SEMINARIO N 1

MECANISMO DE ACCIN
1. Mecanismos de accin y efectos farmacolgicos.
2. Clasificacin de receptores. Definicin. Receptores acoplados a la Protena G.
3. Receptores tipo canal inico.
4. Receptores para hormonas esteroidea.
. Consec!encias de la inter"encin f#rmaco$receptor.
BIBLIOGRAFA
1. Caldern% &roylan.% 'pe($Colom)% *na.+ Receptores de gl!tamato en la retina. *rch ,e!rocien
-Me./.% -4/+ 104$113.% 2222.
2. 'e"enson% *3.% and 4ordan% 5C.+ 3electi"e 6estrogen Receptor Mod!lation+ Molec!lar
Pharmacology for the Milleni!m. 7!ropean 4o!rnal of Cancer.% 3 -14/+ 1804$181% 1888.
3. 5#s9!e(% *lfredo.+ *ntagonistas de los receptores de *ngiotensina ::. Re" C!;ana Med.% 30 -2/+ 13$
82.% 1881.
4. <odener% Donald.% and 'ash% Ro;ert.+ =hyroid disease mediated ;y molec!lar defects in cell s!rface
and n!clear receptors. *m 4. Med.% 12+ 34$31% 1881.
. 3tone% Dennis+ Receptors. 3tr!ct!re and f!nction. *m 4 Med.% 12+224$22% 1881.
>. 4ohnson% Cecilia.+ Receptores de mem;rana y s!s mecanismos en(im#ticos de accin. Patologas
endocrinas asociadas. Re". M)d. Chile.% 12>+ 1314$1382% 1881.
0. ?a!ster% M.% ?a!ssler% C.% 4!r!t@a% P.% and et al.+ =he "itamin D hormone and its n!clear receptor+
molec!lar actions and disease states. 4. 7ndocrinol.% 14 -s!pplA+ 30$03% 1880/
1. Pasch@e% R.% and '!ggate% M.+ =he thyrotropin receptor in thyroid diseases. , 7ngl. 4. Med.% 330
-23A+ 1>0$1>12. 1880/.
8. <arrn% *.% <ermeBo% '.% Castro% :"onne.+ 7l receptor de estrgenos y la gl#nd!la mamaria. Re".
:n"es. Clin.% 48+1$21% 1880.
12. G!erman% =.% 3hone;erg% =.% and 3ch!lt(% G!nter.+ f!nctional and str!ct!ral comple.ity of signal
transd!ction "ia G$Protein$co!pled receptors. *nn!. Re". ,e!rosci.% 22+338$420% 1880.
11. :(a 3toll% *.+ Protenas G heterom)tricas y transd!ccin de seCales ?ipertensin.% 4-1/+12$13% 1881.
12. *c@erman% Michael.% Clapham% Da"id.+ :on channels. <asic 3cience and Clinical disease. , 7ngl 4
Med.% 33>122+ 10$11% 1880.
13. Caldern% Rolando.+ 'as protenas DGE en medicina. Diagnstico.% 3->/+4$0% 1880.
14. &erg!son% 3tephen.% Fhantg% 4ie.% and et al.+ Pleotropic role for GRG3 and <arrestins in receptor
reg!lation+ ,eHs Physiol.+ Dci.% 12+14$12% 1880.
1. &lier% 4effrey.% Inderhill% 'isa.+ *drenergic receptors. 7"ol"ing concepts and clinical complication.
, 7ngl 4. Med.% 334-8/+ 12$1% 188>.
CUESTIONARIO -7l Profesor completar# el c!estionario% segJn lo desarrollado en el 3eminario/.
1. Definicin de mecanismos de accin y efectos farmacolgicos.
2. Clasificacin de receptores.
3. Caractersticas de Receptores tipoKKKKKKK.
4. Caractersticas de Receptores tipoKKKKKKK.
. -&orm!lada por el Profesor/.