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14.03.06 ,
:
..
-
2014
.
.. 5
1.
( ) ..
13
2. .. 40
2.1. 40
2.2. .. 41
2.3. . 43
2.4. 45
2.5.
47
2.6.
...
49
2.7. - ... 50
2.8. . 51
2.9. . 52
2.10. 53
2.11. ...
54
2.12. . 55
2.13. ,
56
2.14. .. 57
3. . 59
3.1. ... 59
3.1.1.
.. 59
3.1.2.
() 61
3.1.3.
. 62
3.1.4. . 64
3.1.5.
65
3.1.6.
.. 66
3.1.7. . 70
3.2.
.. 71
3.2.1. .. 71
3.2.2. ,
CCl4 ... 75
3.2.3. ,
CCl4 ... 76
3.2.4.
, CCl4 ... 82
3.2.5.
,
CCl4 .... 85
3.2.6.
, CCl4 ... 89
4. 98
5. . 120
6. 123
7. - 125
8. 126
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27
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2007). ,
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41
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42
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49
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9).
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( ) 50%-
l4. 50 100%- l4 50 , 0,4 / 50%-
l4 ( 1000 / l4) 1- 4- .
( 50%)
l4 . ,
2000 / l4 .
53
7 , 10-14 :
1 (/) 0,9% ;
2 / l4 + 14
;
3 / l4 + (2,2 /) / 14 ;
4 / l4 + (4,3 /) /
14 ;
5 / l4 + (11,6 /) /
14 ;
6 / l4 + 300
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20
Zorbax C18.
(Sigma, ) . (), (), (), 3,4
(),
(),
5-
56
(5-)
0,1 - , 0,3 , 0,1 10% ( 3,2). +0,7 Ag/AgCl
. 0,8
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1- ()
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,
( .., 2000). 5-7 , 40-60 .
0,9%- .
2- ( ) :
, 25%-
57
58
59
3.
3.1.
3 (4,3 /, 8,6 / 13,4 /)
(5-7 , 1 ) :
, ,
-, ( ),
, .
3.1.1.
(5 )
, (4,38,6-13,4 /) ,
(. 2). ( 3-4 ) ( ), ( 13,4 /)
( 4,3 13,4 /, 8,6 /),
.
8,6 / ,
, , . , () ( , ).
60
2
(4,3-8,6-13,4 /)
( , )
0,9% NaCl
()
4,3 /
8,6 /
13,4 /
17,02,2
6,70,9
4,70,6
3,80,5
1,00,1
24,03,1*
8,01,0
1,00,1**
3,00,4
0,30,1**
25,03,3*
5,30,7
1,50,2**
4,30,6
1,50,2*
25,73,3*
5,50,7
1,50,2**
2,60,3*
0,50,1*
. *<0,05, **<0,01 .
3.1.2.
()
. ,
, , .
,
13, 4 /.
. 3.
, (2,5 /) 4
, (<0,01). (13,4 /)
5 -
61
.
, .
3
(13,4 /)
0,9% NaCl ()
2,5 /
13,4 /
2,20,3
1,70,2
8,31,1**
1,50,2*
6,80,9**
1,80,2
. *<0,05, **<0,01 .
, (13,4 /)
. ( ) .
3.1.3.
() () , .
() , () .
62
4
(4,3-8,6-13,4 /)
0,9% NaCl
()
4,3 /
8,6 /
13,4 /
()
()
0,40,1
4,60,2
10,21,3
6,20,8
0,40,1
4,60,2
5,70,7*
3,70,5*
0,50,1
4,50,2
3,20,4**
10,01,4*
0,20,1*
4,80,3
2,10,3**
3,30,4*
. *<0,05, **<0,01 .
(4,3-8,6-13,4 /)
5
(. 4), 13,4 /
.
, 2-5
2 ( 4,3 13,4 /, 8,6 /). 8,6 /
, ,
.
, , 13,4 /.
63
3.1.4.
-
.
5 -
- ,
( 3,5-7 )
. 13,4 / (. 5).
5
(4,3-8,6-13,4 /)
0,9% NaCl
()
4,3 /
8,6 /
13,4 /
, . .
65,88,6
77,310,1
0,00,0
0,00,0
9,81,3***
14,31,8***
0,00,0
0,00,0
11,11,4***
17,82,3***
0,00,0
0,00,0
13,81,8***
21,32,8***
0,80,1**
0,20,1*
64
, , . , ,
,
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,
() .
