Muscle Paralysis

Flaccid
Bacterium
C. Botulinum
Cleaves synaptobrevin
Neurotoxin
Guanidinium
Tetrodotoxin
Saxitoxin
Blocks Na+
voltage channels
Omega-conotoxin
Blocks presynaptic
Ca2+ channels
Drugs
AchR agonists
Succinylcholine
Broken down by
plasma/liver esterastes
Carbamylchole
Binds to AchR but does not
activate Na+ channels
Nictoine*
AchR antagonist
Curare
(d-tubocurarine)
Binds reversibly to AchR but does not
cause depolarization Alpha-Bungarotoxin
Binds irreversibly to AchR,
blocking Ach binding sites
Kappa-bungarotoxin
Inhibits AchR in
CNS preferentially
Rigid
Bacterium
C. Tetani
Inhibits GABA
Neurotoxin
Dendrotoxin
Blocks K+ channels
Drugs
Inhibit AchE
Physostigmine
DFP