Kriteria septik dan severe sepsis

Sepsis :
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Fever > 38,3oC

Hypothermia (core temperature < 36oC)
HR<90X/min
Tachypnea
Altered mental status
Significant oedem and positive fluid balance (>2oml/Kg over 24 hr)

Hyperglicemia (plasma glucose >140mg/Dl) in the absence of diabetes.

Inflammatory variable :
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Leukocytosis WBC >12000

Leukopenia, WBC<4000
Normal WBC Countwith greater than 10% immmature forms
Plasma reactive protein more than two so above the normal value
Plasma procalcitonin more than two so above the normal value

Hemodynamiic variable :
1. Arterial hypotension (SBP <90 mmHg, MAP < 70 mmHg)
Organ dysfunction variables :
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Arterisl hyposemia (PaO2/FiO2<300)

Acute oliguria (UO <0,5 ml/Kg/hr for at least 2 hours despite fluid resuscitation.
Creatinine increase >0,5 mg/Dl
Coagulation abnormality (INR>1,5 Oor Aptt>60s)
Ileus (absent bowel sound)
Thrombocytopenia (platelet count < 100.000)
Hioerbilirubinemia (plasma total bilirubin > 4mg/Dl)

Tissue perfusion variables :

1. Hyperlactatemia >1
2. Decrease capillary refill or motting