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549

, , 2010
, 2010

BULLETIN
of Peoples Friendship
University
of Russia

SCIENTIFIC JOURNAL

Founded in 1993

Series
MEDICAL

2010, N 4
Series founded in 1997
Peoples Friendship University of Russia

CONTENTS
Cornlissen G., Frolov V., Chibisov S., Kharlitskaya E., Halberg F. Personalized
chronome (time structure) complements genome detecting vascular variability disorders
(vvds), including mesor-hypertension .................................................................................

16

Siatkin S.P., Fedoronchuk T.V., Gridina N.Ya., Neborakh E.A., Shevkhun N.A.,
Sokueva N.A., Ustinova E.V., Sokuev R.I. The influence of chemical analogs of decar-

boxylated ornithine and S-(adenosil)-methionine on the growth of L-cell tissue culture .......

26

Soloveva N.V., Bazhukova T.A., Agafonov V.M. Effectiveness of probiotics use in

patients with chronic viral hepatitis ....................................................................................

32

Schyogolev A.A., AlSabunchi O.A., Klochneva E.., Azimova J.A. Modern treat-

ment strategy of gastroduodenal ulcer bleeding ..................................................................

37

Zagorodny N.V., Volna A.A., Panin M.A. Implants removal ..........................................

44

Eltyshev N.A. Eltyshev N.A. The modern diagnostics and treatment of patients with

pancreatic head cancer, complicated by jaundice syndrome ...............................................

52

Vlasov A.P., Visaitov D.A., Trofimov V.A., Leschankina N.U., Pyanov V.,
Mustaytsa V.F. The lipid structure and functional status of blood cells under endoge-

nous intoxication .................................................................................................................

57

Shcherbenko O.I., Parkhomenko R.A., Zhernov V.A. The laser reflexotherapy in

childrens oncology .............................................................................................................

63

 , , 2010, 4
Khartchenko V.P., Lutfaliev T.A. , Kunda M.A., Chazova N.L., Bershanskaya A.M.,
Eltyshev N.A., Zapirov G.M., Barushnicov V.L. The terms of restoration of functional

and structural liver changes in jaundice, caused by pancreatic head cancer ........................

69

Agaev N.M., Avdoshin V.P., Moskaleva .YU., Popova .N., Severin S.E.

CD25+CD4+ regulatory lymphocytes in peripheral blood of patients with prostate cancer and prostate adenoma .....................................................................................................

77

Shangichev .V. An oxide of nitrogen (NO) is a biochemical inflammation marker of

chronic abacterial prostatitis/syndrome of chronic pelvic pain (CAP/CPPS IIIA) ..............

83

Kirichenko I.M., Shonia L.I. Popadyuk V.I., Daihes N.A. Meaning of circulatory disturbance in vertebrobasilar system in development sensorineural hearing loss ...................

87

Danilenko O.A., Medvedev I.N. he possibilities of complex correction of antiagrega-

tional activity of the vessel wall in patients with arterial hypertension and metabolic syndrome, who suffered from the occlusion of eye vessels ......................................................

94

Volkova N.I., Rymashevsky A.N., Dimitriadi T.A. Clinical application of method diagnostics hyperandrogenism syndrome on women of reproductive age ..............................

99

Prilipko N.S. Normative legal basis for rehabilitation medicine ........................................

104

Polyakova A.G., Drubich T.V. New form of the reducing treatment of patients with the

vegetative disfunctions ........................................................................................................

110

Serebrennikova L.V., Kajdan E.I. The features of collective and personal stressful psy-

chotherapy of hysterical neurosis, hysteria, hysterical psychopathology ............................

115

Goidenko V.S., Fedorova I.L. The complex treatments efficiency of the patients with

vertebrogennoy thoracalgy ..................................................................................................

119

kimkin .., Goncharov E.N., Rodionov A.V., Tereshchenko G.V., Znamenskiy I.A.

agneti-resonance imaging of damage of the shoulder against presence of the accompanying impingement syndrome ..........................................................................................

125

Alaa M. Zourob, Chizhov A.Ya. Estimation activity of structurally functional systems

of the students living in subtropical climate ........................................................................

130

Alekseenko S.P. Complex research of alcohol products consumption and its consequences for health of population of the Rostov region ............................................................

135

Alikova .., Mamsurova I.Ch., Alikova Z.R. Prevalence and the medical and social
importance of the glaucoma in Republic of North OsetiaAlania .....................................

142

Ananev V.N., Anikiev A.V. Influence of inert gases of argon and kripton on oxygen absorption ................................................................................................................................

146

Antropova G.A., Okonenko L.B. Drug assortment formation at the chemist`s shops in
regard of consumers` preferences ........................................................................................

150

Okonenko T.I., Antropova G.A. Spreading of certain ophthalmic diseases related to

Novgorod region ecologic conditions ..................................................................................

154

Ahtiamova S.H. Medical and social characteristic of girls-teenagers wich interputtion

the pregnancy .......................................................................................................................

159

Babushkina I.V., Martyanova V.A., Borodulina E.V., Borovskiy A.L., Sakkala .,

Albubu . Action of copper nanoparticles on clinical strains of gram-negative bacteria ..

162

Bass S.M., Yarygina T.I., Korkodinova L.M., Kurbatov E.R. Elaboration the meth-

ods of valuatoin the quality substance of amide N-allylanthranylic acid .............................

10

165

Contents
Bitsoev V.D. Application of restoration technology of underwater tracture with underwa-

ter phototherapy for treating pathologies of musculoskeletal system .................................

Bolotnikova N.I. The emergent medical help, given to people aged 3034 ....................

168
172

Bronfman S.A., Kudaeva L.M., Agarkov V.A. Latent depression among women with

normagonadotropic amenorrhea ..........................................................................................

Buzlama A.V. Lignogumats action on the cellular and humoral immunity in the experimental inflammation model ................................................................................................
Vinogradova N.A., Vinogradov A.A., Emanuylova N.V. Effect of pentoxifylline on
rheology blood in rheumatoid arthritis with systemic manifestation ..................................

175
179
182

Gerasimova N.G., Gorbatov V.A., Fadeeva N.M., Kovalenko E.N., Kudasheva

O.A., Vaskova N.A. Efficiency of the using singulyar at treatment of the bronchial

asthma beside children ........................................................................................................

Gubareva A.E. The improvement of teaching biological chemistry by educational programm creative person for advanced students .................................................................
Gurko G.I. The chronic obcructive pulmonary disease in military veterans: problems and
perspectives .........................................................................................................................
Guryanov M.S., Archipova N.N. On improvement of cosmetology care by people .......
Davidkin I.L., Kosiakova Y.A., Kurtov I.V., Gricenko T.A., Chairetdinov R.K. State
total microcirculation in patients with hemophilia ..............................................................
Dozmorova N.V., Nepogodina E.., Chekryshkina L.A. Determination application
time new bas, showing antihypertensive activity ................................................................
Domrachev E.O., Valentinovich L.I. Disease of students of medical college .................
Dralova O.V., Maximov M.L., Ermolaeva A.S. Clinical application of direct renin inhibitor aliskiren in combined therapy of patients with arterial hypertension and metabolic
syndrome .............................................................................................................................
Zhukova V.Y., Lobanov Y.F. Health status of adolescent sports Altai .............................
Zaslavskaya R.M., Talipova J.Kh. Influenc of autoimmune thyreoiditis on intellect in
young people in West Kazakhstan ......................................................................................
Ivanova N.A., Vikhareva .V., Suldin .V. Unsuitable to use food supplements as the
waste of the pharmaceutical market ....................................................................................
Ilnitski A.N., Gurko G.I., Medvedev D.S., .., Altuhov ..,
Kunitsyna N.. Depression in elders and non-drug therapy .............................................
Kazantseva I.A. anamnesis of children suffering from herpetic stomatitis .......................
Kaziev A.Ch. Steadiness of treponema pallidum to changes of optimum conditions
of cultivacion .......................................................................................................................
Kachkovskiy .A., Krasnoslobodskaya O.V. Adherence to drug therapy in patients
with atrial fibrillation ..........................................................................................................
Kashaeva M.D. Method of definition of risk of development of hepatic insufficiency
at complicated bililithiasis ...................................................................................................
Kisieva M.T., Zyablitseva N.S., Kompancev V.A., Belousova A.L. Selecting the
conditions of the extraction of the pectin from tubers of jerusalem artichoke (Helianthus
tuberosus L.) with use enzymatic preparation Maksazim NNP K .......................................
Kovalenko T.G. Prevalence of left ventricular hypertrophy myocardium among young
people with chronic hypocapnia ..........................................................................................

185
187
191
194
197
199
203

206
209
212
217
220
223
226
229
234

237
241

11

 , , 2010, 4
Kovyazina N.A., Reshetnikov V.I., Funcner E.V. Development of medical films for
bacteriophage treatment of infection ...................................................................................

245

Kozlova O.G., Shirokova L.U., Bashkina A.S., Dolgova L.N., Nagibin R.M., Shi0
rokova T.U., Kuznecov M.M., Smekalova M.V. Effect of weakness muscle corset

knee on the efficiency of local therapy osteoarthritis knee glucocorticosteroids .................

Koroteeva T.V., Radysh I.V., Khodorovich A.M. Seasonal variation in blood hormone
levels in wumen different ethnic grupps ..............................................................................
Kosyreva T.F., Safroshkina V.V., Bogdasarova I.V. The use of herbal medicines for
the treatment and prevention of periodontal deseases in patients aged from 18 to 22 with
cleft lip and palate during orthodontic treatment with non-removable appliances ..............
Davidkin I.L., Kosiakova Y.A., Kurtov I.V., Stepanova T.Y., Kudinova N.A. Evaluation of anemia syndrom in haemophilia ...............................................................................
Krasovitsky R.A., Blinova A.A., Pashukova E.A., Bushmeleva N.N. Characteristics
of psychoemotional adaptation of finno-ugric women (selcups) to pregnancy ...................
Krylova .., Khomov Y.A., Kataev S.S. Determination of zolpidem in blood by
GC/MS .................................................................................................................................
Khomov Y.A., Krylova .., Kataev S.S. Investigation of zolpidem in real urine samples at therapeutic doses level ..............................................................................................
Kudrin R.A., Lifanova E.V., Akhundova R.E., Fokina A.S., Budnikov M.Y.,
Akhundov E.M. Emotional and cognitive maintenance of operators activity ....................

247
250

254
258
260
264
269
273

Kuznetsova E.V., Shemonaev V.I., Stolyarchuk A.S., Trudov A.F. Testing of bent

wire denture clasp metals hardness and condition after titanium and zirconium nitride
plasma spraying on its surface .............................................................................................
Kuznetsova E.P., Tetelytina F.K., Serebrennicova K.G., Halilov R.Z. Surgical approach to restoring reproductive function in patients with tumors ovarian ..........................
Kuzmin S.A. Results of military-medical examination among boys pre- and military age,
living in Orenburg region ....................................................................................................
Kunitsyna N.., Perelygin .V., Varavina L.Yu., Speranskij S.L. About quality of
othorynolaringological aid for elders ...................................................................................
Kurbatov E.R., Shakirova A.B., Korkodinova L.M., Bass S.M., Yarygina T.I. Synthesis, physical and chemical propaties and biological activity of amide N-allylanthranylic acid ..............................................................................................................................
Kurushina O.V., Barulin A.E. Influence of pain beliefs on resuts of algetic syndrome
treatment ..............................................................................................................................

276
283
288
292

295
298

Ledyaikina L.V., Balyukova L.A., Razdolkina T.I., Naumenko E.I., Vereshagina V.S.,
Samoshkina E.L., Dzubich L.I., Garina S.V. linical manifestation and phatomorpho-

logical illustration of massive hypoxical intraventricular hemorrhages in newborn babies ....

300

Letounovski .V., ishinowich Z.I., rn .S., ris .I., Lichv .I.,

slennikov .S. Metabolic disorders in myocardium at pancreas experimnl damage ..

303

Linchenko I.V., Zukanova F.N. Treatment of compensative horizontal increased dental

abrasion of the second degree ..............................................................................................

Lopukhova V.A., Tarasenko I.V. Regional pharmacotherapy features of a bronchial
asthma and chronic obstructive pulmonary disease .............................................................
Lysov N., Smirnov S. Specific characteristics of profesional diseases in the Samara
regionand the problem of working conditions estimation mark in confirmation in the insurance event .......................................................................................................................

12

306
309

312

Contents
Mavlikaeva Y.A., Bronnikov V.A. Evaluation of complex rehabilitation of disabled people
in a specialized centre .........................................................................................................
Maximov M.L., Dralova O.V. Clinical efficiency of medium and high doses of valsartan
in the treatment of patient with arterial hypertension and chronic kidney diseases ............
Starodubtsev A.K., Maximov M.L., Dralova O.V., Ermolaeva A.S. Clinical efficacy of
AT1-receptors of angiotensin II valsartan in the pharmacotherapy of patients with arterial
hypertension and chronic heart failure ................................................................................
Mamalyga M.L., Mamalyga L.M. Dynamics of RNA quantity change in neuroneglia
system of nucleuses monoaminergic of a brain during deadaptive .....................................
Medvedev D.S. The short-wave-therapy in regulation of general vasus resistance in polymorbidity in elders ...........................................................................................................
Merkulova G.A., Pegova E.V., Tulupova M.S. The use of DgKDT-01 computer technology for health state evaluation of medical personnel .....................................................
Mitrofanov A.V., Ovchinnikova T.A., Komarova T.V., Gasilina E.S. Combination subtoxis diphtheria oropharyngeal and acute cytomegalovirus infection persistence in a case
of Epstein-Barr virus in a child 5 years (clinical case) ........................................................
Mikhaylichenko K.Yu., Nazarov V.A., Kondrashova A.S., Chizhov A.Ya. Parameters of
the school environment as a factor that affects the health of pupils ....................................
Mikhaylov A.V., Bunyatyan N.D. Possibilities of application of benchmarking in increasing of competitive advantages of the chemists organizations ............................................
Mishina N.A., Davydkin I.L., Kupaev V.I. Oxidant-antioxidant status of erythrocytes
in chronic obstructive pulmonary disease ...........................................................................
Molohova .I., Grigoryan L.G. The influence of technological parameters of adjuncts
on the quality of powders with bifidobacteria .....................................................................
Motina N.V., Lepilov A.V., Zharicov A.Yu., Motin Yu.G. Renal structure reorganisation
early in the development of experimental nephrolithiasis model ........................................

316
320

323
326
330
333

338
342
348
354
357
360

Mushnikov D.L., Polakov B.., rlova .V., Bajutin .M., Carpov D.., Schultz S.V.

Communication culture of medical institutions and patients as the factor of maintenance

of efficiency of medical aid .................................................................................................
Uglanova N.N., Mushnikov D.L., Kostin V.V., Kizeev M.V., Stvolygin .V.,
Naumov A.V. Information culture of patients and a way of its increase ............................
Ovod A.I., Mukovnina M.D. Medicosocial research of patients with chronic prostatitis .
Okonenko L.B., Egorova E.S. Eonomic aspects of urogenital chlamidiosis treatment .
Orlova E.V. Use of control cards of Shuhart for certification immunobiological preparations .

362
367
372
379
383

Osadshaya L., Bogachev A., Gretskaya I. Diagnostically effectivness of medical con-

trols methods evaluating functional condition of teenagers backs ...................................

Parhomenko A.N., Shemonaev V.I., Motorkina T.V. The practical importance of diamond burs tearing ..............................................................................................................
Peleneva I.M., Stepanov S.A. About lymphatic and surfactant systems interrelation
in pulmonary tuberculosis ...................................................................................................
Perelygin .V. The vestibular function in elders patient with sensoneural poor hearing ..
Perova E.Y., Gumenjuk E.G. Reducing of early reproductive losses as a reserve of improvement of demographic situation in Cola Polar region (on Monchegorsk for example) ....
Polyakova A.G., Matveeva V.V. Assessment influences of biofeedback in complex
of reabilitation measures patients undergoing stress ...........................................................

386
390
393
398
401
406

13

 , , 2010, 4
Pronyaeva A.I., Kosyreva T.F. Studying of interrelation of quality of potable water in

the zone of residing of children with noncariouses defeats of enamel of the teeth ..............

410

Prosvetov R.S., Torshin V.I., Alchinova I.B., Arkhipova E.N., Antonova N.P.

Prophylactic dental check-up with additional use of laser correlation spectroscopy ...........

416

Prashchayeu K.I., Medvedev D.S., Gurko G.I., Perelygin .V., Kunitsyna N..

Physiotherapy in the system of medical aid for elders .........................................................

Pulina N.A., Yushkova T.A., Krasnova A.I., Yushkov V.V. Directed search of hypoglycemic compounds in the series of aroylpyruvic acid derivatives ....................................
Pyatilyshnova O.M., Zelyaeva N.V. Patient satisfaction quality of care in hospital .......
Razepina J.A., Vihareva E.V., Suldin A.V. The analysis of the problem of the reference of medical-cosmetic production on the example of the chemist's organizations cities
of Perm ................................................................................................................................
Remezova I.P. Development spectrofotometric of the technique of analysis risperidon
in tablets and it validation ....................................................................................................
Rodionova O.M. Endoecology as part of the teaching of human ecology for students
environmental specialties .....................................................................................................
Sarapultsev A.P., Yakusheva M.Y., Sarapultseva L.A. The incentive motives to the
conducting a healthy way of life among teenagers ..............................................................
Sattarova O.E. Designing of electronic terminological dictionary on pharmaceutical
chemistry .............................................................................................................................
Yarygina T.I., Sattarova O.E. The development and approbation of educational information-methodical complex on pharmaceutical chemistry aromatic amines, aminoacids
and their derivatives ...........................................................................................................
Saharov S.P., Ivanov V.V., Ananeva O.V., Ananev V.N. Immunologichesky infringements at children during the sharp period of burn illness ...........................................
Simonova E.Y., Polevichenko E.V. The characteristic of the hospital register of children with splenia, living in the Rostov region and the estimation of its role in the prophylactic of the pneumococcal infection ...................................................................................

420
423
426

429
432
436
440
443

447
451

456

Sovenko G.N., Prashchayeu K.I., Chizhova M.A., Churnosov M.I., Ilnitski A.N.

The genesis of polymorbidity in elder female & the role of neuronspecific enolase ...........
Sultanaeva Z.M., Sharafutdinova N.Kh. Reqional peculiarity of infantile and perinatal
mortality .....................................................................................................................................
Tarasenko I.V., Lopukhova V.A. Pharmacoepidemiological treatment analysis of the
chronic obstructive pulmonary disease and bronchial asthma at the inpatients department
Tlupova T.G. Influence of counter bright light on visual acuity of healthy faces ..............
Torshina I. Analysis of diagnosis errors of viscerasyphilis (according to the Smolensk
region) ..................................................................................................................................
Turyshev A.Y., Sogrina A.N., Yakovlev A.B., Oleshko G.I. Innovations in the medicinal resource science .............................................................................................................
Fateeva N.M., Posokhova .. Study of formation of speech breathing in preschoolage children with speech irregularities ................................................................................
Chekryshkina L.., Sattarova O.E., Yarygina T.I. The development of electronic
catalogue of identity response of pharmaceutical substance ................................................
Chizhova M.A., Sovenko G.N., Zakharova I.S., Pavlova T.V. The clinical and pathopfysiologic basis of ambulatory medical aid for elder patient with coronary heart disease
and fe-deficite anemia ................................................................................................................

14

459
462
466
469
471
475
478
481

486

Contents
Shabalina J.A., Shurygin A.A., Lvova I.I., Varankina A.A. Pulmonary tuberculosis

in adolescents in modern conditions ...................................................................................

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Sharafutdinov M.A. Epidemiological aspects of illnesses of urinogenital system among
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Shmalko T.., Swistova .V., Molohova .I. The organization of manufacture of the
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Bulletin of Peoples Friendship University of Russia, 2010

PERSONALIZED CHRONOME (TIME STRUCTURE)

COMPLEMENTS GENOME DETECTING VASCULAR VARIABILITY
DISORDERS (VVDS), INCLUDING MESOR0HYPERTENSION
G. Cornlissen*, V. Frolov**, S. Chibisov**,
E. Kharlitskaya**, F. Halberg*
*Halberg Chronobiology Center, University of Minnesota
Minneapolis, MN, USA
**Peoples Friendship University of Russia
Miklukho-Maklaya str., 8, Moscow, Russia, 117198
Computer-aided, automatic, inferential statistical, self-help-based preventive health care is better
and cheaper when the personal surveillance is done by a secure Internet, without the need for a care
provider. The introduction of such a system in a medical faculty and then university-wide, and extended
to secondary education, could lead to a universal scientific literacy of the entire population, while it also
promises dividends from research on space weather in the spirit of Alexander Leonidovich Chizhevsky,
that was not possible in the pre-computer era.
Key words: time structure, chronome, monitoring, blood pressure, vascular variability disorders
(VVDs).

Introduction
As compared to a genome-based personalized care in the future, self-care based
on monitoring key marker variables, with data analyzed by computer and interpreted
for their time structure (chronome) as-one-goes could involve most people treated for
high blood pressure (BP). Data analyses can be handled by a computer-savvy individual in a circle of family and friends, as well as offered as part of community services, e.g., in schools. The complexity and cost of a chronobiologic system could be
greatly reduced by automating analyses on a secure website that also offers educative
materials. A summary of results could be returned cost-free to participants, while the
data are archived for later interpretation in the light of outcomes as they become
available. This is now ongoing on a small scale in a project on The Biosphere and the
Cosmos, BIOCOS (corne001@umn.edu). Decades-long time series of around-theclock measurements have become available for the BP and heart rate (HR) of clinically healthy subjects, which served to derive reference values, computed as 90%
prediction intervals qualified by gender, age and ethnicity for circadian parameters as
well as for time-specified values along the 24-hour scale. Outcome studies assessed
the relative risk of morbid events associated with deviations from these norms, thus
identifying Vascular Variability Disorders (VVDs). Among them are MESORhypertension, an elevation of the BP-MESOR (M, Midline-Estimating Statistic Of
Rhythm), and CHAT (Circadian Hyper-Amplitude-Tension), a BP overswing. These
chronobiologically-interpreted records are useful for diagnosis and treatment validation and must be rendered affordable as a step toward a chronome-based personalized
health care, experimentally validated in the context of BP and HR.
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Cornlissen G. et al. Personalized chronome (time structure) complements genome detecting vascular...

Chronobiologically, i.e., time-structurally-interpreted 24-hour/7-day monitoring

of BP and HR is ongoing on a small scale in several geographic locations and, as a
demonstration of its feasibility, also at the Peoples Friendship University of Russia
in Moscow. When the chronobiologic interpretation of a 24-hour/7-day screening record of data collected automatically at 30-min intervals shows abnormality, and the
presence of one or several VVDs is validated in a repeated monitoring session, treatment is instituted, and its kind and timing are guided by the kind of VVDs diagnosed
(chronotheranostics). Once treatment is started, continued weekly analyses of yearslong half-hourly around-the-clock (briefly 24-hour/7-/365-day) records are recommended for the surveillance of treatment efficacy to validate the presence of desired
effects and to identify any undesired effects, such as iatrogenic CHAT as early as
possible, so that they can be eliminated or at least reduced.
As a dividend from the follow-ups on the data flow aimed at the prevention of
life-threatening diseases, of benefit to the individual being screened, medical science
may gain improved reference standards from those who die uneventfully at an advanced age while from those experiencing an adverse event, new harbingers and/or
mechanisms of disease may be detected. Further, these same databases may provide
important information regarding the roles played in human health, disease and other
affairs by the earth, the sun and the broader cosmos, and even help in the development of rational countermeasures to undesired, heretofore undetected environmental
effects. This is the topic of a novel transdisciplinary science in the sense of Vasily
Vasilyevich Dokuchaev and Vladimir Ivanovich Vernadsky, as visualized by Alexander Leonidovich Chizhevsky in the era before computers, and implemented in the
laboratory by one of us (Sergei Mikhailovich Chibisov) with electron microscopy and
physiological studies of association with magnetic storms, amenable to statistical
validation (1).
The conceptual formulation of home- and Internet-based self-help in medicine
has been eloquently and thoroughly visualized as cybercare for 2028 or 2033 by former U.S. Surgeon General C. Everett Koop et al. (2). Recognizing the magnitude of
the problem, these authors start by citing Machiavelli: There is nothing more difficult to take in hand, more perilous to conduct, or more uncertain in its success, than to
take the lead in the introduction of a new order of things. One of us learned it in person when the pursuit of what he called circadian rhythms was dismissed as his paranoia. He lost his laboratory and had to perform his experiments in a former paint
room at a state hospital in the 1950s (3). Ignaz Zadek must have learned this by the
end of his life in 1931, after he wrote as a young fellow in 1880 in his thesis for his
medical degree, as published for the medical profession in 1881, that he was interested (not in inter-individual differences but) in the (we add personalized) changes of
BP within a given person (4). In 1904, Theodore C. Janeway, an opinion leader at
Johns Hopkins University, advocated that frequent readings of patients BP be taken
before a physical examination to establish (we add personalized) normal ranges and
to assess periodic variations (4). And in 1974, Frederic C. Bartter (of Bartters hypokalemic syndrome fame), then head of the Hypertension-Endocrine Branch at the
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U.S. National Institutes of Health and later the head of the institutes clinical center,
checked on his patient whose BP was previously diagnosed differently by spotchecks
made by two physicians who saw him at different times of day (4). Around-the-clock
monitoring at NIH for 17 days provided an explanation for the discordant diagnoses,
as shown in Figure 1. Bartter concluded in print (4).

Figure 1. Blood pressure (BP) measurements taken 6 times each day for 17 days by staff at the Clinical Cen
ter of the U.S. National Institutes of Health on a 61yearold patient show the large withinday variation that
accounts for his diagnosis as normotensive by a physician habitually seen in the morning and as hyperten
sive by another physician regularly seen in the late afternoon. Guidelines of BP assessment can use time
varying rather than fixed limits and can assess daytoday and longerterm variability. The diagnosis of bor
derline hypertension based on casual office measurements assessed by WHO limits resembles flipping
a coin to decide whether to see a physician in the morning or the evening. (Even for patients with a 24hour
mean of SBP/DBP around 149/90 mmHg, hypertension is not detected 22% of the time because of the lack
of consideration of circadian variation in computations based on a circadian amplitude of 20 mmHg [near, but
still below the upper 95% prediction limit in clinically healthy adults] and acrophase of 240 [4 PM].) Limita
tions in dealing with casual measurements or officehour profiles of BP interpreted by fixed limits, irrespec
tive of gender and age, can be replaced by timevarying reference standards (chronodesms) and one must
rely on more than one or a few casual BP measurements. In the absence of a measurement error, the cir
cadian rhythm in BP results in contradictory diagnoses at different clockhours. Halberg.

By conventional standards, this patient is clearly normotensive every morning.

Yet the blood pressure determined each day at 6 in the afternoon provides especially
convincing evidence that this patient is a hypertensive... My plea today is that information contained in such curves [cosinor fits] become a routine minimal amount of
information accepted for the description of a patients blood pressure. The analysis of
this information by cosinor should become a routine. It is essential that enough information be collected to allow objective characterization of a periodic phenomenon,
to wit, an estimate of M... an estimate of [the amplitude] A itself, and finally an estimate of acrophase, phi [a measure of timing]. In this way, a patient can be compared with himself at another time, or under another treatment, and the patient can be
compared with a normal or with another patient.
In 1984, the chronobiology of blood pressure appeared in extenso under the title Chronobiology of blood pressure in 1985, a modification in italics in the title
which had originally been ...in 1984, made by the late, and to us dear, physician/industrialist/publisher Agostino Carandente, whom we then considered a pessimist. In
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Cornlissen G. et al. Personalized chronome (time structure) complements genome detecting vascular...

2010, when we still have to explain what the Chronobiology of BP ought to be, we
realize that Agostino was an optimist (4).
Koop et al. (2) advocate a system change from centralized hospitals to focus on
neighborhoods and the home through technology and aim to merge private health
care, public health care, national security and education. In the broad context of their
detailed, scholarly and hardly improvable vision as to communication, we record
what has already been implemented by us since 2000, in terms of BP and HR monitoring, not only toward their goal of modernizing conventional spotcheck-based care
but also with respect to an improved quality of care, based on self-collected time series rather than upon spotchecks at home, if not in the office of a care provider. Such
screening has been implemented on students at the Peoples Friendship University of
Russia in Moscow. The same kind of BP and HR self-surveillance is also under way
in two Japanese towns, a university hospital in Japan, one in Hong Kong and another
in Italy, a university clinic in the Czech Republic, two hospitals in India, a research
facility in Mexico, and in general practice settings in Belgium. With current technology, this approach can be extended further on an international scale as an immediate
answer to the demands of at least one important BP-related aspect of universally
available computer-aided preventive care at affordable cost, with BP chronobiology
being the first step pertinent to a large segment of the population (4).
Internet-aided self-help in monitoring BP and HR constitutes a step toward
changes from a manual spotcheck-based to cyber-collected and automatically-analyzed data, yielding diagnoses and treatment recommendations based on the chronomes
of BP and HR time series. For screening or self-surveillance during treatment, the
chronome-based approach is cheaper since it does not require a care provider, yet it
automatically provides what is already a sine qua non in research, namely inferential
statistical analyses that include both hypothesis testing and point as well as interval
estimates of parameters. Hence, decisions are better than those based on spotchecks
that may depend on the time of day when a patient is seen by a care provider (4). It
seems pertinent that the complexity of these analyses is no problem when they are
provided automatically by a website or currently by BIOCOS.
Why MESOR and other characteristics rather than only the mean?
It is well recognized that BP is highly variable. Since part of this change is
rhythmic, a diagnosis based on single, albeit repeated measurements runs the risk of
being dependent on the time of day when they were taken, affecting the recommendation of treatment, perhaps for a lifetime. The least squares fitting of models consisting
of one or more cosine curves with anticipated periods (of 24 and 12 hours) accounts
for part of the variability, yielding estimates of the circadian amplitude and acrophase, together with a measure of location, the MESOR, that is usually more accurate
and/or more precise than the arithmetic mean. The circadian parameters further allow
the detection of VVDs that today are not screened for in health care. Examples of
VVDs are illustrated in Figure 2, screened for in a summary called sphygmochron
(4). Some of these conditions can be induced by treatment aimed solely at decreasing
the BP-MESOR, whereby iatrogenically, one may trade a bigger risk, such as CHAT
for the lowering of an elevated BP. Taking the chronome into account is now possible
in the context of an improved yet more affordable health care (4).
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Figure 2. Definitions and illustrations of abstract vascular variability disorders, (a) to (c)
diagnosed by cosinor (parametrically), (d) and (e) diagnosed by thresholds:
(a) MESORhypertension (MH), can be systolic (SMH), diastolic (DMH), mean arterial (MAMH), or a combination of these
conditions, incomplete when demonstrated only parametrically (complete when complemented nonparametrically by an
extent of excess during 24 hours > 50 mm Hg x hour).
(b) Circadian HyperAmplitudeTension (CHAT), which can also be systolic (SCHAT), diastolic (DCHAT), mean arterial (MA
CHAT) or a combination of these conditions.
(c) Odd timing of the circadian rhythm of BP but not of that in HR (BP ecphasia).
(d) Excessive pulse pressure (EPP), when the difference in the MESORs of SBP and DBP for adults exceeds 60 mm Hg, a
threshold that remains to be replaced by reference values from clinically healthy peers (eventually with diseasefree longlife
outcomes) specified further by gender, age, ethnicity and geography.
(e) A deficient HR variability (DHRV), defined as a standard deviation of HR less than 7.5 beats/minute, a threshold that re
mains to be replaced by reference values from clinically healthy peers (eventually with diseasefree longlife outcomes)
specified further by gender, age, ethnicity and geography. Halberg.

