Componies in dpp4

sr 1 2 3 4 5 6 7 8 comony NOVO NORDISK AS (DK) NOVO NORDISK AS (DK) Brief Methods and composition Methods DPP4 inhib compositions Pharma. compositions Pharm..composition DPP4 inhib DPP4 inhib compounds Patent no.

US2007197552 - 2007-08-23
WO2006000567 - 2006-01-05

US2007197522 - 2007-08-23 US2007098781 - 2007-05-03

US2006264433 - 2006-11-23
US2007049596 - 2007-03-01
US2006135767 - 2006-06-22 US2006014764 - 2006-01-19 US2005153973 - 2005-07-14 US2005209249 - 2005-09-22

Pharmaceutical compositions

9 10 11 12 13 14

PFIZER PROD INC (US) PFIZER PROD INC (US) PFIZER PROD INC (US) HOFFMANN LA ROCHE (CH) HOFFMANN LA ROCHE (CH) HOFFMANN LA ROCHE (CH)

Crystal structur

MXPA06014083 - 2007-02-15
MXPA05005260 - 2005-07-25 MXPA04011958 - 2005-03-31

FLUORINATED CYCLIC AMIDES FLUORINATED CYCLIC AMIDES

Substituted benzoquinolizines Pyrido (2,1-A) isoquinoline derivatives N-SUBSTITUTED DERIVATIVES PYRROLIDIN

CA2587524 - 2006-06-08 HK1077069 - 2007-07-06 YU34404 - 2006-08-17

15

HOFFMANN LA ROCHE (CH)

N-SUBSTITUTED DERIVATIVES

PYRROLIDIN

UA76233 - 2004-07-15

16 17

HOFFMANN LA ROCHE (CH) HOFFMANN LA ROCHE (CH)

HEXAHYDROPYRIDOISOQINOLINES

KR20060026431 - 2006-03-23
KR20060015656 - 2006-02-17

PYRIDO[2,1-A]ISOQUINOLINE DERIVATIVES Aminocycloalkanes PYRID (2, 1-A) - ISOQUINOLINE DERIVATIVES HEXAHYDROPYRIDOISOQINOLI NES

18 19

HOFFMANN LA ROCHE (CH) HOFFMANN LA ROCHE (CH)

US2006135512 - 2006-06-22 EP1638970 - 2006-03-29

20

HOFFMANN LA ROCHE (CH)

EP1638968 - 2006-03-29

21 22

HOFFMANN LA ROCHE (CH) NOVARTIS AG (CH); NOVARTIS CONDENSED COMPOUNDS NOVARTIS Dpp4 and antidibetics comb EP1743655 - 2007-01-17 HETEROCYCLIC WO2007071738 - 2007-06-28

PHARMA GMBH (AT); 23 NOVARTIS AG (CH);

PHARMA GMBH (AT);

24

NOVARTIS

AG

(CH);

NOVARTIS

FORMULATION AND PROCESS

WO2006135693 - 2006-12-21

PHARMA GMBH (AT); 25 26 27 SANTHERA SCHWE (CH) 28 SANTHERA SCHWE (CH) 29 SANTHERA SCHWE (CH) 30 SANTHERA SCHWE (CH) PHARMACEUTICALS 1-[(3R)-AMINO-4-(2-FLUORO-PHENYL)BUTYL]-PYRROLIDINE-(2R)CARBOXYLIC DERIVATIVES COMPOUNDS 31 SANTHERA SCHWE (CH) 32 SANTHERA SCHWE (CH) 33 SANTHERA SCHWE (CH) 34 SANTHERA SCHWE (CH PHARMACEUTICALS 1-'(3R)-AMINO-4-(2-FLUORO-PHENYL)BUTYL CARBOXILIC DERIVATIVES COMPOUNDS 35 SANTHERA SCHWE (CH 36 SANTHERA SCHWE (CH 37 SANTHERA SCHWE (CH 38 39 40 SANOFI AVENTIS SANOFI AVENTIS (FR) N-aminoacetyl-pyrrolidine-2-carbonitriles ADAMANTANE AND AZABICYCLONZ535662 - 2007-05-31 KR20060121838 - 2006-11-29 PHARMACEUTICALS DPP4 inhib
WO2006097175 - 2006-09-21

NOVARTIS AG (CH)

