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GENERIC NAME: Domperidone

DRUG CLASS: Dopamine Antagonist, Anti-emetic and anti-vertigo


PHARMACODYNAMICS: Domperidone is a dopamine-receptor blocking agent. Its action on the
dopamine-receptors in the chemo-emetic trigger zone produces an anti-emetic effect.
DOSAGE:
Adults:
Two tablets (20 mg) 3 to 4 times per day, 15 to 30 minutes before meals and, if necessary, before
retiring.
Chronic conditions (mainly dyspepsia) Adults: One tablet (10 mg) taken 3 times per day, 15 to 30
minutes before meals and, if necessary, before retiring. The dosage may be doubled
INDICATIONS: Acute conditions (mainly nausea, vomiting, hiccup)
CONTRAINDICATIONS:
-Known hypersensitivity to domperidone or any of the excipients.
-Prolactin-releasing pituitary tumour (prolactinoma.)
-Domperidone should not be used when stimulation of gastric motility could be harmful: gastro-
intestinal haemorrhage, mechanical obstruction or perforation.
ADVERSE EFFECTS:
Allergic reactions, such as rash or urticaria, have been reported.
Abdominal cramps have been reported.
Dystonic reactions (extrapyramidal phenomena) may occur.
Reversible raised serum prolactin levels have been observed which may lead to galactorrhoea and
gynaecomastia.
Hypertensive crises in patients with phaeochromocytoma may occur with administration of
domperidone.
Where the blood brain barrier is not fully developed (mainly in young babies) or isimpaired, the
possible occurrence of neurological side-effects cannot be totallyexclude
NURSING RESPONSIBILITIES:
1. Assess for extra-pyramidal effects such as jerking and tongue protrusion.
2. Check for hypotension