0.014
0.011
0.010
0.010

Emax-E
99.79
98.82
93.57
71.63
30.46
7.06
1.30
0.00

E/Emax-E
0.002
0.012
0.069
0.396
2.283
13.164
75.923
#DIV/0!

factor
1.5

Modelo Lineal
y = 17.7x - 29.98
R = 0.9186

120
100

3.000
2.000

60

Axis Title

Axis Title

80
40
20
0
-20

-1.000

-3.000

Modelo Lineal Logaritmico

120

y = 17.7x - 29.98
R = 0.9186

100
80
Axis Title

0.000

-2.000
Axis Title

60
40
20
0
-20

1.000

-1.4815 -1.3054 -1.1293 -0.9532 -0.7771

Axis Title

-0.601

-0.4249 -0.2488

LOG(E/Emax-E)
-2.677
-1.923
-1.163
-0.402
0.359
1.119
1.880
#DIV/0!

E/D
6.364
23.838
86.599
254.725
416.251
370.880
262.577
177.357

Emax/E
476.190
84.746
15.552
3.525
1.438
1.076
1.013
1.000

Mod. Efec. Mx. Sigmoide

3.000

y = 0.7599x - 3.4407
R = 1

2.000
1.000
0.000
-1.4815

-1.3054

-1.1293

-0.9532

-1.000
-2.000
-3.000

Axis Title

-0.7771

-0.601

-0.4249

Datos de Dosis-Respuesta de Diacepam

Dosis (mg/kg) Log Dosis
% Efecto
0.88
-0.0555
6.59
1.33
0.1239
18.31
2
0.301
41.26
3
0.4771
68.61
4.5
0.6532
87.18
6.75
0.8293
95.49
10.1025
1.0054
98.5
15.1875
1.1815
99.51

1/D
1.13636364
0.7518797
0.5
0.33333333
0.22222222
0.14814815
0.0989854
0.06584362

1/E
0.15174507
0.05461496
0.02423655
0.01457513
0.01147052
0.0104723
0.01015228
0.01004924

Emax-E
92.92
81.2
58.25
30.9
12.33
4.02
1.01
0

E/Emax-E
0.07092122
0.22549261
0.70832618
2.22038835
7.07055961
23.7537313
97.5247525
#DIV/0!

Modelo lineal logaritmico

140
y = 14.674x - 1.6036
R = 0.9135

120
100
80
60

% Efecto

40

Linear (% Efecto)

20
0

Mod. Efec. Mx. Sigmoide

2.5
2
1.5
1
0.5
0
-0.5
-1
-1.5

LOG(E/Emax-E)
-1.14922379
-0.64686768
-0.14976671
0.34642894
0.84945379
1.37573184
1.98911486
#DIV/0!

E/D
7.48863636
13.7669173
20.63
22.87
19.3733333
14.1466667
9.75006187
6.55209877

Emax/E
15.1001517
5.43473512
2.41177896
1.45037167
1.14143152
1.04209865
1.01025381
1

Modelo lineal
140
120
y = 14.674x - 1.6036
R = 0.9135

100
80
60

% Efecto

40

Linear (% Efecto)

20
0

Mx. Sigmoide
y = 0.5164x - 1.6921
R = 0.9988

LOG(E/Emax-E)
Linear (LOG(E/Emax-E))

Datos de Dosis-Respuesta de Buspirona

Dosis (mg/kg) Log Dosis
% Efecto
0.001
-3
0.07
0.005
-2.301
0.37
0.025
-1.6021
1.96
0.125
-0.9031
9.76
0.625
-0.2041
36.94
3.125
0.4949
76.05
15.625
1.1938
94.51

1/D
1000
200
40
8
1.6
0.32
0.064

1/E
14.2857143
2.7027027
0.51020408
0.10245902
0.02707093
0.01314924
0.01058089

Emax-E
94.44
94.14
92.55
84.75
57.57
18.46
0

E/Emax-E
0.00074121
0.00393032
0.02117774
0.11516224
0.64165364
4.11971831
#DIV/0!

