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BPS Oncology Pharmacy Practice Exam

After reading each question, use the radio buttons provided to select your answer. When
finished, click the Score Test button to submit your answers. Your results will be tabulated
and questions that you missed will be displayed with your answer and, if necessary, the
correct answer.
1. On day 14 after allogeneic stem cell transplant, the patient complains of right-upper-
quadrant pain. He has gained 10 kg over the past 3 days. The preparative regimen for
his AML was cyclophosphamide and busulfan. What is the most likely cause of the
pain?
A. Cytomegalovirus hepatitis
B. Graft-versus-host disease
C. Veno-occlusive liver disease
D. Acute cholecystitis

2. A 50-year-old male presents to the emergency department with a temperature of


39.4°C, severe hypotension, and chills. The patient has a history of hypertension,
diabetes, and coronary artery disease. He received paclitaxel and carboplatin 9 days
ago for non-small-cell lung cancer. His absolute neutrophil count is 56 cells/mm³.
Which of the following interventions would be most appropriate for this patient?
A. Cefepime
B. Imipenem and filgrastim
C. Ceftriaxone and filgrastim
D. Ciprofloxacin and aztreonam

3. Which of the following chemotherapy agents has been associated with severe
extravasation injury?
A. Bleomycin
B. Cyclophosphamide
C. Methotrexate
D. Vincristine

4. A 68-year-old female has been recently diagnosed with stage IV breast cancer. Her
tumor is found to be estrogen-and progesterone-receptor positive. Which of the
following is recommended for initial hormonal management?
A. Anastrozole 1 mg PO q.d.
B. Aminoglutethimide 250 mg PO q.i.d.
C. Tamoxifen 40 mg PO b.i.d.
D. Exemestane 25 mg PO q.d.

5. Which of the following is the most appropriate treatment for Helicobacter pylori -
associated low- grade lymphoma of mucosa-associated lymphoid tissue (MALT)?
A. Omeprazole, amoxicillin, DICE
B. ProMACE cytaBOM
C. Omeprazole, amoxicillin, clarithromycin
D. CHOP, rituximab

6. Which of the following combination chemotherapy regimens is considered first-line


treatment for adults with acute nonlymphocytic leukemia?
A. Mitoxantrone and cytarabine
B. Cytarabine and doxorubicin
C. Mitoxantrone and daunorubicin
D. Cytarabine and daunorubicin

7. Questions 7 and 8 refer to the same patient. S.I. is a 65-year-old female with metatstic
colon cancer. Her treatment plan includes irinotecan,leucovorin, and flourouracil
(IFL). You have been asked to discuss potential side efects and management of them
with her. Which of the following describes the proper management plan for diarrhea
that occurs greater than 24 hours after treatment?
A. Take two atropine tablets at the onset of diarrhea and then repeat
after each loose bowel movement. Continue taking atropine tablets
on this schedule until you are diarrhea free for 12 hours.
B. Drink at least eight 8-oz. glasses of water a day to prevent
dehydration. If symptoms persist for more than 48 hours, call your
physician.
C. Take two loperamide capsules at the onset of diarrhea and then take
one capsule every two hours. Continue taking loperamide on this
schedule until you are diarrhea free for 12 hours.
D. Take two diphenoxylate/atropine tablets at the onset of diarrhea and
then take two tablets after each loose bowel movement. Continue
taking diphenoxylate/atropine tablets every 4 hours until you are
diarrhea free for 12 hours.
8. On day 18 of her treatment course she calls complaining of severe mouth pain and
dizziness. When she arrives at the clinic, she reports that she has been unable to eat or
drink for the past 2 days and for two days prior to that her intake was minimal. Lab
values are as follows: Na 136, K 4.3, CO2 27, C1 102, BUN 34, SCr 1.8, WBC
1800/mm³, Hgb 10.5, Hct 37, Plt 90/mm³, neutrophils (%) 42, lymphocytes (%) 45,
monocytes(%) 12, eosinophils (%) 0.7, basophils (%) 0.3. The fellow asks you if you
think it is going to be necessary to adjust the patient’s next cycle of chemotherapy.
Which of the following represents the most appropriate dosing recommendation to
make at this time?
A. This patient is not going to be able to tolerate further treatment with
chemotherapy. She should be enrolled into an investigational
protocol or receive symptomatic and supportive care.
B. Treatment will need to be delayed. When the patient fully recovers
from the treatment- related toxicities, reduced doses of flourouracil,
and irinotecan will be necessary.
C. Treatment will need to be delayed. When the patient fully recovers
from the treatment-related toxicities, reduced doses of irinotecan will
be necessary. Flourouracil and leucovorin can be resumed at the
original dose.
D. This patient is not going to be able to tolerate further treatment with
this regimen. She should be treated with only flourouracil and
leucovorin when she fully recovers from these treatment-related
toxicities.
9. Which of the following most accurately characterizes the neurotoxicity profile of
oxaliplatin?
A. Acute neurotoxicity can be triggered by exposure to cold
B. Acute neurotoxicity usually does not recur with further dosing.
C. Chronic neurotoxicity can be triggered by exposure to cold
D. Chronic neurotoxicity does not limit further treatment

