Schematic Diagram of the Pathophysiology of Toxic Shock Syndrome
Continued
Staph. Aureus Strep. Pyogenes Production of superantigen toxins and absorption into the systemic circulation Binding of Tcell receptor to MHC II Excessive Tcell proliferation and activation Proinflammatory mediators activation Activation of complement system Cytokines proliferation Activation of Coagulation system Binding to endothelial tissues Vasodilatation, increased vascular permeability Activation of clotting factors; decreased ATIII, protein C and S Endothelial damage Hypotension Microvascular thrombi; DIC Clot formation, thrombosis of small vessels, Decreased tissue perfusion
Pyrogenic effect on the hypothalamus Fever Chills
7
Continuation
Clot formation, thrombosis of small vessels, Decreased tissue perfusion
Brain Heart Skin Gastrointestinal Lungs Kidneys Liver Altered mental status, confusion, headaches, seizures Increased dead space Impaired gas exchange Hypoxemia Tachycardia Salt and water retention Decreased urine output Weakening of the intestinal wall barrier Bacterial/endooxin translocation Nausea, vomiting, diarrhea Damage to hepatocytes Increased liver enzymes, inability to excrete toxins Diffuse rash, desquamation Tachypnea Sepsis Increasd levels of ammonia Encephalopathy