Chronomes and genomes are complementary structures in time and space, respectively. The genetic aspect of a personalized medicine has been thoroughly discussed by Richard Gallagher (5). He rightly lists goals: First, everyones genome will
be sequenced cheaply and the sequence will be interpretable, and predictive. Second,
[a persons] medical problems, discerned by analysis of the sequence, will be avoided
by genetic, lifestyle or therapeutic means. And third, where a disease has to be treated, [medicines will be] exquisitely tailored to... patient and ailment. No risk, no mess,
no problem. Specifically, Gallagher anticipates a $1,000 genome assessment and notes that it would not be useful at $10,000 an interpretation. Gallagher also notes that
the genome is a moving and complex target, and refers to a commercial use, Directto-Consumer genotyping, indicating that it isnt a success. A handful of companies
continue to provide information on ancestry (whimsical), findings on traits (trivial),
and a little advice on disease risk. They need time for research to turn them into a ge20

Cornlissen G. et al. Personalized chronome (time structure) complements genome detecting vascular...

nuinely useful service. In other words, its promise notwithstanding, a genetically

personalized medicine is, to date, too high in cost and too low in benefits.
By comparison, routine chronobiologic 24-hour/7-day screening currently detects, among others, more reliably than conventional care, MESOR-hypertension
(MH, an elevation of the rhythm-adjusted systolic (S) and/or diastolic (D) BP average
or MESOR, M). MH is one of several vascular variability anomalies that become disorders, VVDs, Figure 2, if they are detected in a 7-day record analyzed as a whole. If
replicated, a VVD can constitute a risk of stroke exceeding that of MH in Asians. A
circadian BP overswing (CHAT), another VVD, is a feature common in two components of a pre-metabolic syndrome, namely pre-hypertension and pre-diabetes. CHAT
and/or other VVDs can combine into Vascular Variability Syndromes (VVSs) (4).
In some cases and/or at some clock-hours, depending on the individual, the lowering of a high BP-MESOR is associated with a complication by CHAT, Figure3. The
treatment-induced CHAT can represent a risk of stroke higher than that of MH.
Hence, lasting CHAT and other VVDs should be reduced or eliminated, something
that can be done on occasion by timing, Figure 3. Education of the public in the relative risks of alterations in BP-M and in other circadian parameters (amplitudes, A,
and/or acrophases, phi) of BP and/or HR and in the detection, treatment and further
research on altered circulatory dynamics is within the mandate of state, national and
international health and education departments and related foundations and agencies.

Figure 3. A popular drug, if prescribed without personalized surveillance, can induce a vascular variability
disorder, VVD, such as Circadian HyperAmplitudeTension (CHAT). A change in the time when the drug is
taken can make the same dose of the same drug in the same person beneficial or vice versa. At one admini
stration time (before noon), Hyzaar induces CHAT in diastolic BP and exacerbates a preexisting CHAT in sys
tolic BP. At another time of administration, Hyzaar eliminates a preexisting VVD. These opposite effects were
found in tests at six medication times, each administered for about a month, with halfhourly surveillance of
BP during the last week of each span. These differences occur as a function of the timing of the drugs use
along the scale of 24 hours. Original study by Dr Yoshihiko Watanabe. Halberg.

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Chronome-based care is being implemented cost-free in adults today, although

as yet on small scales. In the future, its application will have to be enlarged as a service available for everyone, starting not later than in early schooling, in middle school
or earlier, preferably at birth, as well as by adult education, including in particular
pregnant women, where it is particularly cost-effective. Starting with the BP and HR,
already-documented great risks that escape conventional diagnoses have been detected and treated by available lifestyle modification and/or by changing the timing of
medications (4). Where a disease has been found, the timing of lifestyle change, such
as exercise, diet or medications, can be tailored according to the chronome determined on the basis of self-monitoring. Harm from any iatrogenic CHAT is detected and
eliminated. Risk may be removed and some handicapping and life-threatening problems may be avoided. For a chronobiologically-implemented diagnosis about the
chronome of BP and HR, the cost of an automatic ambulatory monitor via BIOCOS
(corne001@umn.edu) is $450, a cost that could be lowered (4).
More than a century after Zadeks and Janeways time, the study of periodic variations is facilitated by computers. A website is under construction, with an endeavor
to build affordable tools at a cost below US $100, already demonstrated as practical (4)
(as compared to the as-yet abstract goal of US $1,000 for a personalized genome; 5).
It seems desirable and more important to educate the public and medical students than
to offer postgraduate courses to care providers before the evidence accumulated with
respect to the cost-effectiveness of computer-delivered chronobiology has become part
of the business plans of care providers compensation. False positive and false negative diagnoses of high BP can be reduced by replacing the BP cuff in a physicians office used before a physical examination by the results of a chronobiologically-interpreted self-collected and automatically website-analyzed ambulatory monitoring BP
profile (C-ABPM) of 24-hour/7-day for screening and of 24-hour/365-day when consistent alterations are noted. This education may be more successful when involving
the public than when addressed to care providers paid by the number of patients seen
or by procedures used, rather than by the outcomes of their services. Involving the
public may also be more successful than addressing those insurance executives who
fail to see the savings in both suffering and cost when a program of prehabilitation,
notably of stroke prevention, is implemented by computer-aided self-help for a better
and universal as well as cheaper health care.
Gallagher (5) starts his discussion of the 3-way promise of genetically-personalized medicine under the fitting title Stumbling Towards Nirvana. He concludes
Nirvana is the antithesis of ignorance. And dispelling ignorance of disease is progressing. So far weve stumbled forward a little on the road to (genetic) personalized
medicine, but it looks like the pace towards Nirvana is about to pick up. Let us also
sprint, rather than stumble, towards chronobiologic chronome-based personalization,
an experimentally-validated approach in hand. It is inferentially statistically validatable, and results given based on appropriate time series can be automatically provided
by a website. Complexity is thus removed, and a much-improved diagnosis and the
validation of treatment can be personalized. If, at its current cost, the available instrumentation is used for screening by a neighborhood or a circle of family and friends,
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Cornlissen G. et al. Personalized chronome (time structure) complements genome detecting vascular...

the cost of a 24-hour/7-day record is already reduced to below $2 per weeklong profile, as compared to thousands of dollars for a personalization via the genome. If an
instrument is to be used to 24-hour/365-day records, the cost is now reduced to $450
a go (within the BIOCOS project) in exchange for the data (corne001@umn.edu) and
with cost-free analyses. The cost can be reduced to below $100 an instrument by currently available instrumentation in a government or other public health plan (4). Introduction into secondary education of the already available why and how of chronobiology can be accompanied by a yet-to-be updated book (4).

Figure 4. The incidence of VVDs is assessed herein in a clinic population of 297 patients. Blood pressure
(BP) and heart rate (HR) of each subject were monitored around the clock for 2 days at 15minute intervals at
the start of study. Each record was analyzed chronobiologically and results interpreted in the light of time
specified reference limits qualified by gender and age. On this basis, MESORhypertension, MH (diagnosed
in 176 patients), excessive pulse pressure (EPP), CHAT (a circadian overswing) and a deficient heart rate
variability (DHRV) were identified and their incidence related to outcomes (cerebral ischemic attack, coronary
artery disease, nephropathy, and/or retinopathy). Outcomes, absent at the start of study in these non
diabetic patients, were checked every 6 months for 6 years, to estimate the relative risk associated with each
VVD alone or in combination with 1, 2, or 3 additional VVDs, shown in columns. Earlier work showed that
CHAT was associated with a risk of cerebral ischemic event and of nephropathy higher than MH, and that the
risks of CHAT, EPP, and DHRV were mostly independent and additive. It thus seemed important to determine
the incidence of each VVD, present alone or in combination with one or more additional VVDs. The 176 pa
tients with MH were broken down into 103 (34.7% of the population of 297 patients) with uncomplicated MH,
55 (18.5%) with MH complicated by one additional VVD, 15 (5.1%) and 3 (1.0%) with MH complicated by two
or three additional VVDs (top left). In the latter group, all 3 patients had a morbid outcome within 6 years of
the BP monitoring. Ambulatory BP monitoring over only 48 hours, used for diagnosis, is much better than a
diagnosis based on casual clinic measurements, yet its results apply only to groups. With this qualification, of
the 176 patients with MH, 73 (42.2%) had additional VVDs that further increase their vascular disease risk,
and that are not considered in the treatment plan of these patients since current practice does not assess
these VVDs. This proportion may be smaller in 7day records. Results related to an excessive pulse pressure,
EPP (bottom left), CHAT (upper right), and a deficient heart rate variability, DHRV (bottom right), illustrate
that these conditions can be present in the absence of MH in as many as 12 (4.0%) of the 297 subjects. Since
they do not have MH, it is unlikely that these subjects would be treated from a conventional viewpoint, even
though their vascular disease risk can be as high as or even higher than MH.

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Evidence exists to suggest that treatment of these conditions may translate into a
reduction in morbidity and/or mortality from vascular disease. Another lesson from
these results is that around-the-clock monitoring of BP and HR interpreted chronobiologically is needed, even in the absence of MESOR-hypertension, to detect vascular
disease risk associated with VVDs such as CHAT and DHRV, that cannot be assessed
on the basis of casual clinic measurements, so that non-pharmacologic and/or pharmacologic intervention can be instituted in a timely fashion before the occurrence of
adverse outcomes. Once implemented across the board rather than in selected patient
populations, vascular disease could be curbed to a much larger extent at relatively low
cost if the monitoring is offered directly to the public and care providers become involved only after detection of a VVD. A website has to be built to interest many people
and to provide cost-free analyses in exchange for the data, as is now provided worldwide by the BIOCOS project on a small scale (corne001@umn.edu). Halberg.
Dividends as one goes
The merits of chronobiologic monitoring, if the data are saved, as could be done
on a website, could serve for more than stroke and other life-threatening disease prevention. It would reveal the mechanisms underlying more than the circadian component documented thus far (6, 7). Each newly mapped spectral component could greatly increase the merits of sequencing the chronome for translation from research to
clinical practice. More specifically, a dividend from monitoring BP and HR would allow the uses of novel spectral components to the extent that the mechanisms of these
new entities are clarified by 24-hour/365-day or 24-hour/lifetime data on population
outcomes. Already mapped are about 5-month quinmensal rhythms not only in solar
flares and other environmental features, but also in human physiology, including BP,
HR and melatonin, and in pathology, such as sudden cardiac death (7). Quinmensals
and other newly found frequencies such as transyears (10) are reflected in the breakdown products of steroidal hormones in urine and in the melatonin of circulating blood.
Mapping the chronome is the indispensable counterpart to sequencing genomes. The
latter widely heralded endeavor is but a complement to the former. A decrease in circadian amplitude was associated with a reduction by one half of cardiovascular morbidity (8). Systematic tests to find the optimal time of treatment administration for the
individual patient, to be sure that benefits from a hypotensive effect are not curtailed
by inducing or exacerbating another VVD are a challenge for all those receiving antihypertensive therapy. The percentages involved are estimated in Figure 4, involving
very many millions of people currently diagnosed or misdiagnosed as hypertensive.
The further dividends from monitoring the sun by the data collected for stroke prevention are another story (6, 7), also in the spirit of Vasily Vasilyevich Dokuchaev,
Vladimir Ivanovich Vernadsky and Alexander Leonidovich Chizhevsky (9), with special focus upon the frequencies that can be resolved (7, 10). The chronobiologic path
depends on its being learned in education broadly, not only in universities but also in
secondary schools. Eventually, monitoring of BP and HR will be started most effectively in pregnancy and continued for a lifetime, starting at birth (4).
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[10] Halberg F, Cornelissen G, Katinas G et al. International BIOCOS Group. Chronobiology
's progress: season's appreciations 20042005. Time-, frequency-, phase-, variable-, individual-, age- and site-specific chronomics. J Applied Biomedicine 2006; 4: 138.
http://www.zsf.jcu.cz/vyzkum/jab/4_1/halberg.pdf

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[1] .., .., .. .

// . 1976. . 38. 9. . 3338.
[2] Morgan D.M. Polyamines. An overview // Mol Biotechnol. 1999. V. 11, N 3.
P. 229250.
[3] Wallace H.M., Fraser A.V. Polyamine analogues as anticancer drugs // Biochem. Soc. Trans.
2003. V. 31. N 2. P. 393396.
[4] Seiler N. Thirty years of polyamine-related approaches to cancer therapy. Retrospect and
prospect. Part 1. Selective enzyme inhibitors // Curr. Drug. Targets. 2003. V. 4.
N 7. P. 537564.
[5] Seiler N., Wiechman M. Zum nachweis von aminen in 1010 M masstab. Trennung von l-dimethylaminophtalin-5-sulfonsaureamiden auf dunnschi-chromatogrammen // Experientia.
1965. V. 21. P. 203204.
[6] .., .., .. .

L- // . . . 1991. . 37. 6.
. 7781.
[7] .. // 2002. . 48.
3. . 4748.
[8] .., .., .. . , S- - //
. . 2010.
[9] Eloranta T.O., Khomutov A.R., Khomutov R.M. et al. Aminooxy Analogues of Spermidine as
Inhibitors of Spermine Synthase and Substrates of Hepatic Polyamine Acetylating Activity //
J. Biochem. 1990. V. 108. P. 593598.
[10] Kramer D.L., Khomutov R.M., Bukin Y.V. et al. Cellular characterization of a new irreversible inhibitor of S-adenosylmethionine decarboxylase and its use in determining the relative
abilities of individual polyamines to sustain growth and viability of L1210 cells // Biochem.
J. 1989. V. 259. N 2. P. 325331.

30

 .. . ...

THE INFLUENCE OF CHEMICAL ANALOGS OF DECARBOXYLATED

ORNITHINE AND S0(ADENOSIL)0METHIONINE
ON THE GROWTH OF L0CELL TISSUE CULTURE
S.P. SIatkin, T.V. Fedoronchuk, N.Ya. Gridina,
E.A. Neborakh, N.A. Shevkhun, N.A. Sokueva,
E.V. Ustinova, R.I. Sokuev
Department of biochemistry
Russian Peoples Friendship University
Miklukho-Maklaya str., 8, Moscow, Russia, 117198
The effect of aliphatic amino- and oxy-derivatives of Ornithine and of S-(Adenosil)-methionine
on the growth of L-cells in tissue culture was studied. The common known specific inhibitors of polyamines synthesis enzymes DFMO and MGBG were used for control and monitoring of test compounds
action efficiency. The action of 1-aminooxy-3-aminopropan (APA), S-(5-desoxyadenosile)-S-methyl-thioethyl-hydroxylamine (AMA) individually manner and in combination of one with another was
similar with DFMO and MGBG effect but less pronounced. The degree of L-cell growth inhibition in
the 4th day achieved 5060%. By the 7th day there was observed a tendency not only to the growth rate
stabilization but also to its reconstruction. It is indicative of reversible effect of APA and AMA compounds action on the cell growth that it differs from DFMO and MGBG actions.
Key words: polyamines, Putrescine, Spermidine, Spermine, L-cells, Difluoromethylornithine
(DFMO), Methylglyoxal-bis(guanylhydrazone) (MGBG), cell growth.



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EFFECTIVENESS OF PROBIOTICS USE IN PATIENTS

WITH CHRONIC VIRAL HEPATITIS
N.V. Solovieva1, T.A. Bazhukova2,
V.M. Agafonov3
1

Department of Pathophysiology
2
Department of Microbiology
3
Department of Infectious Diseases
Northern State Medical University
Troitsky Ave., 51, Arkhangelsk, Russia, 163000
It has been shown that liver damages of viral genesis were accompanied by disturbances of the
large intestine microbial ecology and a reliable decrease in the number of bifid and lactic acid bacteria,
increased frequency of staphylococcus occurrence and decreased enterococcus number. It has been
grounded that it was necessary to correct the large intestine flora in patients with chronic hepatitis and
chronic hepatitis by using probiotic preparations stimulating growth and rehabilitation of normal flora
functions.
Key words: microbiocenosis, viral hepatitis and , probiotic preparations.

36



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,
.

[1] .., .., .. : // . 2004.

3. . 5660.
[2] .., .., .. . // .: , 1996. . 149.
[3] .., .., .. . ., 2001. 166 .
[4] .., .., .. . // . 2004. 4. . 4144.
[5] .., .., ..
12- // . 1982. 12. . 2731.
[6] .., .., .. . // . 2001. 3. . 47.
[7] .., .., .. . // . 2002.
5. . 4346.
[8] .. : . ... . . . ., 1993. . 337.
[9] Chung S.C.S. Surgery and gastrointestinal bleeding // Gastrointest. Endosc. Clin. North. Am.
1997. 7. P. 687701.
[10] Schoenberg M.H. Surgical therapy for peptic ulcer and nonvariceal bleeding // Langenbecks
Arch. Surg. 2001. Vol. 386. P. 98103.

42

 .. . ...

MODERN TREATMENT STRATEGY

OF GASTRODUODENAL ULCER BLEEDING
A.A. Schyogolev, O.A. AlSabunchi
Chair surgical disease Muscovite faculty
Russian national medical university
Fortunatovskaya str., 1, Moscow, Russia, 105058

E.. Klochneva
Regional hospital Tambov city
Polevaya str., buil. 4, village Pokrovo-Prigorodnoe, Tambovskaya region, 392524
CRH of Tambovskaya region

J.A. Azimova
Clinic city hospital 36
Fortunatovskaya str., 1, Moscow, Russia, 105058
The problem of acute gastroduodenal hemorrhages remains one of the most urgent and unsolved
tasks of urgent surgery
Our study included 199 patients with hemorrhage from chronic ulcers. The first group (control)
consist 104 patients with hemorrhage of chronic ulcers, in which active tactics was used, based on forecast of rebleeding.
The second group (basic) consist 95 patients with hemorrhage of chronic ulcers, which treated
with endoscopic and drug hemostasis; operation was performed only in the case of rebleeding.
Surgical activity in control group was 45,2% (47 patients). Postoperative death was 8,5% (4 patients). Conservative treatment undergone 57 patients (54,8%). Rebleeding occur in two patients (1,9%).
Common death rate in first group was 10,5% (11 patients).
In basic group rebleeding occur in 3 patients (3,2%), they all were operated. Postoperative rate
death was 40% (2 patients). The Death rate in conservative treatment was 1,1% (1 patient). Common
death was 3,2% (3 patients).
Thus the use of endoscopic hemostasis and conservative treatment in patients with hemorrhage
from the chronic ulcers, reduce quantities of operations, and decrease the percentage of rebleeding with
a reliable decrease in the rate of death.
Key words: ulcer gastroduodenal hemorrhages, endoscopic hemostasis.


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[1] Beaupre G.S., Csongradi J.J. Refracture risk after plate removal in the forearm // J. Orthop.
Trauma. 1996. 10(2). P. 8792.
[2] Bostman O., Pihlajamaki H. Routine implant removal after fracture surgery: a potentially
reducible consumer of hospital resources in trauma units // J Trauma. 1996. 41.
P. 846849.
[3] Breederveld R.S., P. Patka, J.C. van Mourik. Refractures of the femoral shaft // Neth. J. Surg.
1985. Aug; 37(4). P. 114116.
[4] Davison B.L. Refracture following plate removal in supracondylar-intercondylar femur fractures // Orthopedics. 2003. 26(2). P. 157159.
[5] Evans N.A., Evans R.O. Playing with metal: fracture implants and contact sport // Br. J.
Sports Med. 1997. 31. P. 319321.
[6] George B., Gaheer R.S., Ratnam A. Spontaneous femoral neck fracture after removal of Dynamic Hip Screw // J. Orthopaedics. 2007. 4(1). e14.
[7] Gsling T., Hfner T., Hankemeier S., Zelle B.A., Mller-Heine A., Krettek C. Femoral nail removal should be restricted in asymptomatic patients // Clin. Orthop. Relat. Res. 2004.
P. 222226.
[8] Hanson B., Chris van der Werken, Dirk Stengel. Surgeons Beliefs and Perceptions About
Removal of Orthopaedic Implants, BMC Musculoskeletal disorders. 2008. 9. P. 73.
[9] Krischak G.D., Gebhard F., Mohr W., Krivan V., Ignatius A., Beck A., Wachter N.J., Reuter P.,
Arand M., Kinzl L., Claes L.E. Difference in metallic wear distribution released from commercially pure titanium compared with stainless steel plates // Arch. Orthop. Trauma Surg.
2004. 124. P. 104113.
[10] Kukla C., Pichl W., Prokesch R., Jacyniak W., Heinze G., Gatterer R. et al. Femoral neck
fracture after removal of the standard gamma interlocking nail: a cadaveric study to determine factors influencing the biomechanical properties of the proximal femur // J. Biomech.
2001. 34(12). P. 15191526.
[11] Lovell M.E., Galasko C.S., Wright N.B. Removal of orthopedic implants in children: morbidity
and postoperative radiologic changes // J. Pediatr. Orthop. B. 1999. 8(2). P. 144
146.
[12] McGarry S., Morgan S.J., Grosskreuz R.M., Williams A.E., Smith W.R. Serum titanium levels
in individuals undergoing intramedullary femoral nailing with a titanium implant // J. Trauma. 2008. 64(2). P. 430433.
[13] Peterson H.A. Metallic implant removal in children // J. Pediatr. Orthop. 2005. 25.
P. 107115.

50

 .., .., ..

[14] Sanderson P.L., Ryan W., Turner P.G. Complications of metalwork removal // Injury.
1992. 23(1). P. 2930.
[15] Serhan H., Slivka M., Albert T., Kwak S.D. Is galvanic corrosion between titanium alloy and
stainless steel spinal implants a clinical concern? // Spine J. 2004. 4. P. 379387.
[16] Thomas P., Schuh A., Ring J., Thomsen M. Orthopedisch-chirurgische Implantate und Allergien. Gemeinsame Stellungnahme des Arbeitskreises Implantatallergie (AK 20) der Deutschen Gesellschaft fur Orthopedie und Orthopedische Chirurgie (DGOOC), der Deutschen
Kontaktallergie Gruppe (DKG) und der Deutschen Gesellschaft fur Allergologie und Klinische Immunologie (DGAKI) // Orthopade. 2008. 37(1). P. 7588.
[17] Townend M., Parker P. Metalwork removal in potential army recruits. Evidence based changes
to entry criteria // J P Army Med Corps. 2005. 151. P. 24.
[18] Yang K.H, Byun Y.S., Park H.W., Park S.J. Failure on attempted removal of a Gamma nail in
two young patients // J Orthop Trauma. 2003. 17. P. 379382.
[19] Yang Kyu-Hyun, Yoo-Wang Choi, Jung-Hoon Won, Je-Hyun Yoo. Subcapital femoral neck
fracture after removal of Gamma/Proximal Femoral nails: report of two cases // Injury Extra.
2005. V. 36, iss. 7. P. 245248.

IMPLANTS REMOVAL
N.V. Zagorodny, A.A. Volna,
M.A. Panin
Traumatology and orthopedic department
Peoples Friendship University of Russia
Lobachevskogo str., 42, Moscow, Russia, 119415
In spite of the rapid development of the traumatology in the past few years the elaboration of the
new materials for the metal implants and other new devices for the internal fixation, one question stays
opened whether it is necessary to remove the implant. Quite many complications after the removal of
the metal implants, ambiguous specialists opinions, also insufficient attention of the Russian authors
show that a common attitude is needed towards this problem. This article is based on the grounds of the
most citied foreign authors as well as on our clinical experience.
Key words: implants removal, allergie, refracture.


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// .: I
. ., 1996. . 341.
[5] Aoki Y., Katsumi M. Palliative Surgery for Unresectable Carcinoma of the Head of the Pancreas,
Ampulla, and Distal end of the Common Bile Duct in Japan // Amer. J. Surg. 1984.
V. 147. P. 349353.
[6] Flemming B., Bryde A., Brahe N. et al. Pancreaticoduodenectomy for periampullary cancer //
Ugeskr. Laeger. 1995. V. 157. 40. P. 55445548.
[7] Oonner M. Mechanical Biliary Obstruction. A Review of the Multisystemic Consequences
of Obstructive Jaundice and Their Impact on Perioperative Morbidity and Mortality // Amer.
Surg. 1985. V. 51. 5. P. 245251.

THE MODERN DIAGNOSTICS AND TREATMENT

OF PATIENTS WITH PANCREATIC HEAD CANCER,
COMPLICATED BY JAUNDICE SYNDROME
N.A. Eltyshev
Russian Scientific Center of Roentgenoradiology
Profoyuznaya str., 86, Moscow, Russia, 117997
The paper presents the materials on modern diagnostics and treatment of 110 patients with pancreatic head cancer, complicated by jaundice syndrome. The author analyses the results of the modern
instrumental diagnostic methods, which make it possible to stage the tumor and to define the optimal
tactics of treatment. 30 patients got the combined treatment, 54 radiation therapy, 16 complex
treatment, 10 palliative surgery. 5-year survival after the combined treatment was 20,0% 10,3%
Key words: Cancer jaundice, cancer of the head of the pancreas, US tomography, bile cytology,
angiocholangiography, pancreatoduodenal resection, radiation therapy, term results.

56




.. , .. , .. ,
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, ,
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57

 , , 2010, 4

. Ficoll-Pague ( 1,077 /).

- (2 : 1, /) (erk) [3]. // / (60 : 50 : 1 : 4, ). /
/ (60 : 40 : 2, /). . , , -06.
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52,20 0,77

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38,31 1,12*
44,91 2,47*

42,30 1,19

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26,90 1,53*

31,14 1,77*

0,81 0,04

0,68 0,03*

0,57 0,03*

0,70 0,03*

0,23 0,01

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,
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58

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,

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6, 0 0, 7

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7, 8 0, 9
9, 4 0, 7

4, 4 0, 4
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4, 4 0, 6
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7, 5 1, 0
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19,1 0, 8
21, 2 0, 68

35,2 1, 0
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24, 5 0, 7
32, 3 1, 0

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33, 6 2, 0
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44, 8 1, 0
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54, 5 2,1
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10, 4 11
,
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53,1 1, 7
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,
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,

21, 4 1, 0
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(M m)

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I max

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2,16 0,12*

1,96 0,11*

ST max

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1,84 0,08*

1,79 0,08*

1,53 0,07*

tg 1

2,01 0,12

3,44 0,20*

3,36 0,21*

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0,54 0,04

0,52 0,04

: * (p < 0,05), S , I max

, ST max 
,tg 1 
, tg 2
.

59

 , , 2010, 4

()
53,284,1%, 6,37,9 ,
27,434,1%, 30,332,7%,
26,231,8% () 66,1
76,5% ( < 0,05).

() 23,131,0%, 44,363,6%,
60,266,3%, 4,56,5 ,
32,542,9%,
39,447,2%, 26,328,8% ( < 0,05).
()
92,3110,2%, 21,236,8%, 8,18,5 , 97,2103,4%, 54,772,5%, 60,8
75,4% ( < 0,05).
, , ,
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, %

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3
5
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0,46 0,02*
0,62 0,03*

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55,01 2,56*

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, [1, 6]
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, %
, tg a
,

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123,60 5,56

1
3
5
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51,16 2,81*
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, , , . ,
(0,43 0,028 100 ),
() ( 0,82 0,032 100 ).
. (5 ) (5 ) in vitro .
, , , , , ,
, , .
, . .
, - , , .

[1] .., .., .. .

// . .
. 2000. . 129. 6. . 637639.
[2] .., .., .. . // . . .
2002. . 134. 8. . 160162.
[3] . / . .. , .. . .: ,
1990. 424 .
[4] .., .., .. . : - . -, 2000. 208 .
[5] . : . .: , 1997. 624 .
[6] .., .. .
., 1994. 164 .

61

 , , 2010, 4

[7] .., .., .., .. - // . 1999. . 158. . 3. . 4245.

[8] . ., .., .., .. // . 1990. . 55. . 8. . 15071512.
[9] . ., . ., . . - //
. . . 1999. . 127. 6. . 604611.
[10] .., .., .., ..
, //
. 1989. 2. . 1217.

THE LIPID STRUCTURE AND FUNCTIONAL STATUS

OF BLOOD CELLS UNDER ENDOGENOUS INTOXICATION
P. Vlasov, D.A. Visaitov, V.A. Trofimov,
N.U. Leschankina, M.V. Pyanov
Faculty surgery departments, the genetics departments,
faculty of hospital therapy, t he chair of pedagogical psychology and pedagogics
Mordovian state university named N.P. Ogarev
Bolshevitskaya str., 68, Saransk, Russia, 430000

V.F. Mustaytsa
The pathological physiology chair
Peoples Friendship University of Russia
Miklukho-Maklaya str., 6, Moscow, Russia, 117198
The lipids structure of blood cells and plasma has specific modification under endogenous intoxication. The pathological complex of lipid modification is top-ranked reason of blood cells dysfunction
under endogenous intoxication. It is necessary to correct one opportunely.
Key words: endogenous intoxication, blood cells, lipids.


.. , ..


. , 86, , , 117997

. .



. -, 6, , , 117198
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63

 , , 2010, 4

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.
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, . ,
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1990- . . . , ,
. , , [13].
, [8, 12, 14]. , [6, 7]. ,
[15].
[10].
,
,
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. C.Y. Gu et al. (2004)
,
64

 .., .., ..

, . ,
[9]. X.Qiu et al.
(2004) 2 12 (IL-2
IL-12), NK H-22 . , IL-2 IL-12,
NK . ,
, , [11]. J.M. Zhang
et al. (2004)
23 ,
[17].
,
, , .
. .. ( )
19782004 . [2].
(326 )
. 118
. , , , , , . , . 82%
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75%
. 85%.
.
, .
34 2 64% , .
3 .
,
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.
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77 . 65

 , , 2010, 4

[4].
.. (1996) [1]. -01.
1012
. 1 56
. 35 .
: , , , , . ,
, , , .
. - . , ,
( ), - .
, (1959) [5].
. .. [3].
100 -, ,
.
( 90%),
, ,
(, , ).
. .

, , , :
1) ;
2) , , ;
3)
( , , ).
.
, , , , .
66

 .., .., ..

[1] .. : . . ... ... , 1996. 16 .

[2] .. : . . ... ... ,
2007. 30 .
[3] .., .. // . 2007. 1. . 1519.
[4] ..
: . . ... ... , 1989. 21 .
[5] -. - . .:
, 1959. . 215.
[6] Alimi D., Rubino C., Pichard-Leandri E., Fermand-Brule S., Dubreuil-Lemaire M.L., Hill C.
Analgesic effect of auricular acupuncture for cancer pain: a randomized, blinded, controlled
trial // J Clin Oncol. 2003 Nov. 15; V 21(22). . 41204126.
[7] Deng G., Cassileth B.R. Integrative oncology: complementary therapies for pain, anxiety and
mood disturbance // CA Cancer J. Clin. 2005 Mar-Apr; V 55(2). P. 109116.
[8] Ezzo J.M. Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting //
Cochrane Database Syst Rev. 2006. Apr V. 19; (2). CD002285.
[9] Gu C.Y., Lou Y., Cai Y.B., Hu J. Effects of different anesthesia methods on the T lymphocyte
subsets and hemodynamics of patients with abdominal tumor in peri-operational period //
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Nov; V. 24(11). P. 973975.
[10] Ladas E.J., Post-White J., Hawks R., Taromina K. Evidence for symptom management in the
child with cancer // J Pediatr Hematol Oncol. 2006 Sep. 28(9). P. 601615.
[11] Qiu X., Chen K., Tong L., Shu X., Lu X., Wen H., Deng C. Effects of moxibustion at shenque
(CV 8) on serum IL-12 level and NK cell activities in mice with transplanted tumor // J. Tradit. Chin. Med. 2004. Mar; V. 24(1). P. 5658.
[12] Roscoe J., Morrow G., Hickok J. et al. The efficacy of acupressure and acustimulation wrist
bands for the relief of chemotherapy-induced nausea and vomiting. A University of Rochester Cancer Center Community Clinical Oncology Program multicenter study // J. Pain Symptom Manage. 2003. V. 26. P. 731742.
[13] Rosenthal D.S., Dean-Clower E. Integrative medicine in hematology/oncology: benefits,
ethical considerations, and controversies // Hematology. 2005. P. 491497.
[14] Shen J., Wenger N., Glaspy J. et al. Electroacupuncture for control of myeloblative chemotherapy-induced emesis: a randomized controlled trial // JAMA. 2000. V. 284.
P. 27552761.
[15] Vickers A.J., Straus D.J., Fearon B., Cassileth B.R. Acupuncture for postchemotherapy fatigue:
a phase II study // J. Clin. Oncol. 2004. May 1. V. 22(9). P. 17311735.
[16] Wong R., Sagar S. Acupuncture treatment for chemotherapy-induced peripheral neuropathy
a case series // Acupunct. Med. 2006. Jun. V. 24(2). P. 8791.
[17] Zhang J.M., Zhang H., Zhu X.D., Lu S., Liu Z., Chen J., Peng S. Clinical application of acupunctural anesthesia with new combination principle of acupoints in supratentorial craniocerebral operation of tumor in vital functional area or deep site of brain // Zhongguo Zhong
Xi Yi Jie He Za Zhi. 2004. Nov. V. 24(11). P. 969972.

67

 , , 2010, 4

THE LASER REFLEXOTHERAPY

IN CHILDRENS ONCOLOGY
O.I. Shcherbenko, R.A. Parkhomenko
The Leading Researcher
Federal State Enterprise Russian Scientific Center of Roentgenoradiology
Profsoyuznaya str., 86, Moscow, Russia, 117 997

V.A. Zhernov
Restorative Medicine Chair
Peoples Friendship University of Russia
Miklukho-Maklay str., 6, Moscow, Russia, 117198
The article deals with the results of the authors own preliminary results and the data of several
investigations on using reflexotherapy in oncology. The results of those works demonstrate its effectiveness and safety in such manifestations of malignant tumors and complex treatment complications as
pain syndrome, nausea, vomiting, edemas, immunodeficiency. In Russia the great experience in that
field was accumulated by the Medical Radiological Scientific Center and by Research Institute of Pediatric Hematology/Oncology of Russian Oncological Scientific Center. The large-scale investigations in
that field are underway in the US under the auspices of the National Cancer Institute. The well-tested
methods of reflexotherapy should be introduced wider into the oncological practice, the research on that
problem should be expanded.
Key words: oncology, reflexotherapy, laser.



