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Therapeutic action Anti-inflammatory, analgesic, and anti pyretic activities that largely related to inhibition of prostaglandin synthesis. Inhibits both cyclogenase (COX) 1 and 2. Ibuprofen is more selective for COX 2
Indication Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis; relief of mild to moderate pain; fever reduction
Adverse effects CNS: headache, dizziness, fatigue, tinnitus, ophthalmologic effects CV: hypertension, palpitations, arrhythmia, heart failure GI: nausea, GI pain, vomiting, constipation Respiratory: dsypnea, hemoptysis, bronchospasm, rhinitis
Nursing Responsibilities 1. administer drug with foods or after meals if GI upset occurs. 2. discontinue drug if eye changes. 3. use drug as suggested 4. ask patient to report sore throat, fever, rash, itching, swelling in the ankles or fingers.