Brand name: Vessel due F

Generic name: Sulodexide

Indication: Vascular pathologies w/ thrombotic risk, transient ischemic attacks &
cerebrovascular disease, peripheral vascular insufficiency, diabetic retinopathy,
MI, retinal vasal thrombosis.
Mechanism of action: Inhibits coagulation by attacking several sites of the coagulation
system. Its effect is dependent on the presence of antithrombin III, an alpha 2-
globulin whose activity is augmented by heparin. The heparin- antithrombin
complex inactivates factors IXa, Xa, XIa and XIIa, and prevents thrombin
formation. Furthermore, the complex reverses the effect of already formed
thrombin. In high concentrations, heparin also inhibits thrombocyte aggregation.
Drug Classification: Anticoagulant, antithrombotics & fibrinolytics
Dosage: Acute cases 1 amp 10-20 days once daily followed by 1-2 cap bid 30 mins
before meals for 60-90 days. Chronic cases1-2 cap bid 30 mins before meals for
60-90 days.
Special Precaution: Periodically monitor parameters. Pregnancy.
Pregnancy Risk Category: (not yet applicable); Heparin: C
Adverse Reaction: Cap GI disorders: nausea, vomiting, epigastralgia. Amp Pain, burn,
hematoma at the site of injection.
Contraindication: Hypersensitivity to sulodexide, heparin & heparin- like products.
Diathesis & hemorrhagic diseases.
Form: Capsule- 250 LSU; Ampule- 300 LSUx2 mL
Nursing Responsibilities:
 Assess patients for signs of bleeding and hemorrhage (bleeding gums;
nosebleed; unusual bruising; black, tarry stools; hematuria; fall in hematocrit or
blood pressure; guaiac- positive stools). Notify physician if these occur.
 Monitor patient for hypersensitivity reactions (chills, fever, urticaria). Report
signs to physician
 Subcutaneous: observe injection sites for hematomas, ecchymosis, or
inflammation.
 Monitor platelet count every 2-3 days throughout therapy. May cause mild
thrombocytopenia, which appears on the 4th day and resolves despite continued
heparin therapy.