1.

2.
3.
4.
5.

Steps:
Melting the base
Incorporating required medicaments
Pouring into molds
Allowing to cool and congeal
Removing from mold

- Cocoa Butter, Glycerinated gelatin,

Polyethylene Glycol

- Molds are commonly made out of Stainless

steel, Aluminum, Brass or Plastic

Seldom necessary for bases such as Coca butter

and Polyethylene Glycol
For Glycerinated gelatin, thin layer of mineral
oil is necessary
NO material Irritating to mucous membrane
should be used as mold lubricant

Preparation of molded suppositories from

base alone
2. After removal from mold, weighed and the
total weight and average for each is recorded
For volume:
1. Carefully melted in a calibrated beaker
2. Volume of melt is determined for total number
and average for each suppository
1.

Total volume of mold Volume of drug

substance = Volume of base required

Because bases are solid at room temperature,

volume of base may be converted to weight
from the density of material

Weigh the active ingredient for a single

suppository
2. Dissolve with a portion of melted base
insufficient to fill one cavity of mold
3. Add additional melted base to the cavity to fill
it completely
4. Allow to congeal and harden
5. Remove from mold and weigh
Weight of suppository Weight of active
ingredients = Weight of base x Number of supp.
1.

Place all required medicaments for the total

number of suppositories (including one extra)
in a calibrated beaker
Add a portion of melted and incorporate drug
substance
Add sufficient melted base to reach the
required volume of mixture on the original
calibration of the volume of mold