10. With regard to treatment trials, the primary purpose of the informed consent process
is to provide:
A. information regarding the treatment and the financial costs
associated with trial participation.
B. liability coverage for the institution and the participating
investigators.
C. a contract between the investigator and a person participating in the
trial.
D. sufficient information for a potential subject to make a decision
about participating in a trial.
11. When an investigational drug is being studied in a phase II clinical trial which of the
following choices best characterizes the appropriate endpoints of the study?
A. Efficacy and dose limiting toxicity (DLT)
B. Pharmacokinetic and pharmacodynamic parameters
C. Response rate and safety
D. Overall survival or clinical benefit response

12. You have been asked to write a departmental policy to ensure that all thalidomide
capsules are dispensed consistent with the revised S.T.E.P.S. Program. Which of the
following accurately characterizes compliance with this program?
A. Subsequent prescriptions can only be filled if fewer than 7 days of
therapy remain from the previous prescription.
B. A prescription for thalidomide is valid and can be filled up to 14
days after it is written.
C. Up to a 2 month supply of thalidomide can be dispensed at one time
with no refills.
D. Capsules can be removed from the blister packs prior to dispensing
if the patient requests this.
13. A new physician joins the Oncology Division at your hospital. He has several
research protocols that involve the use of gene transfer products and he has submitted
these to the IRB for approval. You sit on the IRB and have concerns about the safety
and proper handling of these agents. Which of the following publications would
provide the best information about the dangers involved in handling these gene
transfer agents and precautions that should be taken to ensure the safety of those
preparing them?
A. CDC/NIH publication - Biosafety in Microbiological and
Biomedical Laboratories
B. ASHP Technical Assistance Bulletin on Handling Cytotoxic and
Hazardous Drugs
C. OSHA Technical Manual - Controlling Occupational Exposure to
Hazardous Drugs
D. JCAHO publication - Comprehensive Accreditation Manual for
Hospitals
14. It is recommended that patients who have had basal cell carcinoma of the skin or
those who are at high risk for skin cancer use a minimum sunblock of SPF:
A. 5.
B. 15.
C. 30.
D. 45.

15. You are participating in an annual patient education program sponsored by your
employer. You have been asked to help staff the booth focusing on current cancer
screening guidelines. A woman asks you about the latest recommendations for the
screening of gynecologic cancers. Which of the following statements accurately
represents the American Cancer Society (ACS) cervical cancer screening guidelines.
A. At age 30 or after, women who have a single normal or negative
cytology result can receive subsequent screening every three years.
B. All women of screening age should receive human papillomavirus
(HPV) DNA testing in conjunction with cytology smears.
C. Women should begin cervical cancer screening no later than age 21
or within 3 years of becoming sexually active, whichever occurs
first.
D. All women who are 70 years of age or older with an intact uterus no
longer require cervical cancer screening.

