AMLODIPINE (Norvasc)

Classification: Calcium Channel Blockers/Anti-Hypertensives

Indications: used for managing Hypertension and Angina Pectoris
Mechanism of Action: Alters the movement of calcium into the myocardial and vascular muscle cells
which leads to alteration of excitation-contraction coupling and subsequent contraction.
Therapeutic Effects: Vasodilation which leads to decreased blood pressure.
Contraindication/s: if the systolic BP reading is less than 90 mmHg
Side Effects: Headache, peripheral edema, hypotension, angina, palpitation
Interactions: NSAIDS decrease efficiency of Amlodipine; if taken with other anti-hypertensive drugs the
client show signs of Hypotension
Nursing Responsibilities:
>Closely monitor vital signs especially BP, Pulse Rate and ECG before and after administration.
>Accurate monitoring of I&O
>Provide health teachings to client (Orthostatic hypotension, compliance to medication therapy,
signs and symptoms of hypotension, signs of angina, etc.)

ESOMEPRAZOLE (Nexium)
Classifications: Proton-Pump Inhibitors, Antiulcer Agents
Indications: GERD/Erosive Esophagitis
Mechanism of Action: Attaches to parietal cells to block the transport (final step) of Hydrogen into the
gastric lumen.
Therapeutic Effects: Decreased amount of gastric acids.
Contraindications: If the client is with known hypersensitivity to proton pump inhibitors
> Use cautiously with hepatic dysfunction, pregnancy and lactation
Side Effects: Abdominal pain, dry mouth, diarrhea
Interactions: Increased serum levels and potential increase in toxicity of benzodiazepines and phenytoin
when taken concurrently.
> May interfere with absorption of drugs dependent upon presence of acidic environment (e.g.
ketoconazole, iron salts, digoxin)
Nursing Responsibilities:
>Ask client frequently if he/she is experiencing pain around the abdomen or epigastric area.

>Give drug 1 hour before meals.

>Observe clients stool, emesis and gastric aspirate.
>Monitor labs especially liver function test in order to determine the effects of the medications
>Monitor electrolytes since this drug can alter the levels of some electrolytes.