PATHOPHYSIOLOGY

Modifiable factors Occupation

Non- modifiable factors Age

acteria enters into t!e blood stream

"rosses t!e blood-brain barrier

acteria proliferates in t!e "S#

Irritates and induces inflammator$ reaction to t!e "S# and meninges

Immune response of astroc$tes% microglia and c$to&ins is released

#e'er

Irritation of ner'e endings Inflammation of t!e Meninges

t!e

Irritabilit$ Muscle rigidit$

Nuc!al rigidit$

Increase in t!e number of ( " Increased blood flo* Lea&ed fluid and proteins mo'e into inflamed tissue

)asodilation

Purulent e+udates formation

Increased permeabilit$

,dema

Irritates ner'e cells of t!e brain

sei-ure

Increased I"P Increase lood pressure