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Cardiac Pharmacology
Shan Nanji


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Anti-Arrhythmics
! Class 1A
! __________________, Disopyrimide, Quinidine
! Class 1B
! __________________, Lidocaine, Tocainide,
__________________
! Class 1C
! ________________,Flecainide, _______________
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Anti-Arrhythmic
! Class 1A Sodium Channel Blocker
! ProcainAMIDE
! DisopyrAMIDE
! Quinidine

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Anti-Arrhythmic
! Class 1A - Na
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Channel Blocker
! S/E:
! Quinidine
! __________________
! Disopyramide
! Heart Failure
! Procainamide
! __________________

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Anti-Arrhythmic
! Class 1B - Na
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Channel Blocker
! Mexiletine
! Lidocaine
! Tocainide
! Phenytoin
! Clinical Use:
! __________________
! Acute Ventricular Arrhythmias
! Digitalis Induced Arrhythmias
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Anti-Arrhythmic
! Class 1B - Na
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Channel Blocker
! S/E:
! Mexiletine
! __________________
! Tocainide
! __________________
! Phenytoin
! Hirsutism
! Gingival Hyperplasia
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Anti-Arrhythmic
! Encainide
! Flecainide
! Propafenone
! Exhibit zero order kinetics
! No Effect on
_______________
! Propafenone
! Is also a
__________________in
addition to being a Na
Channel Blockers
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! Class 1C - Na
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Channel Blocker
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Anti-Arrhythmic
! S/E:
! __________________
! Prolongs AV Node Refractory Period
! CONTRAINDICATED POST-MI
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! Class 1C - Na
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Channel Blocker
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Anti-Arrhythmic
! Class II Beta Blockers
! As discussed in ANS Pharm
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Anti-Arrhythmic
! Ibutilide
! Amiodorone
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! Class III Potassium Channel Blockers
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Anti-Arrhythmic
! S/E:
! HypOthyroidism
! __________________ so check ______
! Hepatic Necrosis
! Corneal Clouding
! Blocks CP450
! Thereby Increasing Levels of:
! Warfarin
! Estrogen
! Phenytoin
! Theophylline
! Digoxin
! Smurff Syndrome
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! Class III Potassium Channel Blockers
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Anti-Arrhythmic
! Class IV Calcium Channel Blockers

! Cardioselective:
! Diltiazem
! Verapimil
! Vasoselective
! Pines
! Nimodipine
! Reduces mortality post sub arachnoid
hemorrhage
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Anti-Arrhythmic
! Class IV Calcium Channel Blockers
! S/E:
! __________________
! Due to Calcium being the Second Messenger for
__________________which Normally __________________
Gut Motility
! Edema
! Flushing
! Cardiovascular Effects
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Anti-Arrhythmic
! Nitroglycerin/Isosorbide Dinitrate
MOA:
! Vasodilation
! Release of Nitric Oxide in Smooth Muscle of
Blood Vessels
! Increase __________________
! _____________ BEFORE _______________
! Clinical Use:
! Angina
! Pulmonary Edema
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Anti-Arrhythmic
! Nitroglycerin/Isosorbide Dinitrate
! S/E:
! __________________
! __________________
! Flushing
! HypOtension
! __________________
! Due to Industrial Exposure
! Development of Tolerance
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Anti-Arrhythmic
! Adenosine
MOA:
! Increases __________________ of Cells
! _________polarization
! Clinical Use:
! __________________
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Anti-Arrhythmic
! Adenosine
! S/E:
! HypOtension
! Flushing
! Note: Adenosine is blocked by ________ and _____________
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Anti-Arrhythmic
! Magnesium (Mg
2+
)

! Clinical Use:
! Torsades De Pointes
! Digoxin
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Anti-Arrhythmic
! Digoxin
MOA:
! Inhibits __________________
! Indirectly inhibits Na
+
/Ca
2+
Exchange
! Clinical Use:
! CHF
! Atrial Fibrillation
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Anti-Arrhythmic
! Digoxin
! S/E:
! Cholinergic Effects
! Nausea, Vomiting, Diarrhea, Blurred Yellow Vision
! EKG:
! Increased __
! Decreased __
! T-wave _________
! AV Block
! ST ____________
! ________________ Poor Prognostic Factor
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