Brand Name: Nafarin

Generic Name: Phenylpropanolamine HCl

Indications: urinary incontinence, relive symptoms of some allergic disorders such as asthma and
hay fever.
Drug Classification: Sympathomimetic
Mechanism of Action: The phenylpropanolamine HCl is a sympathomimetic amine with a
chemical structure and pharmacological actions similar to the ephedrine, but with
fewer central stimulant effects. It is a vasoconstrictor with decongestant action on
the nose and upper respiratory tract mucous membranes. It directly and indirectly
stimulates the a- and b-adrenergic receptors. It exerts this last action by allowing the
norepinephrine liberation (noradrenaline) from its storage sites. Its action on the a-
receptors in the respiratory tract mucosa produces vasoconstriction, which results in
the decrease of the mucosa edema and the consequent increase of the nasal air flow.
Dosage: Adults 25 mg at 4-hr intervals or 50 mg at 8-hr intervals, as indicated.
Children 6-12 yr: 25 mg at 8-hr intervals; 2-6 yr: 12.5 mg q 8 hrs; elixir: 20 mg/ml.
Special Precautions: elderly, hypertension, cardiovascular disease, hyperthyroidism, diabetes,
prostatic enlargement, tricyclic antidepressants.
Pregnancy Risk Category: C
Adverse Reactions:
GI: dry mouth
 GU: urinary retention
Derm: sweating, cold extremities
CNS: anxiety, restlessness, insomia
CV: heartbeat irregularities
Contraindications: Patients with high blood pressure, overactivity of the thyroid gland, coronary
heart disease or diabetes, or who are taking antidepressant drugs
Forms: Sustained-release capsules, dilute syrup, (topical) nasal or throat spray, elixir.
Nursing Responsibilities:
 Administer the medication with a full glass of water after a meal or snack. The
tablet can be broken in half. However, the whole or half tablet should be
swallowed whole.
 Assess for kidney disease, heart disease, lung disease, asthma, emphysema,
high blood pressure, an overactive thyroid, diabetes, glaucoma, prostate
trouble, depression, any allergies of the patient.
 Caution patient not to exceed recommended doses.