,

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. , 86, , , 117997

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69

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(142,4 25,2 /),
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(1,1 0,1), Tmax (25,8 1,6 .), 1/2 (48,0 1,7 .);
(2523,1 36,3 /),
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 , , 2010, 4

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73

 , , 2010, 4

48 . 11 ,
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6,- 12-, 18-, 24- , 6, 12, 18, 24, 30, 36- .
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74

 .. . ...

, , .
.

22 . 6 , , .

,
,
.

.

,
, , , .

[1] .., .., .. . . ,

1971. 228 .
[2] .. : . . ... . . ., 1993. 299 .
[3] ..
. .: ,
/ . .. . ., 1968. 162 .
[4] ..
// . 1990. 1. . 4245.
[5] ..
, : . . ... . . ., 1998. 294 .
[6] .., .., ..
//
. 1986. 9. . 1215.
[7] Beazley R., Hadjis N., Benjamin I. et al. Clinicopathological aspects of high bile duct cancer:
Experiance with resection and bypass surgical treatment // Ann. Surg. 1984. V. 199.
P. 623636.
[8] Gundru S., Strodel W., Knol I. et al. Efficacy of preoperative biliari tract decompession in
patients with obstructive jaundice // Arch. Surgery. 1984. Vol. 119. P. 703708.
[9] Koyama K., Ito K., Fukaya H. et al. Experimental and Clinical Studies of Renal Disturbance
in Obstructive Jaundice // Jap. J. Surg. 1981. V. 11. 6. P. 440448.
[10] Moody F., Rikkers L., Aldrete J. Estimation of the Functional Reserve of Human Liver //
Ann. Surg. 1974. V. 180. 4. P. 592597.

75

 , , 2010, 4

[11] Oonner M. Mechanical Biliary Obstruction. A Review of the Multisystemic Consequences

of Obstructive Jaundice and Their Impact on Perioperative Morbidity and Mortality // Amer.
Surg. 1985. V. 51. 5. P. 245251.

THE TERMS OF RESTORATION OF FUNCTIONAL

AND STRUCTURAL LIVER CHANGES IN JAUNDICE,
CAUSED BY PANCREATIC HEAD CANCER
V.P. Khartchenko, T.A. Lutfaliev, M.A. Kunda,
N.L. Chazova, A.M. Bershanskaya, N.A. Eltyshev,
G.M. Zapirov, V.L. Barushnicov
Chair of Oncology and Roentgenoradiology
Peoples Friendship University of Russia
Profsoyuznaya str., 86, Moscow, Russia, 117997
The article presents the data on functional and structural liver changes in 160 patients with pancreatic head cancer, complicated by jaundice syndrome. The authors investigated the terms of recovery
after various methods of liquidation of obturation cholestasis. Those terms define the main tactic approaches in combined, radiation and complex treatment of pancreatic head cancer.
Key words: structural liver impairment, cancer jaundice, cancer of the head of the pancreas, endobiliar decompression, terms of structural impairments recovery.


+
CD25 CD4 0


+

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29
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CD25+CD4+ , . FOXP3 (,
Scurfin), -2, CTLA-4- -4 (cytotoxic lymphocyte-associated, antigen-4) GITR- TNF (glucocorticoid-induced tumor necrosis
factor reptor) [3].
77

 , , 2010, 4

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[79]. ,
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78

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, 10 . 250 g, .
EPICS-C (Coulter Electronics, Florida, USA).
Argon-Innova
90-6 (Coherent, USA) 488 . () CD8, CD4
CD25- .
: ( , - ) CD25 (
) , CD4 .

Microcal Origin 5,0.
. CD8+, CD4+, CD25+
CD4+CD25+ ()
CD4+ CD8+ . , , - , .
CD8+, CD4+ CD25+ 23 4%, 39 5%
0 0% . . 1.
1
,

()

()

()

CD4, %

45,70 3,40

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50,40 3,20 *23

CD8, %

17,30 1,80

7,90 1,80 *12

14,70 1,00 *23

, . .

2,90 0,50

7,60 2,40 *12

2,50 0,50 *23

CD25, %

0,20 0,04

0,52 0,17

0,89 0,28

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0,11 0,03

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0,47 0,13 *13

: * < 0,05 .

,
, CD25+
, , , .
79

 , , 2010, 4

, CD8+ , , . CD25+-
, ( ).
, CD25+ ( p > 0,05)
.
CD4+CD25+- ,
(. 1) , .
.
, CD4-. , CD4+CD25+-,
CD4+CD25+- CD4+-. , . 1, , ,
CD4+CD25+- CD4+-
. .
, . CD4+CD25+- .

. 1. CD4 CD25 CD4

(),
() ()
* < 0,05

80

 .. . CD25+CD4+ -...

CD4+CD25+-
, ,
, [11].
. 2.

. 2. 

, CD4+CD25+ . , CD4+CD25+- ,
-,
. .

[1] Adler A.J. Mechanisms of T cell tolerance and suppression in cancer mediated by tumor-associated antigens and hormones // Curr Cancer Drug Targets. 2007. 7. P. 314.
[2] Schlom J., Arlen P.M., Gulley J.L. Cancer vaccines: moving beyond current paradigms. //
Clin. Cancer Res. 2007. V. 13. P. 37763782.
[3] Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self // Nat. Immunol. 2005. V. 6. P. 345352.
[4] Curiel T.J., Coukos G., Zou L. et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival // Nat. Med. 2004.
V. 10. P. 942949.
[5] Sasada T., Kimura M., Yoshida Y. et al. CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression //
Cancer 2003. V. 98. P. 108999.

81

 , , 2010, 4

[6] Ko K., Yamazaki S., Nakamura K. et al. Treatment of advanced tumors with agonistic antiGITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells // J. Exp.
Med. 2005. V. 202. P. 885891.
[7] Wolf .M., Wolf D., Steurer M. et al. Increase of regulatory T Cells in theperipheral blood of
cancer patients // Clinical Cancer Research. 2003. V. 9. P. 606612.
[8] Miller M., Lundberg K., Ozenci V. et al. CD4+CD25 T Cells are enriched in the tumor and peripheral blood and prostate cancer patients // J. Immunol. 2006. V. 177. P. 73987405.
[9] Yokokawa J., Cereda V., Remondo C. et al. Enhanced Functionality of CD4+CD25 high
FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer // Clin Cancer Res. 2008. V. 14. 4. . 10321040.
[10] .., .., .. . -
- in vitro // . 2008. 1. . 1015.
[11] Catalona W., Smith D., Ratliff T. et al. Measurement of prostatespecific antigen in serum a screening test for prostate cancer // New Engl. J. Med. 1991. V. 324. P. 11561161.

CD25 CD4 REGULATORY LYMPHOCYTES

IN PERIPHERAL BLOOD OF PATIENTS
WITH PROSTATE CANCER AND PROSTATE ADENOMA
N.M. Agaev, V.P. Avdoshin
Chair of Urology and Operative Nephrology
Medical faculty
Peoples Friendship University of Russia
City Hospital 29
Gospitalnaya sq., 2, Moscow, Russia, 111020

.YU. Moskaleva, .N. Popova,

S.E. Severin
SDH Moscow institute of medical ecology
Sympheropolsky blvd, 8, Moscow, Russia, 117149
CD4+CD25+ regulatory Tcells (Treg) have been shown to inhibit the activation and function of T
cells that participate in antigen-specific immune responses. Higher levels of Tregs have been reported in
the peripheral blood of patients with several types of tumors. The aum of this work was the investigation of the number of CD4+CD25+ cells in peripheral blood of patients with prostate cancer (PC), prostate adenoma (PA) and urolithiasis as control group. Levels of Tregs in the peripheral blood of patients
were measured by flow cytometry. Data were analyzed using unpaired Students t test. The levels of
Tregs in the peripheral blood of patients with PC and PA were significantly higher than those in control
group. These findings show the potential importance of Tregs in modifying immune responses not only
in patients with PC but in patients with PA too. Although longer studies are necessary to confirm these
findings, these studies also show for the first time the differences in Treg level in peripheral blood of
patients with PA, and thus, provide a basis for immunotherapy trials involving the inhibition of Tregs in
prostate adenoma and PCa patients.
Key words: regulatory T lymphocytes, peripheral blood, prostate cancer, prostate adenoma, urolithiasis.

82


/
(/ IIIA)
..


. , 29, --, , 344022
NO ,
III. 36
/ III (1 ). 32 III
(2 ). 17 . 2- (NO) NO (iNOS) 26,86% (p < 0,05),
1- , , 53,26% (p < 0,05) .
(iNOS) 38,9% (p < 0,05) 54,90% ( < 0,05)
. 2- iNOS .
, NO ,
/ III.
: , , , , .

510%
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() [2].
(NIDDK) / (/)
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NO / .
NO ,
- ,
. NO,
( ),
, , , ( ), NO / [3].
83

 , , 2010, 4

NO
NO- (NOS). 3 NO: , . () NO
, , NO-
, .. (iNOS) [4, 5, 6]. NO [7].
NO , .
. 68 , . 36 III 1- ; 32 III 2- . 18 50 5 14 .
17 .
, , () , 4-
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, , ; : , .
NO
, ,
(NO
, ,
). , , NO (L- ) 37 24 ,
(- ) 15
540 [8].
t- Excel 2003.
, < 0,05.
.
IIIA NIH-CPSI
10,84 1,28 , 9,64 1,15 , 11,00 0,91 . III
: 10,9 1,1; 9,3 1,0 10,9 0,99 .
84

 .. ...

IPSS IIIA
13,44 3,91, III 14,1 3,2 .
, 2- , ,
iNOS 26,86% (p < 0,05), 1- , ,
53,26% (p < 0,05)
. , 2,09 (p < 0,05)
NO NOS 1- 2-, / III.
1- NO- 38,9% (p < 0,05) 54,90%
( < 0,05) .
, ,
, iNOS
(. 1).
1
NO iNOS ,

1
2

NO [/ 210 ]10

,
,
26,82,0 0,62 * **
29,02 1,51* **
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18,71 0,79
17,50 0,40
20,90 0,64

,
31,91 0,80* **
18,9 0,61
20,60 1,0

: * (p < 0,05); ** 
1 2 , (p < 0,05).

NO ,
.
NO . NO , -, , / III.
NO / III, -,
[9].
, , NO ,
. ,
NO, iNOS. NO- (-4, -11,-13), . NO [10].
. , NO , / III.
85

 , , 2010, 4

[1]
[2]
[3]
[4]
[5]
[6]

[7]
[8]

[9]
[10]

De la Rosette J.J., Hubregtse M.R., Meuleman E.J. et al. Diagnosis and treatment of 409 patients with prostatitis syndromes // Urology. 1993. 41(4). P. 301307.
Nickel J.C., Weidner W. Chronic prostatitis: current concepts and antimicrobial therapy // Infect Urol. 2000. 13. P. 2228.
.., .., .. NO- // . 2000. 4. . 3034.
.. // . 2000.
4. . 35.
.., .. : , , // ., . . . 2000. 4. . 1621.
.. . // , , . 1997. 1. . 4955.
.., .. //
. 2006. 2. . 7780.
.., .., .., ..
- // .
. . 1998. . 125. 1. . 4850.
.., .., .. . 2001. . 343.
.., .. //
. 2006. 2. . 7780.

AN OXIDE OF NITROGEN (NO)

IS A BIOCHEMICAL INFLAMMATION MARKER
OF CHRONIC ABACTERIAL PROSTATITIS/SYNDROME
OF CHRONIC PELVIC PAIN (CAP/CPPS IIIA)
.V. Shangichev
Department of Urology
Rostov State Medical University
Nahichevanskii str., 29, Rostov on Don, Russia, 344022
A research purpose was an estimation of NO products by phagocyting leucocytes in blood, prostate secretion and ejaculate of patients of CAP/CPPS IIIA. 36 patients with the set diagnosis of CAP/CPPS
IIIA (1 group) were tested and examined. Group of comparison made up 32 patients with CPPS IIIB
(2 group). A control group is 17 healthy men. In group 2 the decline of nitrogen oxide of inducible NO
synthase (INOS) production on 26,86% (p < 0,05) in blood were noticed, otherwise in Group1 the increase on 53,26% (p < 0,05) if compared to the control was noticed. In secretion of prostate and ejaculate an increase (iNOS) on 38,9% (p < 0,05) and 54,90% (p < 0,05) higher similar indexes in a the control group was marked. In group 2 the iNOS activity in prostate secretion and ejaculate did not differ
from the control.
The results of our research showed that increase of NO products by leucocytes in blood, secretion of
prostate and ejaculate are the biochemical inflammatory defeat marker of prostate at CAP/CPPS IIIA.
Key words: chronic abacterial prostatitis, chronic pelvic pain syndrome, blood, prostate secretion, ejaculate.

86


0

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.

- 87

 , , 2010, 4

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91

 , , 2010, 4

. 5. . 67
. .

1. , ,
, ().
2. - ,
,
.
3. , , .

[1] .. , // -. . . 2003. 4. . 25.

[2] .. -
.: , 1980. 311 .
[3] . - //
Consilium Medicum. 2003. . 5. N 2.
[4] .., .., .. - // Consilium Medicum. 2005. . 7. N 2.

92

 .. . - ...

[5] .. //
. 1995. 2 . 2023.
[6] .., .. // . 2001 5. . 2224.
[7] .. . .: , 2008.
273 .
[8] Alexander Gutschalk, Christophe Michey Jennifer R. Melcher, Andr Rupp, Michael Scherg,
Andrew J. Oxenham Neuromagnetic Correlates of Streaming in Human Auditory Cortex // J
Neurosci. 2005. June 1; 25(22). P. 53825388.

MEANING OF CIRCULATORY DISTURBANCE

IN VERTEBROBASILAR SYSTEM IN DEVELOPMENT
SENSORINEURAL HEARING LOSS
I.M. Kirichenko, L.I. Shoniy
Department of ENT the City hospital of Moscow N 4
Pavlovskay str., 25, Moscow, Russia, 115093

V.I. Popaduk
The Department of ENT
Russian Peoples Friendship University
Mikluho-Maklaya str., 8, Moscow, 117198

N.A. Dayhes
State Scientific Clinical Centre of ENT
Gamalei str., 15, Moscow, Russia, 123098
Complete vestibulometric, audiological and otoneurological examinations were make in 60 patients from 28 till 75 years with sensory-neural hearing loss. Obtained data had compared to structural
changes and hemodynamic parameters of a blood flow on vertebral arteries, to internal carotids, and
also with a magnetic resonance imaging (MRI).
Perceptive cochlear-vestibular syndrome was diagnosed in 35 cases. The examination parameters
of the blood flow revealed structural changes vertebral arteries: hypoplasias (24%), deformations (35%),
asymmetries of diameters (32%). Occlusions and stenoses (11% and 18%) are diagnosed seldom.
In 25 cases with the central cochlear-vestibular syndrome diagnoses more rasping structural and
hemodynamic changes: bilaterial deformation vertebral arteries (70%), stenoses and occlusions vertebral arteries (44%), deformation internal carotids (55%), stenosis internal carotids (43%) and occlusion
internal carotids (5%).
Key words: vertebrobasilar insufficiency, vestibulometric, audiological and otoneurological examinations.

 ,


,

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()
. , 12, , , 305035
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95

 , , 2010, 4

-III
, ,
83,2 0,08% 92,1 0,3% , 1,1 0,03. 4 III 11,2%,
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, 9,33 0,2 ., 7,82
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, , .
, 4 , .
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63,8 0,06 ., 4 12 , 128,3 0,04 .
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in vitro.
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. 96

 .., .. , ...

. .
, , , .
, .
III
, .
, ,
, .
, , ,
.
, ,
, , 4- .

1. , , ,
, , 4 , , .
2. 4 .

[1] .., .., .., ..

- . .: . . , 1999. 203 .
[2] .., .., .. // . 1983. 6. . 1720.
[3] .. // . 1987. 9.
. 5153.
[4] .., .. // . 1988. 5. . 103105.
[5] .. // .
. 1999. 217 .

97

[6] .., .., .. . I.

// . 2000. . 6. 2. . 315.
[7] .., .., .., ..
. ,
2000. 167 .
[8] .., ..
// . . 1983. 3. . 3336.
[9] .., ..
. ., 2004. 290 .
[10] .. . . , / . .. , .. . ., 1999. 117 .
[11] Assmann G., Cullen P., Schulte H. The Munster Heart Study (PROCAM), results of follow-up
at 8 years // European Heart Journal. 1998. Vol. 19. P. 311.
[12] Fridwald W.T., Levy R.J., Fredrickson D.S. Estimation of the concentration of low-densitylipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge // Clinical
Chem. 1972. Vol. 18. P. 499502.
[13] Pyorala K., De Backer G., Graham J. et al. Prevention of coronary heart disease in clinical
practice. Recommendation of the Task Forse of the European Society of Cardiology, European
Atherosclerosis Society and European Socienty of Hypertension // European Heart Journal.
1994. Vol. 15. P. 13001331.

HE POSSIBILITIES OF COMPLEX CORRECTION

OF ANTIAGREGATIONAL ACTIVITY OF THE VESSEL WALL
IN PATIENTS WITH ARTERIAL HYPERTENSION
AND METABOLIC SYNDROME, WHO SUFFERED
FROM THE OCCLUSION OF EYE VESSELS
O.A. Danilenko, I.N. Medvedev
Kursk institute of social education (filial) RSSU
Pirogova str., 12, Kursk, Russia, 305035
The aim of this work is to investigate the possibilities of correction of a vessel wall antiaggregational, anticoagulative and fibrinolisative activity in patients with arterial hypertension and metabolic
syndrome, who suffered from occlusion of eye vessels by using complex therapy including Losartan,
Pioglitason and non-medic correction. Its found out that in such patients fosinopril is able to correct a
vessel wall antiaggregational, anticoagulative and fibrinolisative activity after 16 weeks of therapy but
doesnt fully normalize antiaggregational, anticoagulative and fibrinolisative activity. The achieved results are not stable and have the tendention to deterioration during not full non-medic correction in spite
of the medical therapy.
Key words: vessel wall, arterial hypertension, metabolic syndrome, occlusion of eye vessels.

98




..
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1

. , 29, --, , 344022

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, [4].
99

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4. (, , , FerrimanGallwey > 15)
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, , . :
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();
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, , 3 , - () .
4.
\ > 2%, .. .
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2. (), ,
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= ( / /) / 22,5
ro = / / .
, , :
?
?
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20%
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20 . 12% 101

 , , 2010, 4

, ,
Ferriman-Gallwey , 8,
, .
80% , : - ,
. 51% ,
, ,
2% 43% .
31% , , ,
, .

17-. 27% \ 17-,
.
, .. \ , 6% .
. ,
, , , , :
( Ferriman-Gallwey > 15 ) [3];
, ;

, (
80 ), , , , , 20 .

[1] .., .. . .: , 2007.

[2] .., .., .. .
.: -, 2006.
[3] .., .., .. . , , . .: ,
2003.
[4] .., .. , , ( ). .: -, 2005.
[5] Goodman N., Bledsoe M., Cobin R. et al. AACE Hyperandrogenism Guidelines // J. Endocrinol. Pract. 2001. 7(2). P. 120134.
[6] Clinical Guidelines. Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline 2008 // J Clin Endocrinol Metab. 2008. 5.
P. 159163.

102

 . ., . ., .. ...

[7] Cibula D., Citcova R., Clerici A. Increased risk of non-insulin dependent diabetes mellitus,
arterial hypertension and coronary artery disease in perimenopausal women with hystory of
the PCOS // Hum Reprod. 2000. 24. P. 10501052.
[8] Rickenlund A., Carlstrom K., Ekblom B. et al. Hyperandrogenicity is an alternative mechanism underlying oligomenorrhoea or amenorrhoea in female athletes and may improve
physical performance // Fertil Steril. 2003. 79. P. 947955.
[9] Ferriman D., Gallwey J.D. Clinical assessment of body hair growth in women // J Clin Endocrinol Metab. 1961. 21. P. 14401447.

CLINICAL APPLICATION OF METHOD DIAGNOSTICS

HYPERANDROGENISM SYNDROME ON WOMEN
OF REPRODUCTIVE AGE
N.I. Volkova
Internal diseases department 3
Rostov State Medical university
Nahichevansky str., 29, Rostov-on-Don, Russia, 344022

A.N. Rymashevsky
Obstetrics and gynaecology department 1
Rostov State Medical university
Nahichevansky str., 29, Rostov-on-Don, Russia, 344022

T.A. Dimitriadi
Regional Clinico-Diagnostic Center
Pushkinsraya str., 127, Rostov-on-Don, Russia, 344010
Hyperandrogenism is one of the pathology of endocrin system, which is more difficult diagnosed
at reproductive age of women. There is caeful history and assessment clinical presentation which dominate in diagnostics of hyperandrogenism in the contemporary stage. Laboratory tests run by strict reports are to confirm or disprove hypothesis about hyperandrogenism. There is given algorithm diagnostics of patients with hyperandrogenism, which is to reduce hyperdiagnosis of this pathology and
accelerate to diagnose properly. It Includes assessment hyperandrogenism affect on dermatologic,
metabolic, cardiovascular systems, that is why hyperandrogenism needs long-term treatment and careful
observation. 104 women have been examined with the clinical use of the algorithm diagnostics.
Key words: hyperandrogenism, pathology of endocrin system.

0

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26.06.2000 .
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: 09.03.2007 156
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; 06.07.2009 . 389
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[1] : . / .
. .. , .. . 4- . .: -, 2006.
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NORMATIVE LEGAL BASIS

FOR REHABILITATION MEDICINE
N.S. Prilipko
Head of Standardization and Rehabilitation
Medicine Service Organization Department
FGU RNC VMiK of the RF Ministry of Health and Public Development
Pererva str., 33, fl.242, Moscow, Russia, 109341
Normative legal basis in medicine is the cornerstone of some kinds of medical aid rendering organization. The article includes current normative documents at the state as well as municipal level in
the field of rehabilitation treatment and rehabilitation. It concerns the necessity for leading medical institutions of the country and research institutions, solving the problems of rehabilitation medicine, rehabilitation medicine chairs to develop normative documents and acts for the organization of medical aid
to the population in the field of rehabilitation medicine. For this purpose, it is necessary to determine
the rehabilitation medicine stages; the organization of activities of rehabilitation medicine centers, rehabilitation medicine hospitals, rehabilitation medicine polyclinics, rehabilitation medicine and rehabilitation departments, rehabilitation medicine rooms, the equipment table and staff standards for these organizations, rehabilitation medicine technology; rehabilitation medicine standards.
Key words: normative legal documents; Russian Federation laws; the President of Russia decrees; the Russian Federation Government decrees; orders, instructions and regulations by the RF Ministry of Health and Public Development.

109



..


. ., 18/1, , , 603155

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20042008 . -
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[1] .., .., .. : . .: - , 2006. 284 .

[2] .. - :
. , 2002. 57 .
[3] .., .. - . // , .
2007. 1. . 3839.
[4] .., .. .
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. 2006. 2. . 1821.
[5] .. // . 2007. 34 (1516). . 5055.
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113

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[10] .., .., .. . // , . 2007. 3. . 4852.

NEW FORM OF THE REDUCING TREATMENT

OF PATIENTS WITH THE VEGETATIVE DISFUNCTIONS
A.G. Polyakova
Research Institute of Traumatology and Ortopaedics
V. Volzskaya nab., 18/1, N. Novgorod, Russia, 603155

T.V. Drubich
The division head of ship medicine
OOO Company of the river tourism of Volga steam navigation
pl. Markina, 15a, Nizhniy Novgorod, Russia, 603001
Is carried out analysis of the clinical effectiveness of the combination of the methods of physioand reflexotherapies with the landscape and the climatotherapy in the process of the health resorthealth-improvement treatment of the persons with various forms of vegetative disfunctions at the age
from 18 to 69 years under the conditions of river cruise. The control of course effectiveness was
achieved in the dynamics of clinico-functional indices, including data of [refleksodiagnostiki], [kardiointervalografiyu], questionnaires, which characterize the state of psychoemotional sphere, the vital capacity of lungs and dynamometry. The results of the health-improvement- health resort treatment of the
persons with the vegetative disfunctions under the conditions of river cruise confirmed its effectiveness.
Key words: vegetative disfunctions, integral of rezervometriya, [refleksodiagnostika], landshaftoterapiya.


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THE FEATURES OF COLLECTIVE

AND PERSONAL STRESSFUL PSYCHOTHERAPY
OF HYSTERICAL NEUROSIS, HYSTERIA,
HYSTERICAL PSYCHOPATHOLOGY
L.V. Serebrennikova, E.I. Kajdan
Clinical laboratory of mental and biophysical correction
of functional condition of human organism
FGU RNC of restoration medicine and balneology of Roszdrav
Borisiglebskiy pereulok, 9, Moscow, Russia, 121069
Hysterical syndrome in the case of neurosis of different genesis and hysteria, which is resulting
from gene and also the hysterical psychopathology are still not assured as curable using the medicament
therapy. Moreover there is tendency towards growth of hysterical symptomatology because of the urbanization of society, modernization and computerization of production, ecological and radiation
trouble, which affect on moral and psychophysical stresses (which are also stress factors).
Clinic of hysteria and hysterical neurosis in the case of assaults as the consequence is less painful
when its with ornate and demonstrative symptomatology together with behavioral shamelessness and
also when its with not motivated aggression towards human and towards itself (suicides with deliberately low dose of toxic preparation, i.e. false attempts of suicide).
In this investigation we have listed the materials with 5 year experience where we tried to find the
most effective tactics of psychotherapeutic correction and rehabilitation. Also we have analyzed the
mechanisms and specificity of correction results.
Key words: hysteria, hysterical neurosis, hysterical psychopathology, psychotherapy, shock therapy, imperative infusion, relaxation.

118




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[1] .., .. , . .: , 2002. . 267.

[2] B.C., .. . .: , 1998. 71 .
[3] .. .
.: , 1984. 196 .
[4] .. . .: -, 2000. . 5657.
[5] .. (). .: , 2003. . 327337.
[6] .. // . ., 2009. . 124131.
[7] National Sleep Foundation. 1997 Survey on Sleeplessnes, Pain and the Workplace. Washington, DC: National Sleep Foundation; 2000.

THE COMPLEX TREATMENTS EFFICIENCY

OF THE PATIENTS WITH VERTEBROGENNOY THORACALGY
V.S. Goidenko, I.L. Fedorova
Reflexology and manual therapy Department
Russian Medical Academy Postgraduate Education
Polycarpova str., 12, Moscow, Russia, 125284
In article the estimation of the complex treatments efficiency including manual therapy and reflexotherapy of the patients with vertebrogennoy thoracalgy. This is allows to increase antinociceptive
effect of the basic mechanisms regulation nociceptive of sensitivity.
Key words: vertebrogennoy thoracalgy, manual therapy, reflexotherapy.

0


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[1] Bigianni L.U., Morrison D.S. The Morphology of the Acromion and its Relationship to Rotator Cuff Tears // Ortop. Trans. 1996. V. 10. P. 228.
[2] Vahlensieck M., Genant H.K., Reiser M. MRI of the Muskuloskeletal System // Thieme.
2000. P. 4775.
[3] Christine B. Chung and Lynne S. Steinbach. MRI of the upper extremity // Lippincott.
2009. P. 728.

128

 .. . - ...

[4] David W. Stoller. MRI in Orthopaedics and sports medicine // Lippincott. 2007.
P. 2160.
[5] Burgener F.A., Meyers S.P., Tan R.K. et al. Differential Diagnosis in Magnetic Resonance
Imaging // Thieme. 2002. P. 334372.
[6] Vahlensieck M., Genant H.K., Reiser M. MRI of the Muskuloskeletal System // Thieme.
2000. P. 4775.
[7] .., .. - . // . . 2009. 104 .
[8] .. .. . .
.: , 2009. 192 .

AGNETI0RESONANCE IMAGING OF DAMAGE

OF THE SHOULDER AGAINST PRESENCE
OF THE ACCOMPANYING IMPINGEMENT SYNDROME
.. imin, E.N. Goncharov, A.V. Rodionov,
G.V. Tereshchenko, I.A. Znamenskiy
Radiology department
The Central Clinical hospital of the Russian Academy of Sciences
Litovsky bulv., 1A bld, Moscow, Russia, 117593
We present the results of examinations of the patients, suffering from the damage of a humeral joint.
These examinations were carried out by means of a MR tomography using a high-field MR-tomograph
with magnetic field intensity of 1.5 Tl and a flexible surface coil SENSE-Flex-M. There were used three
mutually perpendicular projections (oblique coronal, oblique sagittal, axial), pulse sequences FFE T2W,
proton density-weighted TSE PDW and the sequences with the signal of fatty fabric suppression
TSE PD SPAIR. For all this the great attention was paid to the accompanying degenerative changes in the
rotary cuff muscles.
Key words: the shoulder, the acromion, magnetic resonance (MR) imaging, impingiement syndrome, the rotator cuff, the glenoid labrum.

 574.24+612.11+615.27

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[1] .., .., .. // . . . . -. .,

2004. 17 . . . . .. , -27564 20.12.04.
[2] .., .., .. // . . . : . .. , 2006. . 3133.
[2] .., .., ..
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[4] .. . ., 2001. 596 .
[5] .. . ., 1982. 487 .

133

 , , 2010, 4

ESTIMATION ACTIVITY
OF STRUCTURALLY FUNCTIONAL SYSTEMS
OF THE STUDENTS LIVING IN SUBTROPICAL CLIMATE
Alaa M. Zourob, A.Ya. Chizhov
Department of Ecological Monitoring and Prognostication
Ecological faculty
Peoples Friendship University of Russia
Podolskoye shosse, 8/5, Moscow, Russia, 113093
In clause the results of definition to an estimation activity of structurally functional systems of the
students living in subtropical climate are given. Is established, that the special set of meridians, and also
orientation and degree of deviation them activity from own for group of average size electroconductivity of all meridians is characteristic for the students. So, the average sizes electroconductivity of all meridians of the surveyed students differ from those in control group in the party of a various degree of
increase (79 , at the control 70 ).
Key words: students, subtropical climate, method Nakatani.





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COMPLEX RESEARCH
OF ALCOHOL PRODUCTS CONSUMPTION
AND ITS CONSEQUENCES FOR HEALTH
OF POPULATION OF THE ROSTOV REGION
S.P. Alekseenko
Department of hygiene nourishment and hygiene of children and teenagers
Federal State Institution of Health Center of hygiene and epidemiology in the Rostov region
7-ya Liniya str., 67, Rostov-on-Don, RUSSIA, 344019
Deficit of information, characterizing alcoholic situation, dictates necessity of perfection of information fund data, characterizing alcoholic situation. Examination of the alcohol consumption was conducted
by casual selection of the population at the age of 1875 years in 11 cities and 26 rural districts of the
Rostov region. The examination showed, that actually the women consumer less alcohol, than the men.
Among the women prevail occasionally drinking 65,9%, but among the men-systematically drinking
23,6%. Age dynamics of the amount of consumed alcohol was disclosed. The consumption of alcohol
drinks in general by selection makes up 15,6 g, calculated on basis of pure ethanol with big fluctuations,
for the men the present index makes up 30,2 g, but for the women 7,3 g. 17% of the adult population
of the Rostov region are involved into dangerous for health and life consumption of alcohol. The similar
complex system of information collection, its analysis may be considered as scientifically justified technology of monitoring, providing the institutions of Russian consumer supervision institution with hygienic
information, relating to consumption of alcoholic beverage by the population of the Rostov region.
Key words: alcoholic beverage, alcoholic situation.


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PREVALENCE AND THE MEDICAL

AND SOCIAL IMPORTANCE OF THE GLAUCOMA
IN REPUBLIC OF NORTH OSETIA ALANIA
.. Alikova
Chair of otorinolaringology and ophthalmology
North Osetia state medical academy
Pushkinskaya str., 40, Vladikavkaz, RNOAlania, 362025

I.Ch. Mamsurova
Bureau of medical and social examination for persons
with diseases and defects of an organ of vision on RNOAlinia
Shegren str., 8/2, Vladikavkaz, RNOAlania, 362025

Z.R. Alikova
Chair of public health and public health services
North Osetia state medical academy
Pushkinskaya str., 40, Vladikavkaz, RNOAlania, 362025
Dynamics of disease indicators of glaucoma in RNOAlania tends to growth. Glaucoma stably occupies the first place in the structure of primary physical inability on an eye pathology. The high medical
and social importance of glaucoma specifies in necessity of perfection of struggle against a glaucoma in
republic, considering factors of its formation.
Key word: glaucoma, disease, prevalence, physical inability, tendencies, indicators, structure,
prophylactic medical examination.

145



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. 1. ( 80%, 20%)
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.
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147

 , , 2010, 4

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20%) 60 14,82 //. (160 .).
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20%) 85 12,8 // (185 ).
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(6085 .).

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. (- - ). 148

 .., ..