BPS Oncology Pharmacy Practice Exam Results


You answered 5 of 14 correctly, leaving 1 unanswered.
In the key below, correct answers are marked in green and incorrect answers are marked in
red.
If you did not answer a question, no answer is marked.
Continue Exam
Exit Exam
1. On day 14 after allogeneic stem cell transplant, the patient complains of right-upper-
quadrant pain. He has gained 10 kg over the past 3 days. The preparative regimen for
his AML was cyclophosphamide and busulfan. What is the most likely cause of the
pain?
A. Cytomegalovirus hepatitis
B. Graft-versus-host disease
C. Veno-occlusive liver disease
D. Acute cholecystitis
2. A 50-year-old male presents to the emergency department with a temperature of
39.4°C, severe hypotension, and chills. The patient has a history of hypertension,
diabetes, and coronary artery disease. He received paclitaxel and carboplatin 9 days
ago for non-small-cell lung cancer. His absolute neutrophil count is 56 cells/mm³.
Which of the following interventions would be most appropriate for this patient?
A. Cefepime
B. Imipenem and filgrastim
C. Ceftriaxone and filgrastim
D. Ciprofloxacin and aztreonam
3. Which of the following chemotherapy agents has been associated with severe
extravasation injury?
A. Bleomycin
B. Cyclophosphamide
C. Methotrexate
D. Vincristine
4. A 68-year-old female has been recently diagnosed with stage IV breast cancer. Her
tumor is found to be estrogen-and progesterone-receptor positive. Which of the
following is recommended for initial hormonal management?
A. Anastrozole 1 mg PO q.d.
B. Aminoglutethimide 250 mg PO q.i.d.
C. Tamoxifen 40 mg PO b.i.d.
D. Exemestane 25 mg PO q.d.
5. Which of the following is the most appropriate treatment for Helicobacter pylori -
associated low- grade lymphoma of mucosa-associated lymphoid tissue (MALT)?
A. Omeprazole, amoxicillin, DICE
B. ProMACE cytaBOM
C. Omeprazole, amoxicillin, clarithromycin
D. CHOP, rituximab
6. Which of the following combination chemotherapy regimens is considered first-line
treatment for adults with acute nonlymphocytic leukemia?
A. Mitoxantrone and cytarabine
B. Cytarabine and doxorubicin
C. Mitoxantrone and daunorubicin
D. Cytarabine and daunorubicin
7. Questions 7 and 8 refer to the same patient. S.I. is a 65-year-old female with metatstic
colon cancer. Her treatment plan includes irinotecan,leucovorin, and flourouracil
(IFL). You have been asked to discuss potential side efects and management of them
with her. Which of the following describes the proper management plan for diarrhea
that occurs greater than 24 hours after treatment?
A. Take two atropine tablets at the onset of diarrhea and then repeat
after each loose bowel movement. Continue taking atropine tablets
on this schedule until you are diarrhea free for 12 hours.
B. Drink at least eight 8-oz. glasses of water a day to prevent
dehydration. If symptoms persist for more than 48 hours, call
your physician.
C. Take two loperamide capsules at the onset of diarrhea and then take
one capsule every two hours. Continue taking loperamide on this
schedule until you are diarrhea free for 12 hours.
D. Take two diphenoxylate/atropine tablets at the onset of diarrhea and
then take two tablets after each loose bowel movement. Continue
taking diphenoxylate/atropine tablets every 4 hours until you are
diarrhea free for 12 hours.
8. On day 18 of her treatment course she calls complaining of severe mouth pain and
dizziness. When she arrives at the clinic, she reports that she has been unable to eat or
drink for the past 2 days and for two days prior to that her intake was minimal. Lab
values are as follows: Na 136, K 4.3, CO2 27, C1 102, BUN 34, SCr 1.8, WBC
1800/mm³, Hgb 10.5, Hct 37, Plt 90/mm³, neutrophils (%) 42, lymphocytes (%) 45,
monocytes(%) 12, eosinophils (%) 0.7, basophils (%) 0.3. The fellow asks you if you
think it is going to be necessary to adjust the patient’s next cycle of chemotherapy.
Which of the following represents the most appropriate dosing recommendation to
make at this time?
A. This patient is not going to be able to tolerate further treatment with
chemotherapy. She should be enrolled into an investigational
protocol or receive symptomatic and supportive care.
B. Treatment will need to be delayed. When the patient fully recovers
