Free radical scavenging ability and antioxidant

efficiency of curcumin and its substituted analogue.

M Khopde S, Priyadarsini KI, Venkatesan P, ao M!.
Radiation Chemistry and Chemical Dynamics Division, Bhabha Atomic Research
Centre, Trombay, Mumbai 400085, ndia.
!ree radical reactions o" curcumin and its etho#y substituted derivative $C%& %,'(
bis($4(hydro#y()(etho#y *henyl&(%,+(he*tadiene(),5(dione have been studied
usin, a *ulse radiolysis techni-ue in homo,eneous a-ueous(or,anic solutions li.e
acetonitrile(/ater and iso*ro*anol(/ater mi#tures, as /ell as in neutral T0(%00
and cationic CTAB micellar solutions. The *heno#yl radicals o" curcumin or C%
/ere ,enerated by one(electron trans"er to several o#idants li.e 1$)&$.&, Br$2&$(.&,
CCl$)&3$2&$.&, ,lutathione radicals /hich e#hibit absor*tion "rom a )00(+00(nm
/avelen,th re,ion /ith the ma#imum at 440(500 nm. 3ther im*ortant *ro*erties
o" the *heno#yl radicals such as e#tinction coe""icient, radical li"etime and their
"ormation and decay rate constants /ere also determined in these systems. The
antio#idant *ro*erty o" curcumin and C% /ere estimated in terms o" their ability
to inhibit the li*id *ero#idation in li*osomes and also in terms o" trolo#
e-uivalent antio#idant ca*acity $T5AC&. The results /ere com*ared /ith al*ha(
toco*herol.
6MD7 %'0)0)20 86ubMed9