,
, . , , .
, .
.

[1] .., .., ..

, //
. . . 1998. 6. . 618619.
[2] .., .., ..
- // .
1998. . 32. 4. . 3337.

INFLUENCE OF INERT GASES OF ARGON AND KRIPTON

ON OXYGEN ABSORPTION
V.N. Ananev, A.V. Anikiev
Department baro-physiology, baro-therapy and diving medicine
Institute of medical and biologic problems of the Russian Academy of Sciences
Horoshevsky str., 76a, Moscow, Russia, 123007
Consumption of oxygen by an organism of a rat at long maximum stay in the closed space decreases
twice in oxygen-nitric (2080%) environment. In oxygen-argon (2080%) environment oxygen consumption decreases in 3 times, and in oxygen-kripton (2080%) decrease environment in 5 times.
Key words: the oxygen consumption, the closed space, oxygen, nitrogen, argon, kripton, rats.



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152

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DRUG ASSORTMENT FORMATION

AT THE CHEMISTS SHOPS IN REGARD
OF CONSUMERS PREFERENCES
G.A. Antropova, L.B. Okonenko
Pharmaceutics Department
Novgorod State University named after Yaroslav the Wise
Derzhavina str., 6, Velikiy Novgorod, Russia, 173020
Regularities of assortment formation at the chemist`s shops in regard of consumers preferences
have been reviewed. Factors influencing on evaluation of the pharmaceutical goods and decision to buy
them have been identified. Characteristic behaviors of the consumers depending on their attitude to
drugs have been exemplified.
Key words: pharmaceutical goods, consumers picture, consumers preferences, demand.



.. , ..

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. , 6, , , 173020

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157

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[1] .., .., .. . : . -: , 1989. 15 .

[2] 1997 // . 1998. 2527.
[3] .. /
.. , .. // 2006. 1. . 3537.
[4] - 2008 :
. .: , 2009. 467 .
[5] Saw SM, Chua WH, Wu HM, Yap E, Chia KS, Stone RA. Myopia: gene-environment interaction // Ann Acad Med Singapore. 2000. 29. P. 290297.

SPREADING OF CERTAIN OPHTHALMIC DISEASES

RELATED TO NOVGOROD REGION ECOLOGIC CONDITIONS
T.I. Okonenko, G.A. Antropova
Internal Diseases Department
Novgorod State University named after Yaroslav the Wise
Derzhavina str., 6, Velikiy Novgorod, Russia, 173020
The unfavorable environment impact on spreading of certain ophthalmic diseases in urban population of the Novgorod region has been investigated. The impact of air pollutants content on the frequency of
medical pediatric appointments due to conjunctivitis has been studied. The influence of informed self-treatment on ocular diseases incidence, and the antioxidant therapy necessity have been reviewed.
Key words: ophthalmic diseases, ecologic conditions, myopia, conjunctivitis, pharmacotherapy,
antioxidants.

0
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.
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.
.
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400 -,
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159

 , , 2010, 4

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. , , ( 50,8% ,
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[1] .. . // .
., 2000. 468 .
[2] .., .. //
. ., 2000. . 6668.
[3] .. //
. 1997. 4. . 4446.
[4] .., .. . .:
-, 2001. 568 .

MEDICAL AND SOCIAL CHARACTERISTIC

OF GIRLS0TEENAGERS WICH INTERPUTTION THE PREGNANCY
S.H. Ahtiamova
Ufa medical preventive maintenance centre
Orlovskaya str., 33, Ufa, Russia, 450096
In this article it is shown the analysis of results of reserch a way of life girls-teenagers, who made
abortion. The social status of girls, an education level, relation in family, gynecologic anamnesis, knowledge of contraception and sexyal education have been investigated in this work.
Key words: pregnancy, interruption, abortion, teenagers.

161

 615. 281 [6:539]022.532

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1/ 100 (300 000 /),
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162

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1 /
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.
, , , , ,
, .

[1] .. // . 2003. 1. . 2830.

[2] .., .., .. .
// - (, ,
). --, 2006. . 7273.
[3] .., ., .. . // . .
. 2007. 2 (10). . 7277.

ACTION OF COPPER NANOPARTICLES

ON CLINICAL STRAINS OF GRAM0NEGATIVE BACTERIA
I.V. Babushkina
Laboratory and Functional Diagnostics Department
FGU SarNIITO Rosmedtechnologiy
Chernyishevskogo str., 148, Saratov, Russia, 410002

V.A. Martyanova, E.V. Borodulina, A.L. Borovskiy,

. Sakkala, . Albubu
GOU VPO SGMU Roszdrava
Bolshaya Kazachya str., 112, Saratov, Russia, 410012
Manifested antibacterial action of copper nanoparticles on polyantibioticoresistant clinical strains of
enterobacteria family, exuded from patients with purulent complications of a traumatologic-orthopedic
hospital has been determined in the concentrations from 0,001 mg/ml to 1 mg/ml and in different temporary expositions. It has been revealed high antibacterial activity of copper nanoparticles.
Key words: nanoparticles, copper, gram-negative bacteria.

164


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165

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1.06.10.08
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.

[1] ( 42-0052-07) //
. .: , 2008. . 18. . 101104.
[2] .., .., .. . N-
, , // 2180656, , . 26.07.2000. . . . . 2000119954; . 20.03.02; . 26.07.00. 3 .
[3] 42-0269-07. .

ELABORATION THE METHODS OF VALUATOIN THE QUALITY

SUBSTANCE OF AMIDE N0ALLYLANTHRANYLIC ACID
S.M. Bass, T.I. Yarygina,
L.M. Korkodinova, E.R. Kurbatov
The chair of pharmaceutical chemistry
Perm state pharmaceutical academy
Polevaya str., 2, Perm, Russia, 614081
The physical and chemical properties were studied; the metodics of proof the identity, good quality and quantitative analysis of substance of amide N-allylanthranylic acid are developed. This substance was recommended for predclinical investigation as anti-inflammatory drug.
Key words: amide N-allylanthranylic acid, substance, valuation the quality.



0
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168

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169

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170

 .. ...

3. III
9498%, 26%,
;
8690%, 1015% , .

, .

[1] .. , , //
-
. 2003. . 1014.
[2] .., .., .. // . 2005. . 47. 5. . 446459.
[3] .. . , 2005. 510 .

APPLICATION OF RESTORATION TECHNOLOGY

OF UNDERWATER TRACTURE WITH UNDERWATER
PHOTOTHERAPY FOR TREATING PATHOLOGIES
OF MUSCULOSKELETAL SYSTEM
V.D. Bitsoev
Department of physiotherapy
Municipal clinic 69 of East Autonomous District
2 Vladimirskaya str., 31a, Moscow, Russia, 111401
This study is devoted to a highly efficient method for treating pathologies of musculoskeletal system by means of combined application of the state-of-the-art modifications of underwater countertraction and underwater phototherapy developed by the author. This technology facilitates load relief of
intervertebral discs, increases diastasis between glenoid surfaces of intervertebral and peripheral joints,
and positively affects muscles under spasm resulting in their relaxation. Straining of joint capsules during countertraction and concurrent photo effect normalize microcirculation in encapsulated inflammation site (thus yielding an anti-inflammatory effect) and violated innervation of limbs and reduces or
fully removes pain syndrome.
The number of patients suffering from such diseases increases from year to year and the symptoms of diseases (vertebral osteochondrosis and Blounts disease of the shin bone and knee joint) are
observed increasingly frequently in children as young as 12 to 15 years.
Therefore, one the basis of vast experimental data, one may concluded that the method of underwater countertraction combined with underwater phototherapy is superior to other methods of conservative treatment of musculoskeletal system pathologies.
Key words: osteochondrosis, underwater phototherapy, underwater countertraction of vertebral
column.

171

 ,
3034
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,

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, ,
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, [5]. - .
, 2008 .
3034 . .
.
(-) 3034
(1759 ). Microsoft Excel. , ,
,
(-X).
.
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, 6,5% 2002 .). - 4,8 0,9 3034 ,
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(3,7%), (3,5%);
172

 .. , 3034

2,9 0,1%.
- 3034 . : (13,8%), (10,3%), (7,4%),
(7,1%), (5,4%), (5,0%), (5,0%),
(4,7%), (4,7%), (3,1%). , - 30
34 : (7,8%), (7,5%),
(7,2%), (6,7%),
(6,3%), (5,7%), (4,9%),
(4,3%), (4,2%), (3,5%).
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, ,
( 42,7%, 13,3%,
, - 11,3%,
6,6%, 5,5%), , - . 2008 . (78,3%). (21,7%)
: (5,3%), (4,3%), (3,9%),
(2,3%), - (1,7%).
- 3034 . ,
(47,3%) , (25,9%), (19,8%), (15,1%), (11,0%). - (14,2%),
(44,6%); , - (12,4%), (5,8%),
(54,1%),
(4,8%).
3034 -, (35,8%). (23,8%), (19,6%), (15,0%), (14,2%).
(13,4%),
(11,7%),
(69,0%) (22,6%), ,
- (9,8%), (6,1%), (34,0%)
173

 , , 2010, 4

(31,8%), (5,3%),
(39,4%).
, 57,3% 3034 ,
. 13,2%, - 5,6%; 5,5% , 5,3% ;
4,6%. 3034 , ( ), ,
-, 42,7%, 29,6%
13,1% .
[1]
[2]
[3]

[4]

[5]

.. /
.. , .. // . 2006. 1. . 311.
.. (, , ) / .. . : , 2006. 120 .
..
. - / .. , .. // .
, 1999. . 711.

/ .. , .. //
I . : 2005.
. 3234.
..
: . ... . . . : .
.. , 2004. 16 .

THE EMERGENT MEDICAL HELP,

GIVEN TO PEOPLE AGED 3034
N.I. Bolotnikova
Department of social health and health car with information,
culturology and medicine history courses
Astrakhan State Medical Academy
Bakinskaya str., bld. 12, Astrakhan, Russia, 414040
The abstract: In the structure of calls of BIT-GRIGAZ EMA of Astrakhan sick of sudden diseases
is made 57,3% from total number of persons of 3034 years to which medical aid has been rendered.
The persons of 3034 years injured with accidents (traumas and poisonings) and to which emergency
medical aid has been rendered, is made 42,7%.
Key words: emergency before hospital aid, age-sexual groups of the population.

174



.. , ..


. ..
. , . 8, . 2, , , 119992

..
, . ..
. , 13,
, (
) , .
: , , , .

- . , 2025%
712% [1].
60% [5]. 5065% , , , .
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, ,
[2].


: ( )
2% [4]. ,
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[3].
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1825 , (. , ... .. )
175

 , , 2010, 4

6 ,
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176

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46 , ( , 2 ).

[1] .. : .: , 2007. 256 .

177

 , , 2010, 4

[2] .., .., .., .. : . 4- . .: -, 2008. 576 .

[3] .., .. : . 3-
., . . . .: , 2006. 632 .
[4] . 2 . . 2 / . . . ... , .. . .: , 1998. 432 .
[5] .. // . 1997. . 2. 4.
. 1921.
[6] .. : . . ... . . . ., 2009. 17 .
[7] .., .., .., .. . / . .. . .: ,
2001. 268 .
[8] .., .., .., .. //
: - , 1314 2007 ., . .: - ,
2007. 284 .

LATENT DEPRESSION AMONG WOMEN

WITH NORMAGONADOTROPIC AMENORRHEA
S.A. Bronfman, L.M. Kudaeva
Subdepartment of new non-medicament therapeutic
methods and clinical physiology with course
on psychotherapy and clinical psychology
Sechenov Moscow Medicine Academy
Trubetskaja str., h. 8, bl. 2, Moscow, Russia, 119992

V.A. Agarkov
V.B. Shvyrkov Laboratory for psychophysiology research
Institute of Psychology Russian Academy of Sciences
Yaroslavskaja str., 13, Moscow, Russia, 129366
In this study we investigated anamnestic data, personal traits and types of somatic complains of
women with secondary normagonadotropic amenorrhea (functional hypothalamic amenorrhea FHA).
Among the majority of women with FGA we observed symptoms of latent depression. This finding may
help to optimize treatment regimen for patients with FGA.
Key words: secondary normagonadotropic amenorrhea, personal traits, FGA, depression.

178





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179

 , , 2010, 4

. 1.

2,0%, 17,8% (),
17,4%.
: 15,0% ,
23,5% ; 12,7% 16,5%
.

: /
= 133,5.
( ) (-).
,
. 18,3% 2,64 .


66,7% (. 2).

. 2.

180

 .. ...

. , :
,
;
, ;
, , .

[1] ..
// . 1999. . 7.
6. . 32.
[2] .., .. . .: , 1996. 282 .

LIGNOGUMATS ACTION ON THE CELLULAR

AND HUMORAL IMMUNITY IN THE EXPERIMENTAL
INFLAMMATION MODEL
A.V. Buzlama
Department of pharmacology
Pharmaceutical faculty
Voronezh state university
Studencheskaja str., 3, Voronezh, Russia, 394620
The experimental studies on the acute inflammation model, inducted by formalin, reveal the lignogumats solution ability to increase cellular and humoral immunity that prove its immunostimulating proprieties.
Key words: humic substance, immunity, immunostimulatores, inflammation, pharmacology.




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. .
. 28 , ,
57,2 (48,364,9) , 5,2 (4,19,9) , , DAS28 (ESR) = 5,6 (3,16,8). ACR (1987). () 25
.
(1, 2), () , (2).
(Tk),
() .
Statistica 8.0 (StatSoft. Inc., USA). 25- 75- (Q25Q75). (r). p < 0,05.
182

 .., .., .. ...

. 1, 2
( = 0,0028, = 0,0047, p = 0,0071 ). 2 (p = 0,0065),
(p = 0,023), Tk (p = 0,0054) (. 1).
1

(n = 25)

(n = 28)

1 (*)

3,74 (2,004,01)

5,10 (4,966,13)**

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4,72 (4,125,80)

7,11 (5,939,61)**

(*)

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2,94 (2,684,01)**

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7,36 (7,2918,439)**

Htc (%)
(. .)
Tk (. .)

40,08 (39,1942,11)
0,182 (0,1600,190)
0,801 (0,7600,921)

45,04 (42,5846,75)**
0,335 (0,3200,398)**
1,103 (1,0731,109)**

: * p < 0,05, ** p < 0,01.

k 2 (r = 0,33; < 0,05),

2 (r = 0,47; < 0,01)
. ,
, 1 2 (r = 0,34; <
< 0,05), 2 2 (r = 0,56; < 0,05).
4 100 . 2
( = 0,073).
( = 0,0074) ( = 0,0069). 2
(r = 0,64, < 0,05) Tk (r = 0,81, < 0,05).
.
2 (r = 0,58; p < 0,05). 2 ,
Tk 2 (r = 0,620; p < 0,05).
. ,

.
.

[1] .., .., .. . // . 2004. 10 (3). . 78.

183

 , , 2010, 4

[2] .., .., .. . -

// .
2005. 4 (1). . 7778.
[3] Bascurt O.K., Boynard G.R., Cokelet P. et al. New guidelines for hemorheological ladoratory thechniques // Clin. Hemorheol. Microcirc. 2009. 42. . 7597.
[4] .., .. // . .
2009. 11. . 412.
[5] Coelho da Mota D.S., Furtado E., Bottino D.A. et al. Effects of buflomadil and pentoxifilline
on hamster skin-flap microcirculation: prediction of flap viability using orthogonal polarization spectral imaging // Clinics. 2009. 64 (8). . 797802.

EFFECT OF PENTOXIFYLLINE
ON RHEOLOGY BLOOD IN RHEUMATOID ARTHRITIS
WITH SYSTEMIC MANIFESTATION
N.A. Vinogradova, A.A. Vinogradov,
N.V. Emanuylova
Department of Internal Medicine Propaedeutics
Yaroslavl State Medical Academy
Revolutionary str., 5, Yaroslavl, Russia, 150000
In people with rheumatoid arthritis with systemic manifestations were found significant changes
in hemorheological profile, including increasing the viscosity of whole blood, plasma viscosity, erythrocyte aggregation and deformability. This was combined with reduced transport capacity of blood. A
single infusion of pentoxifylline (100 mg) was accompanied by a positive shift of the rheological characteristics of blood, including red blood cell deformability and aggregation.
Key words: rheumatoid arthritis, blood viscosity, plasma viscosity, deformability, aggregation,
erythrocytes, pentoxifylline.



.. , .. , .. ,
.. , .. , ..
. ..
. , 68, , , 430000

.
: , .

,
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,
, , , [1].

, GINA
(2006, 2007 .) (2008 .).
,
. , , (), ()
, [2].
. ,
.
50 ,
. 25 ,
250500 , 5
1 , 25 ,
( ). , 2- ,
( 1 (1) (). 1 (.. ,
.. , 2002 .).
185

 , , 2010, 4

6 , .
6- I
16% , 2- , 32% , 8%
, 20% . II 28% , 44%, 12%,
32% . 6-
.
12- , I 96% , 92%
, 96% , . 12-
.
12- : I
20% 80% , 2030% 20% . II 20% 56% ,
2030% 36% , 30% 8% .
1 .
,
.

[1] .., .. . .: -, 2006. 685 .

[2] .. . .: , 2008. 267 .

EFFICIENCY OF THE USING SINGULYAR

AT TREATMENT OF THE BRONCHIAL ASTHMA
BESIDE CHILDREN
N.G. Gerasimova, V.A. Gorbatov, N.M. Fadeeva,
E.N. Kovalenko, O.A. Kudasheva, N.A. Vaskova
Chair of pediatrics
Ogarev University of Mordovia
Bolshevitskaya str., 68, Saransk, Russia, 430000
Using singulyar for reinforcement base treatment beside children allows to reach checking on
clinical symptoms of the bronchial asthma and vastly perfect the factors to functions of the external
breathing at more short periods.
Key words: bronchial asthma, singulyar.

186




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. ..
., 18, . 1, . 124, , , 129337
, , .
: , ,
.

, ,
.
,
, , , . .
, , .

; , ; ,
.
, ;

.
, ; , - , .
187

 , , 2010, 4

. , (,
- -
..).
, ,
.
.

,
, .
, ;
. ,
, , ,
. ,
, - , , , , , .
, , , ,
,
. .. . , [1] . .

, ,

.
.
-, 188

 .. ...

. ,
,
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, ,
, . (2 ). , , .
. ,
, , . : , , , ,
.
[2].
.
, . :
;
,

;
, ;
,
,
;
, ,
;
;
-

, , - , , ,
, .
, 189

 , , 2010, 4

, .
, ,
,
. , ,
, . (600 .), , .

[1] .., .., ..

//
. 20. 2009. 1. . 4155.
[2] .., .. ,
. .: , 2007. 261 .

THE IMPROVEMENT OF TEACHING

BIOLOGICAL CHEMISTRY BY EDUCATIONAL PROGRAMM
CREATIVE PERSON FOR ADVANCED STUDENTS
A.E. Gubareva
Biochemistry department
Moscow Medical Sechenov Academy
Yaroslavsky road, 18/1, 124, Moscow, Russia, 129337
The program teaches students productive work by involving them into modeling of elements of
future professional activity through creation of situational problems with cooperation of teachers.
Key words: program Creative person, creativity, improvement of teaching.


:

..


. 3, .-, , 197110
, . .
: , .

. (
, ), .
, , . ,
, , .., ..
[1, 2].

, , , . , , .
. .
,
[1, 2].

; , -

191

 , , 2010, 4

, ;
.
, , [3, 4, 5].
,
, . , 1982 1995 .
41,5% 14 . 1992 . 18,6 100 000 , 1979
1991 . 32,9%. , 25%
. 2,3
41,4 100 000 .
4% 2% 45 .
8 ; ,
3,5 . 8 [1].
(, , .) ,
-1- .
,
, , ,
. ,
, ,

.

.
:
1. ,
, .
192

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2. .
3. , , ,
.
4.
.
5. , ,
, .
6.
, , .

[1] .., .., .. , , // / . .. . .,

1998. . 6682.
[2] .., .., .. // / . .. .
., 1998. . 216234.
[3] .. // / . .. . ., 1998. . 437.
[4] Clary-Meinesz C., Mouroux J., Huitorel P. Ciliary beat frequency in human bronchi and
bronchioles // Chest. 1997. Vol. 111. P. 692697.
[5] Dahl R., Greefhorst L, Novak D. Inhaled Formoterol Dry Powder Versus Ipratropium Bromide
in Chronic Obstructive Pulmonary Disease // Am. J. Respir. Crit. Care. Med. 2001.
Vol. 164. P. 778784.

THE CHRONIC OBCRUCTIVE

PULMONARY DISEASE IN MILITARY VETERANS:
PROBLEMS AND PERSPECTIVES
G.I. Gurko
Department of clinical gerontology
Institute of Bioregulation and Gerontology
Dinamo av., 3, S-Petersburg, Russia, 197110
The prevention and rehabilitation of internal diseases in military veterans is one of the problem of
modern health service. The problem and perspectives of decision in context of chronic obstructive pulmonary disease are presented in this article.
Key words: chronic obstructive pulmonary disease, veterans.

193



..


. , 190, , , 603126

..
-
. , 1-72, , , 603022

, .
: , , .

, , . , , , .
, .

,
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,
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, ,
.
, ,
- .

.
,
-, , . , 194

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, .
.
(, ) , .

, , .
- 560 . , , 56 ,
12
(45,6%) .
(78%) . : 2029 ; 30 39 ; 40
49 ; 50 . 3039 .
, , , ,
- .
(, , ,
.) 57,8 2,1 100 , 54,2% - . , , , ,
,
.
73,6 1,9 100 .
.
, . ,
.
195

 , , 2010, 4

ON IMPROVEMENT
OF COSMETOLOGY CARE BY PEOPLE
M.S. Guryanov
Department of public health and public health service
Nizhegorodskaya state medical academy
. Rodionova str., 190, Nizhniy Novgorod, Russia, 603126

N.N. Archipova
Clinic Byuti-spa
Okskiy sezd str., 72, Nizhniy Novgorod, Russia, 603022
Sociological survey of patients clinics of aesthetic medicine revealed preferences, and grievances
of patients in obtaining medical cosmetic services that can then be used to improve the cosmetic medical care to the population.
Key words: medical services, cosmetology, quality medical care.



.. , .. , .. ,
.. , ..


. , 89, , , 443099
, .
, , .
: , .

. .
.
. 25 20
, .
-02.
[1]. Statistia 6.0.
.
52,6% , 36,8%, 10,6%.
22%, = 0,007,
67% ( = 0,04) (. 1). , 60%
50% .
1

, ..
Kv, %

A max , ..

m
19,37 0,78
16,75 1,51
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10,75 1,74, = 0,047
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1,43 0,09
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0,76 0,11

m
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14,45 1,01, = 0,007
6,45 1,03
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0,91 0,14, = 0,03

: , .

197

 , , 2010, 4

. .

(. 1),
, , - , .
. ,
.

[1] / . .. , .. . .: , 2005. 125 c.

STATE TOTAL MICROCIRCULATION

IN PATIENTS WITH HEMOPHILIA
I.L. Davidkin, Y.A. Kosiakova, I.V. Kurtov,
T.A. Gricenko, R.K. Chairetdinov
Department of Hospital Therapy
Samara State Medical University
Chapaevskaia str., 89, Samara, Russia, 443099
The paper presents the results of the study total microcirculation in patients with hemophilia, obtained using laser Doppler flowmetry. Revealed asymmetric reduction of perfusion, increase the maximum amplitude of violations of microcirculation.
Key words: hemophilia, microcirculation.

 ,

.. , E.. ,
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. , 2, , , 614081
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. 0,01 1 ;
( 0,036 ).
: 196201 .
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-254.
5 ., 25% (17 : 6 : 5) . , 199

 , , 2010, 4

, 15 . -
254 , .
: 0,15 ( ) , , 1 , 10 , 0,15 0,1% 0,1
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, , :
C
10
10
115
t = t +
lg = 60 +
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lg A

lg 2
2030
:
10
10
2030
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5 19 29 .

[1] : 12- . / . . 1. .:
, 2008. . 488492.
[2] . . 42-2-72. ,
, 1972 .
[3] . -42-2-82. .
. 1983 .
[4] .. // . 2000. 2. . 2534.
[5] .. .. ,
// . . 2000. 7. . 472475.

201

 , , 2010, 4

DETERMINATION APPLICATION TIME NEW BAS,

SHOWING ANTIHYPERTENSIVE ACTIVITY
N.V. Dozmorova, E.. Nepogodina,
L.A. Chekryshkina
Chair of pharmaceutical chemistry faculty of pharmaceutical chemistry
additional education and extra-mural education
Perm state pharmaceutical academy
Polevaya str., 2, Perm, Russia, 614081
Tests by method speed test to stabilities were installed with the aim of study of expiration date
of new biologically active substance (AS) N-2 (2-methylphenoxy)-ethylmorpholine hydrochloride, which are shown high antihypertensive activity. Calculating of optimal temperatures of keeping
were obtained.
Key words: expiration date, method speed test to stabilities, optimal temperatures.



..

-
. , 70, , , 660049

..


. . .. -
. , 124, , , 660021
.
3
, , , .
: , , , .

, ,
. , ,
. [1]. ,
, , , ,

, [2].
. - 3
. -
1053 .

, t- , .
. (.). 2006/07 . 203

 , , 2010, 4

- 47,2%; : 24,2%, 10,5%. 2007/08 .

- 37,8%,
28,8%, - 9,4%.

0
2006/09

2006/07 .

2007/08 .

2008/09 .

47,2%

37,8%

18,8%

< 0,05

24,2%

7,9%

27,3%

< 0,05

10,5%

28,8%

13,6%

< 0,05

3,7%

9,4%

14,5%

< 0,05




6,2%

2,9%

2,5%

< 0,05

1,2%

6,9%

6,8%

< 0,05

3,7%

4,9%

11,1%

< 0,05

2,4%

0,9%

5,1%

< 0,05

2008/09 . - 27,3%,
- 18,8%,
- 14,5%.
3- - , 10,8% 2006 .
6,4%.
2007/08 . - 2,6%. - 28,4% 3-
. 2006/08 . 18,3%, 2008/09 . 15,2%.
3,7%.
,
, .
.
r = 3873.
, , 2006/09 . ,

, .
204

 .., ..

[1] .. , // . . 2004. 6. . 4445.

[2] . ., .., .., .. -
// . . 1996. 1. . 3033.

DISEASE OF STUDENTS OF MEDICAL COLLEGE

E.O. Domrachev
Branch Nursing care
Krasnoyarsk mediko-pharmaceutical college
World str., 70, Krasnoyarsk, Russia, 660049

L.I. Valentinovich
Chair Managements of public health services of economy of pharmacy and ON
Krasnoyarsk state medical university of prof. F.V. Vojno
Charles Marxs str., 124, Krasnoyarsk, Russia, 660021
The work purpose to estimate disease of students of medical college. In dynamics of 3 years
deterioration of a state of health of students at the expense of a pathology of respiratory system, LOR
bodies, sight, nervous system is observed.
Key words: students, college, disease, a state of health.




IIIII

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. ..
. , 8, . 2, ,

IIIII
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: , , , , .

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, , , . , ,
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150 1 ; 300 . 1 . 24 .
.
206

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(, Promo-Med, ) (, Novartis Pharma, )
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122 , 3565 , - IIII ( 94 , 30 /2) II
III . 1 300 160
(58 ), 150 (62 )
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207

 , , 2010, 4

( < 0,05); 13,2 1,1 . . ( < 0,05). , 300 160 ,

4 21,1 1,8 . . ( < 0,05);
15,6 1,4 . . ( < 0,05).
.
II ,
, II, - .
- , .

CLINICAL APPLICATION
OF DIRECT RENIN INHIBITOR ALISKIREN
IN COMBINED THERAPY OF PATIENTS WITH ARTERIAL
HYPERTENSION AND METABOLIC SYNDROME
O.V. Dralova, M.L. Maximov, A.S. Ermolaeva
Department of Clinical Pharmacology
I.M. Sechenov MMA
Trubetskaya str., 8, p. 2, Moscow, Russia
The article presents the results of clinical application of direct renin inhibitor aliskiren in combination therapy in patients with arterial hypertension and obesity. The antihypertensive efficacy of aliskiren in
combination with valsartan was demonstrated as dose-dependent, and was well tolerated and high safety of
this combination therapy.
Key words: aliskiren, arterial hypertension, valsartan, combination antihypertensive therapy,
metabolic syndrome.



.. , ..
2

- , 40, , , 656038
.
24,2% , .
: , , , .

.
[1, 2].
- .
. .. (1988) - . 156 -
1218 , 15 0,5 .
67 , ( I), 89 ( II). :
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30.12.2003 . 621
. () , .
-10.
BioStat V.4.03 1998.
2- .

.
. ()
61,2% , , 52,8%
(2 = 0,158, = 0,691).

(. 1).
209

 , , 2010, 4
1
( %)

,
I (n = 67)
61,2
12,4
4
16,4
6

,
II (n = 89)
52,8
0*
18*
27
2,2

: * p < 0,05 III.

: 4
, , , 2
, ( = 3,000,
= 0,083).
,
, , 24,2%
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. 2,
: - 53%;
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2
(%)

10
( 40)
( 41)
( 43)
(H00H59)
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 (G 24)
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 (S00T07)

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29,4
5,9
0
5,9
41,2
0
17,6
0
29,4
0
0
0
0
58,8

II (n = 89)
32,9
6,1
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, , 29,4% (2 = 7,6; p <
210

 .., .. ...

< 0,006). , , , .
. -,
, , 24,2%; 57,6%, 18,2%,
.
.

, , .

[1] ..
// - . . .. /
.. . XV. 4, 2008. .: . , 2008. . 6566.
[2] .. . . .: , 2004. 168 .

HEALTH STATUS OF ADOLESCENT SPORTS ALTAI

V.Y. Zhukova, Y.F. Lobanov
Department of Pediatrics 2
Altai State Medical University
Lenina pr., 4, Barnaul, Russia, 656038
Adolescence is a critical stage in human life. Virtually health is recognized only 24,2% of adolescents, indicating a low level of health.
Key words: adolescents, sportsmen, physical development, health.




..
60
. , 1, , , 111123

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92 ( 19 28 ), 22,3 1,9 .
67 ( ) 25 . () 4 : 1- 25 ; 2- 24
; 3- 22 ; 4- 21 . , - , , . IQ . , .. .
, , , 114 8,1; 103 23,1; 113 15,2.
. .
: , , , .

. ( IQ) 1015 ,
,
[1, 2, 3].
,
(), .

, ( 4) [4,
5]. , ,
212

 .., .. ...

(N. Bleichrodt, 1980; A. Bautista, P.A. Barker, 1982). ,

, .


. , , - .
:

.
. 92 19
28 , (22,3 1,9) . 67 (53 14 ) 25 (5 15 ; ).
(, , ) 4 :
1- , 25 , 2- , 24 , 3- , 22 ,
4- , 21 . , , . , ; ,
.
IQ . , .. . ,
- - ,
.

Excel .
p < 0,05.
.
, , IQ 114 8,1; 103
23,1; 113 15,2.
, . , , IQ 97 12,5; 92 14,2; 95 8,4,
96 10,9; 84 10,0; 94 7,3, 213

 , , 2010, 4

92 12,8; 83 8,9; 92 11,7 .

IQ
(p < 0,05), (.).

. IQ :
1 ; 2 ;
3 ; 4

IQ (70%),
IQ 20% 10% .
IQ 54,2%,
45%.
IQ (63,6%) IQ
(36,4%). IQ (71,4%) IQ (28,6%) (. 1).
1
IQ

IQ

120

10% (n = 2)

110119

70% (n = 18)

45,8% (n = 11)

36,4% (n = 8)

28,6% (n = 6)

90109

20% (n = 5)

25% (n = 6)

40,9% (n = 9)

28,6% (n = 6)

29,2% (n = 7)

22,7% (n = 5)

42,8% (n = 9)

8089

214

 .., .. ...

, , , , -
, , ,
(. 2).
2

14,8 1,7

12,2 1,2

13,4 1,6

31,2 2,2

28,6 3,3

24,6 2,3

13,0 1,5* 11,2 1,6*

12,5 1,6

29,1 2,5*

25,06 3,8*

24,0 2,0

12,7 1,2* 11,1 1,7* 11,4 0,9*

28,3 2,6*

24,0 3,0*

22,0 3,7*

12,1 1,7* 10,1 1,4* 11,3 0,8*

27,8 2,6*

23,9 3,8*

21,1 4,3*

10

11

: 4 , 5 , 8 , 9 , 10
, 11 . * (p < 0,05).

. , ,
, .
.

[1] .. ( ) // . 1997. 3. . 37.

[2] Glinoer D. Autoimmune thyroid disorders, maternal hypothyroxinemia, and its potential repercussion for the progeny // In: The Thyroid and Environment. Merk European Symposium.
Budapest. 2000. P. 121133.
[3] ..
: . . ... . , 2003. 28 .
[4] Dussault J.H. //The Thyroid and Age: Merck European Thyroid Symposium, Italy. 1998.
P. 2935.
[5] Sampson D., Pickard M.R., Sinha A.K. et al. // J. Endocrinol. 2000. V. 167 9.
P. 439445.