Use of dpp4 inhib

MXPA06005518 - 2006-08-17

PHARMACEUTICALS

DPP4 inhib

KR20070027690 - 2007-03-09

PHARMACEUTICALS

DPP4 inhib

KR20070026788 - 2007-0308

PHARMACEUTICALS

DPP4 inhib

EP1791817 - 2007-06-06

EP1791536 - 2007-06-06

ACID-BENZYL AND

AMINE

RELATED

PHARMACEUTICALS

EP1786806 - 2007-05-23

PHARMACEUTICALS

Heterocyclic compounds

EP1778682 - 2007-05-02

PHARMACEUTICALS

Heterocyclic compounds

CA2576028 - 2006-02-09

CA2576236 - 2005-12-22

!-PYRROLIDINE-(2R)ACID-BENZYL AND AMINE RELATED

PHARMACEUTICALS

DPP4 inhib

EP1758861 - 2007-03-07

PHARMACEUTICALS

DPP4 inhib

CA2567854 - 2005-12-01

OCTANE AND NONANE DERIVATIVES, PROCESS OF THEIR PREPARATION

41

ABBOTT LAB

Pyrrolidine-2-carbonitrile derivatives and their pharmaceutical compositions

NZ538567 - 2007-04-27

42 43 44

ABBOTT LAB (US) ABBOTT LAB (US) BIOREXIS PHARMACEUTICAL CORP (US)

Pharm..composition Pharm..composition transferrin fusion proteins comprising GLP-1

WO2007027651 - 2007-03-08
ZA200502218 - 2005-09-16

GB2431583 - 2007-05-02

45 46 WARATAH PHARMACEUTICALS INC (CA); CRUZ ANTONIO (CA) 47 48 NOVARTIS AG (CH); NOVARTIS PHARMA GMBH (AT) 49 NOVARTIS AG (CH) Dpp-iv inhibitors for treating and neurodegeneration cognitive disorders Combo dpp4 +5HT3/4 NOVARTIS AG (CH); NOVARTIS PHARMA GMBH (AT) CN1921856 - 2007-02-28 Combined use WO2007041833 - 2007-04-19

50

NOVARTIS AG (CH) Dpp-iv inhibitors for treating and neurodegeneration cognitive disorders

KR20060124712 - 2006-12-05

51

NOVARTIS AG (CH); NOVARTIS PHARMA GMBH (AT)

COMBINATION OF CA/MG SALT OF AN VALSARTAN WITH

WO2006084757 - 2006-08-17

ANTIDIABETIC AGENT

52

ASTRAZENECA AB (SE)

TETRAHYDROQUINOLONES AND AZAANALOGUES THEREOF

EP1758863 - 2007-03-07

53 54 55 MERCK & CO INC (US); FUSED AMINOPIPERIDINES

WO2007024993 - 2007-0301

56 57

MERCK & CO INC (US); MERCK & CO INC (US);

Hexahydrodiazepinones AMINOCYCLOHEXANES

CN1882551 - 2006-12-20
WO2006127530 - 2006-11-30

58 59 60 61 62 63 64 65 66 67 68 69 70

MERCK & CO INC (US); MERCK & CO INC (US); MERCK & CO INC (US); MERCK & CO INC (US); MERCK & CO INC (US); MERCK & CO INC (US); LILLY CO ELI (US); LILLY CO ELI (US); LILLY CO ELI (US)

BICYCLIC PYRIMIDINES FUSED AMINOPIPERIDINES AMINOPIPERIDINE FUSED TRIAZOLE DERIVATIVES AMINOCYCLOHEXANES

Phenyl compounds 1-amino linked Pyridine derivatives

WO2006078676 - 2006-07-27 WO2006058064 - 2006-06-01 WO2006039325 - 2006-04-13 WO2006023750 - 2006-03-02 WO2006009886 - 2006-01-26

WO2007015807 - 2007-02-08 WO2007015805 - 2007-02-08 WO2007015767 - 2007-02-08

ARRAY BIOPHARMA INC (JP)

DPP inhib

US7169926 - 2007-01-30

GRAFFINITY AG (CH)

PHARMACEUTICALS

DPP4 inhib

CN1905868 - 2007-01-31

71

GRAFFINITY AG (CH)

PHARMACEUTICALS

DPP4 inhib

EP1613304 - 2006-01-11

72 73

PHENOMIX CORP (US) AURIGENE TECHNOLOGIE (IN); DISCOVERY

Heterocyclic boronic acid derivatives NOVEL 5-SUBSTITUTED INDOLE

EP1743676 - 2007-01-17 WO2006134613 - 2006-12-21

DERIVATIVES DPP4 inhib DPP4 inhib Alpha-amino acid derivatives US2006270701 - 2006-11-30 WO2006116157 - 2006-11-02 SI1258476T - 2006-10-31
SI1245568T - 2006-04-30 NZ540108 - 2006-04-28

