Вы находитесь на странице: 1из 63

LOGO

-. , ,


,
Femina-health.org
044 272 10 72
2
() ,

,




1970 .

,
199 ,
23

80
,



()
.., .., .., .. . - . 2007; 1-
57. (.4)
.. . - - . . 2010; 1-94.
(.7,9,13)


Femina-health.org
044 272 10 72
3




.



.


.


(
).


.
.., .., .., .. . - . 2007;
1-57. (. 10)
Femina-health.org
044 272 10 72






-








[D.Dixon, G.P.Flake, A.B.Moore et al., 2002;
R.S.Baban, Al-Zuheiri, Y.Y.Farid, 2008]
Femina-health.org
044 272 10 72
5


-
();
;
.


, .

- ,
.








.., .., .., .. . - . 2007; 1-57.
(. 28)
.. . - - . . 2010; 1-94. (.
37-38)
Femina-health.org
044 272 10 72




(Klibanski et al, 2004)
,
! (Biller A. et al, 2006)




!!!


Colao A. et al., 2000

Femina-health.org
044 272 10 72


(Hedi Orbacha & Yehuda
Shoenfeld; 2007):
1)
,
2) ,
3) ,
4)
5) -1 -2 -
6) --2




;



,







-1




[D.Dixon, G.P.Flake, A.B.Moore et al., 2002;
R.S.Baban, Al-Zuheiri, Y.Y.Farid, 2008]
Femina-health.org
044 272 10 72


(/)
Femina-health.org
044 272 10 72
10

,

.

,
,
.

25-30%

.

.., .., .., .. . - . 2007; 1-57.
(. 12)
.. : . 10/1,
2007 (. 1)
Femina-health.org
044 272 10 72
#






#-














0 5
20


0 5


90




36-90


21


Femina-health.org
044 272 10 72


5 % ;
17 % ;
14 % ;

1,5%-26,7%

King A. et al.,2006
Femina-health.org
044 272 10 72


So-Young Shin et al., Characteristics of menstruation-related problems for adolescents and premarital women in Korea,
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2005, 121:236242
:
-
, Young Lady Clinic (YLC) Samsung
.
1280
:
646 ( 1020, I)
591 ( 2130, II)
Femina-health.org
044 272 10 72


, n = 646 (%) , n = 591 (%)
188 (29,1) 187 (31,6)
- 1,6% 62 (9,6) 32 (5,4)
- 8,8% 126 (19,5) 14,3% 155 (26,2)
7,7% 52 (8,0) 8,0% 50 (8,5)
140 (21,7) 192 (32,5)
- 117 (18,1) 89 (15,1)
- 23 (3,6) 103 (17,4)


3,4% 264 (40,9) 12,0% 158 (26,7)
2 (0,3) 4 (0,7)
78,0% 66,8%


So-Young Shin et al., Characteristics of menstruation-related problems for adolescents and premarital
women in Korea, European Journal of Obstetrics & Gynecology and Reproductive Biology, 2005,
121:236242

Femina-health.org
044 272 10 72
Nahid Eftekhari et al., The prevalence of hyperprolactinemia and galactorrhea in patients with abnormal
uterine bleeding, Gynecological Endocrinology, May 2008; 24(5): 289291


100
:
, ,
(
)
.
Femina-health.org
044 272 10 72
Nahid Eftekhari et al., The prevalence of hyperprolactinemia and galactorrhea in patients with abnormal
uterine bleeding, Gynecological Endocrinology, May 2008; 24(5): 289291

-

39%
61%



Femina-health.org
044 272 10 72
17



:

-


-
-


-




(-)
2 -



.., .., .., .. . - . 2007;
1-57. (. 8)
Femina-health.org
044 272 10 72
18


-
.
().



,
.


1 2.

1- (
), 2-
(
).
.., .., .., .. . - . 2007;
1-57. (. 7-8)
Femina-health.org
044 272 10 72








+
+
-
- -
-
-
-
-
+
-
+
Femina-health.org
044 272 10 72


-




b-
, ,

Femina-health.org
044 272 10 72






,









Femina-health.org
044 272 10 72































, ,
,







.. 2007
Femina-health.org
044 272 10 72
-
,




.
Femina-health.org
044 272 10 72
1/3










Femina-health.org
044 272 10 72
,




,








Femina-health.org
044 272 10 72

()
()

()

Femina-health.org
044 272 10 72
27




( )


.., .., .., .. . - .
2007; 1-57. (. 14)
Femina-health.org
044 272 10 72


:
-
--
()
()

()
()

-
- ()

()
(, b-
,
)


27-
--

II



:
-
()
()
- ()
, --
- ()




Femina-health.org
044 272 10 72
29
,

( )
,


( .. )
( )


( 7-10 )
3-4
(2-3 )
,
.., .., .., .. . - .
2007; 1-57. (. 15)
.. . - - . . 2010; 1-
94. (. 11-12)
Femina-health.org
044 272 10 72

Jet lag
,


.
S.S.Yen, R.B.Jaffe, 1999
11 21
.
Femina-health.org
044 272 10 72









#










Femina-health.org
044 272 10 72



a-




















:
(,
.)

( .)

( .)