215

 , , 2010, 4

INFLUENC OF AUTOIMMUNE THYREOIDITIS

ON INTELLECT IN YOUNG PEOPLE IN WEST KAZAKHSTAN
R.M. Zaslavskaya
City clinic hospital N 60
Novogireevskaya str., 1, Moscow, Russia, 111123

J.Kh. Talipova
West-Kazakstan state medical university
Lenina str., 75, Actobe, Kazakstan, 030020
The authors investigated influence of autoimmune thyreoiditis (AIT) in the phase of euthyreosis and
subclinic hypothyreosis on the level of the intellectual development. There were examined 92 persons
(mean age 22,3 years old). Among them there were 67 pts with AIT (basic group) and 25 healthy people. Intellectual level in AIT was examined in 4 groups. The 1st group of 25 pts is controlled; the 2nd of
24 pts with euthyreosic AIT; the 3rd of 22 pts with subclinic hypothyreosis; the 4th of 21 pts with
manifestal hypothyreosis. There were used clinic, ultrasonic investigations, determing free thyroxin fraction, TTG. The evaluation of mental development with calculating intellectual index IQ was investigated
by means testing of D. Veksler method, adapting by A. Yu. Panasyuk. Data received revealed, that average total, verbal and nonverbal parameters in control group were 114 8,1; 103 23,1; 113 15,2 respectively. AIT development was accompanied by the decrease of intellectual level by data of the same tests.
There were revealed lower levels of memory volume in AIT, than in control group. Conclusion: AIT was
accompanied by decreasing intellect and memory in all investigated groups.
Key words: autoimmune thyreoiditis, clinic hypothyreosis, intellect, memory.




.. , .. , ..


. , 2, , , 614990

() . .
.
: , , .

(), [1].
.


.
, , [2].

(LD50, , )
.
20042009 .
,
(40,74%). .
, 55,6% , 44,4% (. 1).
54% ().

. 1. 20042009 .
.

217

 , , 2010, 4

(. 2)
()
(66%), (19%)
(15%).

. 2. ,

() , - -
[3, 4]
, 358 LD50, , .
, 230
, 0,43% , 10,0%
, 10,87% 78,70% .
( ).
:
, , , .
, .
( , , ).

( ).

.
218

 .., .., .. ...

. .

[1] 2510/1875-04-32 02.03.2004 .

.
[2] : 15.06.2001,
511 // . ., 2001. 19 .
[3] ..
/ .. , .. . .: , 1998. 263 .
[4] / .
.. . .: - , 1998.
896 .

UNSUITABLE TO USE FOOD SUPPLEMENTS

AS THE WASTE OF THE PHARMACEUTICAL MARKET
N.A. Ivanova, .V. Vikhareva, .V. Suldin
Chair of pharmaceutical technology
Perm state pharmaceutical academy
Field str., 2, Perm, Russia, 614990
Presence of a significant amount of forged and rejected food supplements (BUD) in the Russian
pharmaceutical market is established. The qualifier BUD on classes of danger to a surrounding environment is developed. The algorithm of a choice of a rational way of destruction unsuitable to use BUD
is offered.
Key words: food supplements, a dangerous waste, classes of danger to a surrounding environment.



..


. , 27, , , 211440

.. , .. ,
.. , ..


. , 3, .-, , 197110

..

. . , 50, , 308000
.
: , , .

,
. ,
, [1, 2].


.
. 114 ,
. 1- (56 .) -,
, 2-
(58 .) . 64,8 3,4 .
.
.
12% , 27%, > 0,05. , .
, , > 0,05
(. 1).
220

 .
1

()

1,5 0,6

3,4 0,7

< 0,05

1,2 0,5

3,2 0,4

< 0,05

1,4 0,3

3,5 0,5

< 0,05

. , 99,4 0,4%
, 23,2 2,3%, 17,2 2,1%.

. : 98,2 0,4% ; 22,3 2,1%,
24,2 2,1% .
: 98,6 0,2% ,
21,4 2,1% ; 18,3 1,7%. , > 0,05.
. , , .. 21,5 2,1%
, 16,5 1,5% , 24,1 1,7% .
,
.
15,3 2,5%, 11,3 1,7% 13,1 2,5%
.
3,1 1,0% , 10,6 15,7% 9,5 1,3% . 11,9 1,6% ,
11,3 1,4% 9,7 1,4% .
29,1 2,4% , 34,5 2,3%,
34,3 2,2%.
.
.
221

 , , 2010, 4

[1] .. : , // Consilium medicum. 2002. . 4. 10. . 544548.

[2] Wassink A.M., Olijhoek J.K., Visseren F.L. The metabolic syndrome: metabolic changes with
vascular consequences // Eur. J. Clin. Invest. 2007. Vol. 37. N 1. . 817.

DEPRESSION IN ELDERS AND NON0DRUG THERAPY

A.N. Ilnitski
Department of Medical Rehabilitation
Polotsk State University
Blokhina str., 27, Polotsk, 211440

G.I. Gurko, D.S. Medvedev,

.. , .. Altuhov
Department of clinical gerontology
Institute of Bioregulation and Gerontology
Dinamo av., 3, S-Petersburg, Russia, 197110

N.. Kunitsyna
Medical Centre Pokolenije
Khmelnitskogo av., 50, Belgorod, 308000
The problems of non-drug treatment and rehabilitation in elder patient with depression and diabetes mellitus are presented in this article.
Key words: diabetes mellitus, elders, depression.

 ,

..


. , 1, , , 400131
, , .
,
.
: , , , .

() 90 100%
. ()
6 3 .
. , 78 .
[2, 3].

.
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2 12 , ()
50 () 54 .
, , .. , .. [1].
. .
.
. , , , 54,0 7,1% 55,6 6,8%
,
(, ) ( > 0,1). 52,0 7,1%
51,9 6,9% ( > 0,1)
.
(38,0 0,9% 51,9 6,9%; > 0,1).
(60,0 7,0% 53,7
6,8% ; > 0,1). 6 (22,0 5,9% 9,3 4,0%; > 0,05).
223

 , , 2010, 4

. , 94,0 3,4% 92,6 3,6% ( > 0,01)

.


( > 0,05, > 0,1).

. ,
( > 0,1).
- (90,0 4,3% 94,4 3,1% ;
> 0,1). ,
(64,0 6,9% 77,8 5,7%; > 0,1).
(52,0 7,1% 70,4 6,3%; > 0,05).
, 13,0 4,6% , , -
, ; 40,7 6,7%
.
1
,

n = 50

n = 54

p1 m%
32,0 6,7

16

30

p2 m%
55,6 6,8

P12 < 0,05

10,0 4,3

17

31,5 6,4

P12 < 0,01

18

36,0 6,9

32

59,3 6,7

P12 < 0,05

18

36,0 6,9

22

40,7 6,7

P12 > 0,1

P12 > 0,1

4,0 2,8

P12 > 0,1

15

30,0 6,5

16,7 5,1

P12 > 0,1

P12 > 0,1

7,4 3,6

P12 < 0,05

()

: P12 c .

, (. 1). , (36,0 6,9% 59,3 6,7%); -

(36,0 6,9% 40,7 6,7%). , , (55,6 6,8% 32,0 6,7%;
< 0,05), (31,5 6,4% 10,0 4,3%;
< 0,01).
( > 0,1).
.
224

 .. ,

, . ,
- ,
, (10,1 0,3 10,9 0,3; > 0,05).
, , ,
, . , , .

[1] .., .. // . 1984.

2. . 6568.
[2] .., .., ..
. .: -, 2005. 64 .
[3] Stan G. Improving the outcome of facial resurfacing-prevention of herpes simplex virus type
1 reactivation // J. Antimicrob. Chemother. 2001. 47. P. 2934.

ANAMNESIS OF CHILDREN SUFFERING

FROM HERPETIC STOMATITIS
I.A. Kazantseva
Department for Dentistry, College of Advanced Medical Studies
Volgograd State Medical University
Pavshikh Bortsov Sq., 1, Volgograd, 400131
The anamnestic data of children suffering from acute and recurrent herpetic stomatitis are analyzed in this article. The influence of different pathologic factors which can lower childrens organism
resistance and facilitate a manifestation of recurrent herpetic stomatitis is found out.
Key words: herpes, herpetic stomatitis, children, antecedent anamnesis.


()

..
,

. , 310, , 355000
. . (1905 .) 400 . , .
XIX .,
.
. . ,
. .. ., ,
, , . , . ,

.
,
4 1 .
: , ,
.

, .
. . , 1905
- , . ,
. : , 37 , 7
10 . -
, .

.
.
1. , .
2. 4 .
226

 .. ()...

3. .
4. .
. I, II, III, V, VI, VII, VIII,
IX . , , 80 120 .
1. ,
.
2. : .
: 20 1999
. :
1. 20
.
2. 20 , , .. .
3. .
10
. 3
. , 4 .
20 2003 . 34
. 1,5
..
.. , .
. ,
,
.
() ,
.
. , , 3 , , 20 . ,
, (, ).

[1] .. : . .: , 1997. 288 .

[2] .. . .: -, 2000.
. 554556.

227

 , , 2010, 4

[3] .. . // . 1996. 2.
. 2932.
[4] .. // .
1993. 5. . 2125.

STEADINESS OF TREPONEMA PALLIDUM

TO CHANGES OF OPTIMUM CONDITIONS OF CULTIVACION
A.Ch. Kaziev
Department of microbiology, virusology and immunology
Stavropol state medical academy
Mira str., 310, Stavropol, Russia, 355000
By the time of discovery of the causative agent of syphilis by F. Schaudinn and E. Hoffmann
(1905.) the illness itself was spread for more than 400 years. Even after R. Koch had invented the
stages of separation of the pure cultures in the second half of the XIX centuries, scientists were not able
to get the strains of the causative agent of the illness for several decades. Numerous attempts to cultivate the treponema pallidum were ineffectual. The reason of these failures was attributed to the high
needs of these microbes and the conditions of cultivation. So far the opinion that the causative agent of
syphilis could not be cultivated was gradually formed. But the discoveries by R.R. Geltsera and others,
by Nichols, by Reuter denied this assumption, the strains of treponema separated by them are cultivated
in artificial breeding mediums till now, but with strict observance of all parameters of cultivation. In the
scientific literature there are data affirming that treponema pallidum is not steady in the environment.
The point of the given experiment consisted in defining the maximum period of survival rate of treponema pallidum in the situation of changing of their optimum conditions of cultivation. As a result of
the experiment the maximum period of survival rate of treponema pallidum in the condition of action of
several adverse factors was defined as 4 years and 1 month.
Key words: cultivation of treponema pallidum, sensitivity, steadiness of the causative agent of
syphilis.



..


. , 89, , , 443099

..

. , 12, , , , 443041
118 () 45 88 . 63,6% . (94,9%), (49,2%) (40,7%). 25%
44,3% (p = 0,025). . 75 75,8% , 63,6%
. : . , ,
, .
: , ,
.

. 0,41% , 80 10% [1, 2]. [3],

10- 88% [4].
, ,
() [5],
, 5%
[1].
.
. ,
.
. 118 45
88 ( 66,7 1,0 ), 70 (59,3%). 66 . ,
. 2
p < 0,05. 229

 , , 2010, 4

SPSS 11.
. , 36,4% .
,
(. 1).
1

(%)

(n = 66)

(n = 118)

84,8

94,9

0,020

()

89,4

94,9

19,7

49,2

< 0,001

1,5

40,7

< 0,001

28,8

44,1

0,042

71,2

54,2

0,024

71,2

92,4

< 0,001

86,4

87,3

77,3

83,9

10

42,4

54,2

11

36,4

48,3

: / .

, , (89,4%),
(84,8%) , (86,4%).
(71,2%) (71,2%). (42,4%) .

(94,9%; = 0,02), , ,
(94,9%; 89,4%).
(92,4%; < 0,001).
(49,2%, 19,7%; < 0,001)
40,7% (
1,5%; < 0,001). .
230

 .., .. ...

(54,2%) (48,3%).

(. 2).
(r = +0,209; p = 0,023),
(r = +0,197; p = 0,033). ,
, -
.
2

(n = 66)

(n = 118)
%

58

87,9

105

89,0

4,5

44

37,3

< 0,001

6,1

42

35,6

< 0,001

48

72,7

97

82,2

1,71 0,10

2,44 0,11

< 0,001

(25% ) (44,3%; = 0,033).

.
37,8% 43,8% (. 3).
75 24,2%.
3

,

,
(n = 37)

,
6074
(n = 48)

,
75
(n = 33)

23

62,2

27

56,2

25

75,8

13

35,1

26

54,2

19

57,6

11

29,7

21

43,8

20

60,6*

29

78,4

42

87,5

32

97,0*

12

32,4

24

50,0

21

63,6*

. : * p < 0,05.

231

 , , 2010, 4

35,1%
60 54,2% (p = 0,083) 57,6% (p = 0,062).
.
.
75 , 60
(p = 0,01). ,
(97,0%)
(78,4%; p = 0,021). ,
(p = 0,01).
. (r = 0,227; p = 0,014).
(16,7%) (39,4%).

1.
, , , ,
, . .
2.
75 . .
3.
.

[1] .., .., .. // :

/ . .. , .. . .: , 2008. . 746763.
[2] ., . // / . . , . /
. . .: , 2008. . 429474.
[3] Kirch W., Pittrow D., Bosch R.F. et al. Health-related quality of life of patients with atrial
fibrillation managed by cardiologists: MOVE study // Dtsch. Med. Wochenschr. 2010.
Vol. 135. Suppl. 2. P. S2632.
[4] McDonald A.J., Pelletier A.J., Ellinor P.T. et al. Increasing US emergency department visit
rates and subsequent hospital admissions for atrial fibrillation from 1993 to 2004 // Ann.
Emerg. Med. 2008. Vol. 51. 1. P. 5865.
[5] .. // . . . 2005. 3. . 510.

232

 .., .. ...

ADHERENCE TO DRUG THERAPY

IN PATIENTS WITH ATRIAL FIBRILLATION
.A. Kachkovskiy
Samara State Medical University
Chapayevskaya str., 89, Samara, Russia, 443099

O.V. Krasnoslobodskaya
Railway Road Clinical Hospital, Samara
Agibalova str., 12, Samara, Russia, 443041
We studied treatment adherence in 118 patients with atrial fibrillation (AF) who were between the
ages of 45 and 88 years. 63.6% of patients with arrhythmia to take a medicine irregularly. Patients consider as the reasons of an irregular drug intake a large quantity of tablets (94,9%), side effects (49,2%)
the bad control of arrhythmia and pulse increase (40,7%). Only 25% of men and 44,3% of women (p =
0,025) had strict adherence. The patients who know about complications of disease to take medicines
more regularly. 75,8% of patients are more 75 years irregularly accepted medicines, 63,6% from them
considered harmful constant reception of medicines. Conclusions: Patients with atrial fibrillation have
low treatment compliance. The factors improving compliance are the personal motivation of patients,
good informing about diseases and their complications.
Key word: atrial fibrillation, treatment compliance, therapeutic training.



0
..



. -, 41, , 173003
, , 235
, .
.
: , .

,
- () (, ), , ,
[68].
, , , [15]. , .


, , .
.
, ,
235 .
(, )


( ) . , ( 40)
: ( , ), 234

 .. ...

, ; : / 1,0, , ,
, () , ,
, (
0,560,48).
, , . Child-Turcotte
(1964) .
(710 ), (1115 ) ( 15 ) .

, 0,70.
( 0,64)
( 0,56).
, 0,80. , , 80%
.
,
. , ,
.
, - , ,
. , , ()
.
,
.
7080%
.

.
235

 , , 2010, 4

[1] .. // - . .. . , 1994. . 6465.

[2] .., .., .., .. // . 1998. 2. . 119120.
[3] .., .., .. // . , 1994. . 7378.
[4] .., .., ..
. ., 1997. 150 .
[5] .. // . 1983. 11.
. 114116.
[6] .., .., .. . .: , 1982. 239 .
[7] .., .., .., .. // . 1983. 8. . 1417.
[8] .. : . . ... . . .
, 1997. 48 .

METHOD OF DEFINITION OF RISK OF DEVELOPMENT

OF HEPATIC INSUFFICIENCY AT COMPLICATED BILILITHIASIS
M.D. Kashaeva
Chair of morphology of the person
Medical education institute
Novgorod State University of a name of Yaroslava Mudrogo
Big St.-Petersburg str., 41, Great Novgorod, 173003
The retrospective analysis clinical, biochemical is carried out, immunological and the morphological data at 235 patients with complicated biliary the pathology reveals significant indicators of the
risk which account will allow to influence rationally and medical tactics. The estimation of real reserves
of a liver already will allow to lower frequency of development of postoperative hepatic insufficiency to
operation.
Key words: hepatic insufficiency, a functional reserve of a liver.


(HELIANTHUS TUBEROSUS L.)

NNP K
.. , .. ,
.. , ..


. , 2, . 4, . 22, , 357532

NNP K.
NNP K : = 4,5,
1 : 10, 48 60 .
: , , ,
NNP K.

(), .
,
, , , , [3].
12 NNP K [2].

().
[1], - ( ).
NNP K ,
FAO/WHO (JECFA)
(FCC) , .
NNP K , , : = 5,0,
1 : 15, 15 , 50 .
NNP K
, .
237

 , , 2010, 4

. , ..
. , , , .
NNP = 4,25,3,
. :
4,2; 4,5; 4,8; 5,0; 5,3.
: 1 : 15,
15 , 50 .
. 1.
1

, %

4,2

5,72

4,5

5,83

4,8

4,79

5,0

3,51

5,3

3,28

. 5,83% = 4,5.

- , 1 : 30,
. . 2.
2
NNP

, %

1 : 30

3,34

1 : 15

3,51

1 : 10

4,50

1:6

4,80

1 : 6, NNP K
, . 1 : 10.
.
3, 6, 9, 12, 15, 18, 21, 24, 27 .
. 3.
238

 .. . ...
3

, .

, %

2,57

3,32

3,36

12

3,47

15

3,51

18

3,65

21

4,69

24

5,32

27

5,36

24 .
27 .
NNP K, 4065 .
. 4.
4

, %

45

3,26

50

3,51

55

5,20

60

5,37

65

5,40

65 NNP K. . 60 65 , 60 .
, NNP K :
= 4,5, 1 : 10,
24 60 .

[1] .., .., .. . , ,

, . .: . -, 1995. 81 .
[2] .., .., .., ..
(Helianthus tuberosus L.) // , :
. . . : . 2010. . 65. . 195196.

239

 , , 2010, 4

[3] Panouill M., Thibault J.F., Bonnin E. Cellulase and protease preparations can extract
pectins from various plant byproducts // J. Agric. Food. Chem. 2006. 54 (23).
. 89268935.

SELECTING THE CONDITIONS OF THE EXTRACTION

OF THE PECTIN FROM TUBERS OF JERUSALEM ARTICHOKE
(HELIANTHUS TUBEROSUS L.) WITH USE ENZYMATIC
PREPARATION MAKSAZIM NNP K
M.T. Kisieva, N.S. Zyablitseva,
V.A. Kompancev, A.L. Belousova
Chair of inorganic chemistry
Pyatigorskaya state pharmaceutical academy
Panagyurishte str., 16/1, ap. 12, Pyatigorsk, 357532
The purpose given studies a determination of the optimum conditions of the extraction of the
pectin from tubers of Jerusalem artichoke with use enzymatic preparation Maksazim NNP K.
Optimum condition of the enzymatic extraction of the pectin from tubers of Jerusalem artichoke
with use Maksazima NNP K are chose: citrate buffer solution with pH = 4,5, correlation enzyme
a raw material 1 : 10, time of the extraction 24 hours and temperature 60 .
Key words: tubers of Jerusalem artichoke, pectin, enzymatic extraction, Maksazim NNP K.





..
, ,



. , 287, , , 454021
() ( 35 . .) . :

.
: , , .

, ,
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:
.
.
(n = 11 904).

(n = 332 , 90 , 92 , 100 50 )
( ). : ,
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(1, ) . , 20,7 1,13 .
12 (v = 25 /), 3 241

 , , 2010, 4

.
Cardiofax.
()
, . I (2000 .) (2004 .), 140/90 . .

(3-1, 3-3). .
(2) , 2
, LT. .
. I SPSS 11,0, STATISTICA 0,6.
(), (SD). ,
. () 0,05.
. 36 (10,8%) . (15,6%) (20,7%).
. 3 (6,0%)
(. 1).
1

(+)
()

n = 332
.
36
296
332

%
10,8
89,2
100

n = 190
, n = 100
, n = 92
.
%
.
%
0
0
19
20,7
100
100
73
79,3
100
30,1
92
27,7

n = 90
.
14
76
90

%
15,6
84,4
27,1

, n = 50
.
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, 243

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2. 2
. 2 ,
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[1] .., .., .. . , 2005. 135 .

[2] .., .., .. . - // . 2001. 3. . 3944.

PREVALENCE OF LEFT VENTRICULAR HYPERTROPHY

MYOCARDIUM AMONG YOUNG PEOPLE
WITH CHRONIC HYPOCAPNIA
T.G. Kovalenko
Department of therapy, functional diagnostics,
preventive and family medicine
Ural State Medical Academy of Additional Education
Prospect Pobeda, 287, Chelyabinsk, Russia, 454021
The problem of interrelation between left ventricular hypertrophy of the heart (LVH) in terms of
chronic hypocapnia (the level of carbon dioxide in the alveolar air is less than 35 mm Hg) in general
population is not sufficiently studied according to the scientific data. The aim of this research is to
evaluate peak criteria prevalence of left ventricular hypertrophy among young people and to establish
their interrelation with carbon dioxide strain in alveolar air.
Key words: left ventricular hypertrophy, hyperventilation, hypocapnia.



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( ).
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spp., Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli. [1] 103104.
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[2] .., .., .. . - // . 2003. 4. . 2325.
[3] .., .., .. .
- , , // VIII . . . . ., 2001. . 371.
[4] .., .., .. .
() // . . . 2008. 1. . 1618.

DEVELOPMENT OF MEDICAL FILMS

FOR BACTERIOPHAGE TREATMENT OF INFECTION
N.A. Kovyazina, V.I. Reshetnikov, E.V. Funcner
Chair of industrial technology with a biotechnology course
Perm state pharmaceutical academy
Lenins str., 48, Perm, Russia, 614990
The Article is devoted to the development of medicinal biosoluble films Sekstaphag (Piobakteriophag polyvalent). As a result of studying the influence of excipients and technological factors the
base structure has been obtained and the technology on the conservation of specific activity of phages
10-3 and above within 18 months has been optimized.
Key words: bacteriophage, drug film, lytic activity, sekstaphag.

246




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2 : 1) + ( 12 ) 11 (55%); 2) + ( 12 ) 9 (45%).
: -
247

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[4].
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: * < 0,05

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: ,
20% ( < 0,05),
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, 1 + + WOMAC 53,8% ( < 0,05) 21,8% ( < 0,05);
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.
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248

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2.
.
[1]

[2]

[3]
[4]

Hinman R.S., Hunt M.A., Creaby M.W. et al. Hip muscle weakness in individuals with medial knee osteoarthritis // Arthritis Care Res (Hoboken). 2010. V. 62. 8.
P. 11901193.
Amin S., Baker K., Niu J.et al. Quadriceps strength and the risk of cartilage loss and symptom progression in knee osteoarthritis // Arthritis Rheum. 2009. V. 60. 1.
P. 189198.
Jawad A.S., Irving K. Drug treatment modalities in patients with chronic osteoarthritis of the
hip or knee // Saudi. Med. J. 2007. V. 28. 3. P. 375378.
.., .., .. . // - . 2001. 3. . 58.

EFFECT OF WEAKNESS MUSCLE CORSET KNEE

ON THE EFFICIENCY OF LOCAL THERAPY
OSTEOARTHRITIS KNEE GLUCOCORTICOSTEROIDS
O.G. Kozlova
Department of Therapy
Yaroslavl State Medical Academy
Sverdlova str., 102-59, Yaroslavl, Russia, 150054

L.U. Shirokova, A.S. Bashkina,

L.N. Dolgova, R.M. Nagibin
Department of Therapy
Yaroslavl State Medical Academy
Revolutionary str., 5, Yaroslavl, Russia, 150000

T.U. Shirokova, M.M. Kuznecov,

M.V. Smekalova
Department of bioinorganic and biophysical chemistry
Yaroslavl State Medical Academy
Revolutionary str., 5, Yaroslavl, Russia, 150000
The efficiency of the local therapy of osteoarthritis knee of glucocorticosteroids on the power of
quadriceps femoris were studied. It was established that the effectiveness of local treatment of OA is
higher in patients with moderate weakness of thigh.
Key words: osteoarthritis, weak kvadricepsa, local therapy.

249



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.
, .

.
252

 .., .., .. ...

[1] .., .., .., .. , . : - , 2005. 336 .

[1] .., .., .., .. . . . . , 2009. 296 .
[1] .. . .:
, 2000. 768 .
[1] Caro J.F., Kolaczynski J.W. Leptin: the tale of an obesity gene // Diabetes. 1996.
Vol. 45. P. 14551462.
[1] Halberg F. Chibisov S.M., Radysh I.V. et al. Time structures (Chronomes) in us and around
us. M.: PFUR, 2005. 186 p.
[1] Lapauw B., T'Sjoen G., Mahmoud A., Kaufman J.M., Ruige J.B. Short-term aromatase inhibition: effects on glucose metabolism and serum leptin levels in young and elderly men //
European J. Endocrinology. 2009. V. 160. N 3. P. 397402.

SEASONAL VARIATION IN BLOOD HORMONE LEVELS

IN WUMEN DIFFERENT ETHNIC GRUPPS
T.V. Koroteeva, I.V. Radysh,
A.M. Khodorovich
Department Human physiology
Medical faculty
Peoples Friendship University of Russia
Miklukho-Maklaya str., 8, Moscow, Russia, 117198
The article is devoted to study seasonal variation in blood hormone levels in the healthy women. Is
established, that the leptin, insulin, peptid C and total T3 peaks in winter, adiponectin in summer, cortisole and total 4 in autumn, thyroid-stimulating hormone in spring. The average annual meaning of
the thyroid-stimulating hormone, leptin, insulin, peptid C and cortisole significant higher ( < 0,05)
in Greece, adiponectin, total T3 and 4 in Russian. Thus the statistically significant seasonal variation
of hormone levels in healthy women in different phase of the menstrual cycle are revealed.
Key words: season, blood hormone, health women, menstrual cycle.



1822


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,
, .
. 14 ,
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10 2 . 6
8 .
, , , . , ,
, .
, . (HI-s) = 2,35 0,04
; PMA = 65,2 3,2%; SBI = 45,3 0,13%. .

, ,
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-1 : , , B1, ,
, . -1
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. . , , , , , , ,
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. : , , , , . ,
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 , , 2010, 4

: 2
23 , ,
-1 , .
1
. ( ) 34 .
. (
, , ) 2- . 56
, ,
, : OHI-s = 1,2 0,05 ; PMA = 12,8, 2,30,%; SBI = 25
0,11%. 14 : OHI-s = 0,6 0,1 ; PMA = 1,0 0,3,%; SBI = 6,2 0,13.
, ,
, ,
.

.
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. 6
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.
.
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256

 .., .., .. ...

[1] .. -
,
: . ... ... .; ., 2000. . 338.
[2] . : . . ... ... .,
2005. 135 .
[3] ..
. ., 2005. . 1640.

THE USE OF HERBAL MEDICINES FOR THE TREATMENT

AND PREVENTION OF PERIODONTAL DESEASES IN PATIENTS
AGED FROM 18 TO 22 WITH CLEFT LIP AND PALATE
DURING ORTHODONTIC TREATMENT
WITH NON0REMOVABLE APPLIANCES
T.F. Kosyreva, V.V. Safroshkina,
I.V. Bogdasarova
Department of therapeutic dentistry
Medical faculty
Peoples friendship university of Russia
Mickluho-Maclaya str., 8, Moscow, Russia, 117198
It is described in the article the treatment of patients with cleft lip and palate being on orthodontic
treatment with non-removable appliances by herbal medicines: plates CM-1 and Tonsinol. Considerable positive effect on the symptoms of the chronic periodontal inflammation is recorded.
Key words: cleft lip, cleft palate, chronic catarrhal gingivitis.


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[1] .. . - . .: , 2006. 208 .

EVALUATION OF ANEMIA SYNDROM IN HAEMOPHILIA

I.L. Davidkin, Y.A. Kosiakova, I.V. Kurtov,
T.Y. Stepanova, N. A. Kudinova
Department of Hospital Therapy
Samara State Medical University
Chapaevskaia str., 89, Samara, Russia, 443099
In work risk factors of development of an anemia at patients with a hemophilia are analyzed. The
anemia met more often at the heavy form of disease, at persons with A (II) group of blood (40%).
Key words: a hemophilia, an anemia, groups of blood, a hemostasis.

259


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[1] .. -
: . ... - . . , 1970. . 2528.
[2] .. - // . , 2003. . 2832.
[3] .. // , - .
, 2006. . 1518.
[4] .. // . 2007. 5. . 1415.

262

 .. . ...

CHARACTERISTICS OF PSYCHOEMOTIONAL ADAPTATION

OF FINNO0UGRIC WOMEN (SELCUPS) TO PREGNANCY
R.A. Krasovitsky, A.A. Blinova,
E.A. Pashukova, N.N. Bushmeleva
Chair obsterics and gynecology
Izhevsk state medical academy
Kommunarov str., 281, Izhevsk, Russia, 426034
The authors carried out a study of reproductive health of 285 Finno-ugric women. Out of it there
were 100 Selcup women, 140 Udmurt and 50 Russian women. The research results show that the
women in the Far North (Selcups) drink more alcohol and are subjected to chronic nicotine intoxication.
Respiratory illnesses are prevailed in somatic pathology. They show later engagement of menstrual
function, its early decrement and tense reproductive function.
Key words: psycho-emotional adaptation, Finno-Ugric group, Selkups, udmurtki.

 340.67:543:615.214.24

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[6]

[7]

Wyss P.A., Radovanovic D., Meier-Abt P.J. Acute overdose of Zolpidem // Schweiz. Med.
Wochenschr. 1996. V. 126. 18. P. 750756.
Lichtenwalner M., Tully R. A fatality involving zolpidem // J. Anal. Toxicol. 1997.
V. 21. 7. P. 567569.
Levine B., Wu S.C., Smialek J.E. Zolpidem distribution in postmortem cases // J. Forensic
Sci. 1999. V. 44. 2. P. 369371.
de Castro A., Quintela O., Concheiro M. Determinacion de zolpidem plasma por cromatografia Liquida de alta resolucion y deteccion de fluorescencia // Rev. Toxicol. 2003.
V. 20. . 146.
Olubodun J.O., Ochs H.R., von Moltke L.L. et al. Pharmacokinenic propeties of Zolpidem in
elderly and young adult: possible modulation by testosterone in men // J. Clin. Pharmacol.
2003. V. 56. P. 297304.
Gaillard Y., Gay-Montchamp J.P., Ollagnier M. Simultaneous screening and quantitation of
alpidem, zolpidem, buspirone and benzodiazepines by dual-channel gas chromatography using electron-capture and nitrogen-phosporus detection after solid-phase extraction // J. Chromatogr. 1993. V. 622. P. 197208.
, , ; /
. D.R.A. Uges, University Hospital Groningen, The Netherlands. 1996. . 26.
1. 16 .

DETERMINATION OF ZOLPIDEM IN BLOOD BY GC/MS

.. Krylova, Y.A. Khomov
Department of Pharmaceutical Chemistry FDPO PSPA
Pharmaceutical academy
Polevaya str., 2, Perm, Russia, 614081

S.S. Kataev
Department of forensic chemistry
Perm Kray Bureau of Forensic Medicine
Fontannaya str., 12, Perm, Russia, 614002
The solid-phase extraction (SPE) and gas chromatography mass-spectrometry (GC/MS) methods have developed for the quantitative determination of zolpidem in whole blood specimens. The procedure has successfully applied in case of non-mortal poisoning.
Key words: zolpidem, solid-phase extraction, gas chromatography mass-spectrometry.

268

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271

 , , 2010, 4

. , - , ,
. [5], , ,
, P450.
, ,
. ,
, 10
(LOQ),
.
[1]
[2]
[3]
[4]

[5]

Levine B., Wu S.C., Smialek J.E. Zolpidem distribution in postmortem cases // J. Forensic
Sci. 1999. Vol. 44. 2. P. 369371.
Logan B.K., Couper P.D., Couper F.J. Zolpidem and driving impairment // J. Forensic Scince.
2001. Vol. 46. 1. P. 105110.
Hempel G., Blaschke G. Direct determination of zolpidem and its main metabolites in urine
using capillary electrophoresis with laser-induced fluorescence detection // Journal of Chromatography B. 1996. Vol. 675. P. 131137.
.., ..
- // . 2009. 5.
. 165167.
Olubodun J.O., Ochs H.R., von Moltke L.L. et al. Pharmacokinenic propeties of Zolpidem in
elderly and young adult: possible modulation by testosterone in men // J. Clin. Pharmacol.
2003. Vol. 56. P. 297304.