74 75 76 77 78

ALANTOS PHARMACEUTICALS INC ALANTOS PHARMACEUTICALS INC SERVIER LAB (FR) SERVIER LAB (FR) SERVIER LAB (FR)

Sulfonyl derivatives of amino acids New pyrrolidine and thiazolidine compounds

4-PYRIMIDONE DERIVATIVES

79

TAKEDA COMPANY (JP)

PHARMACEUTICAL

MXPA06001601 - 2006-08-25

80

TAKEDA COMPANY (JP)

PHARMACEUTICAL

DPP4 inhib

WO2006068978 - 2006-06-29

81 82

TAKEDA SAN DIEGO INC (US) TAKEDA SAN DIEGO INC (US) TAKEDA SAN DIEGO INC (US) TAKEDA SAN DIEGO INC (US) TAKEDA SAN DIEGO INC (US)

DPP4 inhib DPP4 inhib Dpp inhib Dpp inhib

WO2006020017 - 2006-02-23 WO2005118555 - 2005-12-15 US2005272765 - 2005-12-08 US2005261271 - 2005-11-24

83 84

ASTELLAS PHARMA INC (JP) ASTELLAS PHARMA INC (JP)

2-cyanopyrrolidinecarboxamides 2-cyanopyrrolidinecarboxamides

CN1871237 - 2006-11-29
MXPA06004797 - 2006-07-03

85 86 87 LG LIFE SCIENCES LTD (KR) TORRENT PHARMACEUTICALS LTD (IN) 88 TORRENT PHARMACEUTICALS LTD (IN) 89
GLENMARK (CH) PHARMACEUTICALS S A NEW ADAMANTANE DERIVATIVES WO2006090244 - 2006-08-31

Novel dpp4 inhib AZOLIDINECARBONITRILES

KR20050037973 - 2005-04-25 KR20060086404 - 2006-07-31

AZOLIDINECARBONITRILES

CN1839131 - 2006-09-27

PROCESSES FOR THEIR PREPARATION, AND COMPOSITIONS THEM PHARMACEUTICAL CONTAINING

90

GLENMARK (CH)

PHARMACEUTICALS

Novel dpp4 inhib

US2006142585 - 2006-06-29

91

GLENMARK (CH)

PHARMACEUTICALS

Novel dpp4 inhib

WO2006040625 - 2006-04-20

92

GLENMARK (CH)

PHARMACEUTICALS

Novel dpp4 inhib

WO2006011035 - 2006-02-02

93

SQUIBB BRISTOL MYERS CO (US)

AMMONOLYSIS PROCESS FOR THE PREPARATION OF FOR INTERMEDIATES DPP IV INHIBITORS

WO2006020664 - 2006-02-23

94

SQUIBB BRISTOL MYERS CO (US)

Enzymetic PROCESS

AMMONOLYSIS FOR THE OF FOR

WO2005108594 - 2005-11-17

PREPARATION INTERMEDIATES DPP IV INHIBITORS

95 96

GUILFORD PHARM INC (US) ROYALTY SUSAN MARIE (US)

DPP4 inhib Peptidase inhib

MXPA04006326 - 2005-06-08 WO2006012441 - 2006-02-02

97 98

ROYALTY SUSAN MARIE (US) BOEHRINGER (DE) INGELHEIM PHARMA

Peptidase inhib

WO2006012395 - 2006-02-02

New New New

7-butynyl-8-(3-amino-12-amino-imidazo(4,52-amino-imidazo(4,510A

DE102004032263 - 2006-01-

piperidinyl)xanthine derivatives
INGELHEIM PHARMA

19
DE102004025552 - 2005-12-

99

BOEHRINGER (DE)

d)pyridazin-4-one derivatives
INGELHEIM PHARMA

22
DE102004017739 - 2005-10-

10 0 10 1

BOEHRINGER (DE)

d)pyridazin-4-one derivatives PHOsPHODIESTERASE INHIBITORS TO AMPLIFY THE ACTION OF GLP1-MIMETICS OR DPP-IV INHIBITORS

27
WO2005120474 - 2005-12-22

K U LEUVEN RES AND DEV (BE);