INFEKSI VIRUS PADA REPRODUCTIVE SYSTEM / INFEKSI VIRUS MASA KEHAMILAN

Dr. Gerben F. Hutabarat DTM&H,Msc,SpMK. Bgn : Mikrobilogi FK.USU

I. DNA VIRUS 1. HERPES SIMPLEX VIRUS (HSV) 2. CYTOMEGALO VIRUS (CMV) 3. HUMAN PAPILOMA VIRUS (HPV) 4. PARVO VIRUS (B19VIRUS) (B19V) 5. HEPATITIS B VIRUS (HBV)

II. RNA VIRUS 1. RUBI VIRUS (RUBELLA VIRUS) 2. HUMAN IMMUNODEFICIENCY VIRUS (HIV) 3. MEASLES VIRUS 4. MUMPS VIRUS

HERPES SIMPLEX VIRUS (HSV)

SIFAT VIRUS PENYAKIT : DNA, DOUBLE STRANDED, 100 nm

1. GENITAL HERPES CARA PENULARAN : SEXUAL INTERCOURSE GEJALA PENYAKIT : VESICULAR ERUPTION DIAGNOSA LAB : ISOLASI: VESICLE FLUID, SKIN SWAB

2. NEONATAL HERPES CARA PENULARAN : NEONATALIN FECTION GEJALA PENYAKIT : JOUNDICE, HEPATOSPLENO MEGALI,THOROM BOCYTOPENIA, VESICULAR SKIN DIAGNOSA LAB. A. INOCULASI : VESICLE FLUID : TISSUE CULTURE(BHK4,HELC). B. SEROLOGY.

CYTOMEGALO VIRUS (CMV)

SIFAT VIRUS : DNA PENYAKIT : CYTOMEGALIC INCLUSION DISEASE (CID) CARA PENULARAN : SEXUAL INTERCOUSE BLOOD TRASFUSION FETAL INFECTION TRANSPLAN CENTALLY IN UTERO

GEJALA PENYAKIT PADA FETUS MENTAL RETARDATION JOUNDICE HEPATO-SPELENO MEGALI BLOOD DISCRASI (TROMBO CYTOPENIA,HAEMOLITIC ANMIA) MICROCEPHALI MOTOR DISEASE

DIAGNOSA LABORATORIUM ISOLASI : (URINE, THROAT SWAB) INOCULASI : HELC => CPE: SWALLEN CELL SEROLOGI : CFT,IF.

HUMAN PAPILOMA VIRUS (HPV)

SIFAT VIRUS : DNA DOUBLE STRANDED CIRCULAR (50 nm). PENYAKIT : GENITAL WARTZ (CONDYLOMA ACCUMINATA) CARA PENULARAN : SEXUAL INTERCOUR SE GEJALA PENYAKIT : MARKED FROLIFERATION OF EPITHELIAL (CELL CONDYLOMA ACUMINATA) DIAGNOSA LAB : - KILOCYTES IN THE LESION - SEROLOGY PREVWNTION : NO VACCIN AVIABLE

PARVO VIRUS B19

SIFAT VIRUS : DNA, SINGLE STRANDED PENYAKIT : 1. SLAPPERT CHEEKS SYDROME FIFTH DISEASE APLASTIC ANEMIA CARA PENULARAN : RESPIRATION ROUTE ,BLOOD TRANSFUSIONS DIAGNOSA LAB: DITECTION : IgM , ISOLATION FROM THROAT SWAB, PCR DNA: FOR BLOOD,AMNIOTIC FLUID

2. FETAL INFECTION
CARA PENULARAN : TRANS PLACENTAL TRANS MISSION ( INFECTION FIRST TRISMESTER) GEJALA : FETAL DEATH

RUBI VIRUS (RUBELLA VIRUS)

SIFAT VIRUS : RNA, 50-75 nm PENYAKIT : RUBELLA (GERMAN MEASLES) IN PREGNAN CY), INCUBATION PERIOD : 14-21 DAYS CARA PENULARAN : -RESPIRATORY DROPLET - TRANSPLASCENTALLY GEJALA PENYAKIT : Pd.FETUS - CONGENITAL DEFECT (TRIAD : CATARACT, NERVE DEFNES, CACDIAC ABNORMALITY) - RUBELLA SYNDROME

DIAGNOSA LAB:
SEROLOGI : HI TEST, IgG RISING TITER. IgM : (CFT, RIH) PREVENTION : VACCIN : ONE DOSE S.C (LIVE ATTENUATED) VIRUS VACCIN

MEASLES VIRUS
SIFAT VIRUS: RNA, 120-250 nm, ONE SEROLOGICAL TYPE. PENYAKIT : MEASLES ( RUBEOLA = MORBILI) INCUBATION PERIOD : 10-14 DAYS CARA PENULARAN : INHALATION RESPIRATION SECRETION GEJALA PENYAKIT : PADA IBU : FEVER, CONJUNTIVITIS, RUNNING NOSE, COUGHING, KOPLIC SPOT IN BUCCAL DIAGNOSA LAB: -ISOLATION IN CELL CULTURE -SEROLOGY : RISING TITER (GREATER THAN - 4 FOLD)

PREVENTION
MEASLES VACCIN: ONE DOSE S.C (LIFE ATTENUATED VACCINE).

FETUS. -TRANS PLANCENTALLY -FETAL DEATH

TERIMA KASIH