INVESTIGATION OF ZOLPIDEM
IN REAL URINE SAMPLES AT THERAPEUTIC DOSES LEVEL
Y.A. Khomov, .. Krylova
Department of Pharmaceutical Chemistry FDPO PSPA
Pharmaceutical academy
Polevaya str., 2, Perm, Russia, 614081

S.S. Kataev
Department of foresic chemistry
Perm Kray Bureau of Forensic Medicine
Fontannaya str., 12, Perm, Russia, 614002
The results of determination of zolpidem in urine by solid-phase extraction (SPE) and gas chromatography mass spectrometry (GC/MS) after single therapeutic doses are presented.
Key words: zolpidem, solid-phase extraction, gas chromatography mass spectrometry, single
therapeutic dose.

272



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= 169 ), (EQ = 121168 ), (EQ = 81120
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(IQ). : (IQ = 131 ), (IQ = 116130 ), (IQ =
= 85115 ), (IQ = 8470 ) (IQ = 69
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510 17 34 .
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274

 .. .

[1] .. ( ) //
. 2003. 34 (318).
[2] . . , IQ.
Bloomsbury, 1996.
[3] . : / . , . , . ; . . .: , 2005. 301 .
[4] Boyatzis R.E., Goleman D., Rhee K. Clustering competence in emotional intelligence: Insights from the Emotional Competence Inventory // R. Bar-On, J. D.A. Parker (eds.). Handbook of emotional intelligence. San Francisco: Jossey-Bass, 2000. P. 343362.
[5] ., . EQ: . 2007.
[6] .-., ., ., . // Psychologies. 2007. 18 (). . 2433.

EMOTIONAL AND COGNITIVE MAINTENANCE

OF OPERATORS ACTIVITY
R.A. Kudrin, E.V. Lifanova, R.E. Akhundova,
A.S. Fokina, M.Y. Budnikov,
E.M. Akhundov
Normal physiology department
Volgograd State Medical University
Pl. Pavshikh Bortsov, 1, Volgograd, Russia, 400131
This work is devoted studying of the basic indicators of the emotional and psychometric intelligence providing effective activity of the person in various spheres, including at performance of operators activity.
Key words: emotional intelligence, psychometric intelligence, operators activity.





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[1] , .. : //
. 1999. . 2831.
[2] , . . // . 2002. 1 (29). . 364369.

281

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[3] .., .., .. // . 2002.

1 (29). . 369372.
[4] .., .. . .: , 1969. 248 .
[5] .. (, ).
. : - . . , 2000. 428 .
[6] .., .. :
. . /: , 2007. 206 .
[7] , .. , : . . ... . . . ., 2008. 22 .
[8] .. : . .: , 1985. 232 .
[9] .. .: , 1984.
[10] .., .., .. . :
. .: , 1986. 384 .

TESTING OF BENT WIRE DENTURE

CLASP METALS HARDNESS AND CONDITION
AFTER TITANIUM AND ZIRCONIUM NITRIDE
PLASMA SPRAYING ON ITS SURFACE
E.V. Kuznetsova, V.I. Shemonaev
Dentistry department, prosthetic dentistry chair
Volgograd state medical university
sq. of Pavshih bortsov, 1, Volgograd, Russia, 400131

A.S. Stolyarchuk
Strength of materials chair
Volgograd state engineering university
Lenin avenue, 28, Volgograd, Russia, 400131

A.F. Trudov
Materials technologys chair
Volgograd state engineering university
Lenin avenue, 28, Volgograd, Russia, 400131
The durability comparative analysis of samples after different technologies of bent wire denture
clasp treatment proved statistically significant declination of its density characteristics after titanium
and zirconium nitride plasma spraying on its surface.
This declination is accompanied by experimentally found change in microhardness density distribution after plasma spraying (especially after zirconium nitride plasma spraying). The density declination in comparison with its initial state is one of the main reasons of bent premature denture clasp destruction in human mouth cavity exploitation.
Key words: bent denture clasp, removable, laminar denture, microhardness.

282




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[6], .
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283

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. 923 ( 32,33 9,73 ) . : -
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, ( X,
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(-, ), , , .
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: (r = 0,094, p = 0,004); (r =
= 0,166, p < 0,001); (r = 0,122, p < 0,001),
(r = 0,182, p < 0,001), (r = 0,230, p = 0,03) (r = 0,195,
p = 0,021), (r = 0,246, p = 0,002).
,
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284

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(105/189 ), ( = 0,269) (66/189 ).
(37,48% 0,02) ( = 0,003), (7,58% 0,008), . ,
, 30,31 8,1 .
I ( = 0,010)
(79,17% 0,08),
II ( = 0,004) (60,95%
0,05). ( = 0,053) I (36,37% 0,02), II (22,22% 0,03).
32,78 9,22 .
(17,98% 0,01) (14,52% 0,01),
(3,46% 0,005). 38,1 11,92 .
6 (0,65% 0,003) .
14 (1,52% 0,001) ,
12 . - .
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152 (16,47% 0,01) . , .
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285

 , , 2010, 4

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0,05) . ,
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85
.
.


[3].

[1] .., .., .. . : IV - . ., 2008 . 320.

[2] .. : IV - . ., 2008. C. 388389.
[3] .., .., .. : IX . ., 2007. . 436.
[4] .., .., .. .
//
. ., 2006. . 137138.
[5] .., .., .. . : IV
- . ., 2008. . 455.
[6] .., .., .. . : . , 2007. . 332333.
[7] .., .., .. .
: IV - . ., 2008. C. 476.
[8] Muzii L., Marana R. Postoperative administration of monophasic combined oral contraceptives
after laparoscopic treatment of ovarian endometriomas: a prospective, randomized trial // Am. J
Obstet Gynecol. 2000. 183. P. 588592.
[9] Taylor E., Williams C. Surgical treatment of endometriosis: location and patterns of disease
at reoperation // J. Fertil Steril. 2008.

286

 .. . ...

SURGICAL APPROACH
TO RESTORING REPRODUCTIVE FUNCTION
IN PATIENTS WITH TUMORS OVARIAN
E.P. Kuznetsova, F.K. Tetelytina
Chair obstetrics and gynecology
Izhevsk state medical academy
Komunarov str., 281, Izhevsk, Russia, 426034

K.G. Serebrennicova
Medicine of female with a obstetrics and gynecology course
Moscow state medical academy name Sechenova
Moscow, Trubeckaya str., 8, Moscow, Russia, 426034

R.Z. Halilov
MSP 3
Promushlenay str., 52, Izhevsk, Russia, 426000
Operated 923 patients with benign ovarian tumors. Organ-operative treatment with subsequent
post-operative therapy helped restore have 70 patients (7,58% 0,008). Among the 24 patients (34,28%
0,05) with the primary infertility and 44 (62,86% 0,05) with secondary.
Key words: benign ovarian tumors, surgical treatment.

 0
0

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288

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289

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,
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, , - .
,
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[1] 22 1993 . 5487-1

( . .).
[2] 25 2003 . 123 - .
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[4] 28.03.1998 . 53-
.

RESULTS OF MILITARY0MEDICAL EXAMINATION

AMONG BOYS PRE0 AND MILITARY AGE, LIVING
IN ORENBURG REGION
S.A. Kuzmin
Kafedra social health
Orenburg State Medical Academy
Soviet str., 6, Orenburg, Russia, 460000
The article gives results of military-medical examination among boys pre- and military age, living
in Orenburg region. The period of observation was 20002009 years. The statistical and analytical
methods were used. It was noted that the indicator of worthiness in Orenburg region in last 10 years
were improved. So that, this index at the military registration was 66,09% in 2009 years.
Key words: military-medical examination, health, boys, Orenburg region.

291




..

. . , 50, , 308000

..


. , 3, .-, , 197110

..
1
. , 96, , , 308015

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. , 85, , , 308015

, 708 , .
: , , .

-.
- , - [2]. - .
-
-.
. 708 -
( 60 73 , 65,2 3,4 , 302, 406 ).
.
. , ()
. 176 000 , -

292

 .. . ...

, - . -
[1], .. . 22 (
). - p.
. , , 4 - .
,
. -
. : ,
; , ,

; ; -;
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.

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, .
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293

 , , 2010, 4

ABOUT QUALITY
OF OTHORYNOLARINGOLOGICAL AID FOR ELDERS
N.. Kunitsyna
Medical Centre Pokolenije
Khmelnitskogo av., 50, Belgorod, Russia, 308000

.V. Perelygin
Department of clinical gerontology
Institute of Bioregulation and Gerontology
Dinamo av., 3, S-Petersburg, Russia, 197110

L.Yu. Varavina
1st Belgorod city poloclinic
Belgorodskij av., 96, Belgorod, Russia, 308015

S.L. Speranskij
Department of general surgary
Belgorod State University
Pobedy str., 85, Belgorod, Russia, 308015
The own scientific criteria of quality of gerontological othorynolaringological aid are presented in
this article.
Key words: elders, medical aids quality, othorynolaringology.

, 0

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295

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,
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,
N- ,
. N- 19 . N-
, . , , [6].
, N-
, , , ,

.

[1] .., .., .. . N-

, ,
// . 2180656. . . . . 2000119954; . 26.07.00;
. 20.03.02; . 26.07.00 (). 3 .
[2] .., .., ..
. .: , 1983. . 16.
[3] Eddy N.B., Leimbach D.J. // J. Pharmacol. Exp. Ther. 1953. Soc. 107. . 385393.
[4] Winstein S., Jakobs N.L., Levi E.F. et al. // J. Am. Chem. 1946. Soc. 68. . 27142718.
[5] .. . .: -,
1992.

296

 .. . , - ...

[6] .., .., .. .

N- // : .. , 70- . 2007. 3. . 310312.

SYNTHESIS, PHYSICAL AND CHEMICAL PROPATIES

AND BIOLOGICAL ACTIVITY OF AMIDE
N0ALLYLANTHRANYLIC ACID
E.R. Kurbatov, A.B. Shakirova, L.M. Korkodinova,
S.M. Bass, T.I. Yarygina
The chair of pharmaceutical chemistry
Perm state pharmaceutical academy
Polevaya str., 2, Perm, Russia, 614081
The amide of N-allylanthranylic acid was synthesized; the structure was confirmed by IR-, IMRand chromate-mass spectra, the anti-inflammatory, analgesic, antipyretic, ulcer, antihypoxic activities
and acute toxicity were studied.
Key words: amide N-allylanthranylic acid, anti-inflammatory and analgesic activities, acute toxicity.



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1

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8 (40%)

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,
.

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.
III,
II.
. .
.

[1] .., .. .
// . . 2009. . 1114.
[2] Williams D.A., Keefe F.J. Pain beliefs and the use of cognitive-behavioral coping strategies //
Pain. 1991. Vol. 46. P. 185190.

INFLUENCE OF PAIN BELIEFS ON RESUTS

OF ALGETIC SYNDROME TREATMENT
O.V. Kurushina, A.E. Barulin
Chair of neurology and neurosurgery
Volgograd State Medical University
Pavshih Bortzov sq., 1, Volgograd, Russia, 400135
Pain syndromes are very common and therapeutically resistant, and it is necessary to offer new
approaches with complex examination of the pain. The paper presents data about influence of pain beliefs on results of treatment of algetic syndromes.
Key words: pain, pain beliefs.




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301

 , , 2010, 4

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[4] .., .. - . ., 2000. 219 .

LINICAL MANIFESTATION
AND PHATOMORPHOLOGICAL ILLUSTRATION
OF MASSIVE HYPOXICAL INTRAVENTRICULAR HEMORRHAGES
IN NEWBORN BABIES
L.V. Ledyaikina, L.A. Balyukova, T.I. Razdolkina,
E.I. Naumenko, V.S. Vereshagina, E.L. Samoshkina,
L.I. Dzubich, S.V. Garina
Chair of pediatric
N.P. Ogariov Mordovian State University
Luxemburg str., 15, Saransk, Russia, 430032
We did a prospective study in newborn babies who had transferred from antenatal hypoxia of a
fruit and birth asphyxia. The authors made multifactor analysis of 51 case records of newborns to investigate the clinical features of intraventricular hemorrhages. The spent researches revealed the most frequent clinical symptoms: falling of a muscular tone and disappearance of suckling and swallowing reflexes, apnoea attacks and tachycardia.
Key words: impelent activity, apnoea attacks, eye semiology.




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304

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.

[1] .. , // . 2001. 9. . 1520.

[2] .., .., .., .. , , // . . 2008. 7. . 375378.
[3] .., .., .. // . 1990. 1. . 5256.
[4] .., .. // . 1990. . 110. 1(4). . 2033.

METABOLIC DISORDERS IN MYOCARDIUM

AT PANCREAS EXPERNL DAMAGE
.V. Letounovski, Z.I. ishinowich, .S. rn,
.I. ris, .I. Lichv, .S. slennikov
General and clinic biochemistry department 1
SEE HPE Rostov SMU
, Nakchichevanski str., 29, Rostov-on-Don, 344022
Acute and chronic pancreas damage by Triton X-100 leads to malfunction of lactate and pyruvate
aerobic metabolism and antioxidant defense system imbalance. Combination of acute pancreas damage
and chronic alcohol intake delays metabolic disturbances.
Key words: pancreas, myocardium, alcohol, antioxidant defense system.





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. , 1, , , 400131
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II .
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[1] .. . ., 2004. 178 .

[2] .. - : . ... - . . ., 1997. 151 c.
[3] .. : . ... . . , 1998. 112 .
[4] .. : . ... . . .
, 1999. 94 .

307

 , , 2010, 4

TREATMENT OF COMPENSATIVE
HORIZONTAL INCREASED DENTAL ABRASION
OF THE SECOND DEGREE
I.V. Linchenko, F.N. Zukanova
Chair of orthopedics stomatology
Volgograd State Medical University
Square of Fallen Fighters, 1, Volgograd, 400131
Preliminary orthodontic treatment with using of ondental plastic cup directed to the reconstruction
of myostatic reflex permitted us to find prosthetic space for production of aesthetic crowns and bridge
like prostheses in patients with generalized, horizontal, compensative, increased attriction of the second
degree.
Key words: Ondental plastic cup, increased attriction, myostatic reflex.




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309

 , , 2010, 4

(52%), (38%), (29,7%),

(16%), (.) 12%. , 11%
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310

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[1] .., .. // .
2009. 2. . 6468.
[2] .., .., ..
: //
. 2009. 1. . 8692.
[3] About ATC/DDD system. Oslo: World Health Organization Collaborating Center for Drug
Statistics Methodology // http:// www.whocc.no/atcddd
[4] Langsetmo L., Platt R.W., Ernst P., Bourbeau J. Underreporting exacerbation of chronic obstructive pulmonary disease in a longitudinal cohort // Amer. J. Crit. Care Med. 2008.
177 (4). P. 396401.
[5] Mc Ghan R., Radcliff T., Fish R. Et al. Predictors of rehospitalisation and death after a severe
exacerbation of COPD // Chest. 2007. 132 (6). P. 17481755.
[6] World Health Organization. Introduction to Drug Utilization Research. Oslo, Norway,
2003. P. 147.

REGIONAL PHARMACOTHERAPY FEATURES

OF A BRONCHIAL ASTHMA AND CHRONIC
OBSTRUCTIVE PULMONARY DISEASE
V.A. Lopukhova, I.V. Tarasenko
department for clinical pharmacology and intensive therapy
Volgograd state medical university
Pavshikh Bortsov Sq., 1, Volgograd, Russia, 400131
In article region features of pharmacotherapy patients with a bronchial asthma and chronic obstructive pulmonary disease in out-patient and stationary departments are presented. The received results were
revealed by new data about quality of pharmacotherapy and to estimate efficiency of medical aid.
Key words: ATC/DDD methodology, bronchial asthma, chronic obstructive pulmonary disease,
medications.





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// . . 2001. 5. . 15.
[4] .., .., .. // .. . 2002. . 5. . 333336.
[5] .
. 2.2.2006-05. .:
, 2005. . 129.

SPECIFIC CHARACTERISTICS OF PROFESIONAL DISEASES

IN THE SAMARA REGIONAND THE PROBLEM
OF WORKING CONDITIONS ESTIMATION MARK
IN CONFIRMATION IN THE INSURANCE EVENT
N. Lysov, S. Smirnov
Medicobiologic disciplines subdepartment
Samara Medical Institute REAVIZMinistry of Education and Science RF
Chapaevskaya str., 227, Samara, Russia, 443001
This scientific work is devoted to study the structure of the professional deseases, and to the

detectability problem of professional pathologies, objectiveness in estimation marks working conditions class, which gives a possibility to establish the workers disease character. We made well-founded
conclusion about the necessity changes to the working conditions estimation criteria.
Key words: production and working harmful factor, professional sickness rate, working conditions class, insurance event.

315




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[2] .., ., ., . - . ., 2008. . 296307.

318

 .., .. ...

EVALUATION OF COMPLEX REHABILITATION

OF DISABLED PEOPLE IN A SPECIALIZED CENTRE
Y.A. Mavlikaeva
Department of Public Health and Health Care
Perm State Medical Academy
Petropavlovskaya str., 28, Perm, Russia, 614990

V.A. Bronnikov
Social Work Department
Perm State University
Sivkova str. 14, Perm, Russia, 614022
The article represents an integrative approach to the evaluation of complex rehabilitation of disabled
people based on the International classification of functioning of health and vital activity restrictions (ICF,
2001). There is an algorithm of the evaluation of complex rehabilitation process considering dynamics of
indices that reflect communal, productive, social and professional activity abilities of a disabled person and
also a degree of his or her participation in different social relationships. The final evaluation of rehabilitation effectiveness is given on the basis of comparison between achieved results and initial parameters and
takes into account the degree of vital activity restrictions of a disabled person.
Key words: disabled people, complex rehabilitation, effectiveness.





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 , , 2010, 4

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CLINICAL EFFICIENCY OF MEDIUM AND HIGH DOSES

OF VALSARTAN IN THE TREATMENT OF PATIENT
WITH ARTERIAL HYPERTENSION
AND CHRONIC KIDNEY DISEASES
M.L. Maximov, O.V. Dralova
Department of Clinical Pharmacology
I.M. Sechenov MMA
Trubetskaya str., 8, p. 2, Moscow, Russia
The results of the study, which shows the efficiency of antihypertensive and nephroprotektive angiotensin II receptor blocker valsartan in patients with arterial hypertension of and chronic kidney disease. Dose dependence was confirmed nephroprotective and antihypertensive effects of valsartan, and
also marked by a high safety profile of the drug in the average and maximum therapeutic doses.
Key words: valsartan, BRA, arterial hypertension, chronic kidney disease, nephroprotective.


10 II



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CLINICAL EFFICACY
OF AT1 RECEPTORS OF ANGIOTENSIN II VALSARTAN
IN THE PHARMACOTHERAPY OF PATIENTS
WITH ARTERIAL HYPERTENSION
AND CHRONIC HEART FAILURE
A.K. Starodubtsev, M.L. Maximov,
O.V. Dralova, A.S. Ermolaeva
Department of Clinical Pharmacology
I.M. Sechenov MMA
Trubetskaya str., 8, p. 2, Moscow, Russia
Angiotensin receptor II, combining high efficacy and good tolerability, are one of the main groups
of drugs for the treatment of chronic heart failure. The study examines the efficacy of valsartan in the
clinical picture and laboratory parameters in the treatment of patients with arterial hypertension and
chronic heart failure.
Key words: valsartan, BRA, chronic heart failure.

325





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326

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327

 , , 2010, 4

.
, 15-, 25- 30- ,
.
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328

 .., .. ...

- [2, 3]. -
,
, - [5].
, ,

- - .
-
, .

[1] .., .., .. . .: - , 2006. 284 .

[2] .., .. , . .: , 2004. 362 .
[3] .. . .: , 1993. 138 .
[4] .., .., .. . .: , 2007 493 .
[5] Edenfeld G., Stork T., Klmbt Ch. Neuron-glia interaction in the nervous system // Current
Opinion in Neurobiology. 2005. V. 15. N 1. P. 3439.

DYNAMICS OF RNA QUANTITY CHANGE

IN NEURONEGLIA SYSTEM OF NUCLEUSES
MONOAMINERGIC OF A BRAIN DURING DEADAPTIVE
M.L. Mamalyga
Bakoulev Center for Cardiovascular Surgery
Russian Academy of Medical Sciences
highway Rublevskoe, 135, , Russia, 119049

L.M. Mamalyga
Chair of anatomy and physiology of human and animals
Moscow State Pedagogical University
Kibalchich str., 6, Moscow, Russia, 129164
Influence of deadaptive on RNA quantity changes in neurone-glia system of monoaminergic nucleuses of a brain is studied. Action of a hypoxia during the different periods deadaptive is accompanied
by the greatest vulnerability of cellular structures of dopaminergic and serotoninergic nucleuses of a brain,
it limits functionalities of systems stress-limiting.
Key words: hypoxia, deadaptive, neurone-glia, RNA.

329




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- .
, -
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(, , ,
, , ) 87,3% .
. -
. , -
.
- , -

331

 , , 2010, 4

, ,
- , , . -
(, ).

[1] .., .., .. - . : , 2009. . 3552.

[2] .., .., .. . - // . 2009. 2.
. 2831.
[3] Jones A., Rowe B.H. Bronhopulmonary hygiene physical therapy in bronchiectasis and chronic
obstructive pulmonary disease: a systemic review // Heart. Lung. 2000. 29(2).
P. 125135.
[4] Nolan M., Nolan J. Arhritis and rehabilitation: development in the nurses role // Br. J. Nurs.
1998. 7(1). P. 3739.
[5] Nolan M., Nolan J. Rehabilitation: realising the potential nursing contribution // Br. J. Nurs.
1997. 6(20). P. 11761180.

THE SHORT0WAVE0THERAPY IN REGULATION

OF GENERAL VASUS RESISTANCE
IN POLYMORBIDITY IN ELDERS
D.S. Medvedev
Department of clinical gerontology
Institute of Bioregulation and Gerontology
Dinamo ave., 3, S-Petersburg, Russia, 197110
The non-drug treatment is the one of the field of modern medicine. The role of short-wavetherapy in regulation of some parameters of hemodynamic is describe in this article.
Key words: short-wave-therapy, hemodynamic.

 001

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,
, , - 19 . .
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[1] .., P.M., .. // . .: , 1980. 268 .

[2] .., .., .. // . . 2007. 5.
. 3739.
[3] .., .. // . 2006. 9. . 1318.
[4] .., .., .. // . 2004. 3.
. 139154.

THE USE OF DGKDT001 COMPUTER TECHNOLOGY

FOR HEALTH STATE EVALUATION OF MEDICAL PERSONNEL
G.A. Merkulova, E.V. Pegova
Scientific Center Arktika, Far East Branch RAS
Kirova str., 95, Vladivostok, Russia, 690022

M.S. Tulupova
Medical Centr Paracels
Novoivanovskay str., 4, Vladivostok, Russia, 690005
The use of DgKDT-01 technology for preventive medical examinations helps to differentiate examined patients by integral health indexes, uncover the structure and features of pathological process. It
helps to discover diseases on early stage.
Key words: health, new diagnostics methods.




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[5]. , , .

[1] .., .., .. . .: ,

2000. . 36.
[2] .., .., .. :
. .: , 2004. . 38.
[3] .. . . : , 2007.
. 416432.
[4] .., .. .
// . 2005. . 4. 1. . 611.
[5] .., .. : . . .: -, 2006. . 2021.

COMBINATION SUBTOXIS DIPHTHERIA OROPHARYNGEAL

AND ACUTE CYTOMEGALOVIRUS INFECTION PERSISTENCE
IN A CASE OF EPSTEINBARR VIRUS IN A CHILD 5 YEARS
(clinical case)
A.V. Mitrofanov, T.A. Ovchinnikova,
T.V. Komarova, E.S. Gasilina
Department of childhood infections
Samara State Medical University
MMU City Hospital 5
6-I Dachnaya glade str., Samara, Russia, 443029
The appearance of this article due to a significant deterioration in the process of diphtheria in
children are not vaccinated or vaccinated improperly. This situation is caused by a change in the pathogenicity of the pathogen, but also unreasonably refused by parents of immunization, increasing medical
contraindications to immunization and late dates of the beginning of vaccination, which contributes to
the accumulation of layers of non-immune children.
Key words: subtoxic diphtheria, cytomegalovirus infection, EpsteinBarr virus.

341

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346

 .. . , ...

[1] .., .., .. . /

. . . .. , . .. . .: , 1998. 383 .
[2] : / . . .. . . 3. . 1. . 2. .: , 1999. 544 .
[3] .., .., .. . 50 // . 2009. 2.
. 5781.

PARAMETERS OF THE SCHOOL ENVIRONMENT

AS A FACTOR THAT AFFECTS THE HEALTH OF PUPILS
K.Yu. Mikhaylichenko
Department of Judicial Ecology
Ecological Faculty
Peoples Friendship University of Russia
Podolskoye shosse, 8/5, Moscow, Russia, 113093

V.A. Nazarov
Secondary school 21
Pobratimov str., 28, Lyubertsy, Moscow Region, Russia, 140009

A.S. Kondrashova
Directorate, Testing laboratory
Southern District of Education Department of Moscow
Visokaya str., 14, Moscow, Russia, 115533

A.Ya. Chizhov
Department of Ecological Monitoring and Prognostication
Ecological Faculty
Peoples Friendship University of Russia
Podolskoye shosse, 8/5, Moscow, Russia, 113093
The article studies the influence of environmental factors on the childrens organism of whose
health is an indicator of the ecological situation. School buildings and facilities in many respects do not
meet the standards imposed on such institutions. In this research, measurements were made of physical
factors of the school environment, assess the health status of students.
Key words: sanitary survey, the health of children, physical factors, the maximum allowable levels.

347




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, 8, , , 127051
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Xerox, HP, Dupont, Motorola, Chase, Kodak, Procter&Gamble, IBM, Boeing .

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350

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.. , ..
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351

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;


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;
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;
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[1] .., .. // . XXI . . 2009. . 683685.

352

 A.., .. ...

[2] .., .. // . XVI , . 2009. . 700701.

[3] .., .., .. // . , . . 64. 2009. . 545546.
[4] .. // . 2004.
11. . 37.

POSSIBILITIES OF APPLICATION OF BENCHMARKING

IN INCREASING OF COMPETITIVE ADVANTAGES
OF THE CHEMIST'S ORGANIZATIONS
A.V. Mikhaylov, N.D. Bunyatyan
Federal State Agency Science Center for Drugs Evaluation
Petrovsky blvd., 8, Moscow, Russia, 127051
During the recent years benchmarking has been one of the most effective and well recognized
methods of improving business processes as well as become one the most efficient management instruments. Despite its key practical importance, benchmarking is not widely spread in the chemist's shop
business. The current work provides methodological approach for using benchmarking to identify the
leading chemists shops who would have best combination of competitive advantages. It also identifies
main factors of improvement of competitive position of chemist-shops as well as success factors to decrease competitive gaps.
Key words: chemist-shop, benchmarking, competitive advantages.

0

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..


. , 89, , , 443099
70 - . ,
.
II . III
.
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.

[3]. -
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: 70 . 1-
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3- . 26 .
, , , , , , -6-.

354

 .., .., .. - ...

: 2- . , 34% ( < 0,05) 31% ( < 0,05). , , , -6 50% ( < 0,05), 27% ( < 0,05)
49,7% ( < 0,01) . 3- . 17% ( < 0,05),
, , , -6- 25%, 20%, 24% 22% ( < 0,05). 1-, 2- 3- 47% ( < 0,05), 28% ( < 0,01)
105% ( < 0,01). ( ) 1-
2- , 2- . 3- - .
. 2- ,
. (3- ),
, , .

[1] .., .., ..

// . 2008. 1.
. 4550.
[2] Barnes P.J., Shapiro S.D., Pauwels R.A. Chronic obstructive pulmonary disease: molecular
and cellular mechanisms // European Respiratory Journal. 2003. Vol. 7. P. 672
688.
[3] Dourado V.Z. Systemic manifestations in chronic obstructive pulmonary disease / V.Z. Dourado, S.E. Tanni, S.A. Vale et al. // J. Bras. Pneumol. 2006. Vol. 32. C. 161171.
[4] Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for diognosis,
managemant, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO workshop report. Last updated 2006.
[5] MacNee W. Oxidative stress and lung inflammation in airways disease // European Respiratory Journal. 2001. Vol. 429. P. 195207.

355

 , , 2010, 4

OXIDANT0ANTIOXIDANT STATUS OF ERYTHROCYTES

IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
N.A. Mishina, I.L. Davydkin,
V.I. Kupaev
Chair of Hospital Therapy
Samara Medical University
Chapaevskaya str., 89, Samara, Russia, 443099
In 70 patients with COPD studied mechanisms of oxidative stress on the changes in oxidantantioxidant status of erythrocytes. Found that the intensity of oxidative stress in red blood cells is directly dependent on the severity of the disease. Maximum activity of antioxidant enzymes found in patients with secondary erythrocytosis with stage II disease. In patients with stage III COPD, oxidative
stress was significantly expressed and is associated with a sharp fall in activity of antioxidant systems.
Key words: COPD, oxidative stress, erythrocytes, antioxidant systems, secondary polycythemia.




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. , 48, , , 614990
. , : II, 200 VV, 500.
: ,
.

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357

 , , 2010, 4

. 1 , R 972 V ,
302 18,20%. 500
(0,0200,146). 500 .
508,39 1200,48, 500.
( 1 : 2, 2%) : 1 IX, , I; 2 IX, , II; 3 IX, ,
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23,30 0,04
24,07 0,03
23,83 0,01
21,20 0,01
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,
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358

 .., .. ...

, : II, 200 VV, 500.

[1] .., ..
// - 21 .
, 2003. . 286288.
[2] // . 2005.
6. . 30.

THE INFLUENCE OF TECHNOLOGICAL PARAMETERS

OF ADJUNCTS ON THE QUALITY OF POWDERS
WITH BIFIDOBACTERIA
.I. Molohova, L.G. Grigoryan
Chair of industrial technology with the course of biotechnology
Perm state pharmaceutical academy
Lenin str., 48, Perm, Russia, 614990
Adjuncts for industrial production of powders on the base of bifidobakteria have been investigated in thes work. The Results of the technological properties comparative analysis of the experimental
variants of powders show, that it is the most rational to use the following excipients: Lactose II, Aerosyl
200 VV, microcrystalline cellulose 500.
Key words: dosed powders on the base of bifidobakteria, adjuncts.



.. , .. ,
.. , ..


. , 40, , , 656038
Wistar . , .
: , , .

.

.
.
.
. 30
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.
. .
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360

 .. .

18,0 7,00 . , , ( , , ).
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16,5 6,51 . , .
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RENAL STRUCTURE REORGANISATION EARLY

IN THE DEVELOPMENT OF EXPERIMENTAL
NEPHROLITHIASIS MODEL
N.V. Motina, A.V. Lepilov,
A.Yu. Zharicov, Yu.G. Motin
Histology dept.
Altai State Medical University
Lenin pr., 40, Barnaul, Altai Territory, 656038
The results of kidney medulla morphological study from Wistar rats with ethylenglycol oxalate
nephrolithiasis model are analyzed. Alteration of internal and external medulla, calcium deposits allocation characteristics are evaluated.
Key words: experimental nephrolithiasis, kidney, morphology.




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365

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, : ; ,
; ; ;
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, .

[1] .. . .: -, 2003. 270 .

[2] .., .., .. : : , , . ,
2009. . III. . 142145.
[3] .. . .:
, 2005. 495 .
[4] ., ., . . : . .:
, 2005. 150 .
[5] .., .., .. .
.: -, 2006. 1104 .

COMMUNICATION CULTURE OF MEDICAL INSTITUTIONS

AND PATIENTS AS THE FACTOR OF MAINTENANCE
OF EFFICIENCY OF MEDICAL AID
D.L. Mushnikov, B.. Polakov, .V. rlova,
.M. Bajutin, D.. Carpov, S.V. Schultz
Chair of public health and public health services,
medical computer science and medicine history
Ivanovo state medical academy
F. Engelsa str., 8, Ivanovo, Russia, 153034
Article is devoted communication culture medical establishments and patients as to the factor of
maintenance of efficiency of medical aid. Authors on the basis of studying of communication culture of
medical institutions and patients a different profile conclusions about necessity of management of this
phenomenon on the basis of the complex approach become.
Key words: communication culture, efficiency of medical aid.

366



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367

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,
57,6% , 71,2%, 60,5%, 45,6%, 58,7% (p > 0,05).
: , , . ,

368

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55,6%, 53,9% (p > 0,05); : 52,5%, 58,7%, 57,3%, 55,5% (p > 0,05);
: 46,7%, 40,5%,
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(p > 0,05).

