HYALINE CHANGE

Leiomyoma with Degeneration (Low Power) This low power image shows spindle cells arranged in loose bundles on the left. On the right side of the picture is a predominantly acellular eosinophilic field. No mitotic activity or cellular atypia is seen

Leiomyoma (Medium Power) This medium power photomicrograph shows widely spaced nuclei. The nuclei are spindly and bland with little variation in nuclear shape. The cells are loosely arranged in bundles. Mitoses are absent.

There are two other forms of arteriosclerosis (hardening of the arteries) in addition to atherosclerosis: arteriolosclerosis and medial calcific sclerosis. Arteriolosclerosis is typically seen in the kidneys. One form, called hyaline arteriolosclerosis, is demonstrated by the markedly thickened arteriole to the lower right of this glomerulus with PAS stain. Hyaline arteriolosclerosis is seen in the elderly, but more advanced lesions are seen in persons with diabetes mellitus and/or with hypertension.

TRICHROME STAIN

End Stage Kidney

The majority of the glomeruli are globally sclerosed, hyalinized and acellular. The tubular compartment is nearly absent. The few tubules recognizable as such are severely atrophic.

At high magnification can be seen globular red hyaline material within hepatocytes. This is Mallory's hyaline, also known as Alcoholic" hyaline because it is most often seen in conjunction with chronic alcoholism. The globules are aggregates of intermediate filaments in the cytoplasm resulting from hepatocyte injury.

This Islet of Langerhans demonstrates pink hyalinization (with deposition of amyloid) in many of the islet cells. This change is common in the islets of patients with type II diabetes mellitus.

Normal Ovary - Corpus Albicans The corpus albicans is composed of dense, hyalinized scar with a few residual spindly nuclei. The edge of the corpus is very distinct.

HYALINE CHANGE