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/) .
3.1.5.
.
.
5 ( 4-5 )
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.
( ) ,
, , .
13,4 /
, 4,3 / , 8,6 /
.
65
6
(4,3-8,6-14,3 /)
0,9% NaCl
18,52,4
369,518,0
2,80,4
()
15,32,0
262,747,2*
12,11,6**
4,3 /
18,82,4
353,345,9
15,82,1**
8,6 /
14,31,9*
346,245,0
17,12,2**
13,4 /
. *<0,05, **<0,01 .
, .
.
3.1.6.
( ,
)
( , ). ,
. (, , ) . -
66
, (, , ..).
7 4,3-8,6-13,4 / (.
7). 2 ( )
(13,4 /), ( 18-28%) 4,3-8,6 /. 3- (8,6
13,4 /) 27-39% , . 4-5 8,6 13,4 / (+39%) 3- . 3-
4,3 / (-34%
-11% );
5- , (
, 3-, 4- 5- ).
, ,
8,6 14,3 /,
( 4- 15%, 5- 12-16%).
6- 7-
. (1 /) 35-37%.
, 27-45%, , () .
,
. , , ,
, -
67
7
(4,3-8,6-13,4 /) (1 /)
0,9% NaCl
()
4,3 /
8,6 /
13,4 /
0,9% NaCl
()
4,3 /
8,6 /
13,4 /
0,9% NaCl
()
4,3 /
8,6 /
13,4 /
0,9% NaCl
()
4,3 /
10
1-
16112
14716
(+10%)
12215
14821
(-18%)
11320*
15812
(-28%)
16018
16521
(-3%)
2-
15212
14323
(-6%)
13619*
18823
(-28%)
17221
16920
(+2%)
15713
17122
(-8%)
3-
16111
14424
(-11%)
15517
17023
(-34%)
23222*
18219
(+27%)
24422*
17619
(+39%)
4-
17111
15424
(-11%)
12126*
18217
(-34%)
19123
24618*
0,210,02
0,200,01
0,170,01
0,230,03
0,210,04
0,190,01
0,140.4
0,180,02
0,340,03
0,260,05
0,190,06
0,160,02
0,140,3
0,160,02
0,210,12
0,170,02
0,140,03
0,180,06
0,210,02
0,200,01
0,250,04
0,140,03*
0,200,09
0,180,5
0,160,03
0,180,06
0,150,02
0,210,03*
0,190,05
0,210,03
68
8,6 /
13,4 /
20923
0,9% NaCl
()
4,3 /
8,6 /
13,4 /
14222
0,9% NaCl
()
1 /
16617
4,3 / +
1 /
8,6 / +
1 /
13,4 / + 1 /
0,9% NaCl
()
1 /
4,3 / +
1 /
8,6 / +
1 /
13,4 / + 1 /
20531
21113
22821
18519
(+15%)
24119
(+15%)
5-
15617
(+10%)
17024
(-17%)
24424
(+16%)
25515
(+12%)
6-
15522
(-7%)
25321*
(+37%)
0,130,01
0,190,04*
0,130,04
0,180,03
0,220,05
0,190,04
0,160,11
0,220,01*
0,200,04
0,220,01
0,150,01
0,130,04
0,190,02
0,130,04*
21725
27519*
(+27%)
0,250,03
0,140,04*
22019
28035*
(+27%)
0,210,11
0,190,10
20121
29217*
(+45%)
0,240,06
0,120,02*
0,160,01
0,140,04
0,180,02
0,120,04*
7-
17617
16522
(-6%)
18021
24319*
(+35%)
21230
28834*
(+36%)
0,240,02
0,220,04
21122
29426*
(+39%)
0,120,04
0,230,06
22115
30319*
(+37%)
0,260,05
0,230,06
. *<0,05 .
69
. , , ,
, .
3.1.7.
- ( , , -, , , ). 4,3-8,6-13,4 / (5-7 ).
, () ( , ). (13,4 /) ( ) . () , 13,4 /. -
() .
. (4,3-8,6-13,4 /) . 13,4 /
.
. -
70
. , , ,
,
. , ,
. , (-) .
71
3.2.
3
(2,2 /, 4,3 / 11,6 /) (14 , 1
) :
, ,
-, ,
.
3.2.1.