,
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369

 , , 2010, 4

80,2% (p > 0,05).

: , , .
,
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> 0,05); : 20,4%, 21,8%, 23,2%, 21,5% (p > 0,05); : 21,2%, 22,4%, 22,6%, 20,7% (p > 0,05).
, (p = +0,8). , :
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.

[1] .., .., .. . - , // . 1993. 3. . 78.

[2] .. //
. 1998. 4. . 2426.
[3] ., ., . . : . .:
, 2005. 150 .

INFORMATION CULTURE OF PATIENTS

AND A WAY OF ITS INCREASE
N.N. Uglanova, D.L. Mushnikov, V.V. Kostin,
M.V. Kizeev, .V. Stvolygin, A.V. Naumov
Chair of public health and public health services,
medical computer science and medicine history
Ivanovo state medical academy
F. Engelsa str., 8, Ivanovo, Russia, 153034
Article is devoted the analysis of a current state of information culture of patients of a different
profile. Authors allocate 5 components of information culture of patients, give them characteristic, offer
a set of measures on its increase.
Key words: information culture, patients, medical services.

0

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376

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(12,1%),
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(I-PSS) [5]. , (42%) , (34%) 24%.
, : (38%);
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377

 , , 2010, 4

.

, .
.
, ,
.
, -,
, , .
[1]

[2]
[3]

[4]

[5]
[6]

.., .. , // , .
2001. 5. . 1819.
.., .. //
. 2004. 5. . 2526.
.., .., .. . // . 2001. 7. . 1133.
.., .., ..
// . 2008.
. 16. 17. . 11341138.
.. //
. 2001. 5. . 1619.
: / . .. . .: ,
2000. 560 .

MEDICOSOCIAL RESEARCH
OF PATIENTS WITH CHRONIC PROSTATITIS
A.I. Ovod
Kursk state medical university
Karl Marks str., 3, Kursk, Russia, 305041

M.D. Mukovnina
Voronezh N.N. Burdenko state medical academy
Studencheskaya str., 10, Voronezh, Russia, 394036
Comprehensive medicosocial analysis of patients with chronic prostatitis is carry out in some directions such as socio-demographic characteristic, self-appraisal of medical culture, opinion of risk factors, attitude to disease, quality of life.
Key words: prostatitis, medicosocial research.

378



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.
. , 6, , , 173020
() . , . . - . ,
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1993 . , , - . ,
90 .
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20002001 . 2006
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.

. 1.
1998 2008 .

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[1] .. . ., 2000. 442 .

[2] .., .., .. . . .: , 2000. 80 .

EONOMIC ASPECTS
OF UROGENITAL CHLAMIDIOSIS TREATMENT
L.B. Okonenko, E.S. Egorova
Pharmaceutics Department
Novgorod State University named after Yarosiav the Wise
Derzhavin str., 6, Velikiy Novgorod, Russia, 173020
The investigation of urogenital chlamidiosis treatment in the Novgorod region has been conducted. The incidence of urogenital chlamidiosis in the region has been analyzed as well as the assortment of drugs available in the municipal chemist's shops. Sociodemographic picture of a patient with
UGC has been designed. The most commonly applied drug protocols have been revealed; of them the
most effective and suitable ones have been chosen considering the treatment of side-effects.
Key words: chlamidiosis, parmacoeconomy.



..


. , 46, , , 614070
() [1].
: , (), .

(-, , ), (), (, , ), (, ) : , , , , [2].

. pH
. 42-3874-99 . 42-3874-99, .
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(), . (OEG/UEG), ,
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19 . : 0,15; 6,67,4; 9,510,5%.

383

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OEG (3S) ; M

, ,

. 2
25 .

[1] 50779.42-99 ( 8258-91). .

. 15 1999 .
[2] XI. 1987. . 199.
[3] 5725-1-2002. ( ) . 1. . 23 2002 .
[4] 3.3.2.1886-04. -
: , . 4 2004 .

USE OF CONTROL CARDS OF SHUHART FOR CERTIFICATION

IMMUNOBIOLOGICAL PREPARATIONS
E.V. Orlova
Chair of industrial technology with a biotechnology course
Perm state pharmaceutical academy
Krupskaya str., 46, Perm, 614070
In clause questions of certification medical immunobiological preparations (MIBP) on various parameters with construction of control cards of Shuhart are considered.
Key words: certification, control cards of Shuhart, preparations MIBP.

385





..



. , 1, , , 400131

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. 1315 .
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, , , , , . , ,
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-

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Se Sp ,
.
(55%
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(80% 100%).
,
,
.

[1] .., .., .. . .: , 1980. 260 .

[2] .., .., .. .
: . .: -, 2006. 96 .
[3] .. . .: , 1988.
256 .
[4] .., .. , // : , , . 2001. 4. . 3745.

388

 .., .., .. ...

DIAGNOSTICALLY EFFECTIVNESS
OF MEDICAL CONTROLS METHODS EVALUATING
FUNCTIONAL CONDITION OF TEENAGERS BACKS
L. Osadshaya
Faculty of normal physiology
Volgograd State Medical University
Pavshih Bortcov square, 1, Volgograd, Russia, 4000131

A. Bogachev
Faculty of Theory and methods of adaptive physical culture
Volgograd State Academy of Physical Culture
Lenina avenue, 78, Volgograd, Russia, 400005

I. Gretskaya
Faculty of Sports Medicine
Volgograd State Academy of Physical Culture
Lenina avenue, 78, Volgograd, Russia, 400005.
We evaluated the sensibility, the specificity and the diagnostically effectiveness of the main indexes of functional condition of teenagers backs, which are used in methods of medical control of their
physical training.
Key words: medical control, the functional condition of back, diagnostically effectiveness.



.. , .. ,
..



. , 1, , , 400131
, .
: , , , , .

,
, , , (
), . , , , ,
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[1, 2, 3, 4, 6]. , , , .

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,
, [4].

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). -

390

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, , ,
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, , , , [2].
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3 ;
4 .

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, [4].
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391

 , , 2010, 4

, , , ..
. ,
.
.

[1] .. : // . 2002. 1. . 6465.

[2] .., . // . 2001. 3. . 5860.
[3] .., .., .. . ( II) // . 2007.
1. . 126127.
[4] .. : . .: , 1977. 391 .
[5] . . .: Newdent, 2007. 367 .
[6] .. .
// . 2009. 3. . 411.
[7] .. . -, 1983.
272 .

THE PRACTICAL IMPORTANCE

OF DIAMOND BURS TEARING
A.N. Parhomenko, V.I. Shemonaev,
T.V. Motorkina
Prosthetic dentistry chair
Dentistry department
Volgograd state medical university
sq. of Pavshih bortsov, 1, Volgograd, Russia, 400131
In this article is present consideration to basic reason of tearing of diamond burs, as well as consequences of this process.
Key words: diamond burs, tearing, abrasive grain, operation mode, quality of surface.

392



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. . ..
. , 6-9, , , 614051
,
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. 12 ( ), 90 87,1% 96,7% . 30
, , , 30 2 . .
30 -

393

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(). (). (t),
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394

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~ ( < 0,05, t).

. .
: , , .
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ARDS, ) , ,
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. 1.
( .., 2005)

395

 , , 2010, 4

,
, (.
. 1). , , .
,
, , . ,
.
.
/ (. 1)
, .
(46 ): /, . :
/ (), (rs = 0,863, < 0,01); / () (rs = 0,901, < 0,01) () (rs = 0,893, < 0,01).

,
. , , , .
, , ,
, , [1, 3]. ,
, ,
. . ,
.
, , .
[4]. , -
.
[5]. , , , , . ,

.

396

 .., ..

, , , , ,
.

[1] .., .. // . 2000. 3. . 1925.

[2] .. // . 2004. 3. . 58.
[3] .. // . 1996. 2. . 4550.
[4] Esbenshade A.M., Newman J.H., Lams P.M. et al. Respiratory failure after endotoxin infusion
in sheep: lung mechanics and lung fluid balance // J. Applied Physiology. 2003. Vol. 53.
Is. 4. P. 967976.
[5] Ferguson J.S., Schlesinger L.S. Pulmonary surfactant in innate immunity and the pathogenesis of tuberculosis // Tuber. Lung Dis. 2000. Vol. 80. 45. P. 173184.

ABOUT LYMPHATIC AND SURFACTANT SYSTEMS

INTERRELATION IN PULMONARY TUBERCULOSIS
I.M. Peleneva, S.A. Stepanov
Chair of phthisiopneumology
Perm State Medical Academy
Zvonareva str., 6-9, Perm, Russia, 614051
Abstract: the information about lymphatic and surfactant systems interrelations in pulmonary tuberculosis based on experimental and clinical observations are discussedd in this article. Surfactantprotective effect of lymphotropic therapy have been proved in patients with pulmonary tuberculosis.
Key words: surfactant, tuberculosis, lympha.



..


. , 3, .-, , 197110

.
.
: , .

.
.
, 1950 . 50
214 , 1975 . 350 , 2000 . 590 , 2012 .
1 100 , 15% .
, 75 . 1999 .
30 , 19% , 3,2
80 . 19992009 . .


.
,
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, , - . , ,
[3]. - , 30% [3, 5, 6, 7].
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[8, 9].

398

 .. ...

.
: 37 33 . . 6064 ., 68,2 3,4 .
. . 1

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1

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()
()

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, ,
,
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.
.
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.
.
.

399

 , , 2010, 4

.
, . .

[1] .., .., .. . ,

// . 1995. N 3(4). . 64.
[2] .., .., .., .. // . 1980.
5. . 4145.
[3] .., .., .. . : , 2009. 123 .
[4] Hood J.D., Korres S. Vestibular suppression in peripheral and central vestibular disorders //
Brain. 1979. Vol. 102. N 4. P. 785804.
[5] Hughes R.G. The role of perilymph in human labyrinthine physiology // J. Laryngol. and
Otol. 1971. Vol. 85. N 1. P. 1116.
[6] Infantellina F., Riva Sanseverino E., Urbano A. Electroencephalographic changes as a result
of labyrinthine stimulation after strychninization of the paraflocculus in the dog // Arch. Itol.
Biol. 1963. Vol. 101. P. 430443.
[7] Ishikawa K., Satoh K. Effects of blindfolding a unitatera: eye on so-called central nystagmus //
Arch. Oto-Rhino-Laryngol. 1983. Vol. 238. N 1. P. 6975.
[8] Lovell M. Caring for the elderly: Changing perceptions and attitudes // J. Vasc. Nurs.
2006. Vol. 24(1). . 2226.

THE VESTIBULAR FUNCTION IN ELDERS PATIENT

WITH SENSONEURAL POOR HEARING
.V. Perelygin
Department of clinical gerontology
Institute of Bioregulation and Gerontology
Dinamo ave., 3, S-Petersburg, Russia, 197110
In modern medicine the physiotherapy is one of the main methods o treatment and rehabilitation.
This problem in elders is presented in this article.
Key words: elders, sensoneural poor hearing.

400




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[5, 8].
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[5, 6].
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402

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14 804

2003 .
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15 415

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15 176

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2008 .
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22 . , , .
.

[1] .., .., .. .

, 1997. 168 .
[2] .., .. . .: -, 1997. 188 .
[3] .. ( ) //
. . 2009. 2. . 2429.

404

 .., .. ...

[4] .. // . 2008. 1. . 3133.

[5] .., .., .. .
.: -, 2009. 196 .
[6] / . . .. , .. . .:
, 2005. 448 .
[7] .., .., .. , // . 2004. 3. . 3740.
[8] .., .., .. // . 2008. 10. . 3443.
[9] .. . .: -, 2004. 206 .

REDUCING OF EARLY REPRODUCTIVE

LOSSES AS A RESERVE OF IMPROVEMENT
OF DEMOGRAPHIC SITUATION IN COLA POLAR REGION
(on Monchegorsk for example)
E.Y. Perova
Department of gynecology
Central City Hospital
Kirova str., 6, Monchegorsk, Russia, 184511

E.G. Gumenjuk
Department of obstetrics and gynecology
Petrozavodsk State University
Kirova str., 15, Petrozavodsk, Russia, 185035
In article the analysis of the developed demographic situation in the Kola Polar region is carried
out. 1539 patients with reproductive losses in terms till 22 weeks of pregnancy are surveyed. Risk factors of artificial abortion, miscarriage, ectopic pregnancy are distinguished; the social and medical portrait of women with reproductive losses is composed.
Key words: demographic situation, pregnancy, early reproductive losses, risk, preventive strategies.



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,

407

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[1] ., ..
. .,1997.
[2] .., .. //
, 2007.
[3] ..
: . . ...
... --, 2006.
[4] .., .. - . . , 2007. . 511, 2030.
[5] .. -
// . ., 2009 . 14.

408

 .., .. ...

ASSESSMENT INFLUENCES OF BIOFEEDBACK

IN COMPLEX OF REABILITATION MEASURES
PATIENTS UNDERGOING STRESS
A.G. Polyakova
Research Institute of Traumatology and Ortopaedics
V. Volzskaya nab., 18/1, N. Novgorod, Russia, 603155

V.V. Matveeva
Medical Unit, doctor of recovery medicine
Lenina str., 210, Rostov-on-Don, Russia, 344113
Control of apparatus biocontrol course efficiency followed on dynamic of clinical symptoms, electrocardiogram indexes, ardiointervalographic, questionaries characterizing condition of psycho emotional
sphere. Rehabilitation results of the patients who got BOS therapy proved its efficiency.
Key words: vegetative disfunctions, biocontrol apparatus, heart rate variability.




.
.. , ..



. -, 8, , , 117198
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: , .

. (20072008 .),
, 40% .

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410

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411

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413

 , , 2010, 4

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3. .
4. , .

[1] .. . ., 2009.
236 .
[2] .. . ., 2005. 230 .
[3] .., .. . .: , 2001. 32 .
[4] .. (, , ): . ... . . . , 2002.
[5] William V., Messer L.B., Burrow M.F. Molar Incisor Hypomineralization: Review and Recommendations for Clinical Management // Pediatric Dentistry. 2007. 28:3 P. 224232.

414

 .., .. ...

[6] Rogan W.J., Brady M.T. and the Committee on Environmental Health, and the Committee on
Infectious Diseases Drinking Water From Private Wells and Risks to Children // Pediatrics.
2009. 123. P. 11231137.
[7] Lygidakis N.A., Dimou G., Marinou D. Molar Incisor Hypomineralisation (MIH). A retrospective clinical study in Greek children. II. Possible medical aetiological factors // European
Archives of Paediatric Dentistry. 2008. 9 (4). P. 207217.
[8] .. . ., 1998.

STUDYING OF INTERRELATION OF QUALITY

OF POTABLE WATER IN THE ZONE OF RESIDING
OF CHILDREN WITH NONCARIOUSES DEFEATS
OF ENAMEL OF THE TEETH
A.I. Pronyaeva, T.F. Kosyreva
Department of Pediatric dentistry with course of Orthodontics
Medical faculty
Peoples friendship university of Russia
Miklukho-Maklaya str., 8, Moscow, Russia, 117198
The ecological trouble of water, influencing on the infringement of the mineralization of enamel,
is able to serve as a factor of the stomatologic disease. Enamel hypoplasia is connected with mineralization infringement during the certain age period under the influence of the local and general pathological
factors leading to infringement of formation of an enamel matrix, its mineralization and maturing.
Key words: enamel hypoplasia, water of the centralized water supply.




.. , ..



. -, 8, , , 117198

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. , 8, , , 125315
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416

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. ,
.
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1
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..

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50%
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0%

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417

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400 5067

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418

 .. . ...

,
(, .).

, , , .

[1] .., .. /
: . . .: - , 1987. 166 .
[2] .., .., .., .. . : , 1987. 256 .
[3] .., .. .
: , 2002. 397 .
[4] ., ., . . // Cathedra. 2006. . 5. 3. . 4649.
[5] .. . .: -,
2001. 216 .
[6] Klokkevold P.R. Risk Factors // J Calif Dent Assn. 1999. 27 (2). P. 135142.

PROPHYLACTIC DENTAL
CHECK0UP WITH ADDITIONAL USE
OF LASER CORRELATION SPECTROSCOPY
R.S. Prosvetov, V.I. Torshin
Department of normal physiology
Medicine faculty
Russian Friendship People's University
Miklukho-Maclay str., 8, Moscow, Russia, 117198

I.B. Alchinova, E.N. Arkhipova, N.P. Antonov

Laboratory of polisistem researches
Establishment of the Russian Academy
Medical Sciences Institute of General Pathology and Pathophysiology
Baltic str., 8, Moscow, Russia, 125315
Based on data obtained from the dental check-up with additional study oro-pharyngeal washout
fluid, were evaluated the intensity and prevalence of periodontal diseases of students from Russia and
South Asia of the Russian Friendship Peoples University. In the study of oro-pharyngeal washout fluid
by the method of laser correlation spectroscopy revealed that a group of students from South Asia, with
signs of periodontal disease, there is a shift of the spectrum towards larger particles.
Key words: laser correlation spectroscopy, oro-pharyngeal washout fluid, LC-histograms, tooth,
periodontium, dental check-up, dental index.

419



..
2

. , 85, , , 308015

.. , .. , ..


. , 3, -, , 197110

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: , .

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- .
: 1582 , - .
. 32,2 2,7% , .
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(25,1 2,5%),
(18,3 2,2%).


(29,3 2,6%), < 0,05. , (12,4 1,9% ) , < 0,05. (27,3 2,5%), (31,4 2,6%).
34 : 79,3 2,3% , 68,1 2,6%, 79,2 2,3%.

420

 .. .

, 12 :
17,3 2,2%, 29,0 2,6%, 21,1
2,3%. , , 5
6 (1,7 0,7%).


. 41,7 2,8% 6 10
, 52,1 2,9% 11 15.
.
6 15 (11,2 3,2 ) . 6 10
36,1 2,8%, 11 15 57,9 3,1%. , , , . , 6 10 18,5 2,2% , 11
15 53,5 2,8%, 16 20 21,0 2,3%.
,
. 12,1 1,9% , ; 9,2 1,7% ; 7,3 1,5%
; 6,2 1,4% .
37,5 2,8% .
9,2 1,6%
, 7,1 1,5% , , .
12,3 1,9%
, 11,4 1,8% , 8,1 1,5%
. 52,2 2,9% , 42,4 2,8%.
.
, . , - , .
, .

[1] .., .. - . .: , 2007. 190 .

[2] .. - // -
. 2001. 3. . 1113.

421

 , , 2010, 4

[3] .., .. . .: , 2003. 317 .

[4] .., .., .. - // . 1998. 5. . 36.
[5] .. . .: , 2003. 304 .
[6] Lovell M. Caring for the elderly: Changing perceptions and attitudes // J. Vasc. Nurs.
2006. Vol. 24(1). . 2226.
[7] Mauk K.L., Mauk J.M. Financial gerontology and the rehabilitation nurse // Rehabil. Nurs.
Vol. 31(2). . 5862.

PHYSIOTHERAPY IN THE SYSTEM

OF MEDICAL AID FOR ELDERS
K.I. Prashchayeu
Department of therapy
Belgorod State University
Pobedy str., 85, Belgorod, Russia, 308015

D.S. Medvedev, G.I. Gurko, .V. Perelygin

Department of clinical gerontology
Institute of Bioregulation and Gerontology
Dinamo ave., 3, S-Petersburg, Russia, 197110

N.. Kunitsyna
Medical Centre Pokolenije
Khmelnitskogo ave., 50, Belgorod, Russia, 3221042
In modern medicine the physiotherapy is one of the main methods o treatment and rehabilitation.
This problem in elders is presented in this article.
Key words: elders, non-drug treatment.



*
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* ( 08-03-00488).

423

 , , 2010, 4
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1

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1 ; 2 .

, 16 5
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424

 .. . ...

, .

[1] .., .. - . .: , 2002.

298 .
[2] .., .., .. .
a- // ,
: . . . / . . . . ,
2009. . 64. . 455456.
[3] .., .., .. // . 2008. . 54.
5. . 4350.

DIRECTED SEARCH OF HYPOGLYCEMIC COMPOUNDS

IN THE SERIES OF AROYLPYRUVIC ACID DERIVATIVES
N.A. Pulina, T.A. Yushkova,
A.I. Krasnova, V.V. Yushkov
Dept. of pharmacology, clinical pharmacology
Perm State Pharmaceutical Academy
Lenina str., 48, Perm, Russia, 614990
The article deals with synthesis of new oxovanadium metal complexes in the series of esters and
arylamides of aroylpyruvic acids. Comparative estimation of hypoglycemic activity of original ligands
and obtained chelates is conducted. The introduction of oxovanadium into molecule is found to potentiate sugar-reducing activity.
Key words: oxovanadium complexes, hypoglycemic activity.



.. , ..


. , 10/1, , , 603005

.
: ,
, .

,
, , , .
, , . , , . .. , .. .
: -, , ,
; -, - - [1].
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, ,
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. ,
, . , - ,
,
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426

 .., .. ...

, .
, , ,
.
, ,
,
. .
1128 , 62%
38% . , : 24 ; 25 45 ; 46 60 .
, .
: 11% , 41% , 23% , 25% , .
, , (78,7% ) ,
- , . :
? 65,6% ; 15,1%
; 10,2% ,
;
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; 2,4% , , . : ?
37,6% .
, 38,8% , ,
,
.
: , ? ,
41,3% , . , , 52,7%
, 45,2% , 34,6% 27,5% , 27,1%
,
9,4% , 5,8% -

427

 , , 2010, 4

, 2,3% ( , 100,0%).
,
, ,
, .

[1] .., .., .. // I . .: , 2002. . 3536.

PATIENT SATISFACTION QUALITY

OF CARE IN HOSPITAL
O.M. Pyatilyshnova, N.V. Zelyaeva
Chair of Health Organization and the Organization of Nursing
Nizhny Novgorod state medical academy
Minins str., 10/1, Nizhny Novgorod, 603005
To characterize the quality of the provision of hospital health care workers was studied to assess
their satisfaction with medical care.
Key words: quality of hospital care, patient satisfaction with medical care, health workers.


0

.. , .. ,
..


. , 46, ,
- () . , ,
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: - , ,
.

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6 . ( 2009 .
2010 .) . .
: , , , .
.
1086 .
(75,6%), (24,4%), ! (20,73%),
(4,88%) (2,44%). , ,
30 (92,24%), 81,24% .
, 50% . ,
[3]. -

429

 , , 2010, 4

(87,7%) , , ,
, .
, , - ,
-
. (45,29%) , , 592 (54,71%) ,
.
,
- 5,82% . .
,
.

,
. ,
: Vichy (92,7%), Lierac (70,15%), Bioderma (66,64%), La-Roshe (59,43%) Ducray (8,87%), Avene
(6,93%) Galenik (6,01%).

. 005-93
( 91 5800 ) : (, , , ),
, [3].
. , .
. , - : .

[1] Rivers J.K. The Role of Cosmeceuticals in Antiaging Therapy // Skin Therapy Letter.
2008. 13.
[2] . -
: . . ... . . . ., 2009. 29 .
[3] 005-93 (. 30.12.1993 301.

430

 .., .., .. -...

THE ANALYSIS OF THE PROBLEM OF THE REFERENCE

OF MEDICAL0COSMETIC PRODUCTION
ON THE EXAMPLE OF THE CHEMISTS
ORGANIZATIONS CITIES OF PERM
J.A. Razepina, E.V. Vihareva,
A.V. Suldin
Chair of pharmaceutical technology
Perm state pharmaceutical academy
Krupsky str., 46, Perm, Russia
The analysis of realisation of medical-cosmetic production in the chemist's organisations of Perm
has revealed a number of the problems connected with reference absence of classification on the commodity groups, insufficient level of knowledge of experts of the chemists organisations about properties
of the given goods that leads to decrease in a sales volume of medical-cosmetic production.
Key words: medical-cosmetic production, assortment, classification groups.




..


. , 11, , , 357538
- .
: , , .

(, , , , , , ) [1].
- . [2].
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:
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. , 5 95%. 2,5
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. -

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3%.
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433

 , , 2010, 4
2

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,

- .

[1] Cambell M., Young P.I., Smith J.M., Thomas S.H.L. The use of atypical antipsychotics in the
management of schiizophrenia // British Journal of Clinical Pharmacology. 2000. 6.
P. 432438.

434

 .. ...

[2] .., .. // -, - - : . - .-. ., .. .

., 2007. . 256258.

DEVELOPMENT SPECTROFOTOMETRIC
OF THE TECHNIQUE OF ANALYSIS RISPERIDON
IN TABLETS AND IT VALIDATION
I.P. Remezova
Faculty of toxicological chemistry
Pyatigorsk state pharmaceutical academy
Kalinin rosp., 11, Pyatigorsk, Russia, 357538
For development of the circuit of the toxicological analysis risperidon the technique of its definition in tablets is offered spectrofotometric and carried out it validation.
Key words: atypical antipsychotics, spectrofotometric the analysis, risperidon.




..



, 8/5, , , 113093
,
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, . .
(7090 )

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437

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2006
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438

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II III ;
V (96 ..) .
, ,

.

[1] .. //

. 2008. 44. 83 .
[2] .. XXI //
. .: , 2008. . 1. . 11.
[3] .. . : . .: , 2000. 343 .

ENDOECOLOGY AS PART OF THE TEACHING

OF HUMAN ECOLOGY FOR STUDENTS
ENVIRONMENTAL SPECIALTIES
O.M. Rodionova
Department of Human Ecology
Ecological Faculty
Russian Peoples Friendship University
Podolskoye shosse, 8/5, Moscow, Russia, 113093
The problems of teaching human ecology and the foundations Endoecology the science of the
internal environment of the body, students of environmental disciplines to equip future professionals,
ecologists, the concept of the continuity of the mutual influence of man and his environment, and instill
in them a professional responsibility for the environmental well-being.
Key words: human ecology, endoecology, environmental education




.. , ..


. , 106, , , 620049

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441

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45,5%
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, , , , ,
- ,
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.

[1] .. . : , 1991.
90 .
[2] .. : . ... . . . ., 2002. 196 .
[3] ..
: . ... . . . , 2002. 181 .

THE INCENTIVE MOTIVES

TO THE CONDUCTING A HEALTHY WAY
OF LIFE AMONG TEENAGERS
A.P. Sarapultsev, M.Y. Yakusheva
Laboratory of immunophatophysiology
Institute of Immunology and Physiology
Ural Division of Russian Academy of Sciences
Pervomayskaya str., 106, Ekaterinburg, Russia, 620049

L.A. Sarapultseva
Chair of life safety
Russian State Professional-Pedagogical University
Mashinostroiteley str., 12, Ekaterinburg, Russia, 620012
Research objective was the definition of main goals and incentive motives to conducting a healthy
way of life among pupils of graduation classes, taking into account their gender and a geographical arrangement of an educational institution.
Key words: healthy way of life, school, pupils, graduation classes.

442




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443

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[1] .. // 66- . .. . , 2007. . 401403.

[2] .., .. // . 2002. 8. URL: http://rudoctor.net/
medicine2009/bz-lw/med-zmdyk.htm
[3] .. // . 2004.
1. URL: http://www.provisor.com.ua/archive/2004/N1/art_30.php

DESIGNING OF ELECTRONIC TERMINOLOGICAL DICTIONARY

ON PHARMACEUTICAL CHEMISTRY
O.E. Sattarova
Chair of pharmaceutical chemistry of full-time department
he Perm state pharmaceutical academy
Polevaya str., 2, Perm, Russia, 614990
The electronic terminological dictionary on pharmaceutical chemistry was developed. The peculiarities of desinging of the dictionary and steps of its creation were explored. The electronic terminological dictionary was tested during academic competition on pharmaceutical chemistry. The created dictionary was admitted to use as an electronic educational resource on chair of pharmaceutical chemistry
of full-time department.
Key words: electronic terminological dictionary, pharmaceutical chemistry.

446


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THE DEVELOPMENT AND APPROBATION

OF EDUCATIONAL INFORMATION0METHODICAL COMPLEX
ON PHARMACEUTICAL CHEMISTRY AROMATIC AMINES,
AMINOACIDS AND THEIR DERIVATIVES
T.I. Yarygina, O.E. Sattarova
Chair of pharmaceutical chemistry of full-time department
Perm state pharmaceutical academy
Polevaya str., 2, Perm, Russia, 614990
The educational information-methodical complex on pharmaceutical chemistry Aromatic amines,
aminoacids and their derivatives was elaborated. The distance course with the use of educational information-methodical complex for full-time students was carried out. The results of the experiment on
conducting a distance course are described.
Key words: distance educational technologies, pharmaceutical chemistry, educational informationmethodical complex, distance course, aromatic amines, aminoacids, factor of mastering of knowledge.



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 .. .

[1] .., ..
: . . . II . ., 2008. . 35.
[2] .., .., . . // . . . 2006. 6. . 5354.
[3] .., .., .. .
: , // . 2004. 4. . 5154.
[4] .., .., .. . ,
: . , 2000. 18 .
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[9] .., .., .. . .
: - . . . ., 1997. 352 .

IMMUNOLOGICHESKY INFRINGEMENTS
AT CHILDREN DURING THE SHARP PERIOD OF BURN ILLNESS
S.P. Saharov, V.V. Ivanov, O.V.Ananeva
Tyumen state medical academy Roszdrava
Odessa str., 54, Tyumen, Russia, 625023

V.N. Ananev
Institute of medical and biologic problems
Russian Academy of Sciences
Horoshevsky highway, Moscow, Russia, 123007
The immunodeficiency of a cellular link of the immunity which expressiveness is in direct dependence on weight of a current of a burn shock and the area of the amazed surface of a body develops
in the sharp period of burn illness at children, that, or their combination as a result leads to sepsis and
pneumonia development. The indication in appointment immunoreplaceable an immunostimulating
therapy for preventive maintenance and treatment of infectious complications are children at the age
from 1 year till 3 years with a heavy burn shock and infringements in a cellular link of immune system.
Key words: burn illness, children, immunity.

455


,
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.

[1] .., .., ..

// . 2008. . 5. 1. . 27.
[2] .., .., .. . // . 2008. . 7.
1. . 1315.
[3] .. // . 2009. . 8. 3. . 8288.
[4] .., .., .. . . . .: ,
2009. . 47.

THE CHARACTERISTIC OF THE HOSPITAL REGISTER

OF CHILDREN WITH SPLENIA, LIVING IN THE ROSTOV REGION
AND THE ESTIMATION OF ITS ROLE IN THE PROPHYLACTIC
OF THE PNEUMOCOCCAL INFECTION
E.Y. Simonova
Regional Childrens Hospital
339 Shooting Divisions str., 14, Rostov-on-Don, Russia, 344015

E.V. Polevichenko
Department of pediatrics 1
Rostov State Medical University
339 Shooting Divisions str., 14, Rostov-on-Don, Russia, 344015
The characteristic of the hospital register of children with asplenia, living in the Rostov region is
presented. The differences in prophylectic of a pneumococcal infection at children of various clinical
groups have been established.
Key words: pneumococcal infection, asplenia, register.

.. , .. ,
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-

. , 85, , , 308015

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1. NSE.
2. : NSE , , .

[1] .. // : . , 2008. . 5.
[2] .., .. . .: , 2008. 788 .
[3] Kubesova H. Akutni stavi v geriatrii. Praha: Galen, 2009. S. 7.

460

 .. . ...

THE GENESIS OF POLYMORBIDITY IN ELDER FEMALE

& THE ROLE OF NEURONSPECIFIC ENOLASE
G.N. Sovenko, K.I. Prashchayeu,
M.A. Chizhova M.I. Churnosov
Department of Medical Biology
Belgorod State University
Pobedy str., 85, Belgorod, Russia, 308015

A.N. Ilnitski
Department of Medicak Rehabilitation
Polotsk State University
Blokhina str., 27, Polotsk, Russia, 211440
The problem of correlation between polymorbidity and neuronspecific enolase is presented in this
article.
Key words: neuronspecific enolase, elder, polymorbidity.



.. , ..


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, ..
, . ,
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- .

[1] .., .. . .: , 2006. 328 .

[2] .., .. . .: -, 1997. . 190.
[3] .., .. - // . 2005. 3.
. 1724.
[4] .., .. - // . . 2007. 6.
. 915.

464

 .., .. ...

REQIONAL PECULIARITY OF INFANTILE

AND PERINATAL MORTALITY
Z.M. Sultanaeva, N.Kh. Sharafutdinova
Departament of public health and the organization of health services
Bashkir state medical university
Lenin str., 3, Ufa, Russia, 450077
There are studying dynamics of parameters infantile and perinatal mortality in Republic Bashkortostan for 19982008. Decrease perinatal (on 57,9%) and infantile (on 43,5%) losses is caused first by
reduction of childrens death rate on the first week of life (on 69,0%). There are advancing growth early
neonatal in comparison with postnatal mortality and low rate of the loss mortality of children in the age
of about one year from the external reasons.
Key words: infantile and perinatal mortality, abortive, external reasons.




.. , ..