Modelo lineal logaritmico

120
100

y = 16.774x - 35.714
R = 0.8483

80
60

% Efecto

40

Linear (% Efecto)

20
0
-20

-3

-2.301 -1.6021 -0.9031 -0.2041 0.4949 1.1938

-40

Mod. Efec. Mx. Sigmoide

1
0
-3

-2.301 -1.6021 -0.9031 -0.2041 0.4949

y = 0.7457x
R = 0.9997

-1

LOG(E/Emax-E)

-2

Linear (LOG(E/Emax-E))

-3
-4

LOG(E/Emax-E)
-3.13005794
-2.40557247
-1.67412035
-0.93868989
-0.19269934
0.61486752
#DIV/0!

E/D
70
74
78.4
78.08
59.104
24.336
6.04864

Emax/E
1350.14286
255.432432
48.2193878
9.68340164
2.5584732
1.24273504
1

Modelo lineal
120
100

y = 16.774x - 35.714
R = 0.8483

80
60

% Efecto

40

Linear (% Efecto)

20
0
-20

0.001

-40

moide

y = 0.7457x - 3.8976
R = 0.9997
LOG(E/Emax-E)
Linear (LOG(E/Emax-E))

0.005

0.025

0.125

0.625

3.125 15.625

Datos de Dosis-Respuesta de Etanol

Dosis (mg/kg) Log Dosis
% Efecto
400
2.6021
0
600
2.7782
0.04
900
2.9542
0.64
1350
3.1303
8.46
2025
3.3064
57.1
3037
3.4824
95.04

1/D
1/E
0.0025
#DIV/0!
0.00166667
25
0.00111111
1.5625
0.00074074 0.11820331
0.00049383 0.01751313
0.00032927 0.01052189

Emax-E
95.04
95
94.4
86.58
37.94
0

E/Emax-E
0
0.00042105
0.00677966
0.0977131
1.50500791
#DIV/0!

LOG(E/Emax-E)
0.5
y = 1.1818x - 4.5488
R = 0.9999

0
-0.5

2.7782

2.9542

3.1303

3.3064

-1
LOG(E/Emax-E)

-1.5
-2

Linear (LOG(E/Emax-E))

-2.5
-3
-3.5
-4

Modelo lineal logaritmico

120
100
80
60
40
20
0
-20
-40

2.6021

2.7782

2.9542

3.1303

LOG(E/Emax-E)
E/D
Emax/E
#NUM!
0
#DIV/0!
-3.37566361 6.6667E-05
2376
-2.16879202 0.00071111
148.5
-1.01004722 0.00626667 11.2340426
0.17753878 0.02819753 1.66444834
#DIV/0!
0.03129404
1

Modelo lineal
120
100

y = 18.691x - 38.54
R = 0.7614

80
60

% Efecto

40

Linear (% Efecto)

20
0
-20

400

600

900

1350

-40

delo lineal logaritmico

y = 18.691x - 38.54
R = 0.7614
% Efecto
Linear (% Efecto)

3.1303

3.3064

3.4824

2025

3037

DE50

Mod. Del efecto

max. Sigmoide (
r)

5.93X10-6

0.9997

5.33x10-3

0.9998

Diazepam

psicotrpico
(atarxico, relajante
muscular,
anticonvulsivo)

5.29X10-4

0.9998

Succinilcolina
Rolipram
Rocuronium
Pentobarbital

Antiespasmdico
Antidepresivo
Antiespasmdico
Sedante

2.99X10-5
2.57X10-5
9.39X10-6
2.08X10-4

1
0.9973
0.9998
0.9999

2.11X10-5

0.9994

frmaco

Buspirona
Etanol

Naringenina
Morfina
Hesperidina
Haloperidol
Glucohesperetina
Difenhidramina

descripcin
Ansoltico. se usa
como tratamiento
para la ansiedad.
Depresor del
sistema nervioso