0,4 / 50%- l4 ( 1000 / l4) 1- 4- . , , l4 40%, 50%
(50). l4 . , 2000
/ l4 .
, 16- ,
: , , ,
. , , l4, 2
( 123,114,4 248,610,4 /), 4 ( 22,89,3 88,749,7 /), - ( 1708,840,9 1930,835,4 /), - ( 2,330,83 0,980,97 /), , , .
72
( ), :
- ;
;
.
. 1 (, ) (. 12).
,
,
,
. , ,
, , .
, .
2 (, CCl4 + )
-
, 1/3 2/3
, , (. 13).
, .
2-3 -
73
().
. 12. , ()
. . 200.
. 13. , CCl4 +
()
,
(). .
200.
, CCl4 2000 /
( ),
15 . .
74
3.2.2. , CCl4
CCl4 2000
/ , , 50%
(. 8).
8
, CCl4
(%)
1. ( )
2. CCl4 + .
10
0 (0%)
14
7 (50%)
3. CCl4 + 2,2 /
12
5 (42%)
4. CCl4 + 4,3 /
14
6 (43%)
5. CCl4 + 11,6 /
14
7 (50%)
6. CCl4 + 300 /
( )
7. CCl4 + 300 /
( )
14
6 (43%)
10
10 (100%)
2,2-4,3-11,6 /
, CCl4.
42-50%.
CCl4, 2- 5- . 300 /, , . 300 /, , (100%).
7- . .
75
3.2.3. , CCl4
3.2.3.1.
,
CCl4 (2000 /) 15
(. 14). , , CCl4, ( 3 ) ( 2,5 ) ,
( 5 ) ( 2 ). .
(14 )
,
2,2 4,3 /, 11,6 /. ( ) ( ) ,
. . 300 / .
, , , ()
, CCl4. (2,2 /) (4,3 /) .
76
. - + CCl4
45
. - + CCl4
40
0.5 + CCl4
35
30
25
20
15
0.5 + CCl4
0.75 +
CCl4
1.2 + CCl4
0.75 +
CCl4
1.2 + CCl4
10
- + CCl4
5
0
+
CCl4
- + CCl4
1
0
1
. - + CCl4
10
9
8
7
6
5
4
3
2
1
0
0.5 +
CCl4
10
0.75 +
CCl4
8
0.75 +
CCl4
1.2 +
CCl4
4
1.2 + CCl4
- + CCl4
. - + CCl4
14
12
0.5 + CCl4
+
CCl4
- +
CCl4
2
0
1
+
CCl4
. - + CCl4
2,5
0.5 + CCl4
0.75 +
CCl4
1,5
1
1.2 + CCl4
0,5
- + CCl4
0
1
+
CCl4
. 14.
, CCl4
3.2.3.2.
,
. ()
() ,
77
.
() , () .
CCl4 (2000 /) 14
(. 15). , CCl4, ()
2,5 , 4 ,
10 .
. (2,2-4,3-11,6 /),
() .
. - + CCl4
120
0.5 + CCl4
100
80
0.75 +
CCl4
60
1.2 + CCl4
40
- + CCl4
20
0
+
CCl4
. - + CCl4
12
0.5 + CCl4
10
8
0.75 +
CCl4
1.2 + CCl4
- + CCl4
2
0
+
CCl4
. - + CCl4
25
20
0.5 + CCl4
15
0.75 +
CCl4
10
1.2 + CCl4
- + CCl4
0
1
+
CCl4
. 15.
, CCl4
78
, 14
.
3.2.3.3.
-,
.
CCl4 (2000 /) 15
- . (.
16). (2,2-4,3-11,6 /) 14
,
. ,
.
, -
,
,
( ), .
79
. - + CCl4
200
180
160
140
120
100
80
60
40
20
0
0.5 + CCl4
80
. - + CCl4
4,5
4
3
0.75 +
CCl4
2,5
2
1
- + CCl4
0,5
0
1
- + CCl4
20
0
+
CCl4
. - + CCl4
2,5
0.5 + CCl4
0.75 +
CCl4
1,5
1
1.2 + CCl4
0,5
- + CCl4
1.2 + CCl4
1,5
1.2 + CCl4
40
0.5 + CCl4
3,5
0.75 +
CCl4
60
- + CCl4
+
CCl4
0.5 + CCl4
100
1.2 + CCl4
. - + CCl4
120
0.75 +
CCl4
+
CCl4
+
CCl4
. 16. , CCl4
3.2.3.4. ,
.
