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• Antacids are used to treat gastric

hyperacidity as a one-time dose or as a part of


the treatment of more severe condition as
associated with hyperacidity.
Pharmacodynamics:
•Antacids neutralize gastric acid to bring the pH
above 3.

Pharmacotherapeutics:
•Treatment of hyperacidity associated with mild
conditions such as heartburn and acid indigestion,
Adjunctive treatment for more severe gastric
conditions such as ulcers, hiatal hernia, gastritis,
GERD, Zollinger-Ellison syndrome.
Prevention of ulcers
Used as phosphate binders in clients with renal
failure.

Pharmacokinetics:
•Most preparations are not absorbed and are excreted
through the feces.
Contraindications:
•Solutions high in sodium are contraindicated in
clients with congestive heart failure because they
may cause fluid retention.

•Solutions containing aluminum must be used


cautiously in clients with gastric disease because
they can cause constipation and phosphate depletion.

•Solutions containing magnesium can cause


hypermagnesemia as well as diarrhea.

•Solutions containing sodium bicarbonate can cause


metabolic alkalosis.

•Preparation containing calcium can cause rebound


hyperacidity and metabolic alkalosis.
Drug Interaction:

The presence of antacids in the


stomach may impair absorption of many
other drugs.

Side Effects

G.I: diarrhea, constipation.


Renal: Electrolyte alterations.
COMMON ANTACIDS

Aluminum Hydroxide (ALternaGel,Amphojel )

Indications:
Adults: 500 to 1500 mg P.O. 1 hr after meals and h.s
Or, 300-mg tablet or 600-mg tablet, chewed before
swallowing, taken with milk or water five to six times daily
after meals and h.s.
Calcium Carbonate (Tums)
Magnesium Oxide (Uro-Mag, Maox)