Inhibidor el
sistema
enzimtico
heptico

ventana de
actividad
biolgica

Analgsico
Tratamiento para
varices y hemorrides
antipsictico

2.75X10-4

0.9948

8.82X10-3

0.9898

2.57X10-6
3.95X-5

0.9976
0.9992

Antihistamnico, seda
nte e hipntico

2.10x10-4

0.9995

Dosis
400
600
900
1350
2025
3037
0.001
0.005
0.025
0.125
0.625
3.125
15.625
0.88
1.33
2
3
4.5
6.75
10.1025
15.1875
1
2.1
4.41
9.261
19.4481
40.84
85.766
180.108

log D
2.6021
2.7782
2.9542
3.1303
3.3064
3.4824
-3
-2.301
-1.6021
-0.9031
-0.2041
0.4949
1.1938
-0.0555
0.1239
0.301
0.4771
0.6532
0.8293
1.0054
1.1815
0
0.3222
0.6444
0.9667
1.2889
1.6111
1.9333
2.2555

10

21
44.1
92.61
194.481
408.41
857.66
1801.08

1.3222
1.6444
1.9667
2.2889
2.6111
2.9333
3.2555

1
2.5
6.25
15.625
39.0625
97.656
0.033

0
0.3979
0.7959
1.1938
1.5918
1.9897
-1.4815

%E
0
0.04
0.64
8.46
57.1
95.04
0.07
0.37
1.96
9.76
36.94
76.05
94.51
6.59
18.31
41.26
68.61
87.18
95.49
98.5
99.51
11.27
21.06
35.91
54.06
71.19
83.84
91.6
95.81
0
0.01
0.16
1.73
16.38
68.55
96.04
100
0.18
1.85
16.34
66.89
95.43
99.54
0.06

1/D

1/E

Emax-E

E/Emax-E

0.0025
0.00166667
0.00111111
0.00074074
0.00049383
0.00032927
1000
200
40
8
1.6
0.32
0.064
1.13636364
0.7518797
0.5
0.33333333
0.22222222
0.14814815
0.0989854
0.06584362
1.000
0.476
0.227
0.108
0.051
0.024
0.012
0.006

#DIV/0!
25
1.5625
0.11820331
0.01751313
0.01052189
14.2857143
2.7027027
0.51020408
0.10245902
0.02707093
0.01314924
0.01058089
0.15174507
0.05461496
0.02423655
0.01457513
0.01147052
0.0104723
0.01015228
0.01004924
0.089
0.047
0.028
0.018
0.014
0.012
0.011
0.010

95.04
95
94.4
86.58
37.94
0
94.44
94.14
92.55
84.75
57.57
18.46
0
92.92
81.2
58.25
30.9
12.33
4.02
1.01
0
84.54
74.75
59.90
41.75
24.62
11.97
4.21
0.00

0
0.00042105
0.00677966
0.0977131
1.50500791
#DIV/0!
0.00074121
0.00393032
0.02117774
0.11516224
0.64165364
4.11971831
#DIV/0!
0.07092122
0.22549261
0.70832618
2.22038835
7.07055961
23.7537313
97.5247525
#DIV/0!
0.133
0.282
0.599
1.295
2.892
7.004
21.758
#DIV/0!

0.100

#DIV/0!

100.00

0.000

0.048
0.023
0.011
0.005
0.002
0.001
0.001
1.000
0.400
0.160
0.064
0.026
0.010
30.303

100.000
6.250
0.578
0.061
0.015
0.010
0.010
5.556
0.541
0.061
0.015
0.010
0.010
16.667

99.99
99.84
98.27
83.62
31.45
3.96
0.00
99.36
97.69
83.20
32.65
4.11
0.00
99.50

0.000
0.002
0.018
0.196
2.180
24.253
#DIV/0!
0.002
0.019
0.196
2.049
23.219
#DIV/0!
0.001

0.0495
0.07425
0.111375
0.167062
0.250593
0.37589
0.563835
0.033
0.0825
0.20625
0.515625
1.28906
3.222656
8.05664
20.1415
0.033
0.0495
0.07425
0.111375
0.1670625
0.250593
0.37589
0.563835
10
21
44.1
92.61
194.481
480.4101
857.66
1801.08
0.01
0.021
0.0441
0.09261
0.194481
0.4804101
0.85766
1.80108
10
20
40
80
160
320
640
1280