.
.
CCl4 (2000 /) 14
4
,
(. 17). (,
)
80
. (2,2-4,3-11,6 /)
,
. 300 /
CCl4, .
. - + CCl4
120
0.5 + CCl4
100
80
0.75 +
CCl4
60
1.2 + CCl4
40
- + CCl4
20
0
+
CCl4
. - + CCl4
300
0.5 + CCl4
250
200
0.75 +
CCl4
150
1.2 + CCl4
100
- + CCl4
50
0
+
CCl4
. - + CCl4
80
70
0.5 + CCl4
60
50
40
0.75 +
CCl4
30
1.2 + CCl4
20
- + CCl4
10
0
1
+
CCl4
. 17. , CCl4
, 2,2-4,3-11,6 /
CCl4
. ,
.
81
3.2.4.
, CCl4
,
, (. 9), CCl4
( ) . , CCl4 2,2 / (p < 0,05). -,
CCl4 .
,
CCl4, ,
,
-
(p < 0,05).
,
,
(, , ).
, CCl4,
. ()
CCl4 , , -
82
9
,
CCl4,
,
/
,
/
,
/
,
/
,
/
-, /
, /
,
/
, /
, /
, /
, /
, /
, /
,
/
, /
, /
-, /
(.
)
l4 + .
l4 + 2,2
/
l4 + 4,3 /
72,452,0
70,421,47
65,182,08*
70,140,65
4,850,33
6,340,46*
4,180,44
5,400,21
1,870,11
1,660,09
1,580,04
1,870,13
45,210,95
44,341,10
43,822,47
44,081,08
8,130,27
1708,8340,89
8,140,38
1930,835,4*
8,520,43
2001,654,6*
8,840,35
1719,6144,3
22,769,32
88,7449,68*
133,6850,73** 1659,86156,75**
0,270,008
0,340,03
0,390,02*
0,430,02*
20,03,5
123,114,4
95,93,4
11,241,35*
248,6210,94*
99,928,23
7,661,49**
213,5417,81*
95,226,45
12,881,95*
198,5219,97*
119,5618,30*
14,21,5
7,170,61*
6,080,98*
9,061,13*
531,4540,15
437,863,5
656,1287,95*
604,4849,97
320,049,75
165,417,2*
159,619,55*
214,215,3*
4541,0527,9
3,110,13
0,190,04
5183,4402,80
2,620,12*
0,120,01*
5358,8354,4
2,120,07*
0,170,01
5315,8520,0
2,430,10*
0,180,02
2,330,83
0,980,97*
2,400,84
1,560,90*
. *<0,05; **p<0,01 .
83
9 ()
,
CCl4,
,
/
,
/
,
/
,
/
,
/
-, /
, /
,
/
, /
, /
, /
, /
, /
, /
,
/
, /
, /
-, /
l4 + 11,6 /
l4 + 300 /
()
(.)
l4 +
.
72,452,0
70,421,47
67,40,91
74,161,22
4,850,33
6,340,46*
4,640,72
5,580,48
1,870,11
1,660,09
1,810,06
1,910,17
45,210,95
44,341,10
44,983,17
58,5213,11
8,130,27
1708,8340,89
8,140,38
1930,835,4*
7,650,61
1989,07,97*
11,062,79
1424,2234,16
22,769,32
88,7449,68*
0,270,008
0,340,03
0,370,01*
0,370,03*
20,03,5
123,114,4
95,93,4
11,241,35*
248,6210,94*
99,928,23
6,800,58**
136,8047,79
99,385,89
14,842,21*
212,1211,68*
102,704,79
14,21,5
7,170,61*
6,060,50*
47,7625,16**
531,4540,15
437,863,5
528,8240,58
505,8103,4
320,049,75
165,417,2*
169,812,16*
271,4038,41
4541,0527,9
3,110,13
0,190,04
5183,4402,80
2,620,12*
0,120,01*
5036,80445,16
2,150,48*
0,180,01
4589,20721,59
2,580,12*
0,130,01*
2,330,83
0,980,97*
0,500,30**
1,521,11
1315,52253,22** 1838,90140,54**
. *<0,05; **p<0,01 .
84
(11,6 /), ( ), . , ,
/
,
. -
.