from the treatment- related toxicities, reduced doses of flourouracil,
and irinotecan will be necessary.
C. Treatment will need to be delayed. When the patient fully recovers
from the treatment-related toxicities, reduced doses of irinotecan will
be necessary. Flourouracil and leucovorin can be resumed at the
original dose.
D. This patient is not going to be able to tolerate further treatment
with this regimen. She should be treated with only flourouracil
and leucovorin when she fully recovers from these treatment-
related toxicities.
9. Which of the following most accurately characterizes the neurotoxicity profile of
oxaliplatin?
A. Acute neurotoxicity can be triggered by exposure to cold
B. Acute neurotoxicity usually does not recur with further dosing.
C. Chronic neurotoxicity can be triggered by exposure to cold
D. Chronic neurotoxicity does not limit further treatment
10. With regard to treatment trials, the primary purpose of the informed consent process
is to provide:
A. information regarding the treatment and the financial costs
associated with trial participation.
B. liability coverage for the institution and the participating
investigators.
C. a contract between the investigator and a person participating in the
trial.
D. sufficient information for a potential subject to make a decision
about participating in a trial.
11. When an investigational drug is being studied in a phase II clinical trial which of the
following choices best characterizes the appropriate endpoints of the study?
A. Efficacy and dose limiting toxicity (DLT)
B. Pharmacokinetic and pharmacodynamic parameters
C. Response rate and safety
D. Overall survival or clinical benefit response
12. You have been asked to write a departmental policy to ensure that all thalidomide
capsules are dispensed consistent with the revised S.T.E.P.S. Program. Which of the
following accurately characterizes compliance with this program?
A. Subsequent prescriptions can only be filled if fewer than 7 days of
therapy remain from the previous prescription.
B. A prescription for thalidomide is valid and can be filled up to 14
days after it is written.
C. Up to a 2 month supply of thalidomide can be dispensed at one time
with no refills.
D. Capsules can be removed from the blister packs prior to
dispensing if the patient requests this.
13. A new physician joins the Oncology Division at your hospital. He has several
research protocols that involve the use of gene transfer products and he has submitted
these to the IRB for approval. You sit on the IRB and have concerns about the safety
and proper handling of these agents. Which of the following publications would
provide the best information about the dangers involved in handling these gene
transfer agents and precautions that should be taken to ensure the safety of those
preparing them?
A. CDC/NIH publication - Biosafety in Microbiological and
Biomedical Laboratories
B. ASHP Technical Assistance Bulletin on Handling Cytotoxic and
Hazardous Drugs
C. OSHA Technical Manual - Controlling Occupational Exposure to
Hazardous Drugs
D. JCAHO publication - Comprehensive Accreditation Manual for
Hospitals
14. It is recommended that patients who have had basal cell carcinoma of the skin or
those who are at high risk for skin cancer use a minimum sunblock of SPF:
A. 5.
B. 15.
C. 30.
D. 45.
15. You are participating in an annual patient education program sponsored by your
employer. You have been asked to help staff the booth focusing on current cancer
screening guidelines. A woman asks you about the latest recommendations for the
screening of gynecologic cancers. Which of the following statements accurately
represents the American Cancer Society (ACS) cervical cancer screening guidelines.
A. At age 30 or after, women who have a single normal or negative
cytology result can receive subsequent screening every three years.
B. All women of screening age should receive human papillomavirus
(HPV) DNA testing in conjunction with cytology smears.
C. Women should begin cervical cancer screening no later than age
21 or within 3 years of becoming sexually active, whichever
occurs first.
D. All women who are 70 years of age or older with an intact uterus no
longer require cervical cancer screening.

