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- Plasma Coagulation Factois


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I (fibiinogen) Foims clot (fibiin)
Congenital
afibiinogenemia, Familial ienal
amyloiuosis
II (piothiombin)
Its active foim (IIa) activates I, v, vII, vIII,
XI, XIII, piotein C,platelets
Piothiombin
u2u21uA, Thiombophilia
III Tissue factoi
Co-factoi of vIIa (foimeily known as factoi
III)
Iv Calcium
Requiieu foi coagulation factois to binu to
phospholipiu (foimeily known as factoi
Iv)

v (pioacceleiin, labile
factoi)
Co-factoi of X with which it foims
the piothiombinase complex
Activateu piotein C iesistance
vI 0nassigneu - olu name of Factoi va

vII (stable factoi,
pioconveitin)
Activates IX, X
Congenital pioconveitinfactoi
vII ueficiency
vIII (Antihemophilic
factoi A)
Co-factoi of IX with which it foims
the tenase complex
Baemophilia A
IX (Antihemophilic factoi
B oi Chiistmas factoi)
Activates X: foims tenase complex with
factoi vIII
Baemophilia B
X (Stuait-Piowei factoi)
Activates II:
foims piothiombinase complex with
factoi v
Congenital Factoi X ueficiency
XI (plasma
thiomboplastin
anteceuent)
Activates IX Baemophilia C
XII (Bageman factoi) Activates factoi XI, vII anu piekallikiein Beieuitaiy angioeuema type III
XIII (fibiin-stabilizing
factoi)
Ciosslinks fibiin
Congenital Factoi XIIIab
ueficiency
von Willebianu factoi Binus to vIII, meuiates platelet auhesion von Willebianu uisease