, (2,2-4,3
/) (300 /) -, .
3 ,
.
, , , 11,6 / 300 /
.
3.2.5.
, CCl4
(2,2-4,3-11,6 /) CCl4.
3.2.5.1. 2,2 /
, , CCl4 + 2,2 / (
3), -
85
- , 2/3 ,
, , .
. 18. , CCl4 + . ( )
,
. .
200.
. 19. , CCl4 + 2,2 / ()
,
. . 200.
. 20. , CCl4 + 4,3 / ()
,
. .
200.
86
. 3 (. 19).
3.2.5.2. 4,3 /
, CCl4 + 4,3 /
, . , -
, 1/2 3/4 .
,
.
23 (. 20).
3.2.5.3. 11,6 /
, CCl4 + 11,6 /,
, . ,
- ,
1/3 1/2 . , . 2-
(. 21).
87
3.2.5.4. 300 /
, , , CCl4 + 300 /,
. , - 1/3 , 2/3 . ,
. 1- (. 22).
, CCl4 (2000 /)
().
, ( -
88
),
().
,
11,6 /, .
3.2.6.
, CCl4
, , CCl4,
,
.
() 3 ( , ),
(), ( ) ( ) .
. 23.
89
5-
. 23.
(), (), (), 3,4-
(), (), 5- (5) 6
(),
().
. 24 ( ), . 25 () . 26
( ).
: () 3-
(3-) 3,4- () ().
: () 5--3 (5-).
90
5-
. 24.
, . 23.
5-
. 25.
, . 23.
91
5-
. 26.
, . 23.
, ( )
5-
92
DA ACB
DA
DOPAC
9
8
7
6
5
4
3
2
1
0
HVA
1.5
1.0
* *
1.0
0.5
0.5
g1
g2
g3
g4
g5
g6
0.0
0.0
g1
g2
g3
g4
g5
g6
g1
g2
DOPAC/DA
g3
g4
g5
g6
g5
g6
HVA/DA
0.25
0.125
0.20
0.100
0.15
0.075
0.10
0.050
0.05
0.025
0.00
0.000
g1
g2
g3
g4
g5
g6
g1
g2
g3
g4
. 27.
(/ );
( )
/ ( 3 4 1 2, =0,0412 =0,0390, ).
2,2 4,3 /
( < 0,05), . 28.
93
DA STR
DOPAC
DA
HVA
1.5
10.0
7.5
1.0
* *
5.0
0.5
2.5
0.0
g1
g2
g3
g4
g5
g1
g6
g2
g3
g4
g5
g6
0.0
g1
g2
DOPAC/DA
g3
g4
g5
g6
g5
g6
HVA/DA
0.2
0.2
0.1
0.1
0.0
0.0
g1
g2
g3
g4
g5
g6
g1
g2
g3
g4
. 28.
(/ );
( ) .
, , (
)
( ).
,
/ /
94
,
, /
- ( . 29).
( ),
.
. 29.
,
,
,
5- (. 30). ,
5-/
95
( 6 2, =0,0157).
( < 0,05) 5-/
, , .
( ) .
( .. ., 2006), , , .
SER Frontal cortex
SER
HIAA
2
1
1
0
g1
g2
g3
g4
g5
g6
g1
g2
g3
g4
g5
g6
HIAA/SER
0.8
0.7
0.6
0.5
0.4
0.3
0.2
0.1
0.0
g1
g2
g3
g4
g5
g6
. 30.
(/ );
( ) .
96
, ,
.
97
4.
4,3-8,6-13,4 /
5-7
.
( , -,
,
)
,
( .. .,
2002, 2004, 2006, 2008; Salamone JD, Correa M., 2012).
.
, ( .., 1990; .., 2003,
2009; Curtis J.T., Wang Z., 2005; Comai S, et. al., 2012). , ()
,
(Bjrklund A., Hkfelt T., 1984;
.. ., 1996; .., 1998; Lieu C.A, Subramanian T.,
2012): 1) ( 9, ); 2) (
10, ,
, , , , , ); 3) ( 10, -
98
, 9, , , , ) 4) ( 12-14,
, , ,
). - ( .., .., 1992;
.. ., 1999, 2000, 2002; Amano T. et al,. 2012 ).
1972 . 1978 .
, ,
, ,
35- (), . , , ,
, , ,
- (Kebabian J., Calne D., 1979). . . (Kebabian J., Calne D.,
1979), , D1, , D2,
.
