Вы находитесь на странице: 1из 6

3-, 4- 5-[4].

-
. ,
, , [3].
.
. ,

, .


( ) ,
,
.
67 (,
D ).
D- .
300 , 67 (300:67)
D. ,
D- , ,
, , .
(
) , .
,
,
(, ).
,
, , ,

. ,
,
,
. ,
,
. ,
,
,
.
.
.


, ,
,

.
, ,
[ 1606 ].
,

,
,
, . ,
L-,
,

,
.
,
.
,
, .
, ,
,
[ 1342 ].


:
1. ,
, () ,
;
2. , .
;
3. , ()
.


2005
[5]
[6].


,
.
.
, ,
.
. , 4-
, .

, ,
( ).
, :
, N- - .
, .
. ,
, .
14 , 21
25, .
,
,
.
, , , , .

,
.
.
, ,
,
(, ).


28 , 40 .
,
.
1 ,
. 90 %
I, II,III IV .


- (FACIT)
, - (beaded
filament forming)

,

I, II, III, V, XI, XXIV, XXVII


IX, XII, XIV, XVI, XIX, XX,
XXI, XXII
VI
IV, VIII, X
VII
XIII, XVII, XXIII, XXV/CLACP
XXVIII, XV, XVIII

,
[7][8]. , ,
, -. -
C1q , C1q , ,
, ,
, EMILIN. , ,
.

, , ,
,
. ,
.
.

II

III

IV

VI

VII
VIII

IX

X
XI



,
, ,
,
COL1A1 COL1A2 1(I)22(I), 1(I)3
,
,
, ,
,
.

II
, XI ,
COL2A1
1(II)3 + XI
, ,

,


,
COL3A1
1(III)3
,

COL4A1 COL4A2

1(IV)22(IV),
,
COL4A3 COL4A4
,

COL4A5 COL4A6

1(V)22(V),
,
COL5A1 COL5A2
1(V)2(V)3(V) + , ,
COL5A3

XI

,
COL6A1 COL6A2

1(VI)2(VI)3(VI
,
COL6A3 COL6A4

)

COL6A5 COL6A6

COL7A1
1(VII)3

COL8A1 COL8A2 1(VIII)2(VIII)


,

,
COL9A1 COL9A2 1(IX)2(IX)3(IX ,
,
COL9A3
)


COL10A1
1(X)3

II
COL11A1
1(XI)2(XI)1(II), ,
XI ,
COL11A2
1(XI)2(V)1(II)

XII

COL12A1

1(XII)3

XIII

COL13A1

1(XIII)3

XIV

COL14A1

1(IV)3

XV

COL15A1

1(XV)3

XVI

COL16A1

1(XVI)3

XVII

COL17A1

1(XVII)3

XVIII

COL18A1

1(XVIII)3

XIX

COL19A1

1(XIX)3

XX

COL20A1

1(XX)3

XXI

COL21A1

1(XXI)3

XXII

COL22A1

1(XXII)3

XXIII

COL23A1

1(XXIII)3

XXIV

COL24A1

1(XXIV)3

XXV

COL25A1

1(XXV)3

XXVI
XXVII
XXVIII

COL26A1=EMID
1(XXVI)3
2
COL27A1
1(XXVII)3
COL28A1
1(XXVIII)3



, , (
, ), - ( 14 ),
( , ,
), .
,
, , .
, ,
, - . - ,
, ,
,
.
,
(-, ),

, N- - ,
, , 6, C.
, ,
.
, ,
, , .
,
/ Gly
.
- ( ),
. -
-. ,
, ,
, .
, ,
.

1. Fibrillar collagen: the key to vertebrate evolution? A tale of molecular incest. BootHandford RP, Tuckwell DS. Bioessays. 2003 Feb;25(2):142-51.
2. Di Lullo, Gloria A. (2002). Mapping the Ligand-binding Sites and Disease-associated
Mutations on the Most Abundant Protein in the Human, Type I Collagen. J. Biol. Chem.
277 (6): 42234231. DOI:10.1074/jbc.M110709200. PMID 11704682.
3. (Tropocollagen) dic.academic.ru
4. XuMuK.ru
5. -- | | ? 25
2005 .
6. :
. 20.04.07
7. Franzke CW, Bruckner P, Bruckner-Tuderman L. Collagenous transmembrane proteins:
recent insights into biology and pathology. J Biol Chem. 2005 Feb 11;280(6):4005-8.
8. Hoppe HJ, Reid KB. Collectins--soluble proteins containing collagenous regions and
lectin domains--and their roles in innate immunity. Protein Sci. 1994 Aug;3(8):1143-58