Академический Документы
Профессиональный Документы
Культура Документы
Capability
Using commercial and proprietary flow chemistry equipment CMSE can readily address all areas of the R&D pipeline, including discovery (library generation), and process development and scale-up. Key capabilities include: Corrosive fluids capability (strong acids, strong bases) Organometallic reagents (Grignards, organolithiums) High temperature processing for process intensification (cycloaddition chemistry, thermal rearrangements, pyrolysis chemistries) Continuous flow gas-liquid reactions (hydrogenation, carbonylation and other gas chemistries) Telescoped synthesis (multi-step synthesis of intermediates and products using multiple flow streams) Continuous polymer synthesis using free or controlled radical mechanisms (RAFT polymerisation technology) Continuous flow processing of highly exothermic reactions (ionic liquids) Fast reaction profiling and optimization Use of polymer-supported reagents for heterogeneous reactions (ion exchange, redox chemistry, in-line purification) Laboratory and pilot-scale flow photochemistry Scale-up to kilogram quantities.
Flow processing makes chemical production safer, more reproducible and scalable while offering reduced cost and low environmental impact
purification
analysis
flow reactor
pressure regulator
A
feed tanks
B
product tank
Automated liquid and solid handlers to process multiple batch samples (Chemspeed, Mettler-Toledo) Individually configured reactor set-ups or additions to existing reactor systems comprising HPLC pumps, syringe pumps and standard and specially modified microfluidic tubing and connectors.
Collaborations
Professor Steven Ley and Dr Ian Baxendale, Innovative Technology Centre, University of Cambridge Professor Andrew B. Holmes, University of Melbourne.
> [Above] Schematic diagram of a continuous flow reactor. [Right] CSIROs flow chemistry equipment.
Publications
Brasholz M, Johnson BA, Macdonald JM, Polyzos A, Saubern S, Tsanaktsidis J, Holmes AB, Ryan JH. 2010. Tetrahedron. 66: 6445-6449. Brasholz M, Macdonald JM, Saubern S, Ryan JH, Holmes AB. 2010. Chem. Eur. J. 16: 11471-11480. Brasholz M, von Knel K, Hornung CH, Saubern S, Tsanaktsidis J. 2011. Green Chemistry. 13, in press. Hornung CH, Guerrero-Sanchez C, Brasholz M, Saubern S, Chiefari J, Moad G, Rizzardo E, Thang SH. Org. Proc. Res. Dev., ASAP. Palmieri A, Ley SV, Hammond K, Polyzos A, Baxendale IR. 2009. Tetrahedron Lett. 50:3287-3289. Palmieri A, Ley SV, Polyzos A, Ladlow M, Baxendale IR. 2009. Beilstein J. Org. Chem. 5: No.23, DOI: 10.3762/bjoc.5.23. Polyzos A, OBrien M, Petersen TP, Baxendale IR, Ley SV. 2010. Angew. Chem. Int, Ed. DOI: 10.1002/anie.201006618.
For further information: Technical contact: Dr. John Tsanaktsidis Research Program Leader Functional Small Molecules Phone: 61 3 9545 2487 Fax: 61 3 9545 2446 Email: John.Tsanaktsidis@csiro.au Business contact: Dr. Kirsty Reed Business Development Manager Phone: 61 3 9545 2484 Mobile: 61 4 2105 7428 Fax: 61 3 9545 2446 Email: Kirsty.Reed@csiro.au
Feb 2011