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Insulin
Aging
Resistance
Obesity
Is insulin resistance characteristic of aging
or does physical inactivity and obesity
underlie this aging effect?
Study Design
Younger Older
(24 - 47 yr) (60 - 75 yr)
Athletes 7 12
Normal
11 10
Sedentary
weight
Obese 15 15
Insulin sensitivity
“Hyperinsulinemic Euglycemic clamp”
200 100
150 75
100 50
50 25
Baseline
0 0
0 30 60 90 120 0 30 60 90 120
Time (min) Time (min)
Insulin sensitivity
0
0 30 60 90 120
Time (min)
Hepatic glucose production
“Stable isotope dilution”
14
12
Insulin Sensitivity (Rd)
10
0
Athletes Normal Weight Obese
Conclusions
• IR was not a feature of old age
• Obesity and Physical inactivity underlie
• Hepatic glucose was not a confound
• No mechanisms revealed
• Consistent with literature showing
improved IS with physical activity