, , . .
, : D3, D4 D5/1b. ,
.
99
100
() ,
,
. ,
, (. 31).
101
. 31.
, .
, ,
(Carlezon WA, Jr, Thomas MJ., 2009).
, ()
, ,
.
102
. . ).
( ., 1970;
.., 2008; Cagiano R. et al., 2008).
( . .
., 1988; . ., . ., 1998; .. ., 2004;
DeLeon K.R., 2005; Glimcher P.W. et al., 2011).
1950-
() ( , , , ). .
, (
) , , 5000 1 200 20
, , ,
( . ., 1987; . . ., 1988; Nathaniel T.I.,
2009). ,
,
,
,
, , .
103
. ,
. ,
(-)
, ,
, ,
- ,
, , ,
, - .
.
- .
, ,
,
(, ) . ,
( . . ., 1988; . ., . ., 1989; Blum K.,
2012). 1980- .
(
,
. .).
(-, )
104
. (
) (), , ,
,
. .,
(), , , , , .
105
.
-
, , ,
( .. ,
2006) (. 32).
. 32.
( .. ., 2002)
D1 D2-
(Petrov E.S., Lebedev
A.A., 1997; Panchenko G.N. et al., 1998; .. ., 2002).
,
, , ,
106
( . ., . .,
1994; Aragona B.J., Wang Z.., 2007: Guarraci F.A., 2008).
, ,
( .., 1990; Petrov E.S., Lebedev A.A., 1997).
: ,
(). ,
- ()
( .., .., 1989; Petrov E.S., Lebedev
A.A., 1997).
,
. . (1987),
,
. -,
. .. (1987)
( ),
. ,
(
) .
,
..
..
(1997)
,
, D1- SCH23390
(0,05 /) (1 /)
. SCH23390
(Petrov E.S., Lebedev A.A., 1997).
107
( .., .., 1992, .. ., 1995).
,
,
.
- ,
0,5 5 /
. 1 /
35-40%.
() ()
.
( . ., . ., 1992). ,
(1 /)
,
, , (5 /)
,
.
, :
- ,
( ..,
.., 1989; Burbassi S., Cervo L., 2008).
108
( .., 1983; .. ., 1988).
,
,
, .
, ,
,
,
109
),
.
(-,
-,
-,
-,
( .., 2005).
(Balfour DJ., 2009; Koob G.F., 2011).
,
.
,
( .. ., 2002, 2004, 2006, 2008, 2011; ..,
2012; Tritsch N.X., Sabatini B.L., 2012; Gorwood P. et al., 2012).
, , .
()
( , ).
, ( ),
(Avena N.M., Rada P.V., 2012).
, , (13,4 /) ( ) -
110
( , ,
, ). ( )
.
( , , ,
).
, () , 13,4 /.
, ( , ,
, ).
, ( .., 2008; Dalley J.W., Roiser J.P., 2012).
,
() . 13,4 /
.
(4,3-8,6-13,4 /) . 13,4 / .
.
, ( ).
111
.
. , , ,
, .
, ()
.
,
( ), , , ( 2
, , 4,3 /), ( 8,6 13,4
/ 3-5 ). , -,
, ( , ).
, (-) (Carboni E. et
al., 2004)
(, , ), - - , - ( .., 1988).
, , - ( ..,
2008). -
112
. 0,5 / D2 ,
, ,
. 5 / ( 10 )
D1- D2-
( .. ., 2002; Afonso V.M.et al. 2009; Pare D, Duvarci S., 2012),
( , , , ). , ( , 50-100 ,
) .
.
(),
, , (Adams D.B.. 2006). ,
. (
)
1-2 / 20-25 / ( ) ,
.
, (4,3-8,6-13,4 /),
,
, .
113
. - , . ,
, , ,
, , .
(, ) . .
()
.
, , ,
, , -, , ,
,
(),
(), , , , (), ,
.
(
) , 2-
( 2000 /). CCl4 ( ) 50% , . , 2 , ,
114
, , . () , (),
- -,
, .
, 16- ,
: , , .
, , l4, 2 , 4 ,
-, -, , , .
( ), - ,
. , CCl4,
-,
1/3 2/3 , , . , .
2-3- ().
115
CCl4
,
, ,
.
.. (2006),
, ,
, 5 (1 /). .