BPS Oncology Pharmacy Practice Exam Results


You answered 5 of 14 correctly, leaving 1 unanswered.
In the key below, correct answers are marked in green and incorrect answers are marked in
red.
If you did not answer a question, no answer is marked.
Continue Exam
Exit Exam
1. On day 14 after allogeneic stem cell transplant, the patient complains of right-upper-
quadrant pain. He has gained 10 kg over the past 3 days. The preparative regimen for
his AML was cyclophosphamide and busulfan. What is the most likely cause of the
pain?
A. Cytomegalovirus hepatitis
B. Graft-versus-host disease
C. Veno-occlusive liver disease
D. Acute cholecystitis
2. A 50-year-old male presents to the emergency department with a temperature of
39.4°C, severe hypotension, and chills. The patient has a history of hypertension,
diabetes, and coronary artery disease. He received paclitaxel and carboplatin 9 days
ago for non-small-cell lung cancer. His absolute neutrophil count is 56 cells/mm³.
Which of the following interventions would be most appropriate for this patient?
A. Cefepime
B. Imipenem and filgrastim
C. Ceftriaxone and filgrastim
D. Ciprofloxacin and aztreonam
3. Which of the following chemotherapy agents has been associated with severe
extravasation injury?
A. Bleomycin
B. Cyclophosphamide
C. Methotrexate
D. Vincristine
4. A 68-year-old female has been recently diagnosed with stage IV breast cancer. Her
tumor is found to be estrogen-and progesterone-receptor positive. Which of the
following is recommended for initial hormonal management?
A. Anastrozole 1 mg PO q.d.
B. Aminoglutethimide 250 mg PO q.i.d.
C. Tamoxifen 40 mg PO b.i.d.
D. Exemestane 25 mg PO q.d.
5. Which of the following is the most appropriate treatment for Helicobacter pylori -
associated low- grade lymphoma of mucosa-associated lymphoid tissue (MALT)?
A. Omeprazole, amoxicillin, DICE
B. ProMACE cytaBOM
C. Omeprazole, amoxicillin, clarithromycin
D. CHOP, rituximab
6. Which of the following combination chemotherapy regimens is considered first-line
treatment for adults with acute nonlymphocytic leukemia?
A. Mitoxantrone and cytarabine
B. Cytarabine and doxorubicin
C. Mitoxantrone and daunorubicin
D. Cytarabine and daunorubicin
7. Questions 7 and 8 refer to the same patient. S.I. is a 65-year-old female with metatstic
colon cancer. Her treatment plan includes irinotecan,leucovorin, and flourouracil
(IFL). You have been asked to discuss potential side efects and management of them
with her. Which of the following describes the proper management plan for diarrhea
that occurs greater than 24 hours after treatment?
A. Take two atropine tablets at the onset of diarrhea and then repeat
after each loose bowel movement. Continue taking atropine tablets
on this schedule until you are diarrhea free for 12 hours.
B. Drink at least eight 8-oz. glasses of water a day to prevent
dehydration. If symptoms persist for more than 48 hours, call
your physician.
C. Take two loperamide capsules at the onset of diarrhea and then take
one capsule every two hours. Continue taking loperamide on this
schedule until you are diarrhea free for 12 hours.
D. Take two diphenoxylate/atropine tablets at the onset of diarrhea and
then take two tablets after each loose bowel movement. Continue
taking diphenoxylate/atropine tablets every 4 hours until you are
diarrhea free for 12 hours.
8. On day 18 of her treatment course she calls complaining of severe mouth pain and
dizziness. When she arrives at the clinic, she reports that she has been unable to eat or
drink for the past 2 days and for two days prior to that her intake was minimal. Lab
values are as follows: Na 136, K 4.3, CO2 27, C1 102, BUN 34, SCr 1.8, WBC
1800/mm³, Hgb 10.5, Hct 37, Plt 90/mm³, neutrophils (%) 42, lymphocytes (%) 45,
monocytes(%) 12, eosinophils (%) 0.7, basophils (%) 0.3. The fellow asks you if you
think it is going to be necessary to adjust the patient’s next cycle of chemotherapy.
Which of the following represents the most appropriate dosing recommendation to
make at this time?
A. This patient is not going to be able to tolerate further treatment with
chemotherapy. She should be enrolled into an investigational
protocol or receive symptomatic and supportive care.
B. Treatment will need to be delayed. When the patient fully recovers
