Predisposing factors

*non-modifiable
History of rheumatic fever
Age (44-64y/o)
*modifiable
Living in crowded place
Poor hygiene

Etiology
Group a beta Hemolytic
streptococcus

Invasion of GABHS in the body

Activation of immune system response

Activation of neutrophils
and macrophages

Circulating antibodies (neutrophils & macrophages) in the lymph, blood and connective tissues

Find its way to the hearts connective tissues that have antigens as the GABHS strain

Autoimmune response in which plasma B cells produces an anti-M

protein against M-protein of GABHS

Destruction of the heart valves

Shortening and fibrous scarring of the valves

Valvular stenosis (mitral

valves)

Impedance of blood flow

Incomplete emptying of blood in the left atrium