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Genome
Virus Properties Non-enveloped Icosahedral +ve RNA picornavirus Picornaviridae, Hepatovirus Partially double stranded DNA virus, composed of: o Nucleocapsid core (HBcAg) Appears early o Surround by envelope composed by surface antigen (HBsAg) Appears late Hepadnaviridae, Orthohepadnovirus
Transmission
Outcome
Diagnosis
Prevention
RNA
Killed HAV
Detection of viral Ag by ELISA @ RIA Detection of HBV DNA by PCR Recombinant HBV vaccines characterised by: presence of antiHBcand anti-HBs absence of HBsAg
DNA
Blood-borne 1. Transfer of body fluids 2. Mother to baby 3. Contaminated equipment of blood products & body fluid
Hepatitis C
RNA
Flaviviridae, Pestivirus
Blood-borne
Subclinical, acute, chronic infection, cirrhosis, primary hepatocarcinoma Superinfection Or Coinfection with HBV
HBV vaccine
RNA
Caliciviridae
Fecal-oral
Hepatitis G
RNA
Sexuallt-parentally
HBV vaccine
Serological Markers Clinical condition Acute hepatitis Chronic active hepatitis Asymptomatic carrier Past infection: immunity Past immunisation HBsAg + + +# Anti-HBs + + Anti-HBc(total) + + + + HBV DNA + + -* -