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  • Treatment Goal: Prevent The Recurrence of GI Bleeding and Ulcers

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    erilarchi
    15 просмотров5 страниц
    The treatment goal is to prevent recurrence of GI bleeding and ulcers. According to studies, the most important risk factor for recurrence is a previous history of GI bleed, which increases risk almost fourfold. Managing acute bleeding involves treating patients at high risk or with active bleeding. Suppressing gastric acid production with proton pump inhibitors promotes healing and stabilizes blood clots to prevent recurrence. Esomeprazole, omeprazole, lansoprazole, pantoprazole and rabeprazole are suitable and safe proton pump inhibitor options, though omeprazole and pantoprazole have better cost profiles.

    Исходное описание:

    proton pump inhibitor

    Оригинальное название

    ppi.pptx

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    The treatment goal is to prevent recurrence of GI bleeding and ulcers. According to studies, the most important risk factor for recurrence is a previous history of GI bleed, which increases risk almost fourfold. Managing acute bleeding involves treating patients at high risk or with active bleeding. Suppressing gastric acid production with proton pump inhibitors promotes healing and stabilizes blood clots to prevent recurrence. Esomeprazole, omeprazole, lansoprazole, pantoprazole and rabeprazole are suitable and safe proton pump inhibitor options, though omeprazole and pantoprazole have better cost profiles.

    Авторское право:

    Attribution Non-Commercial (BY-NC)
    Скачайте в формате PPTX, PDF, TXT или читайте онлайн в Scribd
    Отметить как неприемлемый контент
    15 просмотров5 страниц

    Treatment Goal: Prevent The Recurrence of GI Bleeding and Ulcers

    Загружено:

    erilarchi
    The treatment goal is to prevent recurrence of GI bleeding and ulcers. According to studies, the most important risk factor for recurrence is a previous history of GI bleed, which increases risk almost fourfold. Managing acute bleeding involves treating patients at high risk or with active bleeding. Suppressing gastric acid production with proton pump inhibitors promotes healing and stabilizes blood clots to prevent recurrence. Esomeprazole, omeprazole, lansoprazole, pantoprazole and rabeprazole are suitable and safe proton pump inhibitor options, though omeprazole and pantoprazole have better cost profiles.

    Авторское право:

    Attribution Non-Commercial (BY-NC)
    Скачайте в формате PPTX, PDF, TXT или читайте онлайн в Scribd
    Отметить как неприемлемый контент
    из 5

    Treatment Goal

    Prevent the recurrence of GI bleeding and ulcers

    According to Oyetayo et. Al., the most important clinical risk factor for recurrence of GI bleeding was a previous history of GI bleed. It was associated with an almost fourfold increase in the risk of an upper GI bleed in patients admitted for an acute upper GI bleed

    Managing acute upper GI bleeding, preventing recurrences


    According to Albeldawi et. Al, the patients at high risk (ie, older than 60 years, with severe comorbidity, or hemodynamically compromised) who have active bleeding (ie, witnessed hematemesis, red blood per nasogastric tube, or fresh blood per rectum) or a nonbleeding visible vessel Acid and pepsin interfere with the healing of ulcers and other nonvariceal upper GI lesions. Further, an acidic environment promotes platelet disaggregation and fibrinolysis and impairs clot formation.16 This suggests that inhibiting gastric acid secretion and raising the gastric pH to 6 or higher may stabilize clots.
    Cleveland Clinic Journal of Medicine

    Proton Pump Inhibitors and the Prevention of Recurrent GI Bleeding


    According Oyetayo et. Al., A potential strategy for preventing GI bleeding is suppression of gastric acid production to promote healing and stabilize thrombi. PPIs provide more potent and prolonged acid suppression and have emerged as preferred agents

    Efficacy Suitability Safety Esomeprazole ++++ ++++ ++++ Omeprazole ++++ ++++ ++++ Lansoprazole ++++ ++++ ++++ Pantoprazole ++++ ++++ ++++ Rabeprazole ++++ + ++++

    Cost +++ ++++ ++ +

    Omeprazole - P366 Esomeprazole - P1015 Lansoprazole 1174 Pantoprazole P1219

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