2,2-4,3-11,6 /
300 /
14
.
. ,
, CCl4,
,
. ,
(2,2 /)
(4,3 /) ,
(11,6 /).
(), 300 / (!).
, ,
(
116
) ,
CCl4, 100%-
7- .
,
, 2,2
4,3 /, .
.
( 11,6 /)
( )
(), .
,
( ),
CCl4
.
,
(.
3.1). , (4,3-8,6-13,4 /)
, ()
).
),
.
,
CCl4.
117
, , (13,4 /) ( )
. (
) . ,
( ).
, () , 13,4 /.
, ( , ,
, ).
CCl4.
,
() . 13,4 /
.
.
( 3.1),
,
CCl4, -.
( ). .
, -
118
, CCl4, .
, ,
. (11,6
/) (300 /),
, . 2,2 4,3 / , .
. (300 /)
.
,
. .
119
5.
( 95%- , )
(
, , , , , ). 4,3-8,6-13,4 /
(5-7 ).
, () ( , ).
(13,4 /) ( ) . () ,
13,4 /. - () . .
(4,3-8,6-13,4 /) . 13,4 / .
.
. , , , ,
. ,
,
120
. ,
(-) .
, CCl4 . ( ) 2-
CCl4 (2 1 / 3 ). (2,2-4,3-11,6
/) 2 . , ,
.
, (300 /),
( ) .
50% .
, , , . , 16- , : , , .
( ),
- , . CCl4
, , . ,
(2,2-4,3-11,6 /) , CCl4, , -
121
( ). (2,2
/) (4,3 /) ,
(2,2-4,3-11,6 /),
11,6 /.
(300 /). . CCl4, 100%-
7- . , .
122
6.
1. 4,3-8,6-13,4 /
(5-7 ) ( , ), , () ,
.
2. .
,
, . , ,
.
3. , CCl4,
, , CCl4 .
4. 2,2-4,3-11,6 /
,
, CCl4. 300 /
.
5.
,
, ( ),
.
123
6. 2,2-4,3-11,6 /
, CCl4.
,
.
7. 2,2-4,3-11,6 /
300 /
(
), CCl4.
11,6 /
300 /.
8.
2,2-4,3-11,6 /
()
.
.
124
7. -
() ,
( , , )
.
(2,2-4,3 /)
, ,
.
( )
, ,
.
125
8.
1.
, ..
/. //
() / . ... .: , 2002.
. 121-125.
2.
, ..
. 4- ., .
. /.., .. -.: , 2007.
.189.
3.
, .. - -
. /.., . ., . . .: , 1988. 320 .
4.
, . . /.., . . .:
, 1989. 150 .
5.
, ..
/.. // . . . 2000. .6, 12. .13-19.
6.
, .. : /.. . .
. . . .: , 2007. 24 .
7.
, ..
/.. .:
, 2006. 34 .
8.
, .. /.. .- . . . . . .: , 2005. 24 .
126
9.
, .. /.. //
. . . .: , 1988.- . 1.
. 1-166.
10. , . . /. - .:
. 1970. 420 .
11. , ..
-
/..,
. ., . . // . . . . 1995. . 45,
. 2. . 395-401.
12. , ..
/..,
. . // . . . . 1992. . 42, . 4.
. 692-698.
13. , .. / .. //. . .
. . .: , 2012. 22 .
14. , .. : . 15-
. /.. .: , 2008. -.526-528.
15. , .. . /.. : , 2006. 262 .
16. , .. . /.., .. .: -, 2012. 264 .
17. , ..
. / ..
- . . . . . ., 2001. 24 .
127
18. , ..
. / .. . . - . . .,2004. 48 .
19. , .. . /..,
.. .: -, 2007. 368 .
20. , .. -
/.. // . . . 2002. . 2. 2.
. 44-52.
21. , ...
/..,
.., .. // . 2002. 3. . 19-23.
22. , .. : ,
/.. // . / . .. . .: . 1990. 2. . 74-85.
23. , .. . II.
/.., .. .: , 1995. 464 .
24. , .. :
. /.., .., .. .: , 1990. 184 .
25. , ..
. .. . /.. // . . . 1990. . 76, 12. .
1669-1680.
26. , .. . /.. .: ,
1998. 256 .
128
27. , ..
: . /.. - ., 1977. 34 . . ,
2357-77. 42 .
28. , ..
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