The McCune-Albright syndrome consists of at least two

features of the triad of:

1

Polyostotic fibrous dysplasia.
Caf au lait skin pigmentation.
Autonomous endocrine hyperfunction (including precocious
puberty, thyrotoxicosis, pituitary gigantism and Cushing's
syndrome).
It was first described by Fuller Albright and Donovan
McCune in 1937.
Genetics
It is usually caused by mosaicism for a mutation in the Gs
alpha (GNAS1) gene. A mutation in the GNAS1 gene occurs
post-zygotically in a somatic cell. All cells descended from
the mutated cell can manifest features of McCune-Albright
syndrome.
2