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466

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, . . ,
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, (p > 0,05). , ,

467

 , , 2010, 4

2,8 (p < 0,05), .

,
, .

[1] .. . .: -, 2007. 336 .

[2] .. // Consilium medicum. 2009. . 11. 11. . 6974.
[3] Buist A.S., McBurnie M.A., Vollmer W.M. et al. International variation in the prevalence of COPD
(the BOLD Study): a population-based prevalence study // Lancet. 2007. 370.
P. 741750.
[4] About ATC/DDD system. Oslo: World Health Organization Collaborating Center for Drug
Statistics Methodology. URL: http:// www.whocc.no/atcddd
[5] World Health Organization. Introduction to Drug Utilization Research. Oslo, Norway,
2003. P. 147.

PHARMACOEPIDEMIOLOGICAL TREATMENT ANALYSIS

OF THE CHRONIC OBSTRUCTIVE PULMONARY DISEASE
AND BRONCHIAL ASTHMA AT THE INPATIENTS DEPARTMENT
I.V. Tarasenko, V.A. Lopukhova
Department for clinical pharmacology and intensive therapy
Volgograd state medical university
Pavshikh Bortsov Sq., 1, Volgograd, Russia, 400131
The article presents analysis of the drug utilization review study of patients with chronic obstructive pulmonary disease and bronchial asthma at the inpatients department. As a result of the conducted
pharmacoepidemiological comparative analysis consumption tendencies in the most significant pharmacotherapeutic groups have been established. The received results allow to confirm indirectly the efficiency of standardization strategy in public health care.
Key words: chronic obstructive pulmonary disease, bronchial asthma, pharmacoepidemiology,
medications.



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469

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( 2269921) [1], .
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.
25- .

[1] .., .., ..

. 2269921 17.05.2004.
[2] Harms H. Schmangel als Unfallursache // Z. Verkehrssicherb. 1986. B. 32. 1.
S. 3636
[3] Mekuria Z.Z., Gurdulic-Sverko A., Klescic D. Povezanost nekih anomalija vida sa subjektivnim // Coviek i promet. 1988. V. 14. . 233233.
[4] Taylor J.F. Vision and driving // Ophthalm. and Physiol. Optics. 1987. V. 7. 2.
. 187189.

INFLUENCE OF COUNTER BRIGHT LIGHT

ON VISUAL ACUITY OF HEALTHY FACES
T.G. Tlupova
Course of eye illnesses
Medical faculty
Kabardino-Balkarian state university of H.M.Berbekov
Chernyshevsky str., 173, Nalchik, Russia, 360004
50 healthy drivers are surveyed. Absence of the central sight 15 second safter blinding 500 lux
and restoration visual to function only by 25 second at change of light exposure of tests (at 50 and 200 lux)
can lead to creation of heavy emergencies during twilight and night time.
Key words: visual acuity, light exposure.

470



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471

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[1] .. . .: , 1952. 192 .

[2] - .. . : , 1939. 554 .
[3] .., .., .. . // . . 1986. 6. . 7477.
[4] .. : - . 4 . .: , 1996. . 4. 352 .
[5] .., .. // . .
1986. 10. C. 7576.

ANALYSIS OF DIAGNOSIS ERRORS OF VISCERASYPHILIS

(according to the Smolensk region)
I.E. Torshina
Department of dermatology and ourse of cosmetology
Smolensk State Medical Academy
Krupskaya str., 28, Smolensk, Russia, 214019
The article presents data on the analysis of errors in the diagnosis of visceral syphilis and a description of the rare clinical cases from practice. Found that monitoring of cases of syphilis of internal organs
with involvement in the expert group of physicians of various specialties, can reduce the frequency of diagnostic errors in 12,3 times.
Key words: visceral syphilis, diagnostic errors.


.. , .. ,
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. , 2, , , 614990
. .
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476

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352 ., [16] . . .: .
[2] .. / .. , .. , .. , .. // / 15: :
. . 2: , , 29 5
2009 . , 2009. . 563569.

INNOVATIONS IN THE MEDICINAL

RESOURCE SCIENCE
A.Y. Turyshev, A.N. Sogrina,
A.B. Yakovlev, G.I. Oleshko
Chair of pharmacognosy
The Perm state pharmaceutical academy
Polevaya str., 2, Perm, Rusia, 614990
Herbs that only grow in specific environments, types of soil, and unique ecosystems are of particular interest for the development of geoinformational systems (GISs). We have developed an algorithm for the generation of GIS. This algorithm can be used for any herbs, including endangered species. Our geoinformational software can be applied to agrarian herb populations found in any region of
the world. The only requirement is a suitable topographic map.
Key words: pharmacognosy, medicinal plants, geoinformation system, GIS.




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. 9 , 5, , , 625016
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479

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STUDY OF FORMATION OF SPEECH BREATHING

IN PRESCHOOL0AGE CHILDREN
WITH SPEECH IRREGULARITIES
N.M. Fateeva, .. Posokhova
Tyumen State University
9 May str., 5, Tyumen, Russia, 625016
th

In this work the results of studying of speech breathing in preschool-age children with pseudobulbar
disartria were showed, with using of special breathing methods. The positive influence of speech breathing
formation was exposed, both as on the development of speech, and as on the child person in all.
Key words: speech therapy, speech breathing, pseudobulbar disartria.



..




. , 2, , , 614990

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484

 .., .., .. ...

[1] .. // . 2007. 5. URL: http://www.mosapteki.ru/modules/articles/article.php?id=684.

[2] .., .. :
// . 2007. 11. . 1417.

THE DEVELOPMENT OF ELECTRONIC CATALOGUE

OF IDENTITY RESPONSE OF PHARMACEUTICAL SUBSTANCE
O.E. Sattarova
Chair of pharmaceutical chemistry of full-time department
he Perm state pharmaceutical academy
Polevaya str., 2, Perm, Russia, 614990

L.. Chekryshkina, T.I. Yarygina

Chair of pharmaceutical chemistry of full-time department
he Perm state pharmaceutical academy
Polevaya str., 2, Perm, Russia, 614990
The electronic catalogue of identity response of pharmaceutical substances for pharmaceutistsanalysts of chemist's shops. During the classes of further vocational education students there was held
a management game with its use. The results acquired let us make a conclusion about advisability of using
electronic catalogue in practical activity of specialists, dealing in the sphere of quality control of pharmaceutical substances.
Key words: electronic catalogue, identity response, pharmaceutical substances, pharmaceutistanalyst.

0



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[1] .., .., .. . ,

// 2006. 2.
. 8587.
[2] Anand I.S. Pathogenesis of anemia in cardiorenal disease // Rev. Cardiovasc. Med. 2005.
Vol. 6 (Suppl. 3). P. S13S21.
[3] Silverberg D.S., Wexler D., Sheps D. et al. The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous
iron: a randomized controlled study // J. Am. Coll. Cardiol. 2001. Vol. 37.
P. 17751780.
[4] Silverberg D.S., Wexler D., Iaina A. The role of anemia in congestive heart failure and chronic
kidney insufficiency: the cardiorenal anemia syndrome // Perspect. Biol. Med. 2004.
Vol. 47. P. 575589.
[5] Tang Y.D., Katz S.D. Anemia in chronic heart failure. Prevalence, etiology, clinical correlates
and treatment options // Circulation. 2006. Vol. 113. P. 24542461.
[6] Wexler D., Silverberg D., Blum M. Anaemia as a contributor to morbidity and mortality in
congestive heart failure // Nephrol. Dial. Transplant. 2005. Vol. 20 (Suppl. 7).
P. 1115.

487

 , , 2010, 4

THE CLINICAL AND PATHOPFYSIOLOGIC BASIS

OF AMBULATORY MEDICAL AID FOR ELDER PATIENT
WITH CORONARY HEART DISEASE AND FE0DEFICITE ANEMIA
M.A. Chizhova, G.N. Sovenko,
I.S. Zakharova, T.V. Pavlova
Department of Pathology
Belgorod State University
Pobedy str., 85, Belgorod, Russia, 308015
The problem of correlation between coronary heart desease and Fe-deficite anemia is describe
in this article.
Key words: coronary heart disease, anemia, elder.



.. , ..

. . ..
. , 26, , , 614000

..

. . ..
. , 26, , , 614000

..

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. , 26, , , 614000
189
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: , , .

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: 189 , 1 2 : 20012003 . (131 )
20082009 . (58 ). : 51,9% 48,1%
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1617 (73%).
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489

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.
() (63,8%), (43,5%) ( = 0,016).
(63,8% ,
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5,2% , . (20,7%), [2]. ,
- .

(60,3%)
(29,0%, < 0,05). (48,3%)
: , , , ,
, 17,3%
10,3%.
(24,1%). , , .
,
65,5% (38/58) 62,6% (82/131), , 44,7% 63,4%, ( > 0,05). (21% 25,2%). , .
22,4% (13/58) . () 38,5% (5/13).
(76,9%)
. 16,7% (2/12)
4,6 .
20012003 . 32,1%, 18,3%. , , , .

(78,8%, 43/56), (63,4%, 18/28) . 60,5% (26/43) 39% (7/18) .

490

 .. .

51,2% (22/43) 22,2% (4/18) , 8,9% (5/56) 50% (2/4).

14,3% (8/56), 25% (7/28).

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71,4% (5/7) 22,2% (2/7).
25% (3/12), 11,2% (1/9).
- ,
, ,
59,1% , 45,6%
[3]. , (92,3%). Ig G
(> 1 : 600) 80,8% 96,2%, . 80,6% 34,3%, 58,2% 6%
(p < 0,05). , : ; (3208,4), 1,74
(1846,9, = 0,03).
, ,
, - . . .
.

1. , .
2.
.
3. .
4. ,
, -, , , .

[1] .. // . 2009. 1. . 34.

[2] .. : . .: , 2005. 432 .

491

 , , 2010, 4

[3] .. : . ... - .
. , 2004. 250 .
[4] .. ,
: . ... - . . ., 2009. 294 .

PULMONARY TUBERCULOSIS
IN ADOLESCENTS IN MODERN CONDITIONS
J.A. Shabalina, A.A. Shurygin
Department of Phthisiopulmonology
Perm State Academy of Medicine n.a. cad. E.A.Wagner
Petropavlovskaya str., 26, Perm, Russia, 614990

I.I. Lvova
Department of Children Infectious Diseases
Perm State Academy of Medicine n.a. cad. E.A.Wagner
Petropavlovskaya str., 26, Perm, Russia, 614990

A.A. Varankina
Department of Phthisiopulmonology
Perm State Academy of Medicine n.a. cad. E.A.Wagner
Petropavlovskaya str., 26, Perm, Russia, 614990
Comparative analysis of pulmonary tuberculosis peculiarities in 189 adolescents of Perm region
was carried out in 20012002 and 20082009. It was established that fluorography is the most efficient method of tuberculosis reveal. The most frequent clinical form is infiltrative tuberculosis on the
background of opportunistic infections activation with bacterial emission and growth of multiple drug
tolerance of tuberculosis agent.
Key words: tuberculosis, adolescents, opportunistic infections.

 0

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-
. , 95, , , 690022
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493

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;
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5 160 . . ,

495

 , , 2010, 4

.
[3].
.

[1] .., .., .., .., ..

//
. : ,
2008. . 128152.
[2] .. // .
2008. . 39. 4. . 313.
[3] 2321340 , 51 61 B 5/03.
/ .. , .. , .. ,
.. ; .. , .. . 2006124045/14; . 04.07.2006;
. 10.04.2008, . 10.

THE PRINCIPLES OF FUNCTIONAL TOPICAL DIAGNOSTICS

OF DISEASES OF INTERNALS
G.A. Shabanov, Yu.A. Lebedev, E.V. Pegova,
G.A. Merkulova, A.A. Rybchenko
Scientific Center Arktika, Far East Branch RAS
Kirova str., 95, Vladivostok, Russia, 690022
The article reveals the principles of Functional topical diagnostics of diseases of internals, based
on study of rhythmical activity of cerebrum. Segmental Matrix somatical frequency topical frame of
reference is being proposed. Principles of pathology centers reveal, and stages of inflammatory process
are being proposed.
Key words: new diagnostics methods, topical diagnostics.




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. 2013 . , , . 2013 50,0%.
: , , .

, 80- 90- 45% . 57,0%.

, ,
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, 2/3
[1, 4, 5].

.
.
. 12 , , - 20012008 . ,
2013 .
[5].
. (014 ) , 20012008 .
2158,4 3149,2 ( 45,9%), 2173,4 3479,5 ( 60,1%),
2087,5 3335,7 ( 59,8%) 100 .

497

 , , 2010, 4

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2013 . 3515,0 ( 2008 . 11,6%), 3725,1 ( 7,0%), 3917,7
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1

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2001

2158,4

2173,4

2087,5

4653,3

4909,8

4686,9

2002

2493,5

2488,9

2664,1

5125,7

5285,2

5535,9

2003

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2697,1

5269,0

5508,5

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2004

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2881,9

2798,9

5548,5

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2005

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2982,9

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6139,1

6086,6

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3598,4

5927,7

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2008

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3479,5

3335,7

5914,0

6615,8

6124,6

2009

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3556,4

3586,7

6077,1

6722,8

6528,8

2010

3344,0

3613,7

3678,6

6153,8

6834,3

6625,8

2011

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3659,1

3763,7

6224,0

6936,6

6714,8

2012

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3695,5

3843,1

6288,8

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2013

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3917,7

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12 4 .
, 20012008 . , . ( 14,8%)
( 25,9%).
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2008 . 12,3%, 28,3%.
(. 2).
.
,
. 20012008 . 4653,3
5914,0 100 . ( 27,0%), 4909,8 6615,8 ( 34,7%),
4686,9 6124,6 ( 30,7%).
,
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498

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100,0

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100,0

100,0

100,0

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, ( 3,5%).
2013 . 6349,0
( 2008 . 7,4%), 7119,8 ( 7,6%), 6873,7
( 12,2%) (. 1).
,
( 9,1%), ( 35,2%), ( 23,5%). ( 42,8%).
34,6%
23,6%. , 24,0% 26,2%, (20042005 .) 30,0%.
, 20012008 . .
. .

[1] .. // . .
2005. . 4. . 1014.
[2]
2004 . // . . 2006. 4. . 332.
[3] .. //
. 1994. 1. . 2628.
[4] .. - / .. , .. , .. [ .] // . 1997. 3. . 7075.
[5] .., .. - . .: , 2002. 266 .

499

 , , 2010, 4

EPIDEMIOLOGICAL ASPECTS OF ILLNESSES

OF URINOGENITAL SYSTEM AMONG CHILDREN
IN REPUBLIC OF BASHKORTOSTAN
M.A. Sharafutdinov
Faculty of public health and the organization of public health services
Bashkir state medical university
Lenin str., 3, Ufa, Russia, 450000
In article parameters of desease of children by illnesses of urinogenital systems in Republic of
Bashkortostan (RB) are analyzed. It is established, that growth of desease of children by illnesses of urinogenital systems both in the Russian Federation (RF), and in Privolzhskiy federal district (PFD) and
in RB is marked. The forecast of these parameters till 2013 is designed. It was found out, that in RB rate
of growth of desease is higher, than in the Russian Federation. The gain of desease by 2013 more, than
on 50,0% is expected.
Key words: children, illnesses of urinogenital system, desease.



.. , .. ,
..

. . ..
., 26, , , 614000
140 121 , 19. ,
() 0,52, .
: , , , .

140 : 81 () 40 ,
(I II ), 19
(III ). -
39 (32,2%) . 82 (67,8%) (48 (59,3%)
I 34 (85%) II)
(44 (36,4%)), 23 (19%), () 19 (15,7%) () 42 (34,7%) .
46 (56,1%), 36 (43,9%) .
44 (36,4%) 23 (19%) ( 18 (11,6%); 5 (4,1%)).
()
41,22 4,94 /, III 13,77 4,09 / ( < 0,05).
,
35 / [1, 2], 83,3%, 100%,
89,7%.
42 (50,0%) 84 10
III . 23 (27,4%) , 19 (22,6%) .
I, II III : 2,18 0,73,
2,87 0,94 2,49 1,52 / , .
, I II (), ( < 0,05)

501

 , , 2010, 4

.
I
II 1,20 0,54 / 1,18 1,10 / . 2,67 1,05 / 2,56 0,93 /
. ,
, :
(r = 0,655; = 0,01). ,
(), :
= / .
0,83 0,20 / ( < 0,05): I
0,66 0,15 / ( < 0,05), II 1,07 0,44 / ( < 0,05). III
0,20 0,06 / ( < 0,05). , 0,52, 64%, 100%,
94,1%.
, , 0,52 , ,
.

[1] .., .., .. .

// . 2002. 7. . 3236.
[2] .., .., A.M. . - // . 1995. 1. . 4142.

ANALYSIS OF DIAGNOSTIC METHODS

OF TUBERCULOUS EXUDATIVE PLEURISY
A.E. Shirinkina, L.V. Burukhina, A.A. Shurygin
Department of Phthisiopulmonology
Perm State Academy of Medicine n.a. cad. E.A.Wagner
Petropavlovskaya str., 26, Perm, Russia, 614000
Among 140 patients examined with reliable methods tuberculous exudative pleurisy was diagnosed
in 121 patients, nonspecific pleurisy in 19. Comparison of these methods, the study of bronhovesicular
fluid content and activity level of adenosine deaminase permitted to receive ADA () coefficient equal
to 0,52, testifying tuberculous etiology of pleurisy.
Key words: tuberculosis, pleurisy, diagnosis, adenosine deaminase.

502



.. , .. ,
..


. , 48, , , 614990
, , , .
: , .

, , , . (medical
gas) ,
,
. , GMP, .

, , ,
. -

GMP III. 52249-2004
, .
,
52249-2004, Rules Governing Medicinal Products in European Union. Volume 4. EU
Guidelines to Good Manufacturing Practice Medicinal Products for Human and Veterinary Use (, . 4.
),
, . 1. , , .

503

 , , 2010, 4
1
,

522492004
(cylinder) 
150 , 

(gas) , 
1,013 (101,325 ) 
15 
50
3 (300 ) 50
(ISO 10286: 1996 Gas cylinders Terminology.
Bilingual edition)
(area) , 

(container) , 
, , ,
, 

(cryogenic gas) ,
1,013 
150
(cryogenic vessel) 



(maximum theoretical residual
impurity) 


.
. 

,

(bulk gas) ,
,


(blowing down) 

(compressed gas) ,

50 (ISO
10286)
(liquified gas) ,

( ) 
50

504

(cylinder) , 

.

150 ( ). 


( )
(gas) , 

1,013 (101,325 ) 15
3 (300
) 50 (ISO 10286).

(area) ,


(container) ,
, , , 
, 

(cryogenic gas) , 

1,013 150
(cryogenic vessel)
1. ,

.
2.
,

.


(maximum theoretical residual impu
rity) ,



. 

,

(bulk gas)
, 
,

(blowing down)

(compressed gas) ,

50
(ISO 10286)
(liquified gas) ,

( ) 
50

 .., .., ..

522492004
(air separa
tion plant)
, ,
, , 
. ,
(tanker) ,

(air
separation plant)
(,
) 
, , ,

(tanker) , 


,
: (valve) (minimum pressure retention valve) , , ( 35 ).
(manifold), :
,
, ,
.
(purge),

, , , .
. ,
: ,
/ I2I. , , . .
,
. GMP
.

; . ,
. , , .
; -

505

 , , 2010, 4

.
, , ..
. ,
, .
, ,
,

. : ,
,
.

() . , ,
, , .
.
. , , .
, .
.

. ,
. .
, ,
. , ,
. , . , . , ,

506

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, . ,
, , , , . ,
, .
500 ppm (/)
200 .
. ,
. , , , , ,
,
.

[1] .., .., .. . : - .

-, 2008. 262 .
[2] 42-510-98 . 25 1998 .

THE ORGANIZATION OF MANUFACTURE

OF THE MEDICAL GASES IN RUSSIA
T.. Shmalko, .V. Swistova,
.I. Molohova
Chair of industrial technology with a biotechnology course
Perm state pharmaceutical academy
Lenins str., 48, Perm, Russia, 614990
For examination of a domestic production of medical gases terms, garmonyzed with the international standards, and a number of the actions preventing cross kontamination and of products are offered.
Key words: medical gases, manufacture.

507




.. , .. ,
..


. , 48, , , 614990
, , ,
. ,
, .
: , , .

.
, , , ,
(, ), (, ), (), (), (); (), (, ).

(), , , ; ,
, ; ; , ,
.
.

, .
.
. . , , ,
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. . , .
; -

508

 .., .., .. ...

;

[1]. , , , .
: 50%; 70%; 40
70%. 70%
, 40% 70% . 70%, 40% , 70%
, .
, , > 0,25 2 .

[2]. ,
8 ;
6 , 10 . .

.
, , , . . 1. ,
.
1

/
1
2
3
4
5

52,31
36,67
70,12
65,38
59,62

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34,44
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. , ,
.
,
, , .

509

 , , 2010, 4

; .
. ,
.
.

[1] .., .., .. . // . 2006. 5. . 3032.

[2] .. . .: , 1976. 202 .

EXPERIMENTAL SUBSTANTIATION
OF ALCOHOLIC EXTRACTS TECHNOLOGY
FROM THE SCROPHULARIACEAE FAMILY PLANTS
N.I. Shramm, L.K. Babiyan,
V.M. Petrichenko
Chair of botany
Perm state pharmaceutical academy
Lenin str., 48, Perm, Russia, 614990
The optimum preparation conditions of alcoholic extracts from Euphrasia, Melampyrum, Verbascum herbs providing the maximum yield of biologically active substances have been determined.
The technology of dry and liquid Euphrasia extracts, liquid Melampyrum extract, dry Verbascum
extract has been developed.
Key words: Euphrasia extract, Melampyrum extract, Verbascum extract.




..




..
. , 8, . 2, , , 119992
,
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511

 , , 2010, 4

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.
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- . , , , , - ,
.
,
, [3].

, . , .
,
43 , 5 10 ,
: , , ,
, , , , , ,
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, , , ,
,
, . ,
, ,
.
. . 1 , ,
.

512

 .. ...

. 1.

(83%) . (90%) (87%),

(63%), (63%), (63%). - (47%), 1/3
- (37%). 1/3 (27%); 1/4 (20%),
(20%), (20%), (13%).
, , , - (27%), - (20%), (13%). , ,
(50%)
. (47%) ,
, . 1/3 (27%) (23%). -

513

 , , 2010, 4

(20%).
(17%),
(13%). 3% , , , .
. 2 , .

. 2.

. 2,
(63%), (60%), (43%) 1/3 (37%) ().
(80%) , .
,
(67%)
(63%); (50%) (47%);
, .
, , ,
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, [1].

514

 .. ...

, , [4].
- . , .

, .. , .
[1]
[2]
[3]

[4]

[5]

.. : . .: , 1991.
.. . .: ,
2003 20 .
.., .., .. :
. .:
- . -, 2008. 160 .
.., .., ..
/ . . .. .
.: , 2009. 186 .
. . ., 1986.

POSSIBILITIES AND INTRODUCTION PROSPECTS

IN THE EDUCATION SYSTEM OF INTENSIVE
INTERACTIVE TECHNOLOGIES
R.V. Shurupova
Chair of pedagogics
Faculty of additional vocational training of teachers
Moscow state medical university of a name of I.M. Sechenov
Trubetskaya str., 8, bld. 2, Moscow, 199991
For the teacher of the higher medical school it is already not enough to be competent of area of
the speciality and to transfer the huge knowledge base in an audience, today he should know, how it is
better for understanding students this knowledge base to present. And though these new views are not
accepted by some teachers of the higher medical school, it is impossible to ignore the data of researches
which confirm that active methods of training the most effective [5]. It is necessary for teachers to
seize intensive interactive technologies of training purposefully: games, trainings, cases, game designing, creative technicians and many other receptions. All these listed modes of study develop base competence and metacompetence of the student, form skills necessary for a trade, create preconditions for
psychological readiness to introduce in real practice the mastered skills.
Key words: pedagogical activity, intensive interactive technologies of training, the factors interfering introduction of methods of active training.

515




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Asarum europaeum L. ().
, .
: , Asarum europaeum, , , , , , .

, [1]. (), , [2],

.
, , .
() , ,
.
()
, [3], , 70% .

: , , - , .
Agilent
1100 series () -
ChemStation. : Phenomenex Luna 5 C18(2), 5 , 2504,6; : 80% () , = 2,5 20% ()
(. 1).

516

 .., .. ...
1

, /

, /

0,17

9,3

0,18

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0,15

4,1

, : 68% () , = 2,5 32% () (. 2).

2

, /

, /

0,65

0,03

0,49

0,02

4,21

0,09

, . ,
(1,29%), (3,45%) (1,14%);
(103,7 /100 ), (102,9 /100 )
(48,5 /100 ); , . 14 (/, /): (0,07/5,3), (0,11/5,4),
(0,07/2,1), (0,03/3,6), (0,1/13,6), (0,42/69,9), (0,13/18,3), (0,41/12,5), (0,06/14,6), (0,15/14,9),
(0,08/12,8), (0,02/15,8), (0,06/7,5), (0,07/2,4).
, .
750
26,1 /, 0,52 /.
,
.

[1] .., .. . , //
. . 2009. 4. . 175180.
[2] / . .. . .: , 2006. . 140142.
[3] 42-2799-96. .

517

 , , 2010, 4

QUANTITATIVE DEFINITION OF THE BASIC CLASSES

OF BIOLOGICALLY ACTIVE SUBSTANCE FROM LEAVES
AND MATRIX TINCTURE OF ASARUM EUROPAEUM
BY HIGH0PERFORMANCE LIQUID CHROMATOGRAPHY
N.N. Tschurevitch, A.A. Markarian
Department of pharmacy with course social pharmacy
Moscow I. M. Sechenov medical academy
Skladochnaya str., h. 1/17, Moscow, Russia, 127018
The chemical analysis of leaves and matrix tincture from Asarum europaeum L. was studied by
high-performance liquid chromatography (HPLC). HPLC may be used for creation of modern unified
the methodic of quality assurance both raw materials of Asarum europaeum and homoeopathic preparations on its basis.
Key words: Asarum europaeum, HPLC, flavonoids, amino acids, carbohydrates, polyphenols,
homoeopathy.



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, , .
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(, , ) . ,
( , ). , , ,
.
.

[1] .., .., .. - . 15-

. ., 2005. 1006.
[2] .., .., .. - . 15-
. ., 2005. 1007.
[3] .., .. // . 1999.
4. . 8790.

QUESTIONS OF PREVENTIVE MAINTENANCE

POLLINOZY AT URBAN POPULATION
A.M. Jvgildina
Faculty of public health and the organization of public health services
Bashkir state medical university
Lenina str., 3, Ufa, Russia, 450000
Interrogation of the patients consisting on dispansers supervision at the doctor-allergist is lead. It
was found out, that only the third part of patients are informed on risk factors of pollinosis, their displays and preventive maintenance. However measures of the prevention of an aggravation of pollinosis
are carried out only by half interrogated.
Key words: patients, pollinos, preventive maintenance.

521


()
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[1] 42-2852-97. 4%.

[2] .., .., .. // 2167410, , . 03.08.1999. . .
. . 99116880; . 20.05.01; . 03.08.1999. 3 .
[3] .., .., .. // . 2009. 6. . 1618.

524

 .. ()

THE DEVELOPMENT OF THE TECHNOLOGY

OF QUANTITATIVE IDENTIFICATION OF TAUFONUM (TAURIN)
T.I. Yarygina
Chair of pharmaceutical chemistry of full-time department
Perm state pharmaceutical academy
Polevaya str., 2, Perm, Russia, 614990
There was developed and validated the technology of quantitative identification of 4% solution of
taufonum (taurin) with the use of spectrophotometric method of visible region based on reaction with
ninhydrin.
Key words: taurin, taufonum, spectrophotometry, ninhydrin, quality eveluation, validation.




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, ,
, .
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[1] .. . (, , ). .: , 1991. 496 .

[2] .., .. //
. . 1991. 4. . 68.

528

 .. ...

[3] .., ..
. .: , 1973. 320.
[4] .., .. //
. . .: , 1981. . 19. . 6585.

INFLUENCE OF BIOGEOCHEMICAL CONDITIONS

OF CHUVASHIA ON PREVALENCE
OF STOMATOLOGIC DISEASES
R.S. Matveev
Stomatologic chair
The Cheboksary state institute of improvement of doctors
Red Square, 3, Cheboksary, Russia, 418003
In article taking about the prevalence of the basic stomatologic diseases in the Chuvash Republic
into account age features and regional conditions of residing is considered.
Key words: tooth system, biogeochemistry.



.. , ..



. -, 8, , , 117198
, , .
.
: , , , .

.

[1]. [2].
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530

 .., ..

. , 50%
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,

531

 , , 2010, 4

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). 60
1- , ,
, ,
, , , ,
, ,
, , , ..
.
.
1- ; 2-
.

[1] .., .., .. . .: ,

1986. 172 .
[2] .. . / . .. . .:
, 2009. . 332338.

DISTURBANCES OF WILL IN ANOREXIA

NERVOZA PATIENTS
M.S. Artemieva, AR. Arseniev
Department of Psychiatry
Medical faculty
Peoples Friendship University of Russia
Miklukho-Maklaya str., 8, Moscow, Russia, 117198
This article is divided to the one of the main clinical futures, reason and outcomes of anorexia
nervosa pathology of will. Craving is describing as the form of will disturbances; also some other
types of will pathology were studied in anorexia nervosa patients. The difference of this symptoms were
revealed in anorexia nervosa and anorexia nervosa comorbid with schizophrenia.
Key words: anorexia nervosa, bulimia nervosa, craving, binge eating, vomitomania.

 0

..
,

. , 19, , , 355044

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535

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[1] .., .. : 4 . .,
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536

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[2] .. / . .. . .: , ,
2007. 192 .
[3] . ., 1992.
[4] - 2009 . , 2010. . 203.
[5]
2009 . , 2010.
. 719.

FUNCTION EKOLOGO0DEPENDENT DISEASES

AT CHILDREN IN STAVROPOL TERRITORY
D.M. Dementeva
Stavropol base medical college
Cyclic methodological commission special chief subject
Kulakova str., 19, ap. 20, Stavropol, 355044

S.M. Bezrodnova, O.O. Xoreva

Rostrum pediatrics DSPE
Pediatrics department supplementary and postdiploma education
Stavropol national medical academy
Kulakova str., 19, ap. 20, Stavropol, 355044
In work materials on small congenital developmental anomalies of children and their communication with ecological factors in Stavropol Territory are reflected.
Key words: small congenital developmental anomalies, Stavropol Territory.




.. , .. ,
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2
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. ,
. , , ,
.

[1] .. //
. 2009. 4. . 6064.
[2] .., .. : . ., 1999.

542

 .., .., .. ...

[3] .., .., . // i, ii, . 2006. 4. . 192193

[4] .., .., .., .., ..
- // . 2008. 3. . 312.

SEASONAL CHANGES OF SYSTOLIC

AND DIASTOLIC PRESSURE OF STUDENTS
AND TEACHERS OF RPFU
M.S. Zastrozhin, S.M. Chibisov,
R.K. Agarval
Department of the general pathology and pathological physiology
Peoples Friendship University of Russia
Miklukho-Maklaya str., 8, Moscow, Russia, 117198
Under the analysis of statistical data in experiments we try to understand and check how systolic
and diastolic pressure depends on seasons. The hypothesis was created that means there is a correlation
between season and systolic and diastolic pressure.
Key words: cardiovascular system, seasons, monitoring of AP, DP.

 0


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EXPERIENCE OF THE MEDICAL INFORMATION

SYSTEM ANTIBIOTIC IMPLEMENTATION
L.V. Daniliva, E.L. Borchuk
Chair Public health and health service
Orenburg Medical Academy
Soviet str., 6, Orenburg, Russia, 460000

S.B. Choloyan
Municipal childrens hospital
Kobozeva str., 25a, Orenburg, Russia, 460000
Scientific materials about medical information system Antibiotic have shown in this article. There
is description of this medical computer software, results of implementation program, her improvement,
plans for the future in this text.
Key words: informatization of health service, medical information system.

548

Cornlissen G. , (Ph.D, ,

),
, Biokoc ()
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BULLETIN
of Peoples Friendship
University of Russia
Scientific journal

Series
MEDICAL

2010, N 4

Managing editor T.O. Sergeeva

Editor T.O. Sergeeva
Computer design E.P. Dovgolevskaya
Address of the editorial board:
Peoples Friendship University of Russia
Ordzhonikidze str., 3, Moscow, Russia, 115419
Tel. +7 (495) 955-07-16
Address of the editorial board
Series Medical:
Miklukho-Maklaya str., 8, Moscow, Russia, 117198
l. +7 (495) 434-73-03 E-mail: rudnvestnik@yandex.ru
Printing run 500 copies
Address of PFUR publishing house
Ordzhonikidze str., 3, Moscow, 115419
Tel. +7 (495) 952-04-41