-1.3054
-1.1293
-0.9532
-0.7771
-0.601
-0.4249
-0.2488
-1.4815
-1.0835
-0.6856
-0.2877
0.1103
0.5082
0.9062
1.3041
-1.4815
-1.3054
-1.1293
-0.9532
-0.7771
-0.601
-0.4249
-0.2488
1
1.3222
1.6444
1.9667
2.2889
2.6816
2.9333
3.2555
-2
-1.6778
-1.3556
-1.0333
-0.7111
-0.3184
-0.0667
0.2555
1
1.301
1.6021
1.9031
2.2041
2.5051
2.8062
3.1072

0.35
2.2
12.45
47.35
85.05
97.3
99.56
2.89
6.96
15.84
32.14
54.37
74.99
88.3
95
0.21
1.18
6.43
28.37
69.54
92.94
98.7
100
34.97
47.81
60.95
72.67
81.92
89.66
92.93
95.73
0.74
1.94
5.01
12.31
27.2
55.21
72.6
87.58
1.25
4.26
13.5
35.4
65.8
87.11
95.95
98.81

20.202
13.468
8.979
5.986
3.991
2.660
1.774
30.303
12.121
4.848
1.939
0.776
0.310
0.124
0.050
30.303
20.202
13.468
8.979
5.986
3.991
2.660
1.774
0.100
0.048
0.023
0.011
0.005
0.002
0.001
0.001
100.000
47.619
22.676
10.798
5.142
2.082
1.166
0.555
0.100
0.050
0.025
0.013
0.006
0.003
0.002
0.001

2.857
0.455
0.080
0.021
0.012
0.010
0.010
0.346
0.144
0.063
0.031
0.018
0.013
0.011
0.011
4.762
0.847
0.156
0.035
0.014
0.011
0.010
0.010
0.029
0.021
0.016
0.014
0.012
0.011
0.011
0.010
1.351
0.515
0.200
0.081
0.037
0.018
0.014
0.011
0.800
0.235
0.074
0.028
0.015
0.011
0.010
0.010

99.21
97.36
87.11
52.21
14.51
2.26
0.00
92.11
88.04
79.16
62.86
40.63
20.01
6.70
0.00
99.79
98.82
93.57
71.63
30.46
7.06
1.30
0.00
60.76
47.92
34.78
23.06
13.81
6.07
2.80
0.00
86.84
85.64
82.57
75.27
60.38
32.37
14.98
0.00
97.56
94.55
85.31
63.41
33.01
11.70
2.86
0.00

0.004
0.023
0.143
0.907
5.861
43.053
#DIV/0!
0.031
0.079
0.200
0.511
1.338
3.748
13.179
#DIV/0!
0.002
0.012
0.069
0.396
2.283
13.164
75.923
#DIV/0!
0.576
0.998
1.752
3.151
5.932
14.771
33.189
#DIV/0!
0.009
0.023
0.061
0.164
0.450
1.706
4.846
#DIV/0!
0.013
0.045
0.158
0.558
1.993
7.445
33.549
#DIV/0!

0.4771
0.6812
0.8854
1.0895
1.2936
1.4977

0
0.01
0.37
9.11
73
98.65

0.333
0.208
0.130
0.081
0.051
0.032

#DIV/0!
100.000
2.703
0.110
0.014
0.010

98.65
98.64
98.28
89.54
25.65
0.00

0.000
0.000
0.004
0.102
2.846
#DIV/0!

Chart Title
120

100

80

%E

3
4.8
7.68
12.288
19.6608
31.45728

60

40

20

0
0.4771

0.6812

0.8854

1.0895

1.2936

log D

1.4977

log(E/EmaxE)
#NUM!
-3.37566361
-2.16879202
-1.01004722
0.17753878
#DIV/0!
-3.13005794
-2.40557247
-1.67412035
-0.93868989
-0.19269934
0.61486752
#DIV/0!
-1.14922379
-0.64686768
-0.14976671
0.34642894
0.84945379
1.37573184
1.98911486
#DIV/0!
-0.875
-0.550
-0.222
0.112
0.461
0.845
1.338
#DIV/0!

