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GMP

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:
,
50 150


. , 80%
Candida
albicans
( ) . 50%
, 8- 100 000
, .. 75%
.

, ,
. Candida spp.,
,
, Candida spp.
4 [ ..,
.., ..
. - , 2000, .2., N1, c. 24-28. ].
- 8-11
. 27
77% [. Pelz R.K. Lipsett P.A., Swoboda S. et al. Candida Infections: Outcome and Attributable
ICU Costs in Critically Ill Patients. - J Intensive Care Med 2000; 15; 255-261.].
, Candida,
, , , ,
[British Society for Antimicrobial Chemotherapy Working Party. Management of deep Candida
infection in surgical and intensive care unit. - Intensive Care Med, 1994; 20; 522-528. ].
Candida albicans,
Candida, Candida non-albicans.
, , 30
, Candida non-albicans (Candida krusei, Candida
tropicalis Candida parapsilosis) 30% [Walsh T.J. Global expamsion of
nosocomial candidiasis. - Int J Inf Dis, 1997, 1 (Suppl 1), S.1. ].
, C. albicans, .


()
( 1).

. 306.271 g/mol

. 1.

,
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. ,


.

()
.
, -450-
14-,
.
,
.
.
.
[Warnock D.W. Fungal
infections in neutropenia: current problems and chemotherapeutic control. - JAC, 1998, V.41
(Suppl.D), 95-105.]. , ,
.
.



, .. Candida spp.
( ), Cryptococcus
neoformans ( ), Microsporum spp. Ttichoptyton spp;
, Blastomyces dermatitides, Coccidioides immitis,
, Histoplasma capsulatum
.
(.albicans, C.parapsilosis, C.tropicalis, C.lusitaniae .),
, .
, , .
. in vitro C. albicans
. , , , 3,2%
C. albicans 2,4%
[ .., .. :

. - , 2001, .3.
N.6, . 178-182.]. C. non-albicans C. krusei.
C. glabrata.

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( , ).
:
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400 .
:
,
.
, .
, ,
,
.
:
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.

:
.
[Winston D.J., Hathorn J.W., Schuster
M.G. et al. A Multicenter, Randomized Trial of Fluconazole versus Amphotericin B for Empiric
Antifungal Therapy of Febrile Neutropenic Patients with Cancer. - Am J Med, 2000; 108; 282289. ].
, ,
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, , ,
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.
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:
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,
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, , ( .
).
[Ally R., Schurmann D., Kreisel W. et al. A randomized, Double-Blind,
Double-Dummy, Multicenter Trial of Voriconazole and Fluconazole in the Treatment of
Esophageal Candidiasis in Immunocompromised Patients. - Clin Infect Dis, 2001; 33; 144754.].



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