from the treatment- related toxicities, reduced doses of flourouracil,
and irinotecan will be necessary.
C. Treatment will need to be delayed. When the patient fully recovers
from the treatment-related toxicities, reduced doses of irinotecan will
be necessary. Flourouracil and leucovorin can be resumed at the
original dose.
D. This patient is not going to be able to tolerate further treatment
with this regimen. She should be treated with only flourouracil
and leucovorin when she fully recovers from these treatment-
related toxicities.
9. Which of the following most accurately characterizes the neurotoxicity profile of
oxaliplatin?
A. Acute neurotoxicity can be triggered by exposure to cold
B. Acute neurotoxicity usually does not recur with further dosing.
C. Chronic neurotoxicity can be triggered by exposure to cold
D. Chronic neurotoxicity does not limit further treatment
10. With regard to treatment trials, the primary purpose of the informed consent process
is to provide:
A. information regarding the treatment and the financial costs
associated with trial participation.
B. liability coverage for the institution and the participating
investigators.
C. a contract between the investigator and a person participating in the
trial.
D. sufficient information for a potential subject to make a decision
about participating in a trial.
11. When an investigational drug is being studied in a phase II clinical trial which of the
following choices best characterizes the appropriate endpoints of the study?
A. Efficacy and dose limiting toxicity (DLT)
B. Pharmacokinetic and pharmacodynamic parameters
C. Response rate and safety
D. Overall survival or clinical benefit response
12. You have been asked to write a departmental policy to ensure that all thalidomide
capsules are dispensed consistent with the revised S.T.E.P.S. Program. Which of the
following accurately characterizes compliance with this program?
A. Subsequent prescriptions can only be filled if fewer than 7 days of
therapy remain from the previous prescription.
B. A prescription for thalidomide is valid and can be filled up to 14
days after it is written.
C. Up to a 2 month supply of thalidomide can be dispensed at one time
with no refills.
D. Capsules can be removed from the blister packs prior to
dispensing if the patient requests this.
13. A new physician joins the Oncology Division at your hospital. He has several
research protocols that involve the use of gene transfer products and he has submitted
these to the IRB for approval. You sit on the IRB and have concerns about the safety
and proper handling of these agents. Which of the following publications would
provide the best information about the dangers involved in handling these gene
transfer agents and precautions that should be taken to ensure the safety of those
preparing them?
A. CDC/NIH publication - Biosafety in Microbiological and
Biomedical Laboratories
B. ASHP Technical Assistance Bulletin on Handling Cytotoxic and
Hazardous Drugs
C. OSHA Technical Manual - Controlling Occupational Exposure to
Hazardous Drugs
D. JCAHO publication - Comprehensive Accreditation Manual for
Hospitals
14. It is recommended that patients who have had basal cell carcinoma of the skin or
those who are at high risk for skin cancer use a minimum sunblock of SPF:
A. 5.
B. 15.
C. 30.
D. 45.
15. You are participating in an annual patient education program sponsored by your
employer. You have been asked to help staff the booth focusing on current cancer
screening guidelines. A woman asks you about the latest recommendations for the
screening of gynecologic cancers. Which of the following statements accurately
represents the American Cancer Society (ACS) cervical cancer screening guidelines.
A. At age 30 or after, women who have a single normal or negative
cytology result can receive subsequent screening every three years.
B. All women of screening age should receive human papillomavirus
(HPV) DNA testing in conjunction with cytology smears.
C. Women should begin cervical cancer screening no later than age
21 or within 3 years of becoming sexually active, whichever
occurs first.
D. All women who are 70 years of age or older with an intact uterus no
longer require cervical cancer screening.