E/D

Emax/E

factor inicial

farmaco

0
6.6667E-05
0.00071111
0.00626667
0.02819753
0.03129404
70
74
78.4
78.08
59.104
24.336
6.04864
7.48863636
13.7669173
20.63
22.87
19.3733333
14.1466667
9.75006187
6.55209877
11.270
10.029
8.143
5.837
3.661
2.053
1.068
0.532

#DIV/0!
2376
148.5
11.2340426
1.66444834
1
1350.14286
255.432432
48.2193878
9.68340164
2.5584732
1.24273504
1
15.1001517
5.43473512
2.41177896
1.45037167
1.14143152
1.04209865
1.01025381
1
8.501
4.549
2.668
1.772
1.346
1.143
1.046
1.000

1.5

ETANOL

BUSPIRONA

1.5

DIACEPAM

2.1

MORFINA

#NUM!

0.000

#DIV/0!

2.1

NARINJENINA

-4.000
-2.795
-1.754
-0.708
0.338
1.385
#DIV/0!
-2.742
-1.723
-0.707
0.311
1.366
#DIV/0!
-3.220

0.000
0.004
0.019
0.084
0.168
0.112
0.056
0.180
0.740
2.614
4.281
2.443
1.019
1.818

10000.000
625.000
57.803
6.105
1.459
1.041
1.000
553.000
53.805
6.092
1.488
1.043
1.000
1659.333

2.5

PENTOBARBITAL

2.1

ROCURONIUM

-2.452
-1.646
-0.845
-0.042
0.768
1.634
#DIV/0!
-1.503
-1.102
-0.699
-0.291
0.127
0.574
1.120
#DIV/0!
-2.677
-1.923
-1.163
-0.402
0.359
1.119
1.880
#DIV/0!
-0.240
-0.001
0.244
0.498
0.773
1.169
1.521
#DIV/0!
-2.069
-1.645
-1.217
-0.786
-0.346
0.232
0.685
#DIV/0!
-1.892
-1.346
-0.801
-0.253
0.300
0.872
1.526
#DIV/0!

7.071
29.630
111.785
283.428
339.395
258.852
176.576
87.576
84.364
76.800
62.332
42.178
23.270
10.960
4.717
6.364
23.838
86.599
254.725
416.251
370.880
262.577
177.357
3.497
2.277
1.382
0.785
0.421
0.187
0.108
0.053
74.000
92.381
113.605
132.923
139.859
114.923
84.649
48.626
0.125
0.213
0.338
0.443
0.411
0.272
0.150
0.077

284.457
45.255
7.997
2.103
1.171
1.023
1.000
32.872
13.649
5.997
2.956
1.747
1.267
1.076
1.000
476.190
84.746
15.552
3.525
1.438
1.076
1.013
1.000
2.737
2.002
1.571
1.317
1.169
1.068
1.030
1.000
118.351
45.144
17.481
7.115
3.220
1.586
1.206
1.000
79.048
23.195
7.319
2.791
1.502
1.134
1.030
1.000

2.5

ROLIPRAM

1.5

SUCCINILCOLINA

2.1 HESPERIDINA

2.1 HALOPERIDOL

2 GLUCOHESPERETINA

#NUM!
-3.994
-2.424
-0.992
0.454
#DIV/0!

0.000
0.002
0.048
0.741
3.713
3.136

#DIV/0!
9865.000
266.622
10.829
1.351
1.000

1.6 DIFENHIDRAMINA

hart Title

ETANOL
BUSPIRONA
DIACEPAM
MORFINA
NARINJENINA
PENTOBARBITAL
ROCURONIUM
ROLIPRAM
SUCCINILCOLINA
HESPERIDINA
HALOPERIDOL
GLUCOHESPERETINA
DIFENHIDRAMINA