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BIOSINTESIS PROTEIN
Oleh:
BAGIAN BIOKIMIA
FAKULTAS KEDOKTERAN UNS
2008
Structureofeucaryoticcells
lysosomes
nucleus
nucleolus
sEPR
cytoplasm
cellmembrane
mitochondria
rEPR(ribosomes)
centrosome
Golgi
Fungsiorganelasel
organelle
major functions
cell membrane
nucleus
nucleolus
centrosome
cytoplasm
mitochondria
ribosomes
lysosomes
rEPR
sEPR
Golgi
Structureofmammaliangenes
REGUL
ATION
STRUCTURE
I1
REGUL
ATION
E1
Eexons(coding)
Iintrons(noncoding)
I2
E2
E3
promoter
enhancer
silencer
cDNA(mRNA)
5UTR,codingregion,3UTR
nouncodingregionbetweenstartandstop
start(capsite)andstop(polyAtail)
DNA
E1
E2
transcription+capping
stop
E3
polyA
signal
termination
signals
CAP
premRNA
polyadenylation
AAAAAA
mRNA
splicing
start
AAAAA
stop
Jenis RNA
ribosomalRNA(rRNA)
5S,5.8S(160bp),18S(2000bp)and28S(5000bp)RNA
ribosomestructure
transferRNA(tRNA)
smallRNAspecieswithcharacteristicsecondarystructure
(anticodon,aminoacidbinding)
aminoacidtransfer
messengerRNA(mRNA)
matrixforproteinsynthesisattheribosome,different
length
translation
Struktur mRNA
gene
E1
I1
E2
I2
E3
3
PAS
premRNA
AUG
(start)
mRNA
splicingsites
PAS
CAP
5UTR
start
UGA
(stop)
TR
AAAAAAA
3UTR
stop
CAP
regulatoryparts
5UTR
start
codon
structuralpart
TR
3UTR AAAAA
stop
codon
Genetic code
degeneratedcode:
stop
stop
severaltripletscodeforoneaminoacid,
onlymethionine(start)hasjust1codon
stop
Bahasa
Bahasagen
gen
bersifat
bersifat
universal
universal
BIOSINTESIS PROTEIN
PERHATIKAN TEORI DOGMA SENTRAL, PRODUK AKHIR
TABEL KODON
thereareabout20proteinogenicaminoacids
I M UN O BLOTI N G
kDa
97,4 kDa
84,0 kDa
66,0 kDa
55,0 kDa
45,0 kDa
29,0 kDa
20,1 kDa
14,2 kDa
1
APLIKASI KLINIS
WESTERN BLOT UNTUK DIAGNOSIS
HIV
STRUKTUR PROTEIN
Acidic
Basic
Neutral
Hydrophobic
Hydrophilic
Electrostatic
Bioregulator( Hormon)
Biokatalisator ( Enzim )
Protein Transport: Hb, Alb,
Lipoprotein,Transferin
Protein Kontraktil: aktin dan miosin
Protein Struktural:
kolagen,tubulin,keratin,glikopr
Protein Pelindung: Ig, interferon,
perforin,IL
HEALTH
HEALTH is
is better
better
than
than WEALTH
WEALTH
Biomol:
Biomol:Dx
Dxdini,
dini,patogenesis,
patogenesis,
protein
proteinkandidat
kandidatvaksin
vaksindan
dantx
txgen
gen
TERIMA KASIH