(, )


:
(, ,
, ,
, )




Femina-health.org
044 272 10 72



Femina-health.org
044 272 10 72



()

()

!
.
,
.
!
Femina-health.org
044 272 10 72


( (?),
, )









, 6

Femina-health.org
044 272 10 72

10 %
.

30% .
Femina-health.org
044 272 10 72




(Elms AF 2012),

(R. W. Turkington 1971), -

.
!
.
Femina-health.org
044 272 10 72

:

.


.


.

-
.
.. : .
10/1, 2007 (. 1)
38
Femina-health.org
044 272 10 72


(
).

.
25/
1/=21,2/
, (
).



S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of
Hyperprolactinemia: Endocr Society Clinical Practice Guideline
Femina-health.org
044 272 10 72
:

(
).
big-big-
.
big-big-
, .
, 40%
.
20%, /-
45%, 20%.
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of
Hyperprolactinemia: Endocr Society Clinical Practice Guideline
Femina-health.org
044 272 10 72
:hook-effect
:
,
-
= .
.
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of
Hyperprolactinemia: Endocr Society Clinical Practice Guideline
Femina-health.org
044 272 10 72
500/

250/
( 10
)
200/




,

,



S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of
Hyperprolactinemia: Endocr Society Clinical Practice Guideline
Femina-health.org
044 272 10 72

,
:



( , )




,
.
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of
Hyperprolactinemia: Endocr Society Clinical Practice Guideline
Femina-health.org
044 272 10 72

, .


:
-
- , 4
- , /

- , , ,
- 1


( ,
,

,
)!!!
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of
Hyperprolactinemia: Endocr Society Clinical Practice Guideline
Femina-health.org
044 272 10 72
:
(
)
(), - + ,
+
.


();
.


( L-).

()
.

-
( ).
, ,
,
.

, .
.

2 5

( ) - 67%
(Colao A, N. Engl. J. Med. 2003).

, .
.
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of
Hyperprolactinemia: Endocr Society Clinical Practice Guideline
Femina-health.org
044 272 10 72
-

D2


250 2


Femina-health.org
044 272 10 72



:
- 4
0,5 (1 ) 2
( 1/2 )


0,5

.


:
,

.
Femina-health.org
044 272 10 72

1
.
1 , 1 .
,


( , ) 3
.

.

,

, .
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of
Hyperprolactinemia: Endocr Society Clinical Practice Guideline
Femina-health.org
044 272 10 72


2

.

=26-69% Biswas M, 2005.Clin Endocrinol (Oxf) 63:2631 ;Kharlip J 2009 J Clin Endocrinol Metab
94:24282436


.
28%



- 3
, .
- - .

S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of
Hyperprolactinemia: Endocr Society Clinical Practice Guideline
Femina-health.org
044 272 10 72



10%
25%, 80%

S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of
Hyperprolactinemia: Endocr Society Clinical Practice Guideline
Femina-health.org
044 272 10 72


7 50%
.
,
,
, .
(
50 ) ,
.
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of
Hyperprolactinemia: Endocr Society Clinical Practice Guideline
Femina-health.org
044 272 10 72
???

- 9-
, -, , 2005


-
,
, 2011
Femina-health.org
044 272 10 72



( 2014),

.
Femina-health.org
044 272 10 72


,
.

,
,



(Human reproduction.Vol. 22, No 12 pp 3210-3214, 2007)
Femina-health.org
044 272 10 72
Preventing ovarian
hyperstimulation syndrome:
guidance for the clinician. Fertil Steril
2010 :
, , RCT
(OHSS)
OHSS


OHSS :


, (,
)

:

.
P Humaidan et al. Preventing ovarian hyperstimulation syndrome:
guidance for the clinician . Fertil Steril 2010;94:389400
Femina-health.org
044 272 10 72


OHSS

-
(Gomez et al., 2006);
2-
(Alvarez et al., 2007a).
OHSS
:
0,5 / 3- , 1- oocyte
retrieval (Carriza et al., 2008 )
0,5 8 (Alveizer et al., 2007)
0,5 , 2- , 1
, (Salah Edeen et al., 2009);
0,25 8 (Shaltout et al., 2009).
20-
OHSS oocyte retrieval
10
24-48 1
48 (Manno et al., 2005).
Femina-health.org
044 272 10 72
OHSS

OHSS

,


OHSS,
.

:


OHSS.



,



.
Femina-health.org
044 272 10 72



!

.

,

! .

S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of
Hyperprolactinemia: Endocr Society Clinical Practice Guideline
Femina-health.org
044 272 10 72
Results of a Single-Center Observational 10-Year Survey Study on
Recurrence of Hyperprolactinemia after Pregnancy and Lactation
R. S. Auriemma, et al. Endocrine Research 2013
10


:
: 19972008, 143 91
( 30.4 4.7 , 76 , 10
). 6 ..
: 13 (9.1%) , 126 (88.1%)
. . 29 91
(3 ), 6
- , 68%
60 .
. 35 (38.5%) 2 ,
56 (61.5%) 2 6 . %
.
:
.
68%.
.
Femina-health.org
044 272 10 72


Femina-health.org
044 272 10 72



:
- (,
)
- .
- ,

, .

().

.

( ) .

.
,
,
.
.
Femina-health.org
044 272 10 72
LOGO
!
Femina-health.org
044 